{"id":94430,"date":"2023-10-13T10:55:45","date_gmt":"2023-10-13T01:55:45","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=94430"},"modified":"2023-10-13T10:58:10","modified_gmt":"2023-10-13T01:58:10","slug":"1%e5%88%86%e3%81%a7%e8%a3%85%e7%9d%80%e5%8f%af%e8%83%bd%e3%80%81%e8%85%b0%e3%81%a0%e3%81%91%e3%81%a7%e3%81%aa%e3%81%8f%e8%85%95%e3%81%ae%e8%b2%a0%e6%8b%85%e3%82%82%e8%bb%bd%e6%b8%9b%e3%81%99-2-3-4-76","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/94430","title":{"rendered":"\u30d7\u30ea\u30f3\u4ee3\u8b1d\u306b\u3088\u308b\u8133\u767a\u751f\u6a5f\u69cb\u306e\u89e3\u660e"},"content":{"rendered":"<h1><strong>\u30d7\u30ea\u30f3\u4ee3\u8b1d\u3092\u4ecb\u3057\u305f\u8133\u767a\u751f\u5236\u5fa1\u6a5f\u69cb\u3092\u767a\u898b<\/strong><\/h1>\n<p><big><strong>\u795e\u7d4c\u767a\u751f\u904e\u7a0b\u306b\u304a\u3051\u308b\u4e8c\u3064\u306e\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u6642\u7a7a\u9593\u7684\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/big><\/p>\n<h2>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h2>\n<ul>\n<li>\u6b63\u5e38\u306a\u8133\u767a\u751f\u306b\u306f\u3001\u80ce\u751f\u671f\u306b\u304a\u3051\u308b<em>de novo<\/em>\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/li>\n<li><em>de novo<\/em>\u30d7\u30ea\u30f3\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u3068\u3001mTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u6291\u5236\u3055\u308c\u3001\u524d\u8133\u7279\u7570\u7684\u306a\u8133\u5947\u5f62\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002<\/li>\n<li>\u30d7\u30ea\u30f3\u4ee3\u8b1d\u306b\u3088\u308b\u8133\u767a\u751f\u6a5f\u69cb\u306e\u89e3\u660e\u304c\u3001\u69d8\u3005\u306a\u75be\u60a3\u306e\u75c5\u56e0\u8ffd\u7a76\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n<h3><strong>\u6982\u8981<\/strong><\/h3>\n<p>\u65e9\u7a32\u7530\u5927\u5b66<a href=\"https:\/\/www.waseda.jp\/fhum\/\" target=\"_blank\" rel=\"noopener\">\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662<\/a> \u4fee\u58eb\u8ab2\u7a0b2\u5e74\u306e\u6c34\u8d8a \u667a\u4e5f\uff08\u307f\u305a\u3053\u3057 \u3068\u3082\u3084\uff09\u6c0f\u3001<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100003024_ja.html\" target=\"_blank\" rel=\"noopener\">\u5c71\u7530 \u6674\u4e5f\uff08\u3084\u307e\u3060 \u305b\u3044\u3084\uff09\u52a9\u6559<\/a>\u3001<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001065_ja.html\" target=\"_blank\" rel=\"noopener\">\u698a\u539f \u4f38\u4e00\uff08\u3055\u304b\u304d\u3070\u3089 \u3057\u3093\u3044\u3061\uff09\u6559\u6388<\/a>\u306b\u3088\u308b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6b63\u5e38\u306a\u8133\u767a\u751f\u306b2\u3064\u306e\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\uff08<em>de novo<\/em>\u3068salvage\uff09\u306e\u53b3\u5bc6\u306a\u5236\u5fa1\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30d7\u30ea\u30f3\u4ee3\u8b1d\u5236\u5fa1\u306b\u3088\u308b\u8133\u767a\u751f\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3067\u3001\u69d8\u3005\u306a\u75be\u60a3\u306e\u767a\u75c7\u539f\u56e0\u8ffd\u7a76\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u54fa\u4e73\u985e\u306f\u9032\u5316\u306e\u904e\u7a0b\u306b\u304a\u3044\u3066\u5927\u8133\u76ae\u8cea\u306e\u5bb9\u7a4d\u306e\u5272\u5408\u3092\u98db\u8e8d\u7684\u306b\u5897\u52a0\u3055\u305b\u3001\u8a18\u61b6\u7b49\u306e\u9ad8\u6b21\u8133\u6a5f\u80fd\u3092\u7372\u5f97\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u7740\u76ee\u3057\u305f\u30d7\u30ea\u30f3<sup>\u203b1<\/sup>\u306fDNA\u3084RNA\u306e\u91cd\u8981\u306a\u69cb\u6210\u8981\u7d20\u3067\u3042\u308a\u3001\u751f\u7269\u304c\u6d3b\u52d5\u3059\u308b\u305f\u3081\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u6e90\uff08ATP\/GTP\uff09\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u30d7\u30ea\u30f3\u4ee3\u8b1d\u306e\u7570\u5e38\u306f\u75db\u98a8\u306e\u307f\u306a\u3089\u305a\u3001\u3066\u3093\u304b\u3093\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u7cbe\u795e\u75be\u60a3\u3084\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u306a\u3069\u3001\u69d8\u3005\u306a\u75be\u60a3\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30d7\u30ea\u30f3\u4ee3\u8b1d\u304c\u8133\u767a\u751f\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u304b\u306f\u672a\u3060\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u8133\u767a\u751f\u306e\u9032\u884c\u306b\u4f34\u3044\u3001\u99c6\u52d5\u3059\u308b\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u304c\u5207\u308a\u66ff\u308f\u308a\u3001\u521d\u671f\u306e\u5927\u8133\u76ae\u8cea\u5f62\u6210\u306b\u306f<em>de