{"id":75228,"date":"2021-10-25T11:00:31","date_gmt":"2021-10-25T02:00:31","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=75228"},"modified":"2022-02-21T15:55:35","modified_gmt":"2022-02-21T06:55:35","slug":"%ef%bc%88%e4%bb%ae%ef%bc%89%e4%b8%b8%e5%b1%b1%e5%85%88%e7%94%9f","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/75228","title":{"rendered":"\u4e88\u9632\u7684\u306b\u767a\u304c\u3093\u3092\u6291\u5236\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0"},"content":{"rendered":"<h1><strong>\u4e88\u9632\u7684\u306b\u767a\u304c\u3093\u3092\u6291\u5236\u3059\u308b\u4e0a\u76ae\u7d30\u80de\u306b\u3088\u308b\u524d\u304c\u3093\u7d30\u80de\u306e\u8a8d\u8b58\u6a5f\u69cb\u3092\u89e3\u660e<\/strong><\/h1>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-75994\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2021\/10\/maruyama1.jpg\" alt=\"\" width=\"537\" height=\"527\" \/><\/p>\n<h3><strong>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h3>\n<ul>\n<li>\u975e\u514d\u75ab\u7d30\u80de\u3067\u3042\u308b\u4e0a\u76ae\u7d30\u80de\u304c\u3001\u304c\u3093\u306e\u5143\u3068\u306a\u308b\u524d\u304c\u3093\u7d30\u80de\u3092\u8a8d\u8b58\u3057\u3001\u653b\u6483\u30fb\u6392\u9664\u3059\u308b\u3068\u3044\u3046\u514d\u75ab\u7d30\u80de\u69d8\u306e\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/li>\n<li>\u524d\u304c\u3093\u7d30\u80de\u3067\u767a\u73fe\u304c\u4fc3\u9032\u3057\u305fMHC-I\u3092\u8a8d\u8b58\u3059\u308b\u3001\u4e0a\u76ae\u7d30\u80de\u306e\u53d7\u5bb9\u4f53AltR\u3092\u65b0\u898f\u306b\u540c\u5b9a\u3057\u3001\u305d\u306e\u6392\u9664\u80fd\u60f9\u8d77\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u305f\u3002<\/li>\n<li>MHC-I\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30de\u30a6\u30b9\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u524d\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308b\u4e0a\u76ae\u7d30\u80de\u306e\u6392\u9664\u80fd\u304c\u4fc3\u9032\u3055\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u672c\u7814\u7a76\u7d50\u679c\u306f\u3001\u304c\u3093\u3092\u4e88\u9632\u7684\u306b\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u9769\u65b0\u7684\u306a\u533b\u7642\u306e\u78ba\u7acb\u3078\u3068\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n<p><a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001515_ja.html\">\u65e9\u7a32\u7530\u5927\u5b66\u9ad8\u7b49\u7814\u7a76\u6240\u306e\u4e38\u5c71\u525b\uff08\u307e\u308b\u3084\u307e\u305f\u3051\u3057\uff09\u51c6\u6559\u6388<\/a>\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u3053\u306e\u305f\u3073\u3001\u975e\u514d\u75ab\u7d30\u80de\u3067\u3042\u308b\u4e0a\u76ae\u7d30\u80de\u304c\u524d\u304c\u3093\u7d30\u80de\u306eMHC-I<sup>*1<\/sup>\u3092\u8a8d\u8b58\u3057\u3001\u3055\u3089\u306b\u305d\u306e\u4e0a\u76ae\u7d30\u80de\u304c\u524d\u304c\u3093\u7d30\u80de\u3092\u751f\u4f53\u304b\u3089\u6392\u9664\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u80ba\u3084\u8178\u306a\u3069\u306e\u8868\u5c64\u3092\u69cb\u6210\u3059\u308b\u4e0a\u76ae\u7d30\u80de\u306f\u300c\u7d30\u80de\u7af6\u5408\u300d\u3068\u3044\u3046\u3001\u304c\u3093\u306e\u5143\u3068\u306a\u308b\u524d\u304c\u3093\u7d30\u80de\u3092\u6392\u9664\u3059\u308b\u653b\u6483\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3053\u308c\u307e\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u304c\u524d\u304c\u3093\u7d30\u80de\u306e\u4f55\u3092\u8a8d\u8b58\u3057\u3001\u653b\u6483\u6a5f\u80fd\u3092\u4e0a\u6607\u3055\u305b\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002\u4eca\u56de\u89e3\u660e\u3055\u308c\u305f\u4e0a\u76ae\u7d30\u80de\u306b\u3088\u308