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vitro\u30ea\u30f3\u9178\u5316\u30a2\u30c3\u30bb\u30a4\u3092\u884c\u3044\u307e\u3057\u305f\u3002Pak4\u3001Inka2-iBox\u3001Inka1-iBox\u3001\u305d\u3057\u3066Pak4\u306e\u30ea\u30f3\u9178\u5316\u306b\u5fc5\u8981\u306a\u57fa\u8cea\u3092\u53cd\u5fdc\u3055\u305b\u308b\u3068\u3001Inka1-iBox\u3068Inka2-iBox\u3067\u5171\u306b\u3001\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306bPak4\u306e\u9175\u7d20\u6d3b\u6027\u3092\u5f37\u304f\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f32\uff09\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u30b0\u30eb\u30fc\u30d7I\u306ePak\u30d5\u30a1\u30df\u30ea\u30fc\u3078\u306e\u6291\u5236\u52b9\u679c\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001Inka1\u3068Inka2\u304c\u6301\u3064iBox\u306f\u3001\u30b0\u30eb\u30fc\u30d7II\u306ePak\u30d5\u30a1\u30df\u30ea\u30fc\uff08\u7279\u306bPak4\uff09\u306e\u30ea\u30f3\u9178\u5316\u80fd\u3092\u76f4\u63a5\u7684\u306b\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u8131\u91cd\u5408\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-84918\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka1.jpg\" alt=\"\" width=\"503\" height=\"444\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka1.jpg 1812w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka1-610x538.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka1-768x677.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka1-1536x1354.jpg 1536w\" sizes=\"auto, (max-width: 503px) 100vw, 503px\" \/>\u56f32\uff1aInka1\u3068Inka2\u306b\u3088\u308bPak4\u306e\u9175\u7d20\u6d3b\u6027\u306e\u6291\u5236<\/p>\n<p>\u6b21\u306b\u3001\u300cInka1\u3068Inka2\u304c\u3001\u8133\u5185\u3067Pak4\u3092\u8ca0\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u7d30\u80de\u306e\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u5f62\u6210\u3092\u5236\u5fa1\u3059\u308b\u300d\u3068\u3044\u3046\u4eee\u8aac\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u6211\u3005\u306f\u307e\u305a\u3001Inka2\u306e\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30ca\u30eb\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001Inka2\u306e\u8133\u5185\u306b\u304a\u3051\u308b\u7a7a\u9593\u7684\u306a\u767a\u73fe\u5c40\u5728\u3092Lac Z\u67d3\u8272<sup>\u203b3<\/sup>\u3068<em>In situ<\/em> hybridization\u3092\u7528\u3044\u3066\u8abf\u3079\u307e\u3057\u305f\u3002<em>Inka2<\/em> mRNA\u306f\u524d\u8133\u80cc\u5074\u306e\u5927\u8133\u76ae\u8cea\u3084\u6d77\u99ac\u306a\u3069\u306e\u795e\u7d4c\u7d30\u80de\u7279\u7570\u7684\u306b\u8c4a\u5bcc\u306b\u5b58\u5728\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f33\uff09\u3002<\/p>\n<h6 style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-84919\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka2.jpg\" alt=\"\" width=\"497\" height=\"315\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka2.jpg 2353w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka2-610x386.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka2-2000x1266.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka2-768x486.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka2-1536x973.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka2-2048x1297.jpg 2048w\" sizes=\"auto, (max-width: 497px) 100vw, 497px\" \/>\u56f33\uff1a\u30de\u30a6\u30b9\u80cc\u5074\u524d\u8133\u306b\u304a\u3051\u308bInka2 