{"id":77238,"date":"2021-12-13T10:00:46","date_gmt":"2021-12-13T01:00:46","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=77238"},"modified":"2021-12-13T10:05:49","modified_gmt":"2021-12-13T01:05:49","slug":"%e8%84%b3%e3%81%ae%e7%99%ba%e7%94%9f%e3%81%ab%e9%87%8d%e8%a6%81%e3%81%aa%e6%96%b0%e3%81%97%e3%81%84%e5%9b%a0%e5%ad%90%e3%82%92%e7%99%ba%e8%a6%8b-2","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/77238","title":{"rendered":"\u8133\u767a\u751f\u306b\u91cd\u8981\u306a\u65b0\u3057\u3044\u56e0\u5b50\u767a\u898b"},"content":{"rendered":"

\u8133\u306e\u767a\u751f\u306b\u91cd\u8981\u306a\u65b0\u3057\u3044\u56e0\u5b50\u3092\u767a\u898b<\/strong><\/h1>\n

SUMO<\/strong>\u5316\u306b\u3088\u308b<\/strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u5236\u5fa1\u3092\u4ecb\u3057\u305f\u8133\u767a\u751f\u8abf\u7bc0\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b<\/strong><\/h2>\n

\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h3>\n
\u8131SUMO\u5316\u9175\u7d20Senp5\u306e\u65b0\u898f\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0(Senp5S)\u3092\u767a\u898b\u3057\u3001Senp5S\u304c\u4ed6\u306e\u8131SUMO\u5316\u9175\u7d20\u7fa4\u3068\u62ee\u6297\u3059\u308b\u3053\u3068\u3067SUMO\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/h5>\n
SUMO\u5316\u3068\u8131SUMO\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u3088\u308a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u304c\u5236\u5fa1\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/h5>\n
SUMO\u5316\u3068\u8131SUMO\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u6b63\u5e38\u306a\u8133\u306e\u767a\u751f\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/h5>\n

\u65e9\u7a32\u7530\u5927\u5b66\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662<\/a>\u306e\u698a\u539f\u4f38\u4e00\uff08\u3055\u304b\u304d\u3070\u3089\u3057\u3093\u3044\u3061\uff09\u6559\u6388<\/a>\u3068\u5c71\u7530\u6674\u4e5f\uff08\u3084\u307e\u3060\u305b\u3044\u3084\uff09\u52a9\u624b<\/a>\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7ffb\u8a33\u5f8c\u4fee\u98fe(\u203b1)<\/sup>\u306e\uff11\u3064\u3067\u3042\u308bSUMO\u5316(\u203b2)<\/sup>\u306b\u3088\u308b\u65b0\u3057\u3044\u8133\u767a\u751f\u306e\u8abf\u7bc0\u6a5f\u69cb\u3092\u3053\u306e\u305f\u3073\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002SUMO\u5316\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3068\u3057\u3066\u3001SUMO\u3092\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u5207\u308a\u96e2\u3059\u50cd\u304d\u3092\u6301\u3064\u8131SUMO\u5316\u9175\u7d20\u7fa4Senps (Senp1-8)\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002SUMO\u5316\u3068\u8131SUMO\u5316\u306e\u8abf\u7bc0\u30b5\u30a4\u30af\u30eb\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u306e\u795e\u7d4c\u75be\u60a3\u3001\u304c\u3093\u3001\u5fc3\u81d3\u75c5\u306a\u3069\u69d8\u3005\u306a\u75be\u60a3\u306b\u95a2\u4e0e\u3057\u3001\u6211\u3005\u304c\u751f\u304d\u308b\u4e0a\u3067\u91cd\u8981\u306a\u751f\u547d\u73fe\u8c61\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u306f\u672a\u89e3\u660e\u306a\u70b9\u304c\u591a\u304f\u3001\u8133\u306e\u767a\u9054\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u95a2\u3057\u3066\u3082\u4e0d\u660e\u3067\u3057\u305f\u3002<\/p>\n

