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Adaptive 4D-Printed Vascular Stents With Low-Temperature-Activated and Intelligent Deployment（Published in Advanced Functional Materials, April, 2026）

Journal Title
/掲載ジャーナル名		 Advanced Functional Materials
Publication Year and Month
/掲載年月		 April, 2026
Paper Title
/論文タイトル		 Adaptive 4D-Printed Vascular Stents With Low-Temperature-Activated and Intelligent Deployment
DOI
/論文DOI		 10.1002/adfm.202521468
 Author of Waseda University
/本学の著者		 UMEZU, Shinjiro(Professor, Faculty of Science and Engineering, School of Creative Science and Engineering):Correspoinding Author
Related Websites
/関連Web		 –
Abstract
/抄録
The development of patient-specific, adaptively deployable vascular stents is crucial for advancing minimally invasive cardiovascular therapies. Here, we report the fabrication of microarchitected coronary artery stents via projection micro-stereolithography (PµSL) 4D printing using a polycaprolactone (PCL)-based shape memory polymer (SMP) composite. By incorporating diethyl phthalate (DEP) as a plasticizer, we precisely modulated the thermal transition temperature (Ttran) to about 37°C, enabling rapid and autonomous shape recovery under physiological conditions without external heating. The resulting stents exhibit a favorable balance between mechanical flexibility and strength. Finite element simulations validated the uniform stress distribution and structural robustness. A viscoelastic stress relaxation model confirmed the ability of the stents to dissipate internal stress over time, promoting long-term biomechanical compliance. In vitro studies demonstrated excellent cytocompatibility. In vivo implantation experiments in mice further confirmed the possibility of clinical application. Overall, this work provides a robust platform for adaptive vascular stents with programmable thermoresponsive behavior and intelligent deployment, offering significant potential for personalized treatment in anatomically complex vascular structures.
15 APRIL 2026
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