novo<\/em>\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u80ce\u751f\u671f\u306b\u30d7\u30ea\u30f3\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u3068mTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def<sup>\u203b2<\/sup>\u306e\u4f4e\u4e0b\u3092\u4ecb\u3057\u305f\u524d\u8133\u7279\u7570\u7684\u306a\u8133\u5947\u5f62\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f31\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-94433 \" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.1-e1697161350158.jpg\" alt=\"\" width=\"561\" height=\"501\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.1-e1697161350158.jpg 2095w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.1-e1697161350158-610x544.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.1-e1697161350158-2000x1784.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.1-e1697161350158-768x685.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.1-e1697161350158-1536x1370.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.1-e1697161350158-2048x1827.jpg 2048w\" sizes=\"auto, (max-width: 561px) 100vw, 561px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56f31: <em>de novo<\/em>\u30d7\u30ea\u30f3\u5408\u6210\u963b\u5bb3\u306fmTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u6d3b\u6027\u4f4e\u4e0b\u3092\u4f34\u3046\u524d\u8133\u7279\u7570\u7684\u8133\u5947\u5f62\u3092\u5f15\u304d\u8d77\u3053\u3059<\/strong><\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u7c73\u56fd\u306e\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u30b8\u30e3\u30fc\u30ca\u30eb\u300e<a href=\"https:\/\/www.eneuro.org\/\" target=\"_blank\" rel=\"noopener\">eNeuro<\/a>\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b2023\u5e7410\u670811\u65e5\uff08\u6c34\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u306a\u304a\u3001\u5f53\u8a72\u8ad6\u6587\u306f<a href=\"https:\/\/blog.eneuro.org\/2023\/10\/editors_pick_smith\" target=\"_blank\" rel=\"noopener\">\u300cEditor\u2019s pick\u300d<\/a>\u306b\u9078\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff11\uff09\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/h4>\n<p>\u54fa\u4e73\u985e\u3001\u3068\u308a\u308f\u3051\u30d2\u30c8\u306f\u9032\u5316\u3068\u5171\u306b\u5927\u8133\u76ae\u8cea\u306e\u5bb9\u7a4d\u306e\u5272\u5408\u3092\u98db\u8e8d\u7684\u306b\u62e1\u5927\u3055\u305b\u3001\u601d\u8003\u3001\u8a00\u8a9e\u3001\u8a18\u61b6\u306a\u3069\u306e\u9ad8\u6b21\u8133\u6a5f\u80fd\u3092\u7372\u5f97\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u54fa\u4e73\u985e\u306e\u5927\u8133\u76ae\u8cea\u306e\u5f62\u6210\u306b\u306f\u3001\u6642\u7a7a\u9593\u7684\u306b\u5236\u5fa1\u3055\u308c\u305f\u795e\u7d4c\u5e79\u7d30\u80de<sup>\u203b3<\/sup>\u306e\u5897\u6b96\u3068\u3001\u305d\u306e\u5f8c\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5168\u3066\u306e\u771f\u6838\u7d30\u80de\u306e\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u7dad\u6301\u306b\u5fc5\u9808\u306a\u5206\u5b50\u3067\u3042\u308b\u30d7\u30ea\u30f3\u306fDNA\u3084RNA\u3001ATP\/GTP\u306e\u539f\u6599\u3067\u3059\u3002\u30d7\u30ea\u30f3\u306f\u8133\u306e\u6b63\u5e38\u306a\u767a\u9054\u306b\u5fc5\u9808\u3067\u3042\u308a\u3001\u305d\u306e\u4ee3\u8b1d\u7570\u5e38\u306f\u5148\u5929\u6027\u3066\u3093\u304b\u3093\u3084\u7cbe\u795e\u9045\u6ede\u3001\u30ec\u30c3\u30b7\u30e5\u30ca\u30a4\u30cf\u30f3\u75c7\u5019\u7fa4<sup>\u203b4<\/sup>\u306a\u3069\u306e\u91cd\u7be4\u306a\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u54fa\u4e73\u985e\u306f\u65b0\u751f\uff08<em>de