{"id":70339,"date":"2020-09-28T14:00:32","date_gmt":"2020-09-28T05:00:32","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=70339"},"modified":"2020-09-28T14:01:41","modified_gmt":"2020-09-28T05:01:41","slug":"1%e5%88%86%e3%81%a7%e8%a3%85%e7%9d%80%e5%8f%af%e8%83%bd%e3%80%81%e8%85%b0%e3%81%a0%e3%81%91%e3%81%a7%e3%81%aa%e3%81%8f%e8%85%95%e3%81%ae%e8%b2%a0%e6%8b%85%e3%82%82%e8%bb%bd%e6%b8%9b%e3%81%99-2-3-4-27","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/70339","title":{"rendered":"\u65b0\u9175\u7d20\u5275\u51fa\u3000\u74b0\u5883\u8ca0\u8377\u306e\u4f4e\u6e1b\u306b\u671f\u5f85"},"content":{"rendered":"<h2>\u8010\u71b1\u6027\u3068\u5e38\u6e29\u3067\u5341\u5206\u306a\u9175\u7d20\u6d3b\u6027\u3092\u4f75\u305b\u6301\u3064\u9175\u7d20\u3092\u5275\u51fa\u3000\u591a\u304f\u306e\u5de5\u696d\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3044\u3066\u4f4e\u30a8\u30cd\u30eb\u30ae\u30fc\u30b3\u30b9\u30c8\u3001\u74b0\u5883\u8ca0\u8377\u306e\u4f4e\u6e1b\u306b\u671f\u5f85<\/h2>\n<h3>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul 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href=\"https:\/\/www.waseda.jp\/fhum\/\">\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662<\/a>\u306e<a href=\"https:\/\/researchers.waseda.jp\/profile\/ja.477f12d68872d223fc79cce2226e4c52.html\">\u8d64\u6cbc\u54f2\u53f2<\/a>\uff08\u3042\u304b\u306c\u307e\u3000\u3055\u3068\u3057\uff09\u6559\u6388\u3001\u53e4\u5ddd\u9f8d\u592a\u90ce\uff08\u3075\u308b\u304b\u308f\u3000\u308a\u3085\u3046\u305f\u308d\u3046\uff09\u52a9\u6559\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u73fe\u5728\u306e\u81ea\u7136\u754c\u306b\u306f\u5b58\u5728\u3057\u306a\u3044\u304c\u904e\u53bb\u306b\u306f\u5b58\u5728\u3057\u305f\u3068\u63a8\u5b9a\u3055\u308c\u308b\u9175\u7d20\u306e\u7956\u5148\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u4e88\u6e2c\u3057\u3001\u5b9f\u969b\u306b\u5fa9\u5143\u3057\u307e\u3057\u305f\u3002\u5f97\u3089\u308c\u305f\u7956\u5148\u5fa9\u5143\u578b\u9175\u7d20\u306e\u8010\u71b1\u6027\u3068\u9175\u7d20\u6d3b\u6027\u3092\u8abf\u3079\u305f\u7d50\u679c\u3001\u5e38\u6e29\u3067\u306e\u9ad8\u3044\u9175\u7d20\u6d3b\u6027\u3068\u8010\u71b1\u6027\u3092\u4f75\u305b\u6301\u3064\u3001\u73fe\u5b58\u306e\u5929\u7136\u9175\u7d20\u306b\u306f\u3042\u307e\u308a\u898b\u3089\u308c\u306a\u3044\u7279\u6027\u3092\u6301\u3064\u9175\u7d20\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u8010\u71b1\u6027\u9175\u7d20\u306f\u9ad8\u6e29\u3067\u5b89\u5b9a\u3057\u3066\u3044\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u754c\u9762\u6d3b\u6027\u5264\u3084\u9178\u30fb\u30a2\u30eb\u30ab\u30ea\u3001\u6709\u6a5f\u6eb6\u5a92\u306b\u3082\u8010\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u591a\u304f\u3001\u5e38\u6e29\u3067\u3082\u975e\u8010\u71b1\u6027\u9175\u7d20\u306b\u6bd4\u3079\u3066\u534a\u6e1b\u671f(\u6ce81)\u304c\u9577\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u5e38\u6e29\u3067\u306f\u307b\u3068\u3093