\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306fSenp5\u306b\u7740\u76ee\u3057\u3001\u3053\u308c\u307e\u3067\u672a\u5831\u544a\u3067\u3042\u3063\u305fSenp5\u306e\u65b0\u3057\u3044\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0(Senp5S)\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u3053\u306eSenp5S\u3068\u5f93\u6765\u578b\u306eSenp5 (Senp5L)\u304cSUMO\u5316\u3068\u8131SUMO\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u5185\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u3092\u5236\u5fa1\u3057\u3001\u6b63\u5e38\u306a\u8133\u306e\u767a\u751f\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u672c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u3055\u308c\u305fSUMO\u5316\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u5236\u5fa1\u6a5f\u69cb\u304c\u3001\u69d8\u3005\u306a\u75be\u60a3\u767a\u75c7\u539f\u56e0\u306e\u89e3\u660e\u306b\u5bc4\u4e0e\u3067\u304d\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\"\"<\/p>\n

\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u7c73\u56fd\u306e\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u30b8\u30e3\u30fc\u30ca\u30eb\u300eiScience<\/strong>\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b2021\u5e7412\u670810\u65e5\uff08\u91d1\uff09\uff08\u7c73\u56fd\u6771\u90e8\u6a19\u6e96\u6642\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u8ad6\u6587\u540d\uff1a<\/strong>Drp1 SUMO\/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development<\/a><\/p>\n

\uff08\uff11\uff09\u3000\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/strong><\/h3>\n

\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u878d\u5408\u3068\u5206\u88c2\u3092\u884c\u3046\u3053\u3068\u3067\u5f62\u614b\u5909\u5316\u3057\u3001\u305d\u308c\u3089\u306e\u7834\u7dbb\u306f\u8133\u306e\u5f62\u614b\u7570\u5e38\u3092\u542b\u3080\u69d8\u3005\u306a\u767a\u9054\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u88c2\u306fDrp1\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308a\u5236\u5fa1\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u6570\u306e\u7814\u7a76\u304b\u3089\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001Drp1\u304c\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e\uff11\u3064\u3067\u3042\u308bSUMO\u5316\u4fee\u98fe\u3092\u53d7\u3051\u308b\u3053\u3068\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u305f\u3082\u306e\u306e\u3001\u8a73\u7d30\u306a\u5206\u5b50\u6a5f\u69cb\u306b\u95a2\u3057\u3066\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3042\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001SUMO\u5316\u304c\u3069\u306e\u3088\u3046\u306b\u8133\u306e\u767a\u9054\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u306b\u95a2\u3057\u3066\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\uff08\uff12\uff09\u3000\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h3>\n

\u672c\u7814\u7a76\u3067\u306f\u3001SUMO\u5316\u53ca\u3073\u3001\u8131SUMO\u5316\u9175\u7d20Senp5\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u30de\u30a6\u30b9\u8133\u304b\u3089\u9175\u7d20\u6d3b\u6027\u306e\u7121\u3044Senp5\u306e\u65b0\u3057\u3044\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0(Senp5S)\u3092\u767a\u898b\u3057\u307e\u3057\u305f(\u56f32)\u3002\u307e\u305f\u3001\u57f9\u990a\u7d30\u80de\u3068\u30de\u30a6\u30b9\u80ce\u4ed4\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3092\u884c\u3044\u3001\u300cSenp5S\u3068\u5f93\u6765\u306eSenp5(Senp5L)\u304cSUMO\u5316\u3068\u8131SUMO\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u5236\u5fa1\u3092\u4ecb\u3057\u3066\u8133\u767a\u751f\u3092\u53f8\u308b\u300d\u3068\u3044\u3046\u4eee\u8aac\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/p>\n