novo<\/em>\uff09\u7d4c\u8def\u3068\u518d\u5229\u7528\uff08salvage\uff09\u7d4c\u8def\u306e2\u7a2e\u985e\u306e\u30d7\u30ea\u30f3\u7523\u751f\u7d4c\u8def\u3092\u6301\u3061\u3001\u901a\u5e38\u6642\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u30b3\u30b9\u30c8\u306e\u4f4e\u3044salvage\u7d4c\u8def\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u304c\u3001\u7d30\u80de\u5206\u88c2\u306a\u3069\u591a\u91cf\u306b\u6838\u9178\u3092\u5fc5\u8981\u3068\u3059\u308b\u969b\u306f\u3001de novo\u7d4c\u8def\u304c\u99c6\u52d5\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08\u56f32\uff09\u3002\u3057\u304b\u3057\u3001\u8133\u306e\u767a\u9054\u306b\u304a\u3051\u308b\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u6642\u7a7a\u9593\u7684\u306a\u4f7f\u3044\u5206\u3051\u306b\u3064\u3044\u3066\u306f\u672a\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-94434 \" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.2-scaled-e1697161083157.jpg\" alt=\"\" width=\"516\" height=\"526\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.2-scaled-e1697161083157.jpg 2316w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.2-scaled-e1697161083157-610x622.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.2-scaled-e1697161083157-2000x2039.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.2-scaled-e1697161083157-768x783.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.2-scaled-e1697161083157-1507x1536.jpg 1507w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.2-scaled-e1697161083157-2009x2048.jpg 2009w\" sizes=\"auto, (max-width: 516px) 100vw, 516px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56f32: \u54fa\u4e73\u985e\u306b\u304a\u3051\u308b\u4e8c\u3064\u306e\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def<\/strong><\/p>\n<h4>\uff08\uff12\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u307e\u305a\u3001\u300c\u30de\u30a6\u30b9\u8133\u306b\u304a\u3044\u3066\u767a\u751f\u6bb5\u968e\u306b\u3088\u3063\u3066\u99c6\u52d5\u3059\u308b\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u304c\u7570\u306a\u308b\u300d\u3068\u3044\u3046\u4eee\u8aac\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u767a\u751f\u306e\u5404\u6bb5\u968e\uff08\u80ce\u751f13\u65e5\u76ee\u301c\u751f\u5f8c12\u65e5\u76ee\uff09\u306e\u30de\u30a6\u30b9\u5927\u8133\u76ae\u8cea\u306b\u542b\u307e\u308c\u308bPAICS (de novo\u9175\u7d20)\u3068HGPRT (salvage\u9175\u7d20)\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u91cf\u3092\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\u3001\u80ce\u751f\u671f\u306b\u306f<em>de novo<\/em>\u7d4c\u8def\u304c\u512a\u4f4d\u306b\u99c6\u52d5\u3057\u3001\u751f\u5f8c\u4ed8\u8fd1\u3067salvage\u7d4c\u8def\u306b\u5207\u308a\u66ff\u308f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f3\uff13\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-94435\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.3-scaled-e1697161448906.jpg\" alt=\"\" width=\"450\" height=\"353\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.3-scaled-e1697161448906.jpg 2419w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.3-scaled-e1697161448906-610x478.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.3-scaled-e1697161448906-2000x1566.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.3-scaled-e1697161448906-768x601.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.3-scaled-e1697161448906-1536x1203.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.3-scaled-e1697161448906-2048x1604.jpg 2048w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56f33: \u5927\u8133\u76ae\u8cea\u767a\u751f\u904e\u7a0b\u306b\u304a\u3051\u308b\u30d7\u30ea\u30f3\u5408\u6210\u9175\u7d20\u306e\u767a\u73fe\u91cf<\/strong><\/p>\n<p>\u7d9a\u3044\u3066\u3001\u7a7a\u9593\u7684\u306a\u4f7f\u3044\u5206\u3051\u3092\u691c\u8a3c\u3057\u3001\u30de\u30a6\u30b9\u8133\u5185\u306b\u304a\u3051\u308b\u30d7\u30ea\u30f3\u5408\u6210\u9175\u7d20\u7fa4\u306e\u5c40\u5728\u3092\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u67d3\u8272\u3067\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\u3001de