\u3069\u9175\u7d20\u6d3b\u6027\u3092\u793a\u3057\u307e\u305b\u3093\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u672c\u7814\u7a76\u306e\u624b\u6cd5\u3092\u69d8\u3005\u306a\u9175\u7d20\u306b\u9069\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u98df\u54c1\u3084\u98f2\u6599\u306e\u88fd\u9020\u7b49\u3001\u5e38\u6e29\u3067\u306e\u9175\u7d20\u53cd\u5fdc\u3092\u5fc5\u8981\u3068\u3059\u308b\u591a\u304f\u306e\u5de5\u696d\u30d7\u30ed\u30bb\u30b9\u306b\u5229\u7528\u53ef\u80fd\u306a\u8010\u4e45\u6027\u306e\u3042\u308b\u9175\u7d20\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u3010\u8ad6\u6587\u60c5\u5831\u3011<br \/>\n\u30fb\u63b2\u8f09\u8a8c\uff1a<a href=\"https:\/\/www.nature.com\/srep\/\" target=\"_blank\" rel=\"noopener\">Scientific Reports<\/a><br \/>\n\u30fb\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-72418-4\" target=\"_blank\" rel=\"noopener\">Ancestral sequence reconstruction produces thermally stable enzymes with mesophilic enzyme\u2011like catalytic properties<\/a><br \/>\n\u30fb\u63b2\u8f09\u65e5\u6642\uff1a2020\u5e74\uff19\u670823\u65e5\uff08\u30a4\u30ae\u30ea\u30b9\u30fb\u73fe\u5730\u6642\u9593 \u5348\u524d10:00\uff09<br 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id=\"attachment_70342\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-70342 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/09\/pic2-610x515.jpg\" alt=\"\" width=\"610\" height=\"515\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/09\/pic2-610x515.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/09\/pic2.jpg 650w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><p class=\"wp-caption-text\">\u56f3\uff12\uff0e\u30a4\u30bd\u30d7\u30ed\u30d4\u30eb\u30ea\u30f3\u30b4\u9178\u8131\u6c34\u7d20\u9175\u7d20\uff08IPMDH\uff09\u3068\u305d\u306e\u985e\u7e01\u9175\u7d20(ICDH:\u30a4\u30bd\u30af\u30a8\u30f3\u9178\u8131\u6c34\u7d20\u9175\u7d20\u3001HICDH:\u30db\u30e2\u30a4\u30bd\u30af\u30a8\u30f3\u9178\u8131\u6c34\u7d20\u9175\u7d20)\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u304b\u3089\u63a8\u5b9a\u3055\u308c\u305f\u9032\u5316\u7cfb\u7d71\u6a39\u3002\u771f\u6b63\u7d30\u83cc\u7531\u6765IPMDH\u306e\u5171\u901a\u7956\u5148\u306e\u4f4d\u7f6e\u3092\u77e2\u5370\u3067\u8868\u793a\u3057\u305f\u3002\u771f\u6b63\u7d30\u83cc\u306e\u914d\u5217\u3092\u9752\u3001\u53e4\u7d30\u83cc\u306e\u914d\u5217\u3092\u8d64\u3067\u793a\u3057\u305f\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h4>3.\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/h4>\n<p>\u7570\u306a\u308b\u7956\u5148\u914d\u5217\u63a8\u5b9a\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u7528\u3044\u3066\u63a8\u5b9a\u30fb\u5fa9\u5143\u3057\u305f\uff12\u3064\u306e\u771f\u6b63\u7d30\u83ccIPMDH\u306e\u5171\u901a\u7956\u5148\u9175\u7d20\uff08ancIPMDH-IQ\u3068ancIPMDH-ML\uff09\u306f\u3001\u3069\u3061\u3089\u3082\u81f3\u9069\u751f\u80b2\u6e29\u5ea6\u304c27\uff5e37\u2103\u306e\u67af\u8349\u83cc\u304c\u6301\u3064IPMDH\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u8010\u71b1\u6027\u304c\u9ad8\u304f\u3001\u81f3\u9069\u6e29\u5ea670\uff5e75\u2103\u306e\u9ad8\u5ea6\u597d\u71b1\u83ccThermus