\u672c\u7814\u7a76\u3067\u65b0\u898f\u540c\u5b9a\u3057\u305fSenp5S\u306f\u9175\u7d20\u6d3b\u6027\u9818\u57df\u304c\u6b20\u5931\u3057\u3066\u3044\u305f\u305f\u3081(\u56f32)\u3001\u8131SUMO\u5316\u80fd\u304c\u7121\u3044\u3068\u4e88\u60f3\u3055\u308c\u307e\u3057\u305f\u3002\u691c\u8a3c\u306e\u7d50\u679c\u3001Senp5S\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u308b\u3068\u8131SUMO\u5316\u3067\u304d\u306a\u3044\u3060\u3051\u3067\u306a\u304f\u3001\u4ed6\u306eSenps\u3068\u62ee\u6297\u3059\u308b\u3053\u3068\u3067SUMO\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f(\u56f31)\u3002<\/p>\n

\u6b21\u306b\u3001Senp5S\u3068Senp5L\u304cDrp1\u306eSUMO\/\u8131SUMO\u5316\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u3092\u5236\u5fa1\u3059\u308b\u304b\u3092\u3001Drp1\u6b20\u640d\u7d30\u80de\u3068Drp1\u306eSUMO\u5316\u5909\u7570\u4f53(Drp1-4KR)(\u203b3)<\/sup>\u3092\u7528\u3044\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001Senp5S\u306b\u3088\u308bDrp1\u306eSUMO\u5316\u4fc3\u9032\u6761\u4ef6\u3067\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u88c2\u304c\u4fc3\u9032\u3057\u3001Senp5L\u3084Drp1-4KR\u306a\u3069Drp1\u306eSUMO\u5316\u6291\u5236\u6761\u4ef6\u3067\u306f\u5206\u88c2\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f(\u56f33)\u3002<\/p>\n

\u7d9a\u3051\u3066\u3001Drp1\u306eSUMO\u5316\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u5236\u5fa1\u306e\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u2460\u5c0f\u80de\u4f53\u3001\u2461\u30e6\u30d3\u30ad\u30c1\u30f3\u5316(\u203b4)<\/sup>\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002<\/p>\n

    \n
  1. \u8fd1\u5e74\u306e\u7814\u7a76\u3067Drp1\u304c\u5c0f\u80de\u4f53\u306b\u3082\u5c40\u5728\u3057\u3001\u5c0f\u80de\u4f53\u306e\u5f62\u614b\u8abf\u7bc0\u3092\u4ecb\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u88c2\u3092\u884c\u3046\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067Drp1-4KR\u3092\u7528\u3044\u3066\u3001\u5c0f\u80de\u4f53\u306e\u5f62\u614b\u5909\u5316\u3092\u691c\u8a0e\u3057\u305f\u7d50\u679c\u3001Drp1-4KR\u306e\u767a\u73fe\u6642\u3067\u306f\u5c0f\u80de\u4f53\u306e\u7db2\u76ee\u69cb\u9020\u304c\u7834\u7dbb\u3057\u3001\u30b7\u30fc\u30c8\u72b6\u306b\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/li>\n
  2. SUMO\u5316\u304cDrp1\u306e\u5b89\u5b9a\u6027\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001Drp1\u306e\u8131SUMO\u5316\u6642\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306e\u4fc3\u9032\u304c\u8a8d\u3081\u3089\u308c\u3001Drp1\u306e\u5b89\u5b9a\u6027\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3088\u308a\u3001Drp1\u306eSUMO\u5316\u5236\u5fa1\u304c\u5c0f\u80de\u4f53\u306e\u5f62\u614b\u5909\u5316\u3068\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306e\u53cc\u65b9\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u3092\u5236\u5fa1\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ol>\n

    \"\"<\/p>\n

    \u6700\u5f8c\u306b\u8133\u767a\u751f\u6642\u306eSUMO\u5316\u306e\u5f79\u5272\u3092\u8abf\u3079\u308b\u305f\u3081\u3001\u30de\u30a6\u30b9\u80ce\u4ed4\u8133\u5185\u3067Senp5\u306e\u767a\u73fe\u6291\u5236\u3068\u5f37\u5236\u767a\u73fe\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u53cc\u65b9\u306e\u5834\u5408\u3067\u795e\u7d4c\u7d30\u80de\u306e\u79fb\u52d5\u306e\u969c\u5bb3\u3092\u4f34\u3046\u5927\u8133\u76ae\u8cea\u306e\u767a\u751f\u7570\u5e38\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n