b\u524d\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308b\u8a8d\u8b58\u6a5f\u69cb\u3092\u5fdc\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u524d\u304c\u3093\u7d30\u80de\u306e\u52b9\u7387\u7684\u306a\u6392\u9664\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u304c\u3093\u3092\u4e88\u9632\u7684\u306b\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u9769\u65b0\u7684\u306a\u533b\u7642\u306e\u78ba\u7acb\u3078\u3068\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb(AMED) \u306e\u9769\u65b0\u7684\u5148\u7aef\u7814\u7a76\u958b\u767a\u652f\u63f4\u4e8b\u696d\uff08PRIME\uff09\u300c\u751f\u4f53\u7d44\u7e54\u306e\u9069\u5fdc\u30fb\u4fee\u5fa9\u6a5f\u69cb\u306e\u6642\u7a7a\u9593\u7684\u89e3\u6790\u306b\u3088\u308b\u751f\u547d\u73fe\u8c61\u306e\u7406\u89e3\u3068\u533b\u7642\u6280\u8853\u30b7\u30fc\u30ba\u306e\u5275\u51fa\u300d\u7814\u7a76\u958b\u767a\u9818\u57df\u306b\u304a\u3051\u308b\u7814\u7a76\u958b\u767a\u8ab2\u984c\u300c\u6642\u7a7a\u9593\u7684\u7570\u5e38\u30bb\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308b\u304c\u3093\u5909\u7570\u7d30\u80de\u9664\u53bb\u4fee\u5fa9\u300d\uff08<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001515_ja.html\">\u7814\u7a76\u958b\u767a\u4ee3\u8868\u8005\uff1a\u4e38\u5c71\u525b<\/a>\uff09\u7b49\u306e\u652f\u63f4\u306e\u3082\u3068\u884c\u308f\u308c\u305f\u3082\u306e\u3067\u3001<a href=\"https:\/\/www.nature.com\/articles\/s41590-021-01045-6\">\u300eNature Immunology\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b2021\u5e7410\u670822\u65e5\uff08\u91d1\uff09\uff08\u73fe\u5730\u6642\u9593\uff09<\/a>\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\uff08\uff11\uff09\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/strong><\/h3>\n<p>\u54fa\u4e73\u985e\u306e\u4e0a\u76ae\u7d30\u80de\u306f\u3001\u304c\u3093\u5909\u7570\u3092\u751f\u3058\u305f\u7d30\u80de\uff08\u524d\u304c\u3093\u7d30\u80de\uff09\u3092\u653b\u6483\u3057\u3001\u4f53\u5916\u3078\u6392\u9664\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u307e\u3059\uff08\u7d30\u80de\u7af6\u5408\uff09\u3002\u6b63\u5e38\u306a\u4e0a\u76ae\u7d30\u80de\u306f\u524d\u304c\u3093\u7d30\u80de\u306b\u63a5\u89e6\u3059\u308b\u3053\u3068\u3067\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\uff08\u6d3b\u6027\u5316\uff09\u3055\u308c\u3001\u524d\u304c\u3093\u7d30\u80de\u306b\u5411\u304b\u3063\u3066\u7d30\u80de\u9aa8\u683c\u5f62\u6210\u56e0\u5b50\u3092\u96c6\u7a4d\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u5c64\u304b\u3089\u524d\u304c\u3093\u7d30\u80de\u3092\u62bc\u3057\u51fa\u3059\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u3055\u308c\u305f\u4e0a\u76ae\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306a\u30ea\u30ac\u30f3\u30c9\u30fb\u53d7\u5bb9\u4f53\u76f8\u4e92\u4f5c\u7528<sup>*2<\/sup>\u3092\u4ecb\u3057\u3066\u3001\u524d\u304c\u3093\u7d30\u80de\u3092\u8a8d\u8b58\u3057\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002<\/p>\n<h3><strong>\uff08\uff12\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u524d\u304c\u3093\u7d30\u80de\u3092\u8a8d\u8b58\u3059\u308b\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u3055\u308c\u305f\u4e0a\u76ae\u7d30\u80de\u306e\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u3001\u6a5f\u80fd\u304c\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\uff08Ig\uff09\u69d8\u30c9\u30e1\u30a4\u30f3-\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u540c\u5b9a\u3057\u3001\u3053\u308c\u3092<em>Canis<\/em> suboptimal alteration recognizing