Waseda Institute for Advanced Study (WIAS)Waseda University


TANAKA, Masako


TANAKA, Masako


Ph.D. in Medical Science


Assistant Professor



Monthly Spotlight

[Monthly Spotlight] is focusing on a researcher to introduce his/her research.
Elucidation of Stress Responses of Cancer Cells Using Chaperone Interactome Masako Tanaka, Assistant Professor

Research Topic

Molecular Mechanisms of Cancer Chemoresistance by Chaperone Interactome

Chemotherapy is a type of cancer treatment with chemotherapeutic drugs to kill cancer cells. However, cancer cells acquire resistance to the drugs in the short term during continuous administration. Development of chemoresistance therefore remains the major clinical obstacle for successful treatment of cancer. We are now exploring key molecules and pathways involved in chemoresistance by introduction of a revolutionary method “chaperone interactome” that has been developed by us and can detect stress responses without change of gene expression.

Education and Academic Employment

2005: MSc degree from Department of Biology and Geoscience, Graduate School of Science, Osaka City University
2012-2014: JSPS Research Fellowship for Young Scientists (DC2)
2014: PhD degree (Medical Science) from Department of Pharmacology, Osaka City University Graduate School of Medicine
2014-2017: Assistant Professor, Osaka City University Graduate School of Medicine
2017-2018: Assistant Professor, School of Advanced Science and Engineering, Waseda University
2018-present: Assistant Professor, Waseda Institute for Advanced Study, Waseda University

Fields of Research Interests

Chemoresistance, Interactome, Chaperone

Academic Publications
  1. Kita K, Shiota M, Tanaka M et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 108:1820-7 (2017)
  2. Takahashi K, Tanaka M. et al. Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells. Cancer Lett. 378:8-15 (2016)
  3. Tanaka M et al. Identification of low-abundance proteins in serum via the isolation of HSP72 complexes. J Proteomics. 136:214-21 (2016)
  4. Tanaka M et al. Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2. Monoclon Antib Immunodiagn Immunother. 33:261-9 (2014)
  5. Tanaka M et al. Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions. PLoS ONE 9:e96785 (2014)
  6. Takahashi K. Tanaka M et al. Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line. Int J Oncol. 43:1985-91 (2013)
  7. Tanaka M et al. Generation of a rat monoclonal antibody specific for hsp72. Hybridoma 30:397-400 (2011)
  8. Shiota M, Saiwai H, Mun S, Harada A, Okada S, Odawara J, Tanaka M et al. Generation of a rat monoclonal antibody specific for heat shock cognate protein 70. Hybridoma 29:453-6 (2010)
  9. Tanaka M et al. Sensitive stages for photoperiodic induction of pupal diapause in the flesh fly Sarcophaga similis (Meade) (Diptera: Sarcophagidae). Appl Entomol Zool. 43:403-7 (2008)
Other Interests

Japanese pottery and porcelain,
TENUGUI (Japanese hand towel)

Affiliated Academic Organizations

The Japanese Pharmacological Society
Japanese Cancer Association
The Biomedical Society for Stress Response
The Japanese Association of Molecular Target Therapy of Cancer


2017: Young Researcher Award (The 12th Annual Meeting of the Biomedical Society for Stress Response)
2017: The 62nd Award of Osaka City Medical Association
2016: The 61st Award of Osaka City Medical Association
2013: Young Investigator Awards (The 86th Annual Meeting of The Japanese Pharmacological Society)

Related articles

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