Waseda Institute for Advanced Study (WIAS)Waseda University

The research group of Associate Professor MARUYAMA Takeshi discovered a new mechanism in that the immunological ligand–receptor system generates a mechanical force in non-immune epithelial cells to extrude precancerous cells in the same epithelial layer. The research achievements are published on “Nature Immunology” journal.

For further information, please refer to the links below.

Article on “Nature Immunology” journal: “Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction”

Waseda University News (in Japanese) 「予防的に発がんを抑制するメカニズム」