thermophilus\u304c\u6301\u3064IPMDH\u3068\u6bd4\u3079\u3066\u3082\u3001\u308f\u305a\u304b\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3088\u308a\u9ad8\u3044\u6e29\u5ea6\u307e\u3067\u5b89\u5b9a\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f3\uff13\uff09\u3002\u307e\u305f\u3001\u69d8\u3005\u306a\u6e29\u5ea6\u3067\u9175\u7d20\u6d3b\u6027\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u7956\u5148\u578bIPMDH\u306f\u6d3b\u6027\u306e\u6e29\u5ea6\u4f9d\u5b58\u6027\u304c\u7de9\u3044\u305f\u3081\u3001\u5e38\u6e29\u4ed8\u8fd1\u3067\u306f\u597d\u71b1\u83cc\u9175\u7d20\u3088\u308a\u3082\u5927\u304d\u3044\u9175\u7d20\u6d3b\u6027\u3092\u6301\u3061\u3001\u5e38\u6e29\u83cc\u3067\u3042\u308b\u67af\u8349\u83cc\u304c\u6301\u3064IPMDH\u306e\u5e38\u6e29\u3067\u306e\u9175\u7d20\u6d3b\u6027\u306e\u5024\u306b\u8fd1\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f3\uff14\uff09\u3002\u4eca\u56de\u306e\u7d50\u679c\u304b\u3089\u3001\u5168\u751f\u7269\u306e\u5171\u901a\u7956\u5148\u3088\u308a\u3082\u73fe\u4ee3\u306b\u8fd1\u3044\u7956\u5148\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u518d\u69cb\u6210\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u73fe\u5b58\u3059\u308b\u597d\u71b1\u83cc\u9175\u7d20\u3088\u308a\u3082\u9ad8\u3044\u8010\u71b1\u6027\u3092\u6301\u3061\u306a\u304c\u3089\u3082\u3001\u5e38\u6e29\u3067\u306e\u9175\u7d20\u53cd\u5fdc\u306b\u9069\u3057\u305f\u9175\u7d20\u3092\u5408\u6210\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n\u5408\u7406\u7684\u8a2d\u8a08\u3084\u9032\u5316\u5206\u5b50\u5de5\u5b66\u3068\u7570\u306a\u308a\u3001\u60c5\u5831\u79d1\u5b66\u306b\u57fa\u3065\u304f\u5206\u5b50\u7cfb\u7d71\u89e3\u6790\u3068\u5b9f\u9a13\u79d1\u5b66\u306e\u624b\u6cd5\u3067\u3042\u308b\u907a\u4f1d\u5b50\u5de5\u5b66\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u5de5\u5b66\u306e\u6280\u8853\u3092\u878d\u5408\u3057\u305f\u4eca\u56de\u306e\u65b9\u6cd5\u3067\u306f\u3001\uff12\u3064\u306e\u7956\u5148\u578b\u9175\u7d20\u3060\u3051\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u304c\u3001\u3069\u3061\u3089\u3082\u3001\u5f53\u521d\u306e\u671f\u5f85\u901a\u308a\u306e\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u6700\u3082\u53e4\u3044\u7956\u5148\u3088\u308a\u3082\u73fe\u4ee3\u306b\u8fd1\u3044\u5e74\u4ee3\u306e\u9175\u7d20\u3092\u5fa9\u5143\u3059\u308b\u3053\u3068\u3067\u3001\u6bd4\u8f03\u7684\u7c21\u5358\u304b\u3064\u52b9\u7387\u7684\u306b\u8010\u71b1\u6027\u3068\u5e38\u6e29\u6d3b\u6027\u3092\u4f75\u305b\u3082\u3063\u305f\u9175\u7d20\u3092\u4f5c\u88fd\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_70343\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-70343 size-full\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/09\/pic3.jpg\" alt=\"\" width=\"608\" height=\"499\" \/><p