    \u4ee5\u4e0a\u306e\u7d50\u679c\u3088\u308a\u3001Senp5S\u3068Senp5L\u304cDrp1\u306eSUMO\/\u8131SUMO\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u3092\u5236\u5fa1\u3057\u3001\u6b63\u5e38\u306a\u5927\u8133\u76ae\u8cea\u306e\u767a\u751f\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

    \uff08\uff13\uff09\u3000\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h3>\n

    \u8fd1\u5e74\u306e\u7814\u7a76\u304b\u3089SUMO\u5316\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u8abf\u7bc0\u304c\u3001\u8133\u306e\u5f62\u614b\u7570\u5e38\u3092\u542b\u3080\u767a\u9054\u7570\u5e38\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u306e\u795e\u7d4c\u75be\u60a3\u3001\u304c\u3093\u3001\u5fc3\u81d3\u75c5\u306a\u3069\u69d8\u3005\u306a\u75be\u60a3\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u306b\u3088\u308a\u65b0\u898f\u540c\u5b9a\u3055\u308c\u305fSenp5S\u304c\u3001\u767a\u9054\u7570\u5e38\u306b\u95a2\u308f\u308b\u75be\u60a3\u767a\u75c7\u306e\u539f\u56e0\u89e3\u660e\u3084SUMO\u5316\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u5275\u85ac\u958b\u767a\u3078\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

    \uff08\uff14\uff09\u3000\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h3>\n

    \u4eca\u56de\u3001\u5927\u8133\u76ae\u8cea\u767a\u751f\u6642\u306b\u304a\u3051\u308bSenp5\u306e\u5f79\u5272\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u6210\u4f53\u306e\u8133\u3084\u4ed6\u306e\u7d44\u7e54\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u307e\u305f\u3001Senp5\u306e\u4ed6\u306e\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u75be\u60a3\u3068\u306e\u95a2\u9023\u306b\u306f\u4e0d\u660e\u306a\u70b9\u3092\u591a\u304f\u6b8b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8b0e\u3092\u89e3\u304d\u660e\u304b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

    \uff08\uff15\uff09\u3000\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n
    \u203b1: \u7ffb\u8a33\u5f8c\u4fee\u98fe<\/h5>\n

    \u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7ffb\u8a33\u3055\u308c\u305f\u5f8c\u306b\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u4ed8\u52a0\u3055\u308c\u308b\u4fee\u98fe\u306e\u3053\u3068\u3002SUMO\u5316\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3001\u30ea\u30f3\u9178\u5316\u3001\u7cd6\u9396\u4fee\u98fe\u306a\u3069\u304c\u3042\u308a\u3001\u751f\u4f53\u5185\u306b\u304a\u3044\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u767a\u73fe\u3084\u6d3b\u6027\u8abf\u7bc0\u3001\u5b89\u5b9a\u5316\u306a\u3069\u306b\u95a2\u308f\u308b\u3002<\/p>\n

    \u203b2: SUMO\u5316<\/h5>\n

    SUMO\u306fSmall Ubiquitin-related Modifier\u306e\u7565\u3067\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u3068\u69cb\u9020\u304c\u826f\u304f\u4f3c\u305f\u7d04100\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u304b\u3089\u306a\u308b\u4f4e\u5206\u5b50\u91cf\u30bf\u30f3\u30d1\u30af\u8cea\u3002\u30d2\u30c8\u306b\u306fSUMO1-4\u304c\u5b58\u5728\u3059\u308b\u3002SUMO\u5316\u306f\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e1\u3064\u3067\u3001SUMO\u5206\u5b50\u304c\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5171\u6709\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5404\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u8abf\u7bc0\u3084\u5b89\u5b9a\u5316\u3001\u5c40\u5728\u5909\u5316\u306a\u3069\u69d8\u3005\u306a\u7d30\u80de\u5185\u5206\u5b50\u6a5f\u69cb\u3092\u8abf\u7bc0\u3059\u308b\u3002\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089SUMO\u3092\u89e3\u96e2\u3059\u308b\u8131SUMO\u5316\u306fSenps (Senp1-8)\u304c\u62c5\u3046\u3002<\/p>\n