protein\uff08<em>Canis<\/em> AltR\uff09\u3068\u540d\u4ed8\u3051\u307e\u3057\u305f\u3002\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u524d\u304c\u3093\u7d30\u80de\u306b\u63a5\u3059\u308b\u3053\u3068\u3067\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u3055\u308c\u305f\u6b63\u5e38\u7d30\u80de\u3067\u767a\u73fe\u304c\u5897\u52a0\u3057\u307e\u3059\uff08\u56f31\u5de6\u4e0b\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-75994\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2021\/10\/maruyama1.jpg\" alt=\"\" width=\"537\" height=\"527\" \/><\/p>\n<p>\u4e00\u65b9\u3067\u3001\u524d\u304c\u3093\u7d30\u80de\u3067\u306fRasV12\u30bf\u30f3\u30d1\u30af\u8cea<sup>*3<\/sup>\u306e\u767a\u73fe\u306b\u3088\u3063\u3066\u3001MHC-I\u306e\u767a\u73fe\u304c\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002Ig\u69d8\u30c9\u30e1\u30a4\u30f3\u306fMHC-I\u3068\u7d50\u5408\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u30c9\u30e1\u30a4\u30f3\u3068\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6b63\u5e38\u7d30\u80de\u306eIg\u69d8\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u3064\u53d7\u5bb9\u4f53AltR\u306f\u524d\u304c\u3093\u7d30\u80de\u306eMHC-I\u306b\u7d50\u5408\u3059\u308b\u3001\u3059\u306a\u308f\u3061\u4e0a\u76ae\u7d30\u80de\u306fAltR\u306b\u3088\u3063\u3066\u3001\u524d\u304c\u3093\u7d30\u80de\u306eMHC-I\u3092\u8a8d\u8b58\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u4eee\u8aac\u3092\u7acb\u3066\u307e\u3057\u305f\u3002<\/p>\n<p><em>in vitro<\/em>\u306e\u7d30\u80de\u7af6\u5408\u30e2\u30c7\u30eb<sup>\uff0a4<\/sup>\u3092\u7528\u3044\u305f\u89e3\u6790\u306b\u3088\u308a\u3001\u6b63\u5e38\u4e0a\u76ae\u7d30\u80de\u4e0a\u306eAltR\u304c\u3001\u524d\u304c\u3093\u7d30\u80de\u3067\u767a\u73fe\u3059\u308bMHC-I\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u5185\u30c9\u30e1\u30a4\u30f3\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30ea\u30f3\u9178\u5316\u306b\u3088\u308a\u6d3b\u6027\u5316\u3057\u305fAltR\u306f\u4e0b\u6d41\u306eSHP2-ROCK2\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u7d30\u80de\u9aa8\u683c\u5f62\u6210\u56e0\u5b50filamin\u3092\u524d\u304c\u3093\u7d30\u80de\u3068\u306e\u5883\u754c\u9762\u306b\u96c6\u7a4d\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u524d\u304c\u3093\u7d30\u80de\u3092\u62bc\u3057\u51fa\u3059\u529b\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u56f31\u53f3\u4e0b\uff09\u3002<\/p>\n<p>\u3055\u3089\u306bMHC-I\u3068AltR \u306e\u7d50\u5408\u9818\u57df\u306e\u7d5e\u308a\u8fbc\u307f\u306b\u3088\u3063\u3066\u3001MHC-I\u306e\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u3067\u3042\u308b\u03b13\u30c9\u30e1\u30a4\u30f3\u3068AltR\u306e\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u3067\u3042\u308bD1\/2\u30c9\u30e1\u30a4\u30f3\u304c\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001<em>in vitro<\/em>\u7d30\u80de\u7af6\u5408\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001MHC-I \u03b13\u30c9\u30e1\u30a4\u30f3\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea<sup>*5<\/sup>\uff08rec.MHC-I \u03b13\uff09\u3092\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\u3001\u6b63\u5e38\u306a\u4e0a\u76ae\u7d30\u80de\u306b\u3088\u308b\u524d\u304c\u3093\u7d30\u80de\u306e\u6392\u9664\u304c\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u304c\u898b\u51fa\u3055\u308c\u307e\u3057\u305f\uff08\u56f32\u5de6\u3001\u30a4\u30e9\u30b9\u30c8\uff09\u3002\u4e00\u65b9\u3067\u3001AltR\u306eD1\/2\u30c9\u30e1\u30a4\u30f3\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea<sup>*5<\/sup>\uff08rec.AltR D1\/2\uff09\u306e\u6295\u4e0e\u3067\u306f\u3001\u524d\u304c\u3093\u7d30\u80de\u306e\u6392\u9664\u304c\u6291\u5236\u3055\u308c\u307e\u3057\u305f\uff08\u56f32\u4e2d\u592e\u3001\u30a4\u30e9\u30b9\u30c8\uff09\u3002<\/p>\n<p>\u307e\u305f\u3055\u3089\u306b\u3001<em>in