{"id":92658,"date":"2023-08-07T14:00:44","date_gmt":"2023-08-07T05:00:44","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=92658"},"modified":"2023-08-31T12:43:51","modified_gmt":"2023-08-31T03:43:51","slug":"1%e5%88%86%e3%81%a7%e8%a3%85%e7%9d%80%e5%8f%af%e8%83%bd%e3%80%81%e8%85%b0%e3%81%a0%e3%81%91%e3%81%a7%e3%81%aa%e3%81%8f%e8%85%95%e3%81%ae%e8%b2%a0%e6%8b%85%e3%82%82%e8%bb%bd%e6%b8%9b%e3%81%99-2-3-4-77","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/92658","title":{"rendered":"\u30de\u30a4\u30af\u30edRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u3092\u89e3\u660e"},"content":{"rendered":"<h1>\u751f\u4f53\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bmiRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u3092\u89e3\u660e<\/h1>\n<h2>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h2>\n<ul>\n<li>\u30de\u30a6\u30b9\u6210\u719f\u9aa8\u683c\u7b4b\u3067\u65b0\u305f\u306b\u5408\u6210\u3055\u308c\u305fmiRNA\u3092\u6a19\u8b58\u30fb\u8ffd\u8de1\u3059\u308b\u6280\u8853\u304a\u3088\u3073\u9006\u907a\u4f1d\u5b66\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u751f\u4f53\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bmiRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/li>\n<li>\u9aa8\u683c\u7b4b\u306b\u767a\u73fe\u3059\u308bmiRNA\u306f\u3001\u5fc3\u81d3\u3084\u809d\u81d3\u306b\u767a\u73fe\u3059\u308bmiRNA\u3068\u6bd4\u8f03\u3057\u3001\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u304c\u77ed\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002<\/li>\n<li>miRNA\u306f\u52d5\u7269\u306e\u500b\u4f53\u767a\u751f\u3084\u304c\u3093\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u751f\u547d\u73fe\u8c61\u306b\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u975e\u5e38\u306b\u5b89\u5b9a\u306a\u53ef\u80fd\u6027\u304c\u3042\u308b\u751f\u4f53\u9aa8\u683c\u7b4b\u306emiRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u5404\u3005\u306e\u7d44\u7e54\u306b\u304a\u3051\u308bmiRNA\u306e\u4ee3\u8b1d\u52d5\u614b\u306e\u591a\u69d8\u6027\u306b\u95a2\u3057\u3066\u7406\u89e3\u304c\u6df1\u307e\u308b\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n<h3><strong>\u6982\u8981<\/strong><\/h3>\n<p><a href=\"https:\/\/www.waseda.jp\/fsps\/\" target=\"_blank\" rel=\"noopener\">\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662<\/a>\u306e<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000846_ja.html\" target=\"_blank\" rel=\"noopener\">\u79cb\u672c \u5d07\u4e4b\uff08\u3042\u304d\u3082\u3068 \u305f\u304b\u3086\u304d\uff09\u6559\u6388<\/a>\u3001\u53ca\u5ddd \u54f2\u5fd7\uff08\u304a\u3044\u304b\u308f \u3055\u3068\u3057\uff09\u5143\u52a9\u6559\uff08\u73fe\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u30dd\u30b9\u30c9\u30af\uff09\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u7ffb\u8a33\u3055\u308c\u306a\u3044RNA\u306e\uff11\u3064\u3067\u3042\u308b\u30de\u30a4\u30af\u30edRNA\uff08miRNA\uff09\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u5b89\u5b9a\u6027\u306b\u7740\u76ee\u3057\u3001RNA\u3092\u6a19\u8b58\u30fb\u8ffd\u8de1\u3059\u308b\u6280\u8853\u304a\u3088\u3073\u9006\u907a\u4f1d\u5b66\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304b\u3089\u3001\u751f\u4f53\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bmiRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2013.00266\/full\" target=\"_blank\" rel=\"noopener\">The FEBS Journal<\/a>\u306b7\u670831\u65e5\uff08\u6708\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-92659\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1408\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto-scaled.jpg 2560w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto-610x335.