    \u203b3: SUMO\u5316\u5909\u7570\u4f53<\/h5>\n

    \u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306eSUMO\u5316\u7d50\u5408\u90e8\u4f4d\u306eK(\u30ea\u30b8\u30f3)\u3092\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u3059\u308b\u3053\u3068\u3067SUMO\u5316\u3067\u304d\u306a\u304f\u3055\u305b\u305f\u5909\u7570\u4f53\u3002\u672c\u7814\u7a76\u3067\u306f\u3001Drp1\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u4e2d\u30674\u3064\u306eK(\u30ea\u30b8\u30f3)\u3092R(\u30a2\u30eb\u30ae\u30cb\u30f3)\u306b\u7f6e\u63db\u3057\u305fSUMO\u5316\u5909\u7570\u4f53(Drp1-4KR)\u3092\u7528\u3044\u305f\u3002<\/p>\n

    \u203b4: \u30e6\u30d3\u30ad\u30c1\u30f3\u5316<\/h5>\n

    \u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e1\u3064\u3002\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30e6\u30d3\u30ad\u30c1\u30f3\u306e\u4fee\u98fe\u3092\u53d7\u3051\u305f\u5834\u5408\u3001\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u3092\u53d7\u3051\u308b\u3002<\/p>\n

    \uff08\uff16\uff09\u3000<\/strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h3>\n

    \u96d1\u8a8c\u540d<\/strong>\uff1a<\/strong>iScience
    \n\u8ad6\u6587\u540d\uff1a<\/strong>Drp1 SUMO\/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development<\/a>
    \n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong>    Seiya Yamada\uff08\u5c71\u7530\u6674\u4e5f\uff09<\/a>1<\/sup>, Ayaka Sato\uff08\u4f50\u85e4\u5f69\u4f73\uff091<\/sup>, Naotada Ishihara\uff08\u77f3\u539f\u76f4\u5fe0\uff092<\/sup>, Hiroki Akiyama\uff08\u79cb\u5c71\u535a\u7d00\uff091,3<\/sup>*, and Shin-ichi Sakakibara\uff08\u698a\u539f\u4f38\u4e00\uff09<\/a>1<\/sup>*<\/p>\n

    1) \u65e9\u7a32\u7530\u5927\u5b66\u3000\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662\u3000\u5206\u5b50\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u5ba4
    \n2) \u5927\u962a\u5927\u5b66 \u7406\u5b66\u7814\u7a76\u79d1 \u751f\u7269\u79d1\u5b66\u5c02\u653b\u3000\u7d30\u80de\u751f\u547d\u79d1\u5b66\u7814\u7a76\u5ba4
    \n3) \u65e9\u7a32\u7530\u5927\u5b66 \u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662\u3000\u4eba\u9593\u7dcf\u5408\u7814\u7a76\u30bb\u30f3\u30bf\u30fc
    \n*) \u8cac\u4efb\u8457\u8005<\/p>\n

    \u63b2\u8f09\u65e5\uff08\u73fe\u5730\u6642\u9593\uff09\uff1a\u3000<\/strong>2021\u5e7412\u670810\u65e5\uff08\u91d1\uff09\uff08\u7c73\u56fd\u6771\u90e8\u6a19\u6e96\u6642\uff09
    \n\u63b2\u8f09URL\uff1a\u3000<\/strong>    https:\/\/www.cell.com\/iscience\/fulltext\/S2589-0042(21)01455-3<\/a>
    \nDOI<\/strong>\uff1a\u3000<\/strong>    https:\/\/doi.org\/10.1016\/j.isci.2021.103484<\/a><\/p>\n