vivo<\/em>\u30de\u30a6\u30b9\u30e2\u30c7\u30eb<sup>*6<\/sup>\u306b\u304a\u3051\u308b\u816b\u760d\u5f62\u6210\u3068\u767a\u304c\u3093\u306b\u304a\u3044\u3066\u306f\u3001rec.MHC-I \u03b13\u306e\u6295\u4e0e\u306f\u60aa\u6027\u7d50\u7bc0<sup>*7<\/sup>\u306e\u5f62\u6210\u3092\u6291\u5236\u3057\u307e\u3057\u305f\uff08\u56f32\u53f3\u3001\u30a6\u30ec\u30bf\u30f3\u767a\u304c\u3093\u30e2\u30c7\u30eb\u3001\u60aa\u6027\u7d50\u7bc0\uff1a\u5199\u771f\u4e2d\u25b6\uff09\u3002\u3053\u306e\u7d50\u679c\u306f\u3001rec.MHC-I \u03b13\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u3001\u4e0a\u76ae\u7d30\u80de\u306e\u6392\u9664\u6a5f\u80fd\u304c\u4fc3\u9032\u3055\u308c\u3001\u524d\u304c\u3093\u7d30\u80de\u304c\u6392\u9664\u3055\u308c\u305f\u3053\u3068\u3067\u3001\u60aa\u6027\u7d50\u7bc0\u306e\u5f62\u6210\u304c\u6291\u5236\u3055\u308c\u305f\u3053\u3068\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u52a0\u3048\u3066\u3001rec.AltR D1\/2\u306e\u6295\u4e0e\u3067\u306f\u524d\u304c\u3093\u7d30\u80de\u306e\u6392\u9664\u304c\u6291\u5236\u3055\u308c\u305f\u7d50\u679c\u3001\u60aa\u6027\u7d50\u7bc0\uff08\u56f32\u53f3\u3001\u5199\u771f\u4e2d\u25b6\uff09\u306e\u5f62\u6210\u304c\u4fc3\u9032\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u524d\u304c\u3093\u7d30\u80de\u306eMHC-I\u3092\u4e0a\u76ae\u7d30\u80de\u304c\u8a8d\u8b58\u3059\u308b\u3053\u3068\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u304c\u524d\u304c\u3093\u7d30\u80de\u3092\u6392\u9664\u3057\u3001\u767a\u304c\u3093\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-75995\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2021\/10\/maruyama2.jpg\" alt=\"\" width=\"1004\" height=\"525\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2021\/10\/maruyama2.jpg 1004w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2021\/10\/maruyama2-610x319.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2021\/10\/maruyama2-768x402.jpg 768w\" sizes=\"auto, (max-width: 1004px) 100vw, 1004px\" \/><\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u975e\u514d\u75ab\u7d30\u80de\u3067\u3042\u308b\u4e0a\u76ae\u7d30\u80de\u304c\u3001\u524d\u304c\u3093\u7d30\u80de\u306eMHC-I\u3092\u3001AltR\u3092\u4ecb\u3057\u3066\u8a8d\u8b58\u3059\u308b\u3068\u3044\u3046\u514d\u75ab\u7d30\u80de\u69d8\u306e\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u306e\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3092\u3082\u3068\u306b\u3057\u305f\u4e0a\u76ae\u7d30\u80de\u306b\u3088\u308b\u524d\u304c\u3093\u7d30\u80de\u306e\u6392\u9664\u304c\u3001\u767a\u304c\u3093\u3092\u6291\u5236\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<h3><strong>\u00a0<\/strong><strong>\uff08\uff13\uff09\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h3>\n<p>\u4eca\u56de\u89e3\u660e\u3055\u308c\u305f\u6a5f\u69cb\u3092\u3082\u3068\u306b\u3057\u3066\u5f97\u3089\u308c\u305frec. MHC-I \u03b13\u306f\u3001\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u767a\u304c\u3093\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u304c\u3093\u3092\u4e88\u9632\u7684\u306b\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u9769\u65b0\u7684\u306a\u533b\u7642\u3078\u3068\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u7814\u7a76\u306e\u66f4\u306a\u308b\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3><strong>\uff08\uff14\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u3092\u3082\u3068\u306b\u3057\u305f\u304c\u3093\u306e\u4e88\u9632\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u78ba\u7acb\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u304c\u3001\u524d\u304c\u3093\u7d30\u80de\u306f\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u975e\u5e38\u306b\u96e3\u3057\u3044\u305f\u3081\u3001\u524d\u304c\u3093\u7d30\u80de\u3092\u691c\u51fa\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3067\u3059\u3002\u3053\u306e\u691c\u51fa\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001rec.MHC-I \u03b13\u306a\u3069\u3092\u3082\u3068\u306b\u3057\u305f\u6cbb\u7642\u85ac\u304c\u6d3b\u8e8d\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h3><strong>\uff08\uff15\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n<p>\u30d0\u30af\u30c6\u30ea\u30a2\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u611f\u67d3\u75c7\u3067\u306f\u3001\u611f\u67d3\u3092\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308a\u4e88\u9632\u3057\u3001\u611f\u67d3\u8005\u3092\u85ac\u3067\u6cbb\u7642\u3059\u308b\u3068\u3044\u3046\u65b9\u6cd5\u304c\u4e00\u822c\u7684\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u304c\u3093\u306b\u304a\u3044\u3066\u306f\u3001\u767a\u75c7\u5f8c\u306e\u304c\u3093\u6cbb\u7642\u306f\u4e00\u822c\u7684\u3067\u3059\u304c\u3001\u304c\u3093\u3092\u4e88\u9632\u3059\u308b\u3068\u3044\u3046\u6982\u5ff5\u306f\u3042\u307e\u308a\u793e\u4f1a\u306b\u6d78\u900f\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u672c\u7814\u7a76\u306e\u6210\u679c\u304c\u304c\u3093\u306e\u4e88\u9632\u306b\u5411\u3051\u5fdc\u7528\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u306b\u306a\u3089\u306a\u3044\u793e\u4f1a\u306e\u5b9f\u73fe\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\uff08\uff16\uff09\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n<h5>*1 MHC-I<\/h5>\n<ul>\n<li>MHC-I\uff08Major Histocompatibility Complex class I\uff09\u306f\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6297\u539f\u3068\u3057\u3066\u7d30\u80de\u5916\u306b\u63d0\u793a\u3059\u308b\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u306e\u8868\u9762\u306b\u767a\u73fe\u3059\u308b\u3053\u3068\u3067\u3001\u4e00\u822c\u7684\u306b\u514d\u75ab\u7d30\u80de\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u767a\u4fe1\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u50cd\u304f\u3002\u7570\u5e38\u3092\u6301\u3064\u7d30\u80de\u3067\u306fMHC-I\u3092\u7a4d\u6975\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u81ea\u8eab\u304c\u7570\u5e38\u7d30\u80de\u3067\u3042\u308b\u3053\u3068\u3092\u514d\u75ab\u7d30\u80de\u306b\u4f1d\u3048\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<h5>*2\u30ea\u30ac\u30f3\u30c9\uff08MHC-I\uff09\u30fb\u53d7\u5bb9\u4f53\uff08AltR\uff09\u76f8\u4e92\u4f5c\u7528<\/h5>\n<ul>\n<li>\u30ea\u30ac\u30f3\u30c9\u30fb\u53d7\u5bb9\u4f53\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u540c\u58eb\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u4e00\u3064\u3067\u3001\u591a\u304f\u306e\u5834\u5408\u30ea\u30ac\u30f3\u30c9\u304c\u305d\u308c\u3092\u53d7\u5bb9\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u53d7\u5bb9\u4f53\uff09\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u53d7\u5bb9\u4f53\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306e\u7279\u5b9a\u306e\u6a5f\u80fd\u3084\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u306a\u3069\u3092\u6709\u52b9\u5316\u3059\u308b\u3002AltR\uff08suboptimal alteration recognizing