class=\"wp-caption-text\">\u56f3\uff13\uff0e\u7956\u5148\u914d\u5217\u518d\u69cb\u6210\u306b\u3088\u308a\u4f5c\u6210\u3057\u305fancIPMDH-IQ\uff08\u7dd1\uff09\u3068ancIPMDH-ML\uff08\u6a59\uff09\u304a\u3088\u3073\u73fe\u5b58\u306e\u597d\u71b1\u83ccT. thermophilus\u7531\u6765IPMDH\uff08\u8d64\uff09\u3068\u5e38\u6e29\u83cc\u3067\u3042\u308b\u67af\u8349\u83ccIPMDH\uff08\u9752\uff09\u306e\u71b1\u5909\u6027\u66f2\u7dda\u306e\u6bd4\u8f03<\/p><\/div>\n<div id=\"attachment_70344\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-70344 size-full\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/09\/pic4.jpg\" alt=\"\" width=\"521\" height=\"498\" \/><p class=\"wp-caption-text\">\u56f3\uff14\uff0e\u7956\u5148\u914d\u5217\u518d\u69cb\u6210\u306b\u3088\u308a\u4f5c\u6210\u3057\u305fancIPMDH-IQ\uff08\u7dd1\uff09\u3068ancIPMDH-ML\uff08\u6a59\uff09\u304a\u3088\u3073\u73fe\u5b58\u306e\u597d\u71b1\u83ccT. thermophilus\u7531\u6765IPMDH\uff08\u8d64\uff09\u3068\u5e38\u6e29\u83cc\u3067\u3042\u308b\u67af\u8349\u83ccIPMDH\uff08\u9752\uff09\u306e\u89e6\u5a92\u6d3b\u6027\u306e\u53cd\u5fdc\u6e29\u5ea6\u4f9d\u5b58\u6027\u3002<\/p><\/div>\n<h4>\uff14.\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/h4>\n<p>\u751f\u7269\u304c\u6301\u3064\u751f\u4f53\u89e6\u5a92\u3067\u3042\u308b\u9175\u7d20\u306f\u3001\u5316\u5b66\u5de5\u696d\u3067\u3057\u3070\u3057\u3070\u7528\u3044\u3089\u308c\u308b\u7121\u6a5f\u89e6\u5a92\u3068\u6bd4\u8f03\u3057\u3066\u3001\uff11\uff09\u93e1\u50cf\u7570\u6027\u4f53\u3067\u3059\u3089100%\u8b58\u5225\u53ef\u80fd\u306a\u9ad8\u3044\u57fa\u8cea\u7279\u7570\u6027\u3001\uff12\uff09\u526f\u751f\u6210\u7269\u3092\u751f\u3058\u3055\u305b\u306a\u3044100%\u306e\u53cd\u5fdc\u7279\u7570\u6027\u3001\uff13\uff09\u5e38\u6e29\u30fb\u5e38\u5727\u3067\u5316\u5b66\u53cd\u5fdc\u3092\u4fc3\u9032\u3067\u304d\u308b\u4f4e\u30a8\u30cd\u30eb\u30ae\u30fc\u30b3\u30b9\u30c8\u3001\uff14\uff09\u5bb9\u6613\u306b\u30a2\u30df\u30ce\u9178\u3078\u3068\u5206\u89e3\u3055\u308c\u308b\u305f\u3081\u74b0\u5883\u8ca0\u8377\u304c\u5c0f\u3055\u3044\u3001\u3068\u3044\u3063\u305f\u512a\u308c\u305f\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5229\u70b9\u3092\u751f\u304b\u3057\u3001\u65e2\u306b\u591a\u304f\u306e\u907a\u4f1d\u5b50\u64cd\u4f5c\u7528\u9175\u7d20\u3001\u591a\u7a2e\u306e\u6d17\u5264\u7528\u52a0\u6c34\u5206\u89e3\u9175\u7d20\u304c\u4f7f\u308f\u308c\u3001\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u7d20\u6750\u751f\u7523\u3001\u533b\u85ac\u54c1\u88fd\u9020\u3001\u98f2\u98df\u6599\u54c1\u88fd\u9020\u7b49\u3067\u3082\u591a\u304f\u306e\u9175\u7d20\u304c\u5229\u7528\u3055\u308c\u59cb\u3081\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u304b\u3089\u3001\u751f\u7269\u306e\u9032\u5316\u904e\u7a0b\u3092\u9061\u308b\u7956\u5148\u914d\u5217\u518d\u69cb\u6210\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u9ad8\u3044\u8010\u71b1\u6027\u3068\u5e38\u6e29\u3067\u306e\u5341\u5206\u306a\u5927\u304d\u3055\u306e\u9175\u7d20\u6d3b\u6027\