| Journal Title /掲載ジャーナル名 |
Communications Biology |
| Publication Year and Month /掲載年月 |
June, 2023 |
| Paper Title /論文タイトル |
Transposons contribute to the acquisition of cell type-specific cis-elements in the brain |
| DOI /論文DOI |
10.1038/s42003-023-04989-7 |
| Author of Waseda University /本学の著者 |
HAMADA, Michiaki(Professor, Faculty of Science and Engineering, School of Advanced Science and Engineering):Correspoinding Author, Last Author |
| Related Websites /関連Web |
– |
| Abstract /抄録 |
Mammalian brains have evolved in stages over a long history to acquire higher functions. Recently, several transposable element (TE) families have been shown to evolve into cis-regulatory elements of brain-specific genes. However, it is not fully understood how TEs are important for gene regulatory networks. Here, we performed a single-cell level analysis using public data of scATAC-seq to discover TE-derived cis-elements that are important for specific cell types. Our results suggest that DNA elements derived from TEs, MER130 and MamRep434, can function as transcription factor-binding sites based on their internal motifs for Neurod2 and Lhx2, respectively, especially in glutamatergic neuronal progenitors. Furthermore, MER130- and MamRep434-derived cis-elements were amplified in the ancestors of Amniota and Eutheria, respectively. These results suggest that the acquisition of cis-elements with TEs occurred in different stages during evolution and may contribute to the acquisition of different functions or morphologies in the brain. |