protein\uff09\u306fMHC-I\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3046\u308bIg\u69d8\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\uff09\u3067\u3042\u308b\u304c\u3001\u305d\u306e\u6a5f\u80fd\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u3002\u4eca\u56de\u3001\u4e0a\u76ae\u7d30\u80de\u306f\u524d\u304c\u3093\u7d30\u80de\u3068\u63a5\u89e6\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u53d7\u5bb9\u4f53\uff08AltR\uff09\u306e\u767a\u73fe\u91cf\u3092\u4e0a\u6607\u3055\u305b\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bMHC-I\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u53d7\u5bb9\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002<\/li>\n<\/ul>\n<h5>*3 RasV12\u30bf\u30f3\u30d1\u30af\u8cea<\/h5>\n<ul>\n<li>\u539f\u304c\u3093\u907a\u4f1d\u5b50<em>Ras<\/em>\u306e12\u756a\u76ee\u306e\u30b0\u30ea\u30b7\u30f3\uff08G\uff09\u304c\u30d0\u30ea\u30f3\uff08V\uff09\u306b\u5909\u7570\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u907a\u4f1d\u5b50<em>RASV12<\/em>\u3068\u306a\u308b\u3002\u3053\u306e\u304c\u3093\u907a\u4f1d\u5b50<em>RASV12<\/em>\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304cRasV12\u3067\u3042\u308b\u3002RasV12\u306f\u30bf\u30f3\u30d1\u30af\u8ceaRas\u306e\u6052\u5e38\u6d3b\u6027\u578b\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u306b\u304a\u3044\u3066\u306f\u7d30\u80de\u6975\u6027\u5d29\u58ca\u3084\u7d30\u80de\u5897\u6b96\u4fc3\u9032\u3055\u305b\u308b\u306a\u3069\u306b\u3088\u308a\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u4fc3\u9032\u306e\u539f\u56e0\u3068\u306a\u308b\u3002<\/li>\n<\/ul>\n<h5>*4 <em>in vitro<\/em>\u306e\u7d30\u80de\u7af6\u5408\u30e2\u30c7\u30eb<\/h5>\n<ul>\n<li>\u6b63\u5e38\u306a\u57f9\u990a\u7d30\u80de (\u30a4\u30cc\u814e\u81d3\u4e0a\u76ae\u7d30\u80deMDCK\u7d30\u80de\u3084\u30d2\u30c8\u76ae\u819a\u4e0a\u76ae\u7d30\u80deHaCaT\u7d30\u80de\uff09\u3068RasV12\u3092\u767a\u73fe\u3059\u308b\u524d\u304c\u3093\u7d30\u80de\u3092\u5171\u57f9\u990a\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u7af6\u5408\u73fe\u8c61\u3092<em>in vitro<\/em>\uff08\u57f9\u990a\u30c7\u30a3\u30c3\u30b7\u30e5\u4e0a\uff09\u3067\u518d\u69cb\u7bc9\u3057\u305f\u30b7\u30b9\u30c6\u30e0\u306e\u3053\u3068\u3002\u6b63\u5e38\u7d30\u80de\u3068\u524d\u304c\u3093\u7d30\u80de\u3092\u6df7\u5408\u3057\u5358\u5c64\u3092\u5f62\u6210\u3055\u305b\u305f\u3042\u3068\u306b\u524d\u304c\u3093\u7d30\u80de\u306eRasV12\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u5c64\u4e2d\u306b\u524d\u304c\u3093\u7d30\u80de\u304c\u751f\u3058\u305f\u6bb5\u968e\u3092\u6a21\u5023\u3057\u3066\u3044\u308b\u3002\u7d30\u80de\u5c64\u4e2d\u306e\u524d\u304c\u3093\u7d30\u80de\u306f\u3001\u6b63\u5e38\u7d30\u80de\u306b\u62bc\u3057\u51fa\u3055\u308c\u3066\u6700\u7d42\u7684\u306b\u4e0a\u76ae\u7d30\u80de\u5c64\u306e\u9802\u7aef\u5074\u306b\u6392\u9664\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n<h5>*5 \u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\uff08rec.MHC-I \u03b13\u3082\u3057\u304f\u306frec.AltR D1\/2\uff09<\/h5>\n<ul>\n<li>\u6b63\u5e38\u7d30\u80de\u306eAltR\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u90e8\u4f4d\u3067\u3042\u308bMHC-I\u306e\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u3067\u3042\u308b\u03b13\u30c9\u30e1\u30a4\u30f3\u3001\u307e\u305f\u03b13\u30c9\u30e1\u30a4\u30f3\u306e\u7d50\u5408\u3059\u308bAltR\u306eD1\/2\u30c9\u30e1\u30a4\u30f3\u3092\u305d\u308c\u305e\u308c\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8ceaMHC-I \u03b13\u3068rec.AltR D1\/2\u3068\u3057\u3066\u4eba\u5de5\u7684\u306b\u7cbe\u88fd\u3057\u305f\u3002Rec.MHC-I \u03b13\u306f\u3001\u6b63\u5e38\u7d30\u80de\u306eAltR\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6b63\u5e38\u7d30\u80de\u306e\u653b\u6483\u6a5f\u80fd\u3092\u4fc3\u9032\u3059\u308b\u3002\u4e00\u65b9\u3067\u3001rec.AltR