Name
NISHIDA, Nao
Degree
Ph.D. (Agriculture)
Status
Assistant Professor
HP (URL)
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Research Topic
Spatiotemporal analyses of extracellular vesicle transfer in tumor microenvironment
I aim to understand extracellular vesicle (EV) transfer dynamics in tumors in a tissue context. EVs, nanosized lipid bilayer vesicles, mediates cancer-normal cell interactions to establish a tumor-favorable environment, promoting cancer progression and metastasis. I will track the EV transfer of cancer to normal cells in real-time in tissue culture models. My studies will provide quantitative and spatiotemporal understandings of EV transfer that explain pro-tumoral activities of cancer-derived EVs.
Monthly Spotlight
[Monthly Spotlight] is focusing on a researcher to introduce his/her research.
Exploring the behavior of the intercellular information transmitter “extracellular vesicles”
Education and Academic Employment
2022- Current position
2021-2022 Specially-Appointed Assistant Professor, Tokyo Medical University
2017-2021 Postdoctoral Fellow, Fred Hutchinson Cancer Research Center
2017-2019 JSPS Overseas Research Fellowship
2014-2017 Postdoctoral Fellow, National Cancer Center Research Institute, JSPS Research Fellowship (Postdoc)
2014 PhD (Agriculture), Kyoto University, Graduate School of Agriculture
2012-2014 JSPS Research Fellowship (DC2)
2011 M.Sc, Kyoto University, Graduate School of Agriculture
2009 B.Sc, Kyoto University, Faculty of Agriculture
Fields of Research Interests
Cancer, Cell-cell interaction, extracellular vesicles
Academic Publications
- Nishida-Aoki, N., & Gujral, T.S. Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype. Cancer Res. AACR Publications, 82, 433-446 (2022). Selected as the cover art
- Nishida-Aoki, N., Bondesson, A. J. & Gujral, T.S. Measuring Real-time Drug Responses in Organotypic Tumor Tissue Slices. J Vis Exp. 159, e61036 (2020).
- Nishida-Aoki, N., Tominaga, N., Kosaka, N. & Ochiya, T. Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake. J. Extracell. Vesicles. Taylor & Francis, 9, 1713527 (2020).
- Nishida-Aoki, N., Izumi, Y., Takeda, H., Takahashi, M., Ochiya, T. & Bamba, T. Lipidomic Analysis of Cells and Extracellular Vesicles from High- and Low-Metastatic Triple-Negative Breast Cancer. Metabolites. MDPI, 10, 67 (2020).
- Nishida-Aoki, N., Tominaga, N., Fumitaka, T., Sonoda, T., Yoshioka, Y. & Ochiya, T. Disruption of circulating extracellular vesicles as a novel therapeutic strategy against cancer metastasis. Mol. Ther. Cell Press, 25, 181-191 (2017).
Other Interests
Yoga, Hikes
Affiliated Academic Organizations
American Society of Cellular Biology
American Association for Cancer Research
The International Society of Extracellular Vesicles
The Molecular Biology Society of Japan
Japanese Cancer Association
The Japanese Society for Extracellular Vesicles
Awards
2021 Leading Initiative for Excellent Young Researchers (LEADER), by Japan Society for the Promotion of Science (JSPS)
2018-2019 Interdisciplinary training grant (IDTG) fellowship, Fred Hutch
2017 ISEV2017 Junior Member Scholarship
2016 Cosmo Bio Award (Best article award)
