Name
SHIMURA, Daisuke
Degree
Ph.D. (Science)
HP (URL)
https://researchmap.jp/daisuke_shimura?lang=en
Status
Assistant Professor
Research Topic
A New Paradigm in Heart Disease Therapy: A Novel Strategy to Preserve Cellular Integrity and Function
The organ keeps working through our entire life, “Heart”. Its proper function relies on multiple factors such as the cytoskeleton, which governs contraction and relaxation, mitochondria that produce energy, the cell-cell communication, etc. These complicated cellular networks contribute to a wide array of causes and symptoms in pathological conditions.
Focusing on a special factor that can collectively control these complex intracellular networks aims to develop effective therapeutic strategies for multiple cardiovascular diseases and elucidate their underlying mechanisms.
Education and Academic Employment
Education
| 2011-2016 | Waseda University Graduate School of Advanced Science and Engineering Department of Life Science and Medical Bioscience (Ph.D course) |
| 2007-2011 | Waseda University School of Advanced Science and Engineering Department of Life Science and Medical Bioscience |
Academic Employment
| 2025-Present | Waseda Institute for Advanced Study (WIAS), Junior Associate Professor |
| 2023-2025 | Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Department of Periodontology Junior Associate Professor |
| 2022-2025 | University of Utah School of Medicine, Department of Surgery, Nora Eccles Harrison Cardiovascular Research and Training Institute Assistant Professor |
| 2021-2022 | The University of Utah Nora Eccles Harrison Cardiovascular Research and Training Institute Associate Instructor (Senior Project Leader) |
| 2019-2021 | The University of Utah Nora Eccles Harrison Cardiovascular Research and Training Institute Postdoctoral Fellow |
| 2017-2019 | Cedars-Sinai Medical Center Smidt Heart Institute Postdoctoral Scientist |
| 2016-2016 | Tokyo Women’s Medical University Institute of Advanced Biomedical Engineering and Science |
| 2013-2016 | Waseda University Graduate School of Advanced Science and Engineering |
Fields of Research Interests
GJA1-20k, Mitochondria, Ischemic diseases, Ischemia/Reperfusion Injury, Gap Junction, Arrythmia, Molecular Biology, Physiology
Academic Publications
- Baum R, Nguyen VD, Maalouf M, Shimura D, Waghalter M, Srapyan S, Jin Q, Kuzmanovich L, Gaffney AT, Bell BR, Xiao S, Palatinus JA, Kléber AG, Grintsevich EE, Hong T, Shaw RM. A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43. J Cell Biol. (2025), 224 (3): e202402112.
DOI: 10.1083/jcb.202402112 - Hoshina Y, Delic A, Wong KH, Lyden S, Kadish R, Smith TL, Wright MA, Shimura D, Clardy SL. Vasculitis in the Central Nervous System: Etiology, Characteristics, and Outcomes in a Large Single-Center Cohort. Neurohospitalist. (2024), 14(2), 129-139
DOI: 10.1177/19418744231223283 - Jin Q, Lee KY, Selimi Z, Shimura D, Wang E, Zimmerman JF, Shaw RM, Kucera JP, Parker KK, Saffitz JE, Kleber AG. Determinants of electrical propagation and propagation block in Arrhythmogenic cardiomyopathy. J Mol Cell Cardiol. (2024), 186, 71-80
DOI: 10.1016/j.yjmcc.2023.11.003 - Shimura D* and Shaw RM. Live-cell imaging and analysis of actin-mediated mitochondrial fission. STAR Protoc. (2023), 4(1), 101958, *Technical Corresponding Author
DOI: 10.1016/j.xpro.2022.101958 - Shimura D and Shaw RM. GJA1-20k and Mitochondrial Dynamics. [Review]. Front Physiol. (2022), 13, 867358.
DOI: 10.3389/fphys.2022.867358 - Shimura D, Hunter J, Katsumata M, Shaw RM. Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein. J Vis Exp. (2022), (181).
DOI: 10.3791/63405 - Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw RM. Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. eLife (2021), 10.
DOI: 10.7554/eLife.69207 - Xiao S*, Shimura D*, Baum R, Hernandez DM, Agvanian S, Nagaoka Y, Katsumata M, Lampe PD, Kleber AG, Hong T, Shaw RM. Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias. J Clin Invest. (2020), 130(9), 4858-4870.
*Co-First Author
DOI: 10.1172/JCI134682 - Sjoqvist S, Kasai Y, Shimura D, Ishikawa T, Ali N, Iwata T, Kanai N. Oral keratinocyte-derived exosomes regulate proliferation of fibroblasts and epithelial cells. Biochem Biophys Res Commun. (2019), 514(3), 706-712.
DOI: 10.1016/j.bbrc.2019.04.202 - Nakai G, Shimura D, Uesugi K, Kajimura I, Jiao Q, Kusakari Y, Soga T, Goda N, Minamisawa S. Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice. Heart Vessels. (2019), 34(3), 545-555.
DOI: 10.1007/s00380-018-1293-3 - Sjöqvist S, Ishikawa T, Shimura D, Kasai Y, Imafuku A, Bou-Ghannam S, Iwata T, Kanai N. Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing. J Extracell Vesicles. (2019), 8(1), 1565264.
DOI: 10.1080/20013078.2019.1565264 - Basheer WA, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez DM, Hitzeman TC, Hong T, Shaw RM. Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight. (2018), 3(20).
DOI: 10.1172/jci.insight.121900 - Lü P, Jiao Q, Shimura D, Kusakari Y, Liu F, Minamisawa S. Distinct Vascular Remodeling Pattern of Adult Rats with Carotid-Jugular Shunt. Ann Vasc Surg. (2018), 49, 168-178.
DOI: 10.1016/j.avsg.2017.12.011 - Kusakari Y, Urashima T, Shimura D, Amemiya E, Miyasaka G, Yokota S, Fujimoto Y, Akaike T, Inoue T, Minamisawa S. Impairment of Excitation-Contraction Coupling in Right Ventricular Hypertrophied Muscle with Fibrosis Induced by Pulmonary Artery Banding. PLoS One. (2017), 12(1), e0169564.
DOI: 10.1371/journal.pone.0169564 - Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S. Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats. PLoS One. (2016), 11(2), e0148666.
DOI: 10.1371/journal.pone.0148666 - Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. (2016), 310(1), H92-103.
DOI: 10.1152/ajpheart.00411.2015 - Shimura D, Nakai G, Jiao Q, Osanai K, Kashikura K, Endo K, Soga T, Goda N, Minamisawa S. Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart. Am J Physiol Heart Circ Physiol. (2013), 305(4), H494-505.
DOI: 10.1152/ajpheart.00867.2012
Other Interests
Karate, Swimming, Golf, Surfing, Fishing
Affiliated Academic Organizations
International Society for Heart Research
The Japanese Society of Mitochondrial Research and Medicine
The Japanese Circulation Society
American Heart Association
The Molecular Biology Society of Japan
The Physiological Society of Japan
Awards
2023 Grand Prize of oral presentation The Japanese Society of Mitochondrial Research and Medicine
2023 Star Research Achievement Award GJA1-20K REDUCES RESUSCITATION REQUIREMENTS AND RENAL INJURY POST-REBOA ISCHEMIA-REPERFUSION INJURY Critical Care Medicine
2023 Nominated Sigma-Xi full membership Sigma-Xi
2022 Abstract Presentation Award
2021 JSPS, Leading Initiative for Excellent Young Researchers (LEADER) nominated
2018 New Investigator Travel Award Basic Cardiovascular Sciences Scientific Sessions
2014 The best team presentation award, 6th-HOPE meeting