mRNA\u306e\u7279\u7570\u7684\u306a\u767a\u73fe\u5c40\u5728\uff08\u9752\u8272\uff09<\/h6>\n<p>\u305d\u306e\u4e00\u65b9\u3067\u3001Inka1\u306f\u8133\u5185\u3067\u306e\u767a\u73fe\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002Inka2\u306e\u8133\u5185\u306b\u304a\u3051\u308b\u751f\u7406\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u5168\u8eab\u6027\u306eInka2\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9(Inka2<sup>-\/-<\/sup>)\u3092\u6a39\u7acb\u3057\u307e\u3057\u305f\u3002Inka2<sup>-\/-<\/sup>\u30de\u30a6\u30b9\u306f\u6b63\u5e38\u306b\u6210\u4f53\u3078\u3068\u6210\u9577\u3057\u3001\u8133\u306b\u304a\u3051\u308b\u89e3\u5256\u5b66\u7684\u306a\u5909\u5316\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u795e\u7d4c\u7d30\u80de\u306e\u8a73\u7d30\u306a\u5f62\u614b\u5909\u5316\u3092Golgi\u67d3\u8272<sup>\u203b4<\/sup>\u306b\u3088\u308a\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u751f\u5f8c1\u30f6\u6708\u9f62\u4ee5\u964d\u306eInka2<sup>-\/-<\/sup>\u30de\u30a6\u30b9\u3067\u306f\u3001\u5927\u8133\u76ae\u8cea\u306e\u9310\u4f53\u795e\u7d4c\u7d30\u80de\u306e\u6a39\u72b6\u7a81\u8d77\u306e\u7570\u5e38\u306a\u5c48\u66f2\u53ca\u3073\u5909\u5316\u6a39\u72b6\u7a81\u8d77\u30b9\u30d1\u30a4\u30f3\u5f62\u6210\u306e\u4e0d\u5168\u304c\u8d77\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f34\uff09\u3002\u307e\u305f\u3001Inka2<sup>-\/-<\/sup>\u30de\u30a6\u30b9\u306e\u30b9\u30d1\u30a4\u30f3\u5f62\u6210\u4e0d\u5168\u306f\u3001Inka2<sup>-\/-<\/sup>\u30de\u30a6\u30b9\u7531\u6765\u306e\u521d\u4ee3\u57f9\u990a\u795e\u7d4c\u7d30\u80de\u3067\u3082\u540c\u69d8\u306b\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u308c\u6545\u3001\u3053\u306e\u8868\u73fe\u7cfb\u306f\u795e\u7d4c\u7d30\u80de\u306e\u5185\u5728\u7684\u306a\u5f71\u97ff\u3067\u3042\u308a\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6210\u719f\u904e\u7a0b\u3067\u8d77\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h6 style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-84920\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka3.jpg\" alt=\"\" width=\"474\" height=\"479\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka3.jpg 844w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka3-610x617.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka3-768x776.jpg 768w\" sizes=\"auto, (max-width: 474px) 100vw, 474px\" \/>\u56f34\uff1aInka2<sup>-\/-<\/sup>\u30de\u30a6\u30b9\u306e\u5927\u8133\u76ae\u8cea\u306e\u9310\u4f53\u795e\u7d4c\u7d30\u80de\u306e\u6a39\u72b6\u7a81\u8d77\u306e\u5f62\u614b\u7570\u5e38\uff08\u77e2\u5370\uff09\u3068\u30b9\u30d1\u30a4\u30f3\u306e\u5f62\u6210\u4e0d\u5168\uff082\uff653\u6bb5\u76ee\uff09<\/h6>\n<p>\u6700\u5f8c\u306bInka2\u306e\u6b20\u640d\u304cPak4\u30b7\u30b0\u30ca\u30eb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3092\u5927\u8133\u76ae\u8cea\u306e\u795e\u7d4c\u7d30\u80de\u306e\u30b7\u30ca\u30d7\u30b9\u304b\u3089\u5358\u96e2\u3057\u305f\u30b7\u30ca\u30d7\u30c8\u30cb\u30e5\u30fc\u30ed\u30bd\u30fc\u30e0(SN)<sup>\u203b5<\/sup>\u3092\u7528\u3044\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002Inka2<sup>-\/-<\/sup>\u7fa4\u306eSN\u3067\u306fPak4\u306e\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u3067\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u91cd\u5408\u3092\u5236\u5fa1\u3059\u308b\u7d4c\u8def\u3067\u3042\u308bLIMK\u3001Cofilin\u306e\u30ea\u30f3\u9178\u5316\u304c\u4ea2\u9032\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f35\uff09\u3002\u5373\u3061\u3001Inka2\u306e\u6b20\u640d\u306b\u3088\u308a\u3001Pak4\u306e\u9175\u7d20\u6d3b\u6027\u304c\u904e\u5270\u4ea2\u9032\u3057\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066Pak4-LIMK-Cofilin\u30b7\u30b0\u30ca\u30eb\u306e\u30ea\u30f3\u9178\u5316\u3082\u4ea2\u9032\u3059\u308b\u3053\u3068\u3067\u3001\u30b9\u30d1\u30a4\u30f3\u5f62\u6210\u306e\u7570\u5e38\u304c\u8d77\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f36\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-84923\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka4-1-scaled.jpg\" alt=\"\" width=\"2560\" height=\"955\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka4-1-scaled.jpg 2560w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka4-1-610x228.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka4-1-2000x746.jpg 2000w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka4-1-768x286.