Name
HOSHINA, Naosuke
Degree
Ph.D. (Science)
Status
Assistant Professor
HP (URL)
https://researchmap.jp/nhoshina?lang=en
Research Topic
Genetic dissection of brain networks
Our feelings, thoughts, and actions are governed by “brain networks,” which are composed of numerous intricately and elaborately connected neurons. However, the specific grouping of neurons that establish brain networks and how they carry out functions are still unknown. By focusing on the genetic characteristics of individual neurons, I will unravel the patterns of neural wiring in the brain networks and explore the mysteries of the brain.
Monthly Spotlight
[Monthly Spotlight] is focusing on a researcher to introduce his/her research.
Synaptic adhesion molecules involved in neuropsychiatric disorders
Education and Academic Employment
Education
| 2009 | Ph.D., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo |
| 2006 | M.S., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo |
| 2004 | B.S., Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo |
Academic Employment
| 2023-Present | Assistant Professor, Waseda Institute for Advanced Study, Waseda University |
| 2022-2023 | Assistant Professor, Graduate School of Medicine, Chiba University |
| 2016-2022 | Research Fellow, Boston Children’s Hospital, Harvard Medical School |
| 2011-2016 | Researcher, Okinawa Institute of Science and Technology Graduate University |
| 2009-2011 | Project Researcher, Institute of Medical Science, The University of Tokyo |
Fields of Research Interests
Brain network, Neural circuit, Neuron, Synapse, Cell adhesion, Genetically engineered mouse
Academic Publications
- Hoshina N, Johnson-Venkatesh EM, Rally V, Sant J, Hoshina M, Seiglie M, Umemori H.
ASD/OCD-linked Protocadherin-10 regulates synapse, but not axon, development in the amygdala and contributes to fear- and anxiety-related behaviors.
J. Neurosci. (2022) - Suzuki T, Hoshina M, Nishijima S, Hoshina N, Kikuguchi C, Tomohiro T, Fukao A, Fujiwara T, Yamamoto T.
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
RNA Biol. (2022) - Hoshina N, Johnson-Venkatesh EM, Hoshina M, Umemori H.
Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder.
Science (2021) - Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM.
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
Neuron (2020) - Chang H#, Hoshina N#, Zhang C#, Ma Y, Cao H, Wang Y, Wu DD, Bergen SE, Landén M, Hultman CM, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, Nöthen MM; Swedish Bipolar Study Group; MooDS Bipolar Consortium, Walter H, Erk S, Heinz A, Amin N, van Duijn CM, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T, Rietschel M, Li M. (#: equally contributed)
The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.
Mol. Psychiatry (2018) - Ihara N, Nakashima A, Hoshina N, Ikegaya Y, Takeuchi H.
Differential expression of axon-sorting molecules in mouse olfactory sensory neurons.
Eur. J. Neurosci. (2016) - Inoue T, Hoshina N, Nakazawa T, Kiyama Y, Kobayashi S, Abe T, Yamamoto T, Manabe T, Yamamoto T.
LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking.
J. Neurosci. (2014) - Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T.
Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits.
Neuron (2013) - Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T.
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.
EMBO J. (2011) - Hirota T, Kon N, Itagaki T, Hoshina N, Okano T, Fukada Y.
Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.
Genes Cells (2010) - Hoshina N, Tezuka T, Yokoyama K, Kozuka-Hata H, Oyama M, Yamamoto T. Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth.
Genes Cells (2007) - Yokoyama K, Tezuka T, Hoshina N, Nakazawa T, Yamamoto T.
Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases.
Biochem. Biophys. Res. Commun. (2006)
Other Interests
Music (listening, singing, playing), Parenting
Affiliated Academic Organizations
The Japan Neuroscience Society
The Molecular Biology Society of Japan
