{"id":78918,"date":"2022-03-11T11:00:21","date_gmt":"2022-03-11T02:00:21","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=78918"},"modified":"2022-03-11T11:05:48","modified_gmt":"2022-03-11T02:05:48","slug":"%e6%98%a5%e3%82%a6%e3%82%b3%e3%83%b3%e3%81%ab%e5%90%ab%e3%81%be%e3%82%8c%e3%82%8b%e6%b4%bb%e6%80%a7%e6%88%90%e5%88%86%e3%82%92%e5%90%8c%e5%ae%9a","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/78918","title":{"rendered":"\u6625\u30a6\u30b3\u30f3\u306b\u542b\u307e\u308c\u308b\u6d3b\u6027\u6210\u5206\u3092\u540c\u5b9a"},"content":{"rendered":"<p style=\"text-align: center;\"><strong>\u8a8d\u77e5\u75c7\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u4e88\u9632\u306b\u5411\u3051\u3066\u671f\u5f85\u9ad8\u307e\u308b<\/strong><\/p>\n<h1 style=\"text-align: center;\"><strong>\u6625\u30a6\u30b3\u30f3\u306b\u542b\u307e\u308c\u308b\uff13\u3064\u306e\u751f\u7269\u6d3b\u6027\u6210\u5206\u3092\u540c\u5b9a<\/strong><\/h1>\n<h2 style=\"text-align: center;\"><strong>coronarin D<\/strong><strong>\u304c\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u5f37\u304f\u4fc3\u9032<\/strong><\/h2>\n<p><strong>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/p>\n<h4>\u79cb\u30a6\u30b3\u30f3\u3068\u6bd4\u3079\u3066\u7814\u7a76\u304c\u9045\u308c\u3066\u3044\u308b\u6625\u30a6\u30b3\u30f3\u306b\u3064\u3044\u3066\u3001<em>in vitro<\/em>\u795e\u7d4c\u5206\u5316\u8a98\u5c0e\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\u30af\u30eb\u30af\u30df\u30f3\u4ee5\u5916\u306e\u6d3b\u6027\u6210\u5206\u306e\u63a2\u7d22\u3092\u884c\u3063\u305f<\/h4>\n<h4>\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u5f37\u304f\u4fc3\u9032\u3059\u308b\u6625\u30a6\u30b3\u30f3\u306e\u6d3b\u6027\u6210\u5206\u3068\u3057\u3066\u3001coronarin D\u3092\u898b\u51fa\u3059\u3053\u3068\u304c\u51fa\u6765\u305f<\/h4>\n<h4>\u8a8d\u77e5\u75c7\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4e88\u9632\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3078\u306ecoronarin D\u306e\u6a5f\u80fd\u5fdc\u7528\u304c\u671f\u5f85\u3067\u304d\u308b<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78922\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/06a920d0d2622594d84b422600f5664c.jpg\" alt=\"\" width=\"1647\" height=\"1041\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/06a920d0d2622594d84b422600f5664c.jpg 1647w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/06a920d0d2622594d84b422600f5664c-610x386.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/06a920d0d2622594d84b422600f5664c-768x485.jpg 768w\" sizes=\"auto, (max-width: 1647px) 100vw, 1647px\" \/><\/p>\n<p><a href=\"https:\/\/www.waseda.jp\/fsci\/\">\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662<\/a>\u306e\u5927\u585a\u609f\u53f2\uff08\u304a\u304a\u3064\u304b\u3055\u3068\u3057\uff09\u62db\u8058\u7814\u7a76\u54e1\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u304a\u3088\u3073<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000906_ja.html\">\u4e2d\u5c3e\u6d0b\u4e00\uff08\u306a\u304b\u304a\u3088\u3046\u3044\u3061\uff09\u6559\u6388<\/a>\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6625\u30a6\u30b3\u30f3<em>Curcuma aromatica<\/em>\u306b\u542b\u307e\u308c\u308b\u751f\u7269\u6d3b\u6027\u6210\u5206\u3068\u3057\u3066\u2460coronarin C\u3001\u2461coronarin D\u3001\u2462(<em>E<\/em>)-labda-8(17),12-diene-15,16-dial\u306e3\u7a2e\u985e\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u3046\u3061\u3001coronarin D\u306b\u306f\u795e\u7d4c\u5e79\u7d30\u80de<sup>\u203b1<\/sup>\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8<sup>\u203b2<\/sup>\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u5f37\u304f\u4fc3\u9032\u3059\u308b\u6d3b\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u7c73\u56fd\u5316\u5b66\u4f1a\u8a8c\u300e<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c00020\"><strong>Journal