| Journal Title /掲載ジャーナル名 |
Geroscience |
| Publication Year and Month /掲載年月 |
April, 2023 |
| Paper Title /論文タイトル |
Moderate protein intake percentage in mice maintaining metabolic health during approach to old age |
| DOI /論文DOI |
10.1007/s11357-023-00797-3 |
| Author of Waseda University /本学の著者 |
KONDO, Yoshitaka(Assistant Professor, Faculty of Human Sciences):First Author |
| Related Websites /関連Web |
– |
| Abstract /抄録 |
Nutritional requirements for maintaining metabolic health may vary with each life stage, such as young, middle, and old age. To investigate the appropriate ratio of nutrients, particularly proteins, for maintaining metabolic health while approaching old age, young (6-month-old) and middle-aged (16-month-old) mice were fed isocaloric diets with varying protein percentages (5%, 15%, 25%, 35%, and 45% by calorie ratio) for two months. The low-protein diet developed mild fatty liver, with middle-aged mice showing more lipids than young mice, whereas the moderate-protein diet suppressed lipid contents and lowered the levels of blood glucose and lipids. Self-organizing map (SOM) analysis revealed that plasma amino acid profiles differed depending on age and difference in protein diet and were associated with hepatic triglyceride and cholesterol levels. Results indicate that the moderate protein intake percentages (25% and 35%) are required for maintaining metabolic health in middle-aged mice, which is similar to that in young mice. |
