Research Activities早稲田大学 研究活動

Purpose

This study estimated an individual’s genetic liability to cardiometabolic risk factors by polygenic risk score (PRS) construction and examined whether high cardiorespiratory fitness (CRF) modifies the association between PRS and cardiometabolic risk factors.

Methods

This cross-sectional study enrolled 1,296 Japanese adults aged ≥40 years. The PRS for each cardiometabolic trait (blood lipids, glucose, hypertension, and obesity) was calculated using the LDpred2 and clumping and thresholding methods. Participants were divided into low-, intermediate-, and high-PRS groups according to PRS tertiles for each trait. CRF was quantified as peak oxygen uptake (VO₂peak) per kg body weight. Participants were divided into low-, intermediate-, and high-CRF groups according to the tertile VO₂peak value.

Results

Linear regression analysis revealed a significant interaction between PRS for triglyceride (PRS_TG) and CRF groups on serum TG levels regardless of the PRS calculation method, and attenuated the association between PRS_TG and TG levels in the high-CRF group. Logistic regression analysis revealed a significant sub-additive interaction between LDpred2 PRS_TG and CRF on the prevalence of high TG, indicating that high CRF attenuated the genetic predisposition to high TG. Furthermore, a significant sub-additive interaction between PRS for body mass index and CRF on obesity was detected regardless of the PRS calculation method. These significant interaction effects on high TG and obesity were diminished in the sensitivity analysis using VO₂peak per kg fat-free mass as the CRF index. Effects of PRSs for other cardiometabolic traits were not significantly attenuated in the high-CRF group regardless of PRS calculation methods.

Conclusions

The findings of the present study suggest that individuals with high CRF overcome the genetic predisposition to high TG levels and obesity.