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Measuring the heat production of a single cell? Solving the discrepancy between theoretical calculation and real-time measurements
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Measuring the heat production of a single cell? Solving the discrepancy between theoretical calculation and real-time measurements

Wed, Sep 2, 2015
Measuring the heat production of a single cell? Solving the discrepancy between theoretical calculation and real-time measurements
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A research team comprised of Researcher and Professor Madoka Suzuki (Organization for University Research Initiatives) and Shin’ichi Ishiwata (Faculty of Science and Engineering and WASEDA Bioscience Research Institute in Singapore (WABIOS)) presented their plans to resolve the “105 gap issue,” a topic of interest among the international science community concerning calculation and measurement in single-cell thermometry.

Scientists are conducting research on measuring methods of single cell temperatures as a way to understand the heat production of important cells in the human body. The “105 gap issue” refers to the difference between measured increases in single cell temperatures using cellular thermometry and theoretically calculated measurements.

The research team suspects that cell type, stimulation, measuring distance from the heat source, and special characteristics of cells can account for the “105 gap issue.” Investigating the validity of this conjecture will surely become an important topic in the field of cell heat production.

This research will reexamine the “temperature” parameter for cells from an entirely new perspective. Researchers expect it to lead to great physiological research achievements that will influence the medical field and the field of biology.

Nature Publishing Group’s online Science Journal Nature Methods published this research plan on August 28.
The 105 gap issue between calculation and measurement in single-cell thermometry


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