Waseda Institute for Advanced Study (WIAS)Waseda University

Name

OTA, Eisuke

Degree

Ph.D. in Science

HP (URL)

http://www.jyamaguchi-lab.com/en/member/eisukeota

Status

Associate Professor

Research Topic

Visible Light Driven Transformations for Natural Resources

Natural resources often contain chemical structures found in medicinal and agrochemical agents. The technology to “cut and paste” these structures, which are difficult to construct through chemical synthesis, would contribute to shortening the synthetic process of medicinal and agrochemical agents. However, transformations targeting natural resources require highly chemoselective cleavage of stable bonds in the presence of diverse functional groups, making these types of transformations elusive. In this study, we aim to develop innovative photocatalytic reactions to transform natural resources using visible light. Achieving challenging bond cleavage reactions would not only advance synthetic organic chemistry but also contribute to the field of drug discovery by creating highly biologically active molecules.

Education and Academic Employment

Education

Academic Employment

Fields of Research Interests

Synthetic Organic Chemistry, Chemical Biology, Organic Photochemistry

Academic Publications

• Saito, A. N.; Ota, E.; Nakamichi, N.; Yamaguchi, J. “Development of Plant Circadian Clock Modulators”, J. Synth. Org. Chem. Jpn. 2023, 81, 718-730.
• Ota, E.; Takeda, D.; Oonuma, K.; Kato, M.; Matoba, H.; Yoritate, M.; Sodeoka, M.; Hirai, G. “Synthesis and Biological Activity of Ganglioside GM3 Analogues with a (S)-CHF-Sialoside Linkage and an Alkyne Tag” Glycoconj. J. 2023, 40, 333–341.
• Okita, T.; Aida, K.; Tanaka, K.; Ota, E.*; Yamaguchi, J.* “Chlorine Atom Transfer of Unactivated Alkyl Chlorides Enabled by Zirconocene and Photoredox Catalysis” Precis. Chem. 2023, 1, 112–118.
• Nakamichi, N.; Yamaguchi, J.; Sato, A.; Fujimoto, K. J.; Ota, E. “Chemical biology to dissect molecular mechanisms underlying plant circadian clocks” New Phytologist, 2022, 235, 1336–1343.
• Aida, K.; Hirao, M.; Funabashi, A.; Sugimura, N.; Ota, E.*; Yamaguchi, J.* “Catalytic Reductive Ring Opening of Epoxides Enabled by Zirconocene and Photoredox Catalysis” Chem 2022. 8, 1762–1774.
• Hirai, G.; Kato, M.; Koshino, H.; Nishizawa, E.; Oonuma, K.; Ota, E.; Watanabe, T.; Hashizume, D.; Tamura, Y.; Okada, M.; Miyagi, T.; Sodeoka, M. “Ganglioside GM3 Analogues Containing Monofluoromethylene-Linked Sialoside: Synthesis, Stereochemical Effects, Conformational Behavior, and Biological Activities” JACS Au 2021, 1, 137–146.
• Ota, E.; Wang, H.; Frye, N. L.; Knowles, R. R. “A Redox Strategy for Light-Driven, Out-of-Equilibrium Isomerizations and Application to Catalytic C-C Bond Cleavage Reactions,” The Journal of American Chemical Society, 2019, 141, 1457–1462.
• Ota, E.; Usui, K.; Oonuma, K.; Koshino, H.; Nishiyama, S.; Hirai, G.; Sodeoka, M. “Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling,” ACS Chemical Biology, 2018, 13, 876-880.

Other Interests

Running, singing, badminton, walking in the back street

Affiliated Academic Organizations

The Chemical Society of Japan
The Society of Synthetic Organic Chemistry, Japan
The Japanese Society of Carbohydrate Research
The Kinka Chemical Society, Japan
The Japanese Photochemistry Association
American Chemical Society

Awards

2024 CSJ Young Scholar Lecture, The 104th CSJ Annual Meeting
2023 Oral Speaker Award, IUPAC The 23rd International Conference on Organic Synthesis (23-ICOS)
2023 WASEDA e-Teaching Award (Good Practice Award), Waseda University
2021 Konica Minolta Award, Synthetic Organic Chemistry Japan
2020 Satomi Award, The Satomi Scholarship Foundation