D1\/2\u306fMHC-I\u3068AltR\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u7af6\u5408\u7684\u306b\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u6b63\u5e38\u7d30\u80de\u306e\u653b\u6483\u6a5f\u80fd\u306e\u60f9\u8d77\u3092\u963b\u5bb3\u3059\u308b\u3002<\/li>\n<\/ul>\n<h5>*6 <em>in vivo<\/em>\u30de\u30a6\u30b9\u30e2\u30c7\u30eb<\/h5>\n<ul>\n<li>\u30de\u30a6\u30b9\u306b\u816b\u760d\u5f62\u6210\u3084\u767a\u304c\u3093\u3055\u305b\u308b\u5b9f\u9a13\u7cfb\u3067\u3042\u308a\u3001\u760d\u5f62\u6210\u904e\u7a0b\u306e\u89b3\u5bdf\u3084\u767a\u304c\u3093\u3078\u306e\u95a2\u4e0e\u3092\u89e3\u6790\u3067\u304d\u308b\u3002\u816b\u760d\u5f62\u6210\u306b\u95a2\u3057\u3066\u306f\u3001\u30de\u30a6\u30b9\u306b\u6b63\u5e38HaCaT\u7d30\u80de\u3068\u524d\u304c\u3093\u7d30\u80de\u3092\u6df7\u5408\u3057\u76ae\u4e0b\u79fb\u690d\u3059\u308b\u3053\u3068\u3067\u3001\u30de\u30a6\u30b9\u306e\u76ae\u4e0b\u306b\u304a\u3051\u308b\u816b\u760d\u5f62\u6210\u904e\u7a0b\u3092\u89b3\u5bdf\u3067\u304d\u308b\u3002\u767a\u304c\u3093\u306b\u95a2\u3057\u3066\u306f\u3001\u30de\u30a6\u30b9\u306b\u30a6\u30ec\u30bf\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3068\u80ba\u306b\u304a\u3044\u3066\u539f\u304c\u3093\u907a\u4f1d\u5b50<em>Ras<\/em>\u306b\u304c\u3093\u5909\u7570\u304c\u751f\u3058\u3001\u767a\u304c\u3093\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3002\u767a\u304c\u3093\u306e\u521d\u671f\u6bb5\u968e\u3067\u306f\u80ba\u306b\u60aa\u6027\u7d50\u7bc0<sup>*7<\/sup>\u304c\u5f62\u6210\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n<h5>*7 \u60aa\u6027\u7d50\u7bc0<\/h5>\n<ul>\n<li>\u80ba\u306b\u304a\u3044\u3066\u7d30\u80de\u304c\u7570\u5e38\u306b\u5897\u6b96\u3057\u305f\u7d50\u679c\u3001\u7d30\u80de\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u308b\u75c5\u5909\u90e8\u4f4d\u304c\u7d50\u7bc0\u3067\u3042\u308b\u3002\u304c\u3093\u306e\u524d\u75c5\u5909\u3067\u3042\u308b\u60aa\u6027\u7d50\u7bc0\u3067\u306f\u3001\u767a\u304c\u3093\u306e\u521d\u671f\u6bb5\u968e\u306b\u89b3\u5bdf\u3055\u308c\u308b\u3002\u30a6\u30ec\u30bf\u30f3\u3092\u7528\u3044\u305f<em>in vivo<\/em>\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u306f\u3001\u60aa\u6027\u7d50\u7bc0\u4e2d\u306e\u7d30\u80de\u306b\u304a\u3044\u3066\u539f\u304c\u3093\u907a\u4f1d\u5b50<em>Ras<\/em>\u306b\u304c\u3093\u5909\u7570\u304c\u751f\u3058\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<h3><strong>\uff08\uff17\uff09\u8ad6\u6587\u60c5\u5831<\/strong><\/h3>\n<p><strong>\u96d1\u8a8c\u540d\uff1a<\/strong><a href=\"https:\/\/www.nature.com\/ni\/\">Nature Immunology<\/a><br \/>\n<strong>\u8ad6\u6587\u540d\uff1a<\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41590-021-01045-6\">Epithelial cells remove precancerous cells by cell competition via class I MHC-LILRB3 interaction<\/a><br \/>\n<strong>\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong>\u9b8e\u5ddd\u5fd7\u512a<sup>1<\/sup>, \u9d28\u4e0b\u6e1a<sup>2\u2020<\/sup>, \u4e2d\u5c71\u6df3<sup>1\u2020<\/sup>, \u5bfa\u672c\u9f8d\u5e73<sup>1<\/sup>, Novalia Pishesha<sup>3<\/sup>, \u5927\u5ead\u8ce2\u4e8ca<sup>4<\/sup>, \u4f50\u85e4\u5948\u6ce2<sup>5<\/sup>, \u5c0f\u6fa4\u6176<sup>5<\/sup>, \u5b89\u90e8\u5149<sup>1<\/sup>, \u4ed9\u6ce2\u61b2\u592a\u90ce<sup>1<\/sup>, \u5408\u7530\u4e98\u4eba<sup>1<\/sup>, \u85e4\u7530\u606d\u4e4b<sup>5,6<\/sup>, <a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001515_ja.html\">\u4e38\u5c71\u525b<\/a><sup>2,*<\/sup><\/p>\n<p>(<sup>1<\/sup> \u65e9\u7a32\u7530\u5927\u5b66\u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b, <sup>2<\/sup> \u65e9\u7a32\u7530\u5927\u5b66\u9ad8\u7b49\u7814\u7a76\u6240, <sup>3<\/sup> \u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66, <sup>4<\/sup> \u81ea\u6cbb\u533b\u79d1\u5927\u5b66\u5206\u5b50\u75c5\u614b\u6cbb\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u907a\u4f1d\u5b50\u6cbb\u7642\u7814\u7a76\u90e8, <sup>5<\/sup> \u5317\u6d77\u9053\u5927\u5b66\u907a\u4f1d\u5b50\u75c5\u5236\u5fa1\u7814\u7a76\u6240\u5206\u5b50\u816b\u760d\u5206\u91ce, <sup>6<\/sup> \u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u5206\u5b50\u816b\u760d\u5b66, <sup>\u2020<\/sup> These