of Agricultural and Food Chemistry<\/strong><\/a>\u300f\u306b2022\u5e743\u67084\u65e5\uff08\u91d1\uff09\u4ed8\u3051\u3067\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h5><strong>\u3010\u8ad6\u6587\u60c5\u5831\u3011<\/strong><\/h5>\n<p><strong>\u96d1\u8a8c\u540d\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c00020\">Journal of Agricultural and Food Chemistry<\/a><br \/>\n<strong>\u8ad6\u6587\u540d\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c00020\">Coronarin D, a Metabolite from the Wild Turmeric, <em>Curcuma aromatica<\/em>, Promotes the Differentiation of Neural Stem Cells into Astrocytes<\/a><\/p>\n<h3><strong>\u00a0<\/strong><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/strong><\/h3>\n<p>\u6625\u30a6\u30b3\u30f3\uff08<em>Curcuma aromatica<\/em>\uff09\u306f\u30012000\u5e74\u4ee5\u4e0a\u524d\u304b\u3089\u30a2\u30b8\u30a2\u3092\u4e2d\u5fc3\u306b\u6f22\u65b9\u3084\u751f\u85ac\u3068\u3057\u3066\u5e83\u304f\u89aa\u3057\u307e\u308c\u3066\u304d\u305f\u98df\u6750\u3067\u3042\u308a\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3084\u3001\u6297\u9178\u5316\u4f5c\u7528\u3001\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\u306a\u3069\u69d8\u3005\u306a\u751f\u7269\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u591a\u69d8\u306a\u6625\u30a6\u30b3\u30f3\u306e\u52b9\u80fd\u304c\u7d4c\u9a13\u7684\u306b\u84c4\u7a4d\u3055\u308c\u3066\u304d\u305f\u7d50\u679c\u3001\u73fe\u4ee3\u3067\u3082\u6f22\u65b9\u3084\u751f\u85ac\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u6625\u30a6\u30b3\u30f3\u306e\u6709\u52b9\u6210\u5206\u306b\u3064\u3044\u3066\u6a5f\u80fd\u89e3\u6790\u304c\u9032\u3081\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u591a\u304f\u306f\u30a6\u30b3\u30f3\u7531\u6765\u306e\u4e3b\u8981\u306a\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u6709\u540d\u306a\u30af\u30eb\u30af\u30df\u30f3\u304c\u4e2d\u5fc3\u3067\u3042\u308a\u3001\u305d\u306e\u4ed6\u306e\u6709\u52b9\u6210\u5206\u306e\u63a2\u7d22\u304a\u3088\u3073\u6a5f\u80fd\u89e3\u6790\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u30af\u30eb\u30af\u30df\u30f3\u306b\u306f\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3084\u30cb\u30e5\u30fc\u30ed\u30f3<sup>\u203b3<\/sup>\u3078\u306e\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u4f5c\u7528\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u4ee5\u5916\u306e\u6625\u30a6\u30b3\u30f3\u6210\u5206\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3001\u5206\u5316\u8abf\u7bc0\u6d3b\u6027\u306b\u3064\u3044\u3066\u306f\u6df1\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u6210\u4eba\u8133\u5185\u306e\u4e00\u90e8\u306e\u9818\u57df\u306b\u5b58\u5728\u3059\u308b\u795e\u7d4c\u5e79\u7d30\u80de\u306f\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u30b0\u30ea\u30a2\u7d30\u80de<sup>\u203b4<\/sup>\u306a\u3069\u306e\u795e\u7d4c\u7cfb\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u3053\u3068\u3067\u4e2d\u67a2\u795e\u7d4c\u7cfb\u6a5f\u80fd\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3063\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u30b0\u30ea\u30a2\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u3064\u30a2\u30df\u30ed\u30a4\u30c9\u03b2<sup>\u203b5<\/sup>\u306e\u5206\u89e3\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u7570\u5e38\u3084\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u6570\u306e\u6e1b\u5c11\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u3046\u3064\u75c7\u72b6\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u80cc\u666f\u304b\u3089\u3001\u6a5f\u80fd\u7570\u5e38\u306b\u9665\u3063\u305f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u56de\u5fa9\u3092\u6a19\u7684\u3068\u3057\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