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto-2000x1100.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto-768x422.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto-1536x845.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto-2048x1126.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<h4>\uff08\uff11\uff09\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/h4>\n<p>miRNA\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u7ffb\u8a33\u3055\u308c\u306a\u3044RNA\uff08\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\uff09\u306e\uff11\u3064\u3067\u3042\u308a\u3001\u6a19\u7684\u3068\u3059\u308b\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\uff08mRNA\uff09\u306b\u50cd\u304d\u304b\u3051\u308b\u3053\u3068\u3067\u3001mRNA\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u306e\u7ffb\u8a33\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u73fe\u5728\u307e\u3067\u306bmiRNA\u306f\u3001\u52d5\u7269\u306e\u500b\u4f53\u767a\u751f\u3084\u304c\u3093\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u751f\u547d\u73fe\u8c61\u306b\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306bmiRNA\u306e\u751f\u5408\u6210\u306b\u95a2\u3059\u308b\u7814\u7a76\u3082\u7cbe\u529b\u7684\u306b\u9032\u3081\u3089\u308c\u3001\u751f\u5408\u6210\u3084\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5f90\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u4e00\u65b9\u3067\u3001miRNA\u306e\u5b89\u5b9a\u6027\u3084\u5206\u89e3\u304a\u3088\u3073\u305d\u308c\u3089\u3092\u8abf\u7bc0\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307b\u3068\u3093\u3069\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u305f\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306a\u3069\u304b\u3089\u3001miRNA\u306fmRNA\u3068\u6bd4\u3079\u3066\u7d0410\u500d\u4ee5\u4e0a\u306e\u5b89\u5b9a\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u306e\u7d44\u7e54\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u3082\u3001\u534a\u6e1b\u671f\u304c10\u65e5\u4ee5\u4e0a\u3068\u63a8\u5b9a\u3055\u308c\u308bmiRNA\u304c\u5fc3\u81d3\uff08miR-208a\uff09\u3084\u809d\u81d3\uff08miR-122\uff09\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\u3053\u3068\u304b\u3089\u3001miRNA\u306f\u751f\u4f53\u7d44\u7e54\u306b\u304a\u3044\u3066\u7279\u306b\u5b89\u5b9a\u3057\u3066\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u3082\u3001miRNA\u306e\u751f\u5408\u6210\u306b\u5fc5\u9808\u306e\u907a\u4f1d\u5b50\u3067\u3042\u308bDicer1\u3092\u85ac\u5264\u8a98\u5c0e\u6027\u306b\u6b20\u640d\u3055\u305b\u305f\u3068\u3053\u308d\u30014\u9031\u9593\u5f8c\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bmiRNA\u306e\u767a\u73fe\u91cf\u306f50%\u307b\u3069\u3057\u304b\u4f4e\u4e0b\u3057\u306a\u3044\u3053\u3068\u3092\u89b3\u5bdf\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u751f\u4f53\u9aa8\u683c\u7b4b\u306emiRNA\u306f\u975e\u5e38\u306b\u5b89\u5b9a\u306a\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u751f\u4f53\u5185\u306b\u9577\u3044\u6642\u9593\u5b58\u5728\u30fb\u6a5f\u80fd\u3057\u3001\u305d\u306e\u534a\u6e1b\u671f\u306f\u7d044\u9031\u9593\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<h4>\uff08\uff12\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/h4>\n<p>\u9aa8\u683c\u7b4b\u306b\u5b58\u5728\u3059\u308bmiRNA\u304c\u512a\u308c\u305f\u5b89\u5b9a\u6027\u3092\u6709\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u4eca\u56de\u6211\u3005\u306f\u30de\u30a6\u30b9\u6210\u719f\u9aa8\u683c\u7b4b\u3067\u65b0\u305f\u306b\u5408\u6210\u3055\u308c\u305fmiRNA\u3092\u6a19\u8b58\u30fb\u8ffd\u8de1\u3059\u308b\u6280\u8853\u3068\u9006\u907a\u4f1d\u5b66\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7528\u3044\u3066\u3001\u30de\u30a6\u30b9\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bmiRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>RNA\u3092\u69cb\u6210\u3059\u308b\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\uff11\u3064\u3067\u3042\u308b\u30a6\u30ea\u30b8\u30f3\u3068\u985e\u4f3c\u3057\u305f\u69cb\u9020\u3092\u6301\u30645-Ethynyl