novo\u9175\u7d20\u3068salvage\u9175\u7d20\u306f\u7570\u306a\u308b\u8133\u9818\u57df\u306b\u304a\u3044\u3066\u767a\u73fe\u304c\u898b\u3089\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u8133\u306e\u767a\u9054\u6bb5\u968e\u53ca\u3073\u7279\u5b9a\u306e\u8133\u9818\u57df\u306b\u304a\u3044\u3066\u3001\u6642\u9593\u30fb\u7a7a\u9593\u7684\u306b2\u3064\u306e\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u4f7f\u3044\u5206\u3051\u304c\u751f\u3058\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u7279\u5b9a\u306e\u6642\u671f\u306b\u304a\u3051\u308b\u30d7\u30ea\u30f3\u5408\u6210\u963b\u5bb3\u304c\u8133\u306e\u767a\u9054\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u7279\u5b9a\u306e\u9175\u7d20\u3092\u6a19\u7684\u3068\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u963b\u5bb3\u5264\u3092\u7528\u3044\u3066\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u307e\u305a\u300cde novo\u7d4c\u8def\u304c\u80ce\u751f\u671f\u306b\u512a\u4f4d\u306b\u99c6\u52d5\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u80ce\u751f\u671f\u306b\u8c4a\u5bcc\u306b\u5b58\u5728\u3059\u308b\u795e\u7d4c\u5e79\u7d30\u80de\u306fde novo\u7d4c\u8def\u963b\u5bb3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u300d\u3068\u3044\u3046\u4eee\u8aac\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u6211\u3005\u306f\u30de\u30a6\u30b9\u80ce\u5150\u5927\u8133\u76ae\u8cea\u304b\u3089\u5358\u96e2\u3057\u305f\u521d\u4ee3\u57f9\u990a\u795e\u7d4c\u5e79\u7d30\u80de\u306b\u5bfe\u3057\u3066de novo\u7d4c\u8def\u3001salvage\u7d4c\u8def\u3092\u5404\u3005\u7279\u7570\u7684\u306b\u963b\u5bb3\u3059\u308b\u85ac\u5264\uff08Mycophenolate mofetil(MMF)\u3001Forodesine\uff09\u3067\u51e6\u7406\u3092\u884c\u3044\u3001\u30c1\u30df\u30b8\u30f3\u306e\u30a2\u30ca\u30ed\u30b0\u3067\u3042\u308bBrdU<sup>\u203b5<\/sup>\u306e\u53d6\u308a\u8fbc\u307f\u7387\u306b\u3088\u308a\u5897\u6b96\u6027\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002De novo\u7d4c\u8def\u3092\u963b\u5bb3\u3057\u305f\u6642\u306e\u307f\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u6027\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u305f\u7d50\u679c\uff08\u56f3\uff14; \u6700\u4e0b\u6bb5\u4e2d\u592e\u30d1\u30cd\u30eb\u3068\u30b0\u30e9\u30d5\u53f3\u7aef\uff09\u304b\u3089\u3001\u80ce\u751f\u671f\u306e\u5927\u8133\u76ae\u8cea\u62e1\u5927\u3067\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u62c5\u3046\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u306b\u306fde novo\u7d4c\u8def\u304c\u5fc5\u8981\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-94436\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.4-scaled-e1697161534971.jpg\" alt=\"\" width=\"916\" height=\"387\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.4-scaled-e1697161534971.jpg 2560w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.4-scaled-e1697161534971-610x258.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.4-scaled-e1697161534971-2000x845.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.4-scaled-e1697161534971-768x324.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.4-scaled-e1697161534971-1536x649.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.4-scaled-e1697161534971-2048x865.jpg 2048w\" sizes=\"auto, (max-width: 916px) 100vw, 916px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56f34: \u30d7\u30ea\u30f3\u5408\u6210\u963b\u5bb3\u5264\u304c\u521d\u4ee3\u57f9\u990a\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u6027\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/p>\n<p>\u6b21\u306b\u3001\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u751f\u4f53\u5185\u3067\u30d7\u30ea\u30f3\u5408\u6210\u963b\u5bb3\u3092\u884c\u3046\u3068\u8133\u767a\u751f\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u80ce\u751f\u521d\u671f\u306b\u304a\u3051\u308b MMF\u306e\u9023\u7d9a\u7684\u306a\u85ac\u5264\u6295\u4e0e\u5b9f\u9a13\u306b\u3088\u308b<em>de novo<\/em>\u7d4c\u8def\u963b\u5bb3\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u91ce\u751f\u578b\u306e\u8133\u3067\u306f\u6c34\u5e73\u65ad\u9762\u306b\u304a\u3044\u3066Pax6\u967d\u6027\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u3068Doublecortin (DCX) \u967d\u6027\u306e\u5e7c\u5f31\u306a\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u7dba\u9e97\u306a\u5c64\u69cb\u9020\u3092\u5f62\u6210\u3059\u308b\u4e00\u65b9\u3067\u3001<em>de novo<\/em>\u7d4c\u8def\u304c\u963b\u5bb3\u3055\u308c\u305f\u500b\u4f53\u306f\u3001\u5927\u8133\u76ae\u8cea\u306e\u5f62\u6210\u963b\u5bb3\u3001\u7279\u306b\u524d\u982d\u8449\u306e\u6b20\u5931\u304c\u8d77\u3053\u3063\u3066\u304a\u308a\u3001Pax6\u306e\u767a\u73fe\u304c\u898b\u3089\u308c\u306a\u3044\u7279\u5fb4\u7684\u306a\u8133\u5947\u5f62\u3092\u751f\u3058\u3055\u305b\u307e\u3057\u305f\uff08\u56f35;\u4e2d\u6bb5\u4e2d\u592e\u30d1\u30cd\u30eb\uff09\u3002\u307e\u305f\u3001\u3053\u306e\u9818\u57df\u306b\u306f\u672c\u6765\u4e0b\u65b9\u306b\u4f4d\u7f6e\u3059\u308b\u306f\u305a\u306eGsh2\u967d\u6027\u306e\u5927\u8133\u57fa\u5e95\u6838\u539f\u57fa<sup>\u203b6<\/sup>\u304c\u5f62\u6210\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\uff08\u56f35;\u6700\u4e0b\u6bb5\u4e2d\u592e\u30d1\u30cd\u30eb\uff09\u3002\u3064\u307e\u308a\u3001<em>de novo<\/em>\u7d4c\u8def\u963b\u5bb3\u304c\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u8133\u90e8\u4f4d\u3054\u3068\u306b\u7570\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u30d7\u30ea\u30f3\u306e\u611f\u53d7\u6027\u306f\u5f8c\u982d\u8449\u304b\u3089\u524d\u982d\u8449\u306b\u304b\u3051\u3066\u6fc3\u5ea6\u52fe\u914d\u304c\u3042\u308a\u30012\u3064\u306e\u7d4c\u8def\u306e\u4f7f\u3044\u5206\u3051\u304c\u8133\u9818\u57df\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u3092\u793a\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u6700\u5f8c\u306b\u3001\u3053\u306e<em>de novo<\/em>\u7d4c\u8def\u963b\u5bb3\u306b\u3088\u308b\u8133\u5947\u5f62\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u62c5\u3046mTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002mTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306b\u306f4E-BP1\/eIF4E \u3068S6K\/S6\u3068\u3044\u3046\u4e8c\u3064\u306e\u4e0b\u6d41\u7d4c\u8def\u304c\u3042\u308a\u307e\u3059\u304c\u3001<em>de novo<\/em>\u7d4c\u8def\u306e\u963b\u5bb3\u306b\u3088\u3063\u3066\u8133\u5947\u5f62\u304c\u751f\u3058\u305f\u500b\u4f53\u3067\u306fS6K\/S6\u7d4c\u8def\u304c\u8457\u3057\u304f\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\uff08\u56f35;\u53f3\u56f3\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-94437\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.5-scaled-e1697161690797.jpg\" alt=\"\" width=\"831\" height=\"455\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.5-scaled-e1697161690797.jpg 2527w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.5-scaled-e1697161690797-610x334.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.5-scaled-e1697161690797-2000x1095.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.5-scaled-e1697161690797-768x420.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.5-scaled-e1697161690797-1536x841.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/10\/sakakibara_fig.5-scaled-e1697161690797-2048x1121.jpg 2048w\" sizes=\"auto, (max-width: 831px) 100vw, 831px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56f35: <em>de novo<\/em>\u7d4c\u8def\u963b\u5bb3\u306fmTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u6291\u5236\u3092\u4ecb\u3057\u305f\u8133\u5947\u5f62\u3092\u5f15\u304d\u8d77\u3053\u3059<\/strong><\/p>\n<p>\u305d\u3053\u3067mTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u85ac\u5264\uff08MHY1485\uff09\u3092<em>de novo<\/em>\u963b\u5bb3\u5264\u3068\u4f75\u7528\u3057\u305f\u3068\u3053\u308d\u3001<em>de novo<\/em>\u7d4c\u8def\u963b\u5bb3\u306b\u3088\u308b\u8133\u5947\u5f62\u306f\u751f\u3058\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u56f35;\u53f3\u5217\u30d1\u30cd\u30eb\uff09\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u3001<em>de