u73fe\u6642\u70b9\u3067\u306f\u201c\u6b63\u5e38\u306a\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u305d\u306e\u3082\u306e\u306e\u6570\u3092\u5897\u52a0\u3055\u305b\u308b\u201d\u3068\u3044\u3063\u305f\u4e88\u9632\u533b\u5b66\u7684\u89b3\u70b9\u306b\u7acb\u3063\u305f\u533b\u85ac\u54c1\u306e\u958b\u767a\u7814\u7a76\u4f8b\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u305d\u3053\u3067\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u672a\u3060\u7814\u7a76\u306e\u4f59\u5730\u304c\u6b8b\u3055\u308c\u3066\u3044\u308b<\/p>\n<p><strong>\u201d<\/strong><strong>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u4fc3\u3059\u3053\u3068\u3067\u6b63\u5e38\u306a\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u6570\u3092\u5897\u3084\u3059\u201d<\/strong><\/p>\n<p>\u3068\u3044\u3046\u4e88\u9632\u533b\u5b66\u7684\u306a\u76ee\u6a19\u3092\u8a2d\u5b9a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u3046\u3048\u3067\u3001\u672a\u77e5\u306e\u751f\u7269\u6d3b\u6027\u6210\u5206\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u6625\u30a6\u30b3\u30f3\u304b\u3089\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u4fc3\u9032\u6d3b\u6027\u6210\u5206\u3092\u63a2\u7d22\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u5177\u4f53\u7684\u306b\u306f\u3001\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u30de\u30a6\u30b9ES\u7d30\u80de<sup>\u203b6<\/sup>\u7531\u6765\u795e\u7d4c\u5e79\u7d30\u80de\u306e<em>in vitro<\/em>\u795e\u7d4c\u5206\u5316\u8a98\u5c0e\u30b7\u30b9\u30c6\u30e0<sup>\u203b7<\/sup>\u306b\u3088\u308b\u30a2\u30c3\u30bb\u30a4\u7cfb<sup>\u203b8<\/sup>\u3092\u7528\u3044\u3066\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u4fc3\u9032\u3059\u308b\u6d3b\u6027\u6210\u5206\u306e\u63a2\u7d22\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u4fc3\u9032\u6d3b\u6027\u3092\u6307\u6a19\u3068\u3057\u3066\u3001\u6625\u30a6\u30b3\u30f3\u62bd\u51fa\u7269\u304b\u3089\u5404\u7a2e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u3088\u3063\u3066\u6d3b\u6027\u6210\u5206\u306e\u7cbe\u88fd\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u30e9\u30d6\u30c0\u30f3\u9aa8\u683c<sup>\u203b9<\/sup>\u3092\u6709\u3059\u308b3\u7a2e\u985e\u306e\u5316\u5408\u7269\u3092\u6d3b\u6027\u672c\u4f53\u3068\u3057\u3066\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6d3b\u6027\u5316\u5408\u7269\u306b\u3064\u3044\u3066MS\u304a\u3088\u3073NMR\u306a\u3069\u306e\u5404\u7a2e\u30b9\u30da\u30af\u30c8\u30eb\u89e3\u6790\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u305d\u308c\u305e\u308c\u2460 coronarin C\u304a\u3088\u3073 \u2461 coronarin D\u3001\u2462 (<em>E<\/em>)-labda-8(17),12-diene-15,16-dial\u3068\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\uff08\u56f31\uff09\u3002<\/p>\n<p><strong>\u00a0<\/strong><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-78921\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/be8f52127d09ec280e37d0b67485ec33.jpg\" alt=\"\" width=\"600\" height=\"281\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/be8f52127d09ec280e37d0b67485ec33.jpg 1207w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/be8f52127d09ec280e37d0b67485ec33-610x286.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/be8f52127d09ec280e37d0b67485ec33-768x360.jpg 768w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\u5404\u5316\u5408\u7269\u306e\u6d3b\u6027\u3092\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u30013\u3064\u306e\u5316\u5408\u7269\u306e\u4e2d\u3067\u306fcoronarin D\u304c\u4e00\u756a\u5f37\u304f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u4fc3\u9032\u3057\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u6761\u4ef6\u306b\u6bd4\u3079\u3066\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u5206\u5316\u7387\u304c\u7d043\u500d\uff083.19\u00b10.366\uff09\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\uff08\u56f32\u4e0b\uff09\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001coronarin