Uridine\uff085-EU\uff09\u3092\u30de\u30a6\u30b9\u3078\u6295\u4e0e\u3057\u3001\u305d\u306e\u5f8c\u3001\u9aa8\u683c\u7b4b\u3092\u7d4c\u6642\u7684\u306b\u63a1\u53d6\u3057\u3066miRNA\u306b\u542b\u307e\u308c\u308b5-EU\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u65b0\u3057\u304f\u5408\u6210\u3055\u308c\u305fmiRNA\u3092\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001miRNA\u306e\u534a\u6e1b\u671f\u306f\u6bd4\u8f03\u7684\u77ed\u3044\uff0811~20\u6642\u9593\u7a0b\u5ea6\uff09\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u9ad8\u3044\u5b89\u5b9a\u6027\u3092\u6301\u3064\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u305fmiR-23a\u3092\u85ac\u5264\u8a98\u5c0e\u6027\u306b\u6b20\u640d\u3059\u308b\u30de\u30a6\u30b9\u3092\u65b0\u305f\u306b\u4f5c\u51fa\u3057\u3001\u85ac\u5264\u6295\u4e0e\u5f8c\u306emiR-23a\u306e\u767a\u73fe\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001miR-23a\u306f\u9aa8\u683c\u7b4b\u4e2d\u3067\u901f\u3084\u304b\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-92660\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto1-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1001\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto1-scaled.jpg 2560w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto1-610x239.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto1-2000x782.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto1-768x300.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto1-1536x601.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2023\/08\/Akimoto1-2048x801.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56f3\uff11<\/strong>\uff1amiRNA\u3092\u6a19\u8b58\u30fb\u8ffd\u8de1\u3059\u308b\u6280\u8853\u3092\u7528\u3044\u3066\u6e2c\u5b9a\u3057\u305f\u30de\u30a6\u30b9\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bmiRNA\u306e\u76f8\u5bfe\u767a\u73fe\u91cf\uff08\u5de6\uff09\u3068\u305d\u308c\u3089\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\uff08\u53f3\uff09<\/h6>\n<p>\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\u3001\u79c1\u305f\u3061\u304c\u7acb\u3066\u305f\u5f53\u521d\u306e\u4eee\u8aac\u3068\u306f\u7570\u306a\u308a\u3001\u6210\u719f\u3057\u305f\u9aa8\u683c\u7b4b\u306emiRNA\u306f\u901f\u3084\u304b\u306b\u4ee3\u8b1d\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h4>\uff08\uff13\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u304a\u3088\u3073\u77e5\u898b<\/h4>\n<p>\u672c\u7814\u7a76\u304b\u3089\u3001\u5fc3\u81d3\u3084\u809d\u81d3\u306b\u767a\u73fe\u3059\u308bmiRNA\u3068\u6bd4\u8f03\u3057\u3066\u3001\u9aa8\u683c\u7b4b\u306b\u767a\u73fe\u3059\u308bmiRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u304c\u77ed\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u5404\u3005\u306e\u7d44\u7e54\u306b\u304a\u3051\u308bmiRNA\u306e\u4ee3\u8b1d\u52d5\u614b\u306e\u591a\u69d8\u6027\u306b\u95a2\u3057\u3066\u7406\u89e3\u304c\u6df1\u307e\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u305d\u306e\u591a\u69d8\u6027\u3092\u8abf\u7bc0\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3057\u3066\u4eca\u5f8c\u7814\u7a76\u304c\u767a\u5c55\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff14\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u4eca\u56de\u3001\u6210\u719f\u9aa8\u683c\u7b4b\u306emiRNA\u306f\