    \uff08\uff17\uff09\u3000<\/strong>\u7814\u7a76\u52a9\u6210<\/strong><\/h3>\n

    \u7814\u7a76\u8cbb\u540d\uff1a\u57fa\u76e4\u7814\u7a76(C)
    \n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u65b0\u898fSUMO\u5316\u8abf\u7bc0\u6a5f\u69cb\u306b\u3088\u308b\u795e\u7d4c\u7a81\u8d77\u767a\u9054\u5236\u5fa1
    \n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u79cb\u5c71\u535a\u7d00 (\u65e9\u7a32\u7530\u5927\u5b66)<\/p>\n

    \u7814\u7a76\u8cbb\u540d\uff1a\u57fa\u76e4\u7814\u7a76(C)
    \n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306e\u5f62\u614b\u30fb\u79fb\u52d5\u3092\u5236\u5fa1\u3059\u308b\u65b0\u898f\u5206\u5b50\u7fa4\u306e\u6a5f\u80fd\u89e3\u660e
    \n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u698a\u539f\u4f38\u4e00 (\u65e9\u7a32\u7530\u5927\u5b66)<\/p>\n

    \uff08\uff18\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n

    \u672c\u7814\u7a76\u306f\u65e9\u7a32\u7530\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7(\u5c71\u7530\u6c0f\u3001\u4f50\u85e4\u6c0f\u3001\u79cb\u5c71\u5148\u751f)\u3068\u5927\u962a\u5927\u5b66\u306e\u77f3\u539f\u5148\u751f\u3001\u7686\u69d8\u306e\u5354\u529b\u306b\u3088\u308a\u8ad6\u6587\u5316\u3067\u304d\u307e\u3057\u305f\u3002SUMO\u5316\u306f\u591a\u6570\u306e\u75be\u60a3\u306b\u3082\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u751f\u547d\u73fe\u8c61\u3067\u3059\u3002\u672c\u7814\u7a76\u306f\u3001SUMO\u5316\u306e\u65b0\u305f\u306a\u8abf\u7bc0\u6a5f\u69cb\u3092\u767a\u898b\u3057\u305f\u3053\u3068\u3001\u307e\u305fSUMO\u5316\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u5236\u5fa1\u3001\u8133\u767a\u751f\u3092\u7d50\u3073\u3064\u3051\u308b\u77e5\u898b\u3092\u5f97\u305f\u3053\u3068\u304b\u3089\u3001\u4eca\u5f8c\u306e\u57fa\u790e\u7814\u7a76\u3078\u306e\u5f71\u97ff\u306e\u307f\u306a\u3089\u305a\u81e8\u5e8a\u7684\u306a\u89b3\u70b9\u304b\u3089\u3082\u793e\u4f1a\u7684\u306a\u610f\u7fa9\u306f\u5927\u304d\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u8133\u306e\u767a\u751f\u306b\u91cd\u8981\u306a\u65b0\u3057\u3044\u56e0\u5b50\u3092\u767a\u898b SUMO\u5316\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u5236\u5fa1\u3092\u4ecb\u3057\u305f\u8133\u767a\u751f\u8abf\u7bc0\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u8131SUMO\u5316\u9175\u7d20Senp5\u306e\u65b0\u898f\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0(Senp5S)\u3092\u767a\u898b\u3057\u3001Senp5S\u304c\u4ed6\u306e\u8131SUM […]<\/p>\n","protected":false},"author":1,"featured_media":77248,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,204,5],"class_list":["post-77238","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-highlight","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/77238","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=77238"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/77238\/revisions"}],"predecessor-version":[{"id":77249,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/77238\/revisions\/77249"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/77248"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=77238"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=77238"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=77238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}