C\u304a\u3088\u3073(<em>E<\/em>)-labda-8(17),12-diene-15,16-dial\u306f\u3001\u985e\u4f3c\u306e\u69cb\u9020\u90e8\u5206\u3092\u5171\u6709\u3059\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001coronarin D\u3068\u6bd4\u8f03\u3057\u3066\u5f31\u3044\u52b9\u679c\uff08\u305d\u308c\u305e\u308c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u6bd41.30\u00b10.121\u30011.45\u00b10.265\uff09\u3057\u304b\u793a\u3055\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f32\u4e0b\uff09\u3002\u4ee5\u4e0a\u306e\u3088\u3046\u306a\u69cb\u9020\u2015\u6d3b\u6027\u76f8\u95a2\u89e3\u6790\u306e\u7d50\u679c\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u4fc3\u9032\u6d3b\u6027\u306b\u306f\u4e8c\u74b0\u6027\u90e8\u5206\uff08\u56f3\uff11\u9752\u67a0\u90e8\u5206\uff09\u306b\u52a0\u3048\u3066\u300115-\u30d2\u30c9\u30ed\u30ad\u30b7-\u0394<sup>12<\/sup>-\u03b3-\u30e9\u30af\u30c8\u30f3\u69cb\u9020\u306b\u542b\u307e\u308c\u308b\u4e8c\u91cd\u7d50\u5408\u306e\u4f4d\u7f6e\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\uff08\u56f31\u8d64\u4e38\u90e8\u5206\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-78919\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/5d1ca0b5fd8c8a10c9c3a31f11044d23.jpg\" alt=\"\" width=\"1150\" height=\"864\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/5d1ca0b5fd8c8a10c9c3a31f11044d23.jpg 1556w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/5d1ca0b5fd8c8a10c9c3a31f11044d23-360x270.jpg 360w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/5d1ca0b5fd8c8a10c9c3a31f11044d23-610x458.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/5d1ca0b5fd8c8a10c9c3a31f11044d23-768x577.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/5d1ca0b5fd8c8a10c9c3a31f11044d23-720x540.jpg 720w\" sizes=\"auto, (max-width: 1150px) 100vw, 1150px\" \/><\/p>\n<p>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u904e\u7a0b\u3067\u6d3b\u6027\u5316\u3055\u308c\u308b\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u3072\u3068\u3064\u306bJAK\/STAT<sup>\u203b10<\/sup>\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u3042\u308a\u307e\u3059\u3002\u8ee2\u5199\u56e0\u5b50\u306eSTAT3<sup>\u203b11<\/sup>\u306f\u6d3b\u6027\u578b\u306eJAK \u306b\u3088\u308a\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\uff08pSTAT3\uff09\u3068\u3001\u6838\u5185\u79fb\u884c\u3057\u3066GFAP\u306a\u3069\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3067\u591a\u304f\u767a\u73fe\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3059\u308b\u7d50\u679c\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u3001coronarin D\u304c\u672c\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u304b\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3092\u7528\u3044\u3066pSTAT3\u967d\u6027\u7d30\u80de\u7387\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001coronarin D\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u6bd4\u3079\u3066pSTAT3\u967d\u6027\u7d30\u80de\u7387\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001JAK\/STAT\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u4fc3\u9032\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\uff08\u56f33\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-78920\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/d3dcfa482e2a8ad5fb5c9c2e28e80112.jpg\" alt=\"\" width=\"1150\" height=\"547\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/d3dcfa482e2a8ad5fb5c9c2e28e80112.jpg 1535w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/d3dcfa482e2a8ad5fb5c9c2e28e80112-610x290.