u5b89\u5b9a\u3057\u305f\u5206\u5b50\u3067\u306f\u306a\u304f\u3001\u901f\u3084\u304b\u306b\u4ee3\u8b1d\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u3088\u3046\u306amiRNA\u306e\u7d20\u65e9\u3044\u4ee3\u8b1d\u304c\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u304b\u306f\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3055\u3089\u306b\u4eca\u56de\u306e\u7814\u7a76\u304b\u3089\u3001\u6bd4\u8f03\u7684\u512a\u308c\u305f\u5b89\u5b9a\u6027\u3092\u6709\u3059\u308bmiRNA\uff08miR-133a\uff09\u3068\u305d\u3046\u3067\u306a\u3044\u3082\u306e\uff08miR-1, miR-206\uff09\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u3001miRNA\u306e\u5b89\u5b9a\u6027\u3084\u5206\u89e3\u3092\u8abf\u7bc0\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63a2\u7d22\u3059\u308b\u3068\u5171\u306b\u3001\u500b\u3005\u306emiRNA\u306e\u5b89\u5b9a\u6027\u306e\u9055\u3044\u3084\u305d\u308c\u3089\u304c\u5982\u4f55\u306b\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3082\u691c\u8a0e\u3092\u884c\u3063\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff15\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/h4>\n<p>\u308f\u305a\u304b20\u5e74\u307b\u3069\u524d\u306b\u767a\u898b\u3055\u308c\u305f\u3053\u306e\u5c0f\u3055\u306aRNA\u306e\u751f\u4f53\u306b\u304a\u3051\u308b\u6a5f\u80fd\u304c\u5f90\u3005\u306b\u660e\u3089\u304b\u306b\u3055\u308c\u308b\u306b\u3064\u308c\u3001\u3053\u306e\u7a2e\u306eRNA\u304c\u6211\u3005\u306e\u8eab\u4f53\u3067\u5927\u304d\u306a\u50cd\u304d\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u7406\u89e3\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002miRNA\u306fRNA\u5275\u85ac\u306e\u6a19\u7684\u3068\u3057\u3066\u3082\u6709\u529b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u3053\u308c\u3089\u306eRNA\u306e\u8a73\u7d30\u306a\u52d5\u614b\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u4eba\u306e\u300c\u77e5\u300d\u3084\u300c\u5065\u5eb7\u300d\u306b\u5c11\u3057\u3067\u3082\u8ca2\u732e\u3067\u304d\u308c\u3070\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff16\uff09\u7528\u8a9e\u89e3\u8aac<\/h4>\n<p><strong>\u203b\uff11\uff1a\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA<br \/>\n<\/strong>\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u7ffb\u8a33\u3055\u308c\u308bmRNA\u3068\u53cd\u5bfe\u306b\u3001RNA\u305d\u306e\u3082\u306e\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308bRNA\u306e\u7dcf\u79f0\u3002\u7d0420\u5869\u57fa\u9577\u306emiRNA\u304b\u3089\u3001200\u5869\u57fa\u9577\u3092\u8d85\u3048\u308b\u9577\u9396\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u304c\u5b58\u5728\u3059\u308b\u3002<\/p>\n<p><strong>\u203b\uff12\uff1a\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f<br \/>\n<\/strong>\u7d44\u7e54\u306b\u5b58\u5728\u3059\u308b\u7279\u5b9a\u306e\u7269\u8cea\u306e\u91cf\u304c\u3001\u4ee3\u8b1d\u306a\u3069\u306b\u3088\u3063\u3066\u5f53\u521d\u306e\u91cf\u306e1\/2\u307e\u3067\u6e1b\u5c11\u3059\u308b\u6642\u9593\u306e\u3053\u3068\u3002<\/p>\n<p><strong>\u203b\uff13\uff1a\u9006\u907a\u4f1d\u5b66<br \/>\n<\/strong>\u3042\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3092\u9078\u629e\u7684\u3042\u308b\u3044\u306f\u8a98\u5c0e\u7684\u306b\u7834\u58ca\u3057\u3066\u8868\u73fe\u578b\u3092\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u65b9\u6cd5\u306e\u3053\u3068\u3002<\/p>\n<h4>\uff08\uff17\uff09\u8ad6\u6587\u60c5\u5831<\/h4>\n<p>\u96d1\u8a8c\u540d\uff1a<a href=\"https:\/\/febs.onlinelibrary.wiley.com\/journal\/17424658?utm_source=google&amp;utm_medium=paidsearch&amp;utm_campaign=R3MR425&amp;utm_content=LifeSciences&amp;gclid=Cj0KCQjwib2mBhDWARIsAPZUn_lqTRVIToCqQrtSs8KBLmusc9F54aZ3s-tu4h10sMWC3miERhtv1t4aApFhEALw_wcB\" target=\"_blank\" rel=\"noopener\">The