First demonstration of protonic biotransducer connecting to living mitochondria

Scientists from Waseda University and Tokyo University of Agriculture and Technology developed a protonic biotransducer that monitors and modulates H+ concentration (pH) by controlling the flow of H+ between a conductive polymer (sulfonated polyaniline) and solution. By connecting the biotransducer to a living mitochondria, they became the first to successfully modulate the rate of ATP synthesis.

A protonic biotransducer controlling ATP synthesis in mitochondria

“In future applications, this device could integrate with pH dependent biological samples (such as membrane proteins and transporters) and may allow further control of biological functions,” says Takeo Miyake, associate professor of bioelectronics at Waseda University and member of the research team.

This study was published in Scientific Reports on July 12, 2018.

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