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2022\/03\/d3dcfa482e2a8ad5fb5c9c2e28e80112-768x365.jpg 768w\" sizes=\"auto, (max-width: 1150px) 100vw, 1150px\" \/><\/p>\n<h3><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h3>\n<p>\u9ad8\u9f62\u5316\u304c\u9032\u3080\u308f\u304c\u56fd\u306b\u304a\u3044\u3066\u306f\u3001\u8a8d\u77e5\u75c7\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u60a3\u8005\u6570\u306e\u5897\u52a0\u3068\u3001\u305d\u308c\u306b\u4f34\u3046\u533b\u7642\u8cbb\u8ca0\u62c5\u306e\u5897\u5927\u304c\u554f\u984c\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u305d\u306e\u5bfe\u7b56\u306f\u6025\u52d9\u3068\u8a00\u3048\u307e\u3059\u3002\u52a0\u9f62\u306b\u4f34\u3063\u3066\u751f\u3058\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3078\u306e\u5bfe\u7b56\u306b\u306f\u3001\u6cbb\u7642\u85ac\u30fb\u4e88\u9632\u85ac\u306e\u958b\u767a\u304c\u91cd\u8981\u306a\u306e\u306f\u3082\u3061\u308d\u3093\u3067\u3059\u304c\u3001\u65e5\u3005\u6442\u53d6\u3059\u308b\u98df\u54c1\u3082\u3057\u304f\u306f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u901a\u3057\u3066\u4e88\u9632\u304c\u3067\u304d\u308c\u3070\u3001\u305d\u306e\u6ce2\u53ca\u52b9\u679c\u306f\u5927\u304d\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u5f37\u304f\u4fc3\u9032\u3059\u308b\u6625\u30a6\u30b3\u30f3\u306e\u6d3b\u6027\u6210\u5206\u3068\u3057\u3066\u3001coronarin D\u3092\u898b\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u6625\u30a6\u30b3\u30f3\u306f\u751f\u85ac\u3084\u6f22\u65b9\u3082\u3057\u304f\u306f\u98df\u54c1\u3068\u3057\u3066\u3082\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u6b74\u53f2\u304c\u3042\u308a\u307e\u3059\u3002\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u4fc3\u9032\u6210\u5206\u3068\u3057\u3066\u4eca\u56de\u6211\u3005\u304c\u898b\u51fa\u3057\u305f\u6625\u30a6\u30b3\u30f3\u7531\u6765\u306ecoronarin D\u3092\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u901a\u3057\u3066\u7d99\u7d9a\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u52a0\u9f62\u306b\u3088\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4e88\u9632\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001coronarin D\u306f\u5143\u6765\u98df\u54c1\u6210\u5206\u3067\u3042\u308b\u305f\u3081\u306b\u3001\u5b89\u5168\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u5929\u7136\u6210\u5206\u3068\u3057\u3066\u533b\u85ac\u54c1\u958b\u767a\u3078\u306e\u5fdc\u7528\u3082\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3><strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h3>\n<p>\u4eca\u56de\u306e\u6210\u679c\u3067\u306f\u3001coronarin D\u304cJAK\/STAT\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u5206\u5316\u3092\u4fc3\u9032\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u305f\u3081\u3001\u4eca\u5f8c\u306f\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u3084\u7a2e\u3005\u306e\u751f\u4f53\u5206\u5b50\u306b\u6ce8\u76ee\u3057\u3066coronarin D\u306e\u7cbe\u5bc6\u306a\u4f5c\u7528\u6a5f\u5e8f\u89e3\u6790\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u4eca\u56de\u306f\u30de\u30a6\u30b9ES\u7d30\u80de\u7531\u6765\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u7528\u3044\u3066\u6d3b\u6027\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u304c\u3001\u4eca\u5f8c\u306f\u30d2\u30c8iPS\u7d30\u80de\u7531\u6765\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u7528\u3044\u3066\u30d2\u30c8\u7d30\u80de\u306b\u304a\u3051\u308b\u6d3b\u6027\u306e\u78ba\u8a8d\u3084\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f<em>in vivo<\/em>\u6d3b\u6027\u306e\u8a55\u4fa1\u3092\u884c\u3063\u305f\u4e0a\u3067\u3001\u81e8\u5e8a\u5fdc\u7528\u306b\u5411\u3051\u305f\u77e5\u898b\u3092\u7a4d\u307f\u91cd\u306d\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3><strong>\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n<p>\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u3092\u8abf\u7bc0\u3059\u308b\u98df\u54c1\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u898b\u51fa\u3057\u305f\u6625\u30a6\u30b3\u30f3\u7531\u6765\u306ecoronarin