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka4-1-1536x573.jpg 1536w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/10\/Inka4-1-2048x764.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<h4><strong>\uff08\uff13\uff09<\/strong><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h4>\n<p>Pak\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u3088\u308b\u30b9\u30d1\u30a4\u30f3\u5f62\u6210\u5236\u5fa1\u306f\u3001\u7d71\u5408\u5931\u8abf\u75c7\u3084\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u69d8\u3005\u306a\u7cbe\u795e\u75be\u60a3\u3084\u767a\u9054\u969c\u5bb3\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u307e\u305f\u3001Pak\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u795e\u7d4c\u7cfb\u4ee5\u5916\u306b\u304a\u3044\u3066\u3082\u304c\u3093\u3092\u59cb\u3081\u3068\u3057\u305f\u69d8\u3005\u306a\u75be\u60a3\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067Inka2\u304c\u3001\u8133\u5185\u306b\u304a\u3051\u308b\u521d\u3081\u3066\u306ePak4\u963b\u5bb3\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8cInka2\u304c\u95a2\u4e0e\u3059\u308b\u75be\u60a3\u767a\u75c7\u306e\u539f\u56e0\u89e3\u660e\u3084Inka2\u306b\u3088\u308bPak\uff14\u963b\u5bb3\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u5275\u85ac\u958b\u767a\u3078\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4><strong>\uff08\uff14\uff09<\/strong><strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n<p>\u4eca\u56de\u3001\u8133\u5185\u306b\u304a\u3051\u308bInka2\u306e\u5f79\u5272\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u4ed6\u306e\u7d44\u7e54\u306b\u304a\u3044\u3066\u306eInka1\u3068Inka2\u306e\u5404\u3005\u306e\u5f79\u5272\u306f\u672a\u3060\u4e0d\u660e\u3067\u3059\u3002\u307e\u305f\u3001Inka2\u304cPak4\u4ee5\u5916\u306e\u30b0\u30eb\u30fc\u30d7II\u306ePak\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u963b\u5bb3\u52b9\u679c\u3092\u6301\u3064\u304b\u306b\u3064\u3044\u3066\u3082\u4e0d\u660e\u306a\u70b9\u3092\u591a\u304f\u6b8b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8b0e\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4><strong>\uff08\uff15\uff09<\/strong><strong>\u7814\u7a76\u8005\u304b\u3089\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h4>\n<p>\u672c\u7814\u7a76\u306f\u65e9\u7a32\u7530\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\uff08\u5c71\u7530 \u6674\u4e5f\u52a9\u6559, \u6c34\u8d8a \u667a\u4e5f\u6c0f\uff09\u3068\u798f\u4e95\u5927\u5b66\u306e\u5fb3\u6c38 \u6681\u61b2\u51c6\u6559\u6388\u3001\u7686\u69d8\u306e\u5354\u529b\u306b\u3088\u308a\u8ad6\u6587\u5316\u3067\u304d\u307e\u3057\u305f\u3002\u7d30\u80de\u5185\u306e\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u30b9\u30d1\u30a4\u30f3\u5f62\u6210\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u3067\u591a\u6570\u306e\u7cbe\u795e\u75be\u60a3\u306b\u3082\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u751f\u547d\u73fe\u8c61\u3067\u3059\u3002\u672c\u7814\u7a76\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u306e\u65b0\u305f\u306a\u8abf\u7bc0\u6a5f\u69cb\u3092\u767a\u898b\u3057\u305f\u3053\u3068\u3001\u307e\u305f\u8133\u5185\u3067Pak4\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u50cd\u304d\u3092\u6301\u3064\u65b0\u305f\u306a\u56e0\u5b50\u3092\u767a\u898b\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u4eca\u5f8c\u306f\u57fa\u790e\u7814\u7a76\u306e\u307f\u306a\u3089\u305a\u3001\u81e8\u5e8a\u7684\u306a\u89b3\u70b9\u304b\u3089\u3082\u793e\u4f1a\u7684\u306a\u610f\u7fa9\u306f\u5927\u304d\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>\uff08\uff16\uff09<\/strong><strong>\u7528\u8a9e\u8aac\u660e<\/strong><\/h4>\n<p><strong>\u203b1 Pak<\/strong><strong>\u30d5\u30a1\u30df\u30ea\u30fc<br \/>\n<\/strong>Pak4\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u69cb\u9020\u7684\u30fb\u751f\u5316\u5b66\u7279\u5fb4\u304b\u3089Pak1\u20133\u306e\u30b0\u30eb\u30fc\u30d7I\u3068Pak4\u20136\u306e\u30b0\u30eb\u30fc\u30d7II\u306b\u5206\u3051\u3089\u308c\u308b\u3002Rho GTPase\u306b\u95a2\u4e0e\u3059\u308b\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u306e\uff11\u3064\u3067\u3042\u308a\u3001Rac\u3084Cdc42\u306e\u4e0b\u6d41\u56e0\u5b50\u3001LIMK-Cofilin\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u4e0a\u6d41\u56e0\u5b50\u3068\u3057\u3066\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u91cd\u5408\u3092\u5236\u5fa1\u3059\u308b\u3002<\/p>\n<p><strong>\u203b2 <\/strong><strong>\u30bb\u30ea\u30f3\u30fb\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc<br \/>\n<\/strong>ATP\u304b\u3089\u30ea\u30f3\u9178\u57fa\u3092\u3001\u57fa\u8cea\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30bb\u30ea\u30f3\u30fb\u30b9\u30ec\u30aa\u30cb\u30f3\u6b8b\u57fa\u3078\u5171\u6709\u7d50\u5408\u3055\u305b\u308b\u9175\u7d20\u3067\u3042\u308a\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u306e\uff11\u7a2e\u3002\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u3068\u5171\u5f79\u3059\u308b\u3053\u3068\u3067\u3001\u30ea\u30f3\u9178\u5316\u30fb\u8131\u30ea\u30f3\u9178\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5236\u5fa1\u3055\u308c\u3001\u7d30\u80de\u9aa8\u683c\u5f62\u6210\u3084\u7d30\u80de\u63a5\u7740\u306a\u3069\u306e\u591a\u69d8\u306a\u751f\u7406\u73fe\u8c61\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\u3002<\/p>\n<p><strong>\u203b3 LacZ<\/strong><strong>\u67d3\u8272<br \/>\n<\/strong>\u76ee\u7684\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5224\u5225\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u308b\u30ec\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50LacZ\u306e\u67d3\u8272\u6cd5\u3002\u7d30\u80de\u5185\u3067LacZ\u3092\u767a\u73fe\u3059\u308b\u3068\u3001\u305d\u306e\u7ffb\u8a33\u7269\u3067\u3042\u308b\u03b2\u30ac\u30e9\u30af\u30c8\u30b7\u30bf\u30fc\u30bc\u304cX-gal \u57fa\u8cea\u306e\u52a0\u6c34\u5206\u89e3\u3092\u89e6\u5a92\u3057\u3001LacZ\u767a\u73fe\u7d30\u80de\u306f\u9752\u8272\u306b\u767a\u8272\u3059\u308b\u3002\u672c\u7814\u7a76\u3067\u7528\u3044\u305fInka2\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30ca\u30eb\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306b\u306f\u3001Inka2\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306bLacZ\u304c\u633f\u5165\u3055\u308c\u3066\u304a\u308a\u3001Inka2\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u9752\u8272\u306b\u53ef\u8996\u5316\u3067\u304d\u308b\u3002<\/p>\n<p><strong>\u203b4 Golgi<\/strong><strong>\u67d3\u8272<br \/>\n<\/strong>\u795e\u7d4c\u7d30\u80de\u306e\u5f62\u614b\u3092\u53ef\u8996\u5316\u3059\u308b\u305f\u3081\u306e\u934d\u9280\u67d3\u8272\u6cd5\u306e\u2f00\u7a2e\u3002\u8133\u5185\u306e\u7d30\u80de\u304c\u30e9\u30f3\u30c0\u30e0\u306b\u3001\u305d\u3057\u3066\u758e\u3089\u306b\u9ed2\u304f\u67d3\u8272\u3055\u308c\u308b\u305f\u3081\u3001\u5fae\u7d30\u69cb\u9020\u306e\u89b3\u5bdf\u304c\u7d44\u7e54\u30ec\u30d9\u30eb\u3067\u53ef\u80fd\u3068\u306a\u308b\u3002<\/p>\n<p><strong>\u203b5 <\/strong><strong>\u30b7\u30ca\u30d7\u30c8\u30cb\u30e5\u30fc\u30ed\u30bd\u30fc\u30e0\uff08SN\uff09<br \/>\n<\/strong>\u8133\u5185\u306e\u795e\u7d4c\u7d30\u80de\u304c\u6301\u3064\u30dd\u30b9\u30c8\u30b7\u30ca\u30d7\u30b9\u3068\u30d7\u30ec\u30b7\u30ca\u30d7\u30b9\u3092\u7279\u7570\u7684\u306b\u5206\u753b\u3057\u305f\u3082\u306e\u3002\u30b7\u30ca\u30d7\u30c8\u30cb\u30e5\u30fc\u30ed\u30bd\u30fc\u30e0\u306e\u5206\u753b\u306b\u3088\u308a\u3001\u30b7\u30ca\u30d7\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u56e0\u5b50\u7fa4\uff08PSD95\u306a\u3069\uff09\u306e\u307f\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u305d\u308c\u3089\u306e\u5c40\u6240\u7684\u306a\u767a\u73fe\u91cf\u306a\u3069\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n<h4><strong>\uff08\uff17\uff09\u8ad6\u6587\u60c5\u5831<\/strong><\/h4>\n<p>\u96d1\u8a8c\u540d\uff1a<a