authors are equally contributed, <sup>*<\/sup> \u8cac\u4efb\u8457\u8005)<\/p>\n<p><strong>\u63b2\u8f09\u65e5\u6642\uff08\u73fe\u5730\u6642\u9593\uff09\uff1a<\/strong>2021\u5e7410\u670822\u65e5\uff08\u91d1\uff09<br \/>\n<strong>\u63b2\u8f09URL\uff1a<\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41590-021-01045-6\">https:\/\/www.nature.com\/articles\/s41590-021-01045-6<\/a><br \/>\n<strong>DOI<\/strong><strong>\uff1a<\/strong>10.1038\/s41590-021-01045-6<\/p>\n<h3><strong>\uff08\uff18\uff09\u7814\u7a76\u52a9\u6210<\/strong><\/h3>\n<p><strong>\u7814\u7a76\u8cbb\u540d\uff1a<\/strong>AMED\u9769\u65b0\u7684\u5148\u7aef\u7814\u7a76\u958b\u767a\u652f\u63f4\u4e8b\u696d\uff08PRIME\uff09<br \/>\n<strong>\u7814\u7a76\u8ab2\u984c\u540d\uff1a<\/strong>\u6642\u7a7a\u9593\u7684\u7570\u5e38\u30bb\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308b\u304c\u3093\u5909\u7570\u7d30\u80de\u9664\u53bb\u4fee\u5fa9<br \/>\n<strong>\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong><a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001515_ja.html\">\u4e38\u5c71\u3000\u525b\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/a><\/p>\n<p><strong>\u7814\u7a76\u8cbb\u540d\uff1a<\/strong>JST\u3055\u304d\u304c\u3051<br \/>\n<strong>\u7814\u7a76\u8ab2\u984c\u540d\uff1a<\/strong>\u5149\u64cd\u4f5c\u578b-\u751f\u4f53\u5185\u4e0d\u5747\u4e00\u5909\u7570\u7d30\u80de\u8a98\u5c0e\u3068\u5909\u7570\u7d30\u80de\u306e\u6319\u52d5\u89e3\u660e<br \/>\n<strong>\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong><a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001515_ja.html\">\u4e38\u5c71\u3000\u525b\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e88\u9632\u7684\u306b\u767a\u304c\u3093\u3092\u6291\u5236\u3059\u308b\u4e0a\u76ae\u7d30\u80de\u306b\u3088\u308b\u524d\u304c\u3093\u7d30\u80de\u306e\u8a8d\u8b58\u6a5f\u69cb\u3092\u89e3\u660e \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u975e\u514d\u75ab\u7d30\u80de\u3067\u3042\u308b\u4e0a\u76ae\u7d30\u80de\u304c\u3001\u304c\u3093\u306e\u5143\u3068\u306a\u308b\u524d\u304c\u3093\u7d30\u80de\u3092\u8a8d\u8b58\u3057\u3001\u653b\u6483\u30fb\u6392\u9664\u3059\u308b\u3068\u3044\u3046\u514d\u75ab\u7d30\u80de\u69d8\u306e\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002 \u524d\u304c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":75999,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,204,316,5],"class_list":["post-75228","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-highlight","tag-rpd","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/75228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=75228"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/75228\/revisions"}],"predecessor-version":[{"id":78545,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/75228\/revisions\/78545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/75999"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=75228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=75228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=75228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}