FEBS Journal<\/a><br \/>\n\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/febs.16917\" target=\"_blank\" rel=\"noopener\">Metabolic dynamics of microRNA in adult skeletal muscle<\/a><br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u53ca\u5ddd \u54f2\u5fd7\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001Shuaibang Yuan\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001\u52a0\u85e4 \u7fa9\u96c4\uff08\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240\uff09\u3001\u79cb\u672c \u5d07\u4e4b\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u73fe\u5730\u6642\u9593\uff09\uff1a2023\u5e747\u670831\u65e5\uff08\u6708\uff09<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u65e5\u672c\u6642\u9593\uff09\uff1a2023\u5e747\u670831\u65e5\uff08\u6708\uff09<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/febs.16917\" target=\"_blank\" rel=\"noopener\">https:\/\/febs.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/febs.16917<\/a><br \/>\nDOI\uff1a<a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/febs.16917\" target=\"_blank\" rel=\"noopener\">10.1111\/febs.16917<\/a><\/p>\n<h4>\uff08\uff18\uff09\u7814\u7a76\u52a9\u6210<\/h4>\n<ul style=\"list-style-type: square;\">\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\uff08\u57fa\u76e4\u7814\u7a76(A)\uff09<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u904b\u52d5\u5fdc\u7b54\u6027\u30de\u30a4\u30af\u30edRNA\u306b\u3088\u308b\u5bff\u547d\u306e\u5236\u5fa1<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u79cb\u672c\u5d07\u4e4b\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/li>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\uff08\u6311\u6226\u7684\u7814\u7a76\uff08\u958b\u62d3\uff09\uff09<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u904b\u52d5\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u5206\u5b50\u57fa\u76e4<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u79cb\u672c\u5d07\u4e4b\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/li>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\uff08\u57fa\u76e4\u7814\u7a76(B)\uff09<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u904b\u52d5\u306b\u3088\u308b\u9aa8\u683c\u7b4b\u6bdb\u7d30\u8840\u7ba1\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u518d\u69cb\u7bc9\u306b\u304a\u3051\u308b\u30de\u30a4\u30af\u30edRNA\u306e\u5f79\u5272<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u79cb\u672c\u5d07\u4e4b\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/li>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\uff08\u7814\u7a76\u6d3b\u52d5\u30b9\u30bf\u30fc\u30c8\u652f\u63f4\uff09<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u751f\u4f53\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u30de\u30a4\u30af\u30edRNA\u306e\u4ee3\u8b1d\u52d5\u614b\u306e\u89e3\u6790<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u53ca\u5ddd\u54f2\u5fd7\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/li>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u65e9\u7a32\u7530\u30aa\u30fc\u30d7\u30f3\u30fb\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u30fb\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u6311\u6226\u7684\u7814\u7a76\u30d7\u30ed\u30b0\u30e9\u30e0<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30e1\u30ab\u30cb\u30ab\u30eb\u30b9\u30c8\u30ec\u30b9\u8a98\u5c0e\u6027\u7b4b\u80a5\u5927\u306b\u304a\u3051\u308bmiR-23\u30af\u30e9\u30b9\u30bf\u30fc\u30de\u30a4\u30af\u30edRNA\u306e\u6a5f\u80fd\u89e3\u6790<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1aShuaibang 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