href=\"https:\/\/journals.plos.org\/plosgenetics\/\">PLOS Genetics<\/a><br \/>\n\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010438\">Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development<\/a><br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a \u5c71\u7530 \u6674\u4e5f<sup>1<\/sup>, \u6c34\u8d8a \u667a\u4e5f<sup>1<\/sup>, \u5fb3\u6c38 \u6681\u61b2<sup>2<\/sup>, \u698a\u539f \u4f38\u4e00<sup>1<\/sup>*<br \/>\n1\uff09\u65e9\u7a32\u7530\u5927\u5b66 \u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662 \u5206\u5b50\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u5ba4<br \/>\n2\uff09\u798f\u4e95\u5927\u5b66 \u30e9\u30a4\u30d5\u30b5\u30a4\u30a8\u30f3\u30b9\u652f\u63f4\u30bb\u30f3\u30bf\u30fc\u751f\u7269\u8cc7\u6e90\u90e8\u9580<br \/>\n*\uff09\u8cac\u4efb\u8457\u8005<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u73fe\u5730\u6642\u9593\uff09\uff1a10\u670827\u65e5\uff08\u6728\uff0911:00\uff08\u592a\u5e73\u6d0b\u6642\u9593\uff09\/14:00\uff08\u7c73\u6771\u90e8\u6642\u9593\uff09<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u65e5\u672c\u6642\u9593\uff09\uff1a10\u670828\u65e5\uff08\u91d1\uff093:00<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010438\">https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010438<\/a><br \/>\nDOI\uff1a<a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010438\">https:\/\/doi.org\/10.1371\/journal.pgen.1010438<\/a><\/p>\n<h4>\uff08\uff18\uff09\u7814\u7a76\u52a9\u6210<\/h4>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u57fa\u76e4\u7814\u7a76\uff08C\uff09<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306e\u5f62\u614b\u30fb\u79fb\u52d5\u3092\u5236\u5fa1\u3059\u308b\u65b0\u898f\u5206\u5b50\u7fa4\u306e\u6a5f\u80fd\u89e3\u660e<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u698a\u539f \u4f38\u4e00\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/p>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u57fa\u76e4\u7814\u7a76\uff08C\uff09<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u6a39\u72b6\u7a81\u8d77\u30b9\u30d1\u30a4\u30f3\u306e\u5f62\u6210\u30fb\u5b89\u5b9a\u6027\u3092\u62c5\u3046\u65b0\u305f\u306a\u30a2\u30af\u30c1\u30f3\u9aa8\u683c\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u698a\u539f \u4f38\u4e00\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u795e\u7d4c\u7d30\u80de\u306e\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u3092\u62c5\u3046\u56e0\u5b50\u3092\u767a\u898b \u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u767a\u75c7\u539f\u56e0\u306e\u89e3\u660e\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u3092\u671f\u5f85 \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u5927\u8133\u306e\u795e\u7d4c\u7d30\u80de\u306b\u767a\u73fe\u3059\u308bInka2\u304c\u3001Pak4\u306e\u30ea\u30f3\u9178\u5316\u3092\u76f4\u63a5\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u306e\u5f62\u6210\u3092\u8abf\u7bc0\u3059\u308b\u3053 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":84927,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,5],"class_list":["post-84905","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/84905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=84905"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/84905\/revisions"}],"predecessor-version":[{"id":85168,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/84905\/revisions\/85168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/84927"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=84905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=84905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=84905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}