D\u306e\u4f5c\u7528\u6a5f\u5e8f\u89e3\u660e\u304c\u9032\u3081\u3070\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u82e6\u3057\u3080\u60a3\u8005\u3092\u6551\u3046\u533b\u85ac\u54c1\u958b\u767a\u3084\u3001\u52a0\u9f62\u306b\u4f34\u3046\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u4e88\u9632\u3092\u901a\u3057\u3066\u3001\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u9577\u306b\u8ca2\u732e\u3067\u304d\u308b\u3068\u4fe1\u3058\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n<h5>\u203b1\u3000\u795e\u7d4c\u5e79\u7d30\u80de<\/h5>\n<p>\u795e\u7d4c\u6d3b\u52d5\u3092\u62c5\u3046\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u3001\u305d\u306e\u6a5f\u80fd\u3092\u652f\u6301\u3059\u308b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306a\u3069\u306e\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u80fd\u529b\u3092\u6301\u3064\u5e79\u7d30\u80de\u3002\u6210\u4eba\u8133\u5185\u306e\u6d77\u99ac\u3084\u5074\u8133\u5ba4\u306a\u3069\u306b\u5206\u5e03\u3057\u3066\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u6daf\u3092\u901a\u3058\u3066\u795e\u7d4c\u7cfb\u7d30\u80de\u3092\u4f9b\u7d66\u3057\u7d9a\u3051\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<h5>\u203b2\u3000\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8<\/h5>\n<p>\u30b0\u30ea\u30a2\u7d30\u80de\u306e\u3072\u3068\u3064\u3067\u661f\u72b6\u81a0\u7d30\u80de\u3068\u3082\u547c\u3070\u308c\u3066\u3044\u308b\u3002\u795e\u7d4c\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u69cb\u9020\u306e\u7dad\u6301\u306e\u307b\u304b\u3001\u5404\u7a2e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u3084\u308a\u53d6\u308a\u306b\u3082\u95a2\u4e0e\u3057\u3001\u8133\u306e\u6a5f\u80fd\u7dad\u6301\u3084\u53ef\u5851\u6027\u306b\u8abf\u7bc0\u3057\u3066\u3044\u308b\u3002<\/p>\n<h5>\u203b3\u3000\u30cb\u30e5\u30fc\u30ed\u30f3<\/h5>\n<p>\u795e\u7d4c\u7d30\u80de\u3002\u6a39\u72b6\u7a81\u8d77\u3067\u4ed6\u306e\u795e\u7d4c\u7d30\u80de\u304b\u3089\u53d7\u3051\u53d6\u3063\u305f\u523a\u6fc0\u3092\u3001\u8ef8\u7d22\u3092\u901a\u3058\u3066\u5225\u306e\u7d30\u80de\u306b\u4f1d\u9054\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u4f1d\u9054\u6a5f\u80fd\u3092\u62c5\u3046\u3002<\/p>\n<h5>\u203b4\u3000\u30b0\u30ea\u30a2\u7d30\u80de<\/h5>\n<p>\u795e\u7d4c\u7cfb\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306e\u3046\u3061\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u4ee5\u5916\u306e\u7d30\u80de\u306e\u7dcf\u79f0\u3002\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3084\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306a\u3069\u306e\u30b0\u30ea\u30a2\u7d30\u80de\u304c\u30cb\u30e5\u30fc\u30ed\u30f3\u3068\u5354\u8abf\u3057\u3066\u795e\u7d4c\u6d3b\u52d5\u3092\u652f\u3048\u3066\u3044\u308b\u3002<\/p>\n<h5>\u203b5\u3000\u30a2\u30df\u30ed\u30a4\u30c9\u03b2<\/h5>\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u3072\u3068\u3064\u3067\u3042\u308b40\u500b\u7a0b\u5ea6\u306e\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u30da\u30d7\u30c1\u30c9\u3002\u3053\u308c\u304c\u7570\u5e38\u51dd\u96c6\u3057\u305f\u3082\u306e\u304c\u8001\u4eba\u6591\u3068\u3057\u3066\u8133\u5185\u306b\u84c4\u7a4d\u3059\u308b\u3053\u3068\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u7406\u5b66\u7684\u7279\u5fb4\u306e\u4e00\u3064\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<h5>\u203b6\u3000\u30de\u30a6\u30b9ES\u7d30\u80de<\/h5>\n<p>\u30de\u30a6\u30b9\u80da\u6027\uff08embryonic