novo<\/em>\u30d7\u30ea\u30f3\u5408\u6210\u306f\u3001mTORC1\/S6K\/S6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6642\u7a7a\u9593\u7684\u5236\u5fa1\u3092\u4ecb\u3057\u3066\u5927\u8133\u76ae\u8cea\u306e\u767a\u9054\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>\uff08\uff13\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u304a\u3088\u3073\u77e5\u898b<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u8133\u767a\u751f\u306e\u9032\u884c\u306b\u4f34\u3044\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u304c\u5207\u308a\u66ff\u308f\u308b\u3053\u3068\u3068\u3001\u305d\u306e\u5236\u5fa1\u306e\u5d29\u58ca\u306fmTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u6291\u5236\u3092\u4ecb\u3057\u3066\u8133\u5947\u5f62\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u3057\u305f\u5927\u8133\u76ae\u8cea\u306b\u304a\u3051\u308b\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u6642\u7a7a\u9593\u7684\u5236\u5fa1\u306e\u89e3\u660e\u306f\u3001\u9032\u5316\u306e\u904e\u7a0b\u3067\u5de8\u5927\u306a\u5927\u8133\u3092\u7372\u5f97\u3057\u305f\u54fa\u4e73\u985e\u306b\u7279\u6709\u306e\u9ad8\u6b21\u8133\u6a5f\u80fd\u3092\u53f8\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u304a\u3088\u3073\u3001\u305d\u306e\u7834\u7dbb\u304b\u3089\u8d77\u304d\u308b\u7cbe\u795e\u75be\u60a3\u3084\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u306e\u8ffd\u7a76\u306b\u5bc4\u4e0e\u3067\u304d\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u30d7\u30ea\u30f3\u4ee3\u8b1d\u306e\u7570\u5e38\u306b\u3088\u308b\u75be\u60a3\u306f\u7a2e\u3005\u306e\u304c\u3093\u3068\u306e\u95a2\u9023\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u5916\u74b0\u5883\u306b\u4f9d\u5b58\u3059\u308b\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u5207\u308a\u66ff\u3048\u306f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u304c\u3093\u5e79\u7d30\u80de\u3084\u4ed6\u306e\u7d44\u7e54\u5e79\u7d30\u80de\u306b\u3082\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u6297\u304c\u3093\u5264\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u5275\u85ac\u958b\u767a\u306b\u3068\u3063\u3066\u8cb4\u91cd\u306a\u8996\u70b9\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff14\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u4eca\u56de\u3001\u8133\u306e\u767a\u751f\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u3001<em>de novo<\/em>\u304b\u3089salvage\u3078\u306e\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u5207\u308a\u66ff\u3048\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u7d4c\u8def\u306e\u5207\u308a\u66ff\u3048\u3092\u4fc3\u9032\u3059\u308b\u8981\u56e0\u3084\u3001<em>de novo<\/em>\u30d7\u30ea\u30f3\u5408\u6210\u963b\u5bb3\u5264\u306b\u3088\u308b\u8133\u5947\u5f62\u306e\u8a73\u7d30\u306a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u672a\u3060\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8b0e\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff15\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/h4>\n<p>\u672c\u7814\u7a76\u306f\u65e9\u7a32\u7530\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\uff08\u5c71\u7530\u5148\u751f\u3001\u6c34\u8d8a\u6c0f\uff09\u306e\u5354\u529b\u306b\u3088\u308a\u8ad6\u6587\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u30d7\u30ea\u30f3\u4ee3\u8b1d\u7570\u5e38\u306b\u3088\u308b\u75be\u60a3\u306e\u591a\u304f\u306f\u539f\u56e0\u304c\u4e0d\u660e\u3067\u3042\u308a\u3001\u6cbb\u7642\u6cd5\u3082\u305d\u306e\u591a\u304f\u304c\u5bfe\u75c7\u7642\u6cd5\u3067\u3042\u308a\u9650\u5b9a\u7684\u3067\u3059\u3002\u672c\u7814\u7a76\u306f\u3001<em>de novo<\/em>\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306fmTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u5236\u5fa1\u3057\u3001\u521d\u671f\u80da\u306e\u5927\u8133\u76ae\u8cea\u5f62\u6210\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3053\u3068\u3067\u3001\u4eca\u5f8c\u306e\u8133\u767a\u9054\u306b\u95a2\u308f\u308b\u57fa\u790e\u7814\u7a76\u306e\u307f\u306a\u3089\u305a\u3001\u81e8\u5e8a\u7684\u306a\u89b3\u70b9\u304b\u3089\u3082\u793e\u4f1a\u7684\u306a\u610f\u7fa9\u306f\u5927\u304d\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\uff08\u698a\u539f\uff09<\/p>\n<h4>\uff08\uff16\uff09\u7528\u8a9e\u89e3\u8aac<\/h4>\n<p><strong>\u203b\uff11\uff1a\u30d7\u30ea\u30f3<\/strong><br \/>\n\u30a2\u30c7\u30cb\u30f3\u3084\u30b0\u30a2\u30cb\u30f3\u306a\u3069\u3092\u4ee3\u8868\u3059\u308b\u30d7\u30ea\u30f3\u9aa8\u683c\u3082\u6301\u3064\u7269\u8cea\u3067\u3042\u308a\u3001\u5c3f\u9178\u307e\u3067\u4ee3\u8b1d\u3055\u308c\u3066\u6392\u51fa\u3055\u308c\u308b\u3002\u6838\u9178\u306e\u69cb\u6210\u6750\u6599\u3084\u9175\u7d20\u53cd\u5fdc\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u6709\u540d\u3060\u304c\u3001\u30d7\u30ea\u30f3\u4f5c\u52d5\u6027\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u7d30\u80de\u5916\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u3082\u95a2\u4e0e\u3057\u3001\u7d30\u80de\u904a\u8d70\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u5897\u6b96\u30fb\u5206\u5316\u306a\u3069\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u7dad\u6301\u306e\u305f\u3081\u306b\u69d8\u3005\u306a\u7d30\u80de\u6a5f\u80fd\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3002<\/p>\n<p><strong>\u203b\uff12\uff1amTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def<br \/>\n<\/strong>\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\uff64\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\uff64\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff64\u8102\u8cea\u5408\u6210\uff64\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4ee3\u8b1d\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u6570\u591a\u304f\u306e\u7d30\u80de\u5185\u30d7\u30ed\u30bb\u30b9\u306e\u5236\u5fa1\u3092\u901a\u3057\u3066\u7d30\u80de\u306e\u6a5f\u80fd\u8abf\u7bc0\u3092\u3057\u3066\u3044\u308b\u3002mTORC1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u306b\u4e0d\u53ef\u6b20\u306a\u5f79\u5272\u3092\u6301\u30642\u3064\u306e\u4e0b\u6d41\u30ab\u30b9\u30b1\u30fc\u30c9(4E-BP1\/eIF4E \u3068S6K\/S6)\u304c\u5b58\u5728\u3059\u308b\u3002<\/p>\n<p><strong>\u203b\uff13\uff1a\u795e\u7d4c\u5e79\u7d30\u80de<br \/>\n<\/strong>\u80ce\u751f\u671f\u306b\u8c4a\u5bcc\u306b\u5b58\u5728\u3057\u3001\u7d30\u80de\u5206\u88c2\u3092\u7e70\u308a\u8fd4\u3059\u81ea\u5df1\u5897\u6b96\u80fd\u3068\u591a\u6570\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u751f\u307f\u51fa\u3059\u591a\u5206\u5316\u80fd\u3092\u6301\u3064\u7d30\u80de\u3067\u3001\u8133\u306e\u767a\u751f\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u62c5\u3046\u3002\u751f\u5f8c\u306b\u304a\u3044\u3066\u3082\u4e00\u90e8\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u306f\u6d77\u99ac\u6b6f\u72b6\u56de\u3084\u5074\u8133\u5ba4\u5468\u56f2\u306b\u5b58\u5728\u3057\u3001\u751f\u6daf\u306b\u308f\u305f\u308a\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u3092\u884c\u3046\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<p><strong>\u203b\uff14\uff1a\u30ec\u30c3\u30b7\u30e5\u30ca\u30a4\u30cf\u30f3\u75c7\u5019\u7fa4<br \/>\n<\/strong>Salvage\u7d4c\u8def\u306e\u9175\u7d20\u3067\u3042\u308bHGPRT\u907a\u4f1d\u5b50\u304c\u5148\u5929\u7684\u306b\u5909\u7570\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u5f15\u304d\u8d77\u3053\u3055\u308c\u3001\u75c7\u72b6\u3068\u3057\u3066\u306f\u9ad8\u5c3f\u9178\u8840\u75c7\u3001\u30b8\u30b9\u30c8\u30cb\u30a2\u3001\u767a\u9054\u9045\u5ef6\u306b\u52a0\u3048\u3066\u5f37\u8feb\u7684\u306a\u81ea\u50b7\u884c\u70ba\u304c\u7279\u5fb4\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u8a73\u7d30\u306a\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u4e0d\u660e\u3067\u3042\u308a\u3001\u6839\u672c\u7684\u6cbb\u7642\u6cd5\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3042\u308b\u3002<strong><br \/>\n<\/strong><\/p>\n<p><strong>\u203b\uff15\uff1aBrdU<br \/>\n<\/strong>\u6838\u9178\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30c1\u30df\u30b8\u30f3\u3068\u985e\u4f3c\u3057\u305f\u69cb\u9020\u3092\u6301\u3064\u7269\u8cea\u3067\u3042\u308a\u3001\u7d30\u80de\u5468\u671fS\u671f\u306e\u8907\u88fd\u4e2d\u306b\u30c1\u30df\u30b8\u30f3\u306e\u4ee3\u308f\u308a\u306bDNA\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u6027\u8cea\u3092\u6301\u3064\u3002\u305d\u306e\u6027\u8cea\u3092\u6d3b\u304b\u3057\u3001\u5897\u6b96\u6027\u7d30\u80de\u306e\u691c\u51fa\u30c4\u30fc\u30eb\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3002<strong><br \/>\n<\/strong><\/p>\n<p><strong>\u203b\uff16\uff1a\u5927\u8133\u57fa\u5e95\u6838\u539f\u57fa<br \/>\n<\/strong>\u7d42\u8133\u306e\u8179\u5074\u306b\u4f4d\u7f6e\u3057\u3001\u5c06\u6765\u306e\u5927\u8133\u57fa\u5e95\u6838(\u7dda\u6761\u4f53\u3084\u6de1\u84bc\u7403\u306a\u3069)\u3092\u5f62\u6210\u3059\u308b\u8133\u9818\u57df\u3002GABA\u4f5c\u52d5\u6027\u306e\u6291\u5236\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u751f\u307f\u51fa\u3057\u3001\u751f\u307f\u51fa\u3055\u308c\u305f\u7d30\u80de\u306f\u63a5\u7dda\u65b9\u5411\u306b\u79fb\u52d5\u3057\u3066\u5927\u8133\u57fa\u5e95\u6838\u306b\u5165\u308a\u8fbc\u3080\u3002\u5927\u8133\u57fa\u5e95\u6838\u306e\u6a5f\u80fd\u7570\u5e38\u306f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u821e\u8e0f\u75c5\u306a\u3069\u3092\u4ee3\u8868\u3059\u308b\u91cd\u7be4\u306a\u904b\u52d5\u6a5f\u80fd\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<strong><br \/>\n<\/strong><\/p>\n<h4>\uff08\uff17\uff09\u8ad6\u6587\u60c5\u5831<\/h4>\n<p>\u96d1\u8a8c\u540d\uff1a<a href=\"https:\/\/www.eneuro.org\/\" target=\"_blank\" rel=\"noopener\">eNeuro<\/a><br \/>\n\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/www.eneuro.org\/content\/10\/10\/ENEURO.0159-23.2023\" target=\"_blank\" rel=\"noopener\">Spatiotemporal Regulation of <em>De novo<\/em> and Salvage Purine Synthesis during Brain Development<\/a><br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u6c34\u8d8a \u667a\u4e5f<sup>1<\/sup>\u3001\u5c71\u7530 \u6674\u4e5f<sup>1<\/sup>*\u3001\u698a\u539f \u4f38\u4e00<sup>1<\/sup>*<br \/>\n1) \u65e9\u7a32\u7530\u5927\u5b66 \u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662 \u5206\u5b50\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u5ba4\u3001*) \u8cac\u4efb\u8457\u8005<br \/>\n\u63b2\u8f09\u65e5\u6642\uff1a2023\u5e7410\u670811\u65e5\uff08\u6c34\uff09<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/www.eneuro.org\/content\/10\/10\/ENEURO.0159-23.2023\" target=\"_blank\" rel=\"noopener\">https:\/\/www.eneuro.org\/content\/10\/10\/ENEURO.0159-23.2023<\/a><br \/>\nDOI\uff1a<a href=\"https:\/\/doi.org\/10.1523\/ENEURO.0159-23.2023\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1523\/ENEURO.0159-23.2023<\/a><\/p>\n<h4>\uff08\uff18\uff09\u7814\u7a76\u52a9\u6210<\/h4>\n<ul style=\"list-style-type: square;\">\n<li>\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\uff0819K06931, 21K20701\uff09<\/li>\n<li>\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u75db\u98a8\u30fb\u5c3f\u9178\u8ca1\u56e3\u7814\u7a76\u52a9\u6210\uff082020, 2022\uff09<\/li>\n<li>\u65e9\u7a32\u7530\u5927\u5b66\u7279\u5b9a\u8ab2\u984c\u7814\u7a76\u52a9\u6210\u8cbb\uff082021C-611\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u30d7\u30ea\u30f3\u4ee3\u8b1d\u3092\u4ecb\u3057\u305f\u8133\u767a\u751f\u5236\u5fa1\u6a5f\u69cb\u3092\u767a\u898b \u795e\u7d4c\u767a\u751f\u904e\u7a0b\u306b\u304a\u3051\u308b\u4e8c\u3064\u306e\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u6642\u7a7a\u9593\u7684\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u6b63\u5e38\u306a\u8133\u767a\u751f\u306b\u306f\u3001\u80ce\u751f\u671f\u306b\u304a\u3051\u308bde novo\u30d7\u30ea\u30f3\u5408\u6210\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":94438,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,53,5],"class_list":["post-94430","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-health","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/94430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=94430"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/94430\/revisions"}],"predecessor-version":[{"id":94458,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/94430\/revisions\/94458"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/94438"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=94430"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=94430"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=94430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}