stem\uff09\u5e79\u7d30\u80de\u3002\u53d7\u7cbe\u5f8c3\u30014\u65e5\u76ee\u306e\u80da\u76e4\u80de\u304b\u3089\u53d6\u308a\u51fa\u3057\u3066\u4f5c\u88fd\u3055\u308c\u308b\u591a\u80fd\u6027\u5e79\u7d30\u80de\u306e\u4e00\u3064\u3067\u3001\u81ea\u5df1\u8907\u88fd\u80fd\u3068\u3042\u3089\u3086\u308b\u7d44\u7e54\u306e\u7d30\u80de\u3078\u306e\u5206\u5316\u80fd\u3092\u6301\u3064\u7d30\u80de\u306e\u3053\u3068\u3067\u3042\u308b\u3002<\/p>\n<h5>\u203b7\u3000<em> in vitro<\/em>\u795e\u7d4c\u5206\u5316\u8a98\u5c0e\u30b7\u30b9\u30c6\u30e0<\/h5>\n<p>\u751f\u4f53\u5185\u3067\u8d77\u3053\u308b\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306a\u3069\u306e\u795e\u7d4c\u7cfb\u7d30\u80de\u3078\u306e\u5206\u5316\u8a98\u5c0e\u904e\u7a0b\u3092\u57f9\u990a\u5668\u5185\u3067\u518d\u73fe\u3057\u305f\u3082\u306e\u3002\u4eca\u56de\u306f\u30de\u30a6\u30b9ES\u7d30\u80de\u7531\u6765\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u7528\u3044\u3066\u304a\u308a\u3001\u57f9\u990a\u6761\u4ef6\u3092\u5909\u3048\u308b\u3053\u3068\u3067\u7d30\u80de\u5897\u6b96\u3068\u5206\u5316\u8a98\u5c0e\u306e\u5272\u5408\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3002<\/p>\n<h5>\u203b8\u3000<em>\u30a2\u30c3\u30bb\u30a4\u7cfb<\/em><\/h5>\n<p>\u88ab\u9a13\u7269\u8cea\u306e\u5b58\u5728\u3001\u91cf\u3001\u307e\u305f\u306f\u6a5f\u80fd\u6d3b\u6027\u3092\u5b9a\u6027\u7684\u3082\u3057\u304f\u306f\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\u3001\u6e2c\u5b9a\u3059\u308b\u305f\u3081\u306e\u8a66\u9a13\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u5404\u5316\u5408\u7269\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u52b9\u7387\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n<h5>\u203b9\u3000\u30e9\u30d6\u30c0\u30f3\u9aa8\u683c<\/h5>\n<p>\u5929\u7136\u306e\u4e8c\u74b0\u6027\u30b8\u30c6\u30eb\u30da\u30f3\u3067\u3042\u308b\u30e9\u30d6\u30c0\u30f3\u3092\u57fa\u672c\u69cb\u9020\u3068\u3057\u3001\u30e9\u30d6\u30c0\u30f3\u307e\u305f\u306f\u30e9\u30d6\u30c0\u30f3\u30b8\u30c6\u30eb\u30da\u30f3\u3068\u7dcf\u79f0\u3055\u308c\u308b\u5e45\u5e83\u3044\u5929\u7136\u5316\u5408\u7269\u3092\u69cb\u6210\u3059\u308b\u57fa\u672c\u9aa8\u683c\u3002\u30e9\u30d6\u30c0\u30f3\u9aa8\u683c\u3092\u6709\u3059\u308b\u5316\u5408\u7269\u306b\u306f\u6297\u83cc\u4f5c\u7528\u3084\u6297\u708e\u75c7\u4f5c\u7528\u306a\u3069\u69d8\u3005\u306a\u751f\u7406\u6d3b\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<h5>\u203b10\u3000JAK\/STAT<\/h5>\n<p>\u7d30\u80de\u9593\u306e\u60c5\u5831\u4f1d\u9054\u3092\u884c\u3046\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u3072\u3068\u3064\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306a\u3069\u306e\u5206\u5b50\u304c\u7d30\u80de\u8868\u9762\u306e\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3057\u305fJAK\uff08\u30ea\u30f3\u9178\u5316\u9175\u7d20\u306e\u3072\u3068\u3064\uff09\u304c\u8ee2\u5199\u56e0\u5b50STAT3\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\u30b7\u30b0\u30ca\u30eb\u304c\u4f1d\u9054\u3055\u308c\u308b\u3002<\/p>\n<h5>\u203b11\u3000STAT3<\/h5>\n<p>\u7d30\u80de\u306e\u5897\u6b96\u3084\u5206\u5316\u3001\u7d30\u80de\u6b7b\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3002\u975e\u6d3b\u6027\u5316\u72b6\u614b\u3067\u306f\u7d30\u80de\u8cea\u306b\u5b58\u5728\u3059\u308b\u304c\u3001JAK \u306b\u3088\u308a\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\uff08pSTAT3\uff09\u3068\u3001\u6838\u5185\u79fb\u884c\u3057\u3066\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3059\u308b\u3002\u6d3b\u6027\u578b\u3067\u3042\u308bpSTAT3\u306b\u3088\u3063\u3066\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<h3><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h3>\n<p><strong>\u96d1\u8a8c\u540d\uff1a<\/strong>Journal of Agricultural and Food Chemistry<br \/>\n<strong>\u8ad6\u6587\u540d\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c00020\">Coronarin D, a Metabolite from the Wild Turmeric, <em>Curcuma aromatica<\/em>, Promotes the Differentiation of Neural Stem Cells into Astrocytes<\/a><br \/>\n<strong>\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong>\u5927\u585a\u609f\u53f2<sup>1\u30012<\/sup>\u3001\u5ddd\u6751\u7dd1<sup>1<\/sup>\u3001\u85e4\u91ce\u4fee\u592a\u90ce<sup>1<\/sup>\u3001\u4e2d\u6751\u6587\u5f6c<sup>1<\/sup>\u3001\u65b0\u4e95\u5927\u7950<sup>1<\/sup>\u3001\u4f0f\u8c37\u4f38\u5b8f<sup>2\u30013<\/sup>\u3001<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000906_ja.html\">\u4e2d\u5c3e\u6d0b\u4e00<\/a><sup>1\u30012\uff0a<\/sup>(1\uff1a\u65e9\u7a32\u7530\u5927\u5b66\u5148\u9032\u7406\u5de5\u5b66\u90e8\u3000\u5316\u5b66\u30fb\u751f\u547d\u5316\u5b66\u79d1\u30012\uff1a\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u7dcf\u5408\u7814\u7a76\u6240\u30013\uff1a\u4e00\u822c\u8ca1\u56e3\u6cd5\u4eba\u3000\u51fd\u9928\u56fd\u969b\u6c34\u7523\u30fb\u6d77\u6d0b\u90fd\u5e02\u63a8\u9032\u6a5f\u69cb\u3001\uff0a\u8cac\u4efb\u8457\u8005)<br \/>\n<strong>\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u65e5\uff1a<\/strong>2022\u5e743\u67084\u65e5\uff08\u91d1\uff09<br \/>\n<strong>\u63b2\u8f09URL\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c00020\">https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c00020<\/a><br \/>\n<strong>DOI<\/strong><strong>\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c00020\">10.1021\/acs.jafc.2c00020<\/a><\/p>\n<h3><strong>\u7814\u7a76\u52a9\u6210<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u306f\u3001\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\uff08JSPS\uff09\u79d1\u7814\u8cbb 21H02073\u300118H02100\uff08<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000906_ja.html\">\u4e2d\u5c3e\u6d0b\u4e00<\/a>\uff09\u300126221204\uff08\u5409\u7530\u7a14\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u3000\u7406\u5316\u5b66\u7814\u7a76\u6240\uff09\u300120KK0130\uff08\u4e2d\u5c71\u4e8c\u90ce\u3001\u4e5d\u5dde\u5927\u5b66\u3000\u8fb2\u5b66\u7814\u7a76\u9662\uff09\u3001\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u8fb2\u696d\u30fb\u98df\u54c1\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6a5f\u69cb\u751f\u7269\u7cfb\u7279\u5b9a\u7523\u696d\u6280\u8853\u7814\u7a76\u652f\u63f4\u30bb\u30f3\u30bf\u30fc\u300c\u9769\u65b0\u7684\u6280\u8853\u5275\u9020\u4fc3\u9032\u4e8b\u696d\u300d\uff08\u7570\u5206\u91ce\u878d\u5408\u5171\u540c\u7814\u7a76\uff09\uff0814538918\u3001<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000906_ja.html\">\u4e2d\u5c3e\u6d0b\u4e00<\/a>\uff09\u306e\u52a9\u6210\u3092\u53d7\u3051\u3066\u884c\u308f\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8a8d\u77e5\u75c7\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u4e88\u9632\u306b\u5411\u3051\u3066\u671f\u5f85\u9ad8\u307e\u308b \u6625\u30a6\u30b3\u30f3\u306b\u542b\u307e\u308c\u308b\uff13\u3064\u306e\u751f\u7269\u6d3b\u6027\u6210\u5206\u3092\u540c\u5b9a coronarin D\u304c\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u5f37\u304f\u4fc3\u9032 \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u79cb\u30a6\u30b3\u30f3\u3068\u6bd4\u3079\u3066\u7814 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":78926,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,93,5],"class_list":["post-78918","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-alumni","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/78918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=78918"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/78918\/revisions"}],"predecessor-version":[{"id":78927,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/78918\/revisions\/78927"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/78926"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=78918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=78918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=78918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}