u3092\u4f75\u305b\u6301\u3063\u305f\u3001\u73fe\u5b58\u306e\u5929\u7136\u9175\u7d20\u306b\u306f\u7a00\u306a\u7279\u6027\u3092\u6301\u3064\u9175\u7d20\u3092\u4f5c\u88fd\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n\u60c5\u5831\u79d1\u5b66\u3068\u5b9f\u9a13\u79d1\u5b66\u306e\u878d\u5408\u306b\u3088\u308b\u7956\u5148\u914d\u5217\u518d\u69cb\u6210\u306f\u3001\u5f93\u6765\u306e\u9175\u7d20\u6539\u5909\u30fb\u8a2d\u8a08\u6280\u8853\u3067\u3042\u308b\u5408\u7406\u7684\u8a2d\u8a08\u6cd5\u3001\u9032\u5316\u5206\u5b50\u5de5\u5b66\u7684\u624b\u6cd5\u3068\u6bd4\u3079\u3066\u3001\u6bd4\u8f03\u7684\u5c11\u306a\u3044\u5b9f\u9a13\u91cf\u3067\u9ad8\u3044\u5e38\u6e29\u6d3b\u6027\u3092\u6301\u3064\u8010\u71b1\u6027\u9175\u7d20\u3092\u5275\u51fa\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u672c\u7814\u7a76\u306e\u77e5\u898b\u3092\u57fa\u306b\u3001\u98df\u54c1\u3084\u98f2\u6599\u3001\u7d19\u30fb\u30d1\u30eb\u30d7\u88fd\u54c1\u7b49\u306e\u751f\u7523\u306b\u304a\u3044\u3066\u6709\u7528\u306a\u69d8\u3005\u306a\u9175\u7d20\u3092\u5275\u51fa\u3059\u308b\u3053\u3068\u3067\u3001\u4eca\u5f8c\u3055\u3089\u306a\u308b\u9175\u7d20\u5229\u7528\u306e\u63a8\u9032\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001\u672c\u7814\u7a76\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u6301\u7d9a\u53ef\u80fd\u306a\u958b\u767a\u76ee\u6a19(SDGs\uff09\u306e\u3046\u3061\u3001\u300c\uff17\uff0e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u307f\u3093\u306a\u306b \u305d\u3057\u3066\u30af\u30ea\u30fc\u30f3\u306b\u300d\u3001\u300c\uff19\uff0e\u7523\u696d\u3068\u6280\u8853\u9769\u65b0\u306e\u57fa\u76e4\u3092\u3064\u304f\u308d\u3046\u300d\u3001\u300c\uff11\uff13\uff0e\u6c17\u5019\u5909\u52d5\u306b\u5177\u4f53\u7684\u306a\u5bfe\u7b56\u3092\u300d\u306e\u9054\u6210\u3078\u306e\u8ca2\u732e\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>5.\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u304b\u3089\u306f\u3001\u904e\u53bb\u306b\u9061\u308b\u3053\u3068\u3067\u5177\u4f53\u7684\u306b\u3069\u306e\u3088\u3046\u306a\u9175\u7d20\u5185\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5909\u5316\u304c\u8d77\u3053\u308a\u3001\u9ad8\u3044\u8010\u71b1\u6027\u3068\u5e38\u6e29\u3067\u306e\u5927\u304d\u306a\u9175\u7d20\u6d3b\u6027\u304c\u9054\u6210\u3067\u304d\u305f\u306e\u304b\u306f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u308c\u3092\u89e3\u660e\u3057\u3066\u3044\u304f\u305f\u3081\u306b\u3001\u5206\u5b50\u52d5\u529b\u5b66\u8a08\u7b97\u3084\u8a73\u7d30\u306a\u7acb\u4f53\u69cb\u9020\u306e\u89e3\u6790\u304c\u5fc5\u8981\u3067\u3059\u3002\u307e\u305f\u3001\u4eca\u56de\u306f\u771f\u6b63\u7d30\u83cc\u7531\u6765IPMDH\u306e\u5171\u901a\u7956\u5148\u914d\u5217\u306e\u307f\u3092\u518d\u69cb\u6210\u3057\u307e\u3057\u305f\u304c\u3001\u3055\u3089\u306b\u73fe\u4ee3\u306b\u8fd1\u3044\u7956\u5148\u914d\u5217\u3092\u518d\u69cb\u6210\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7570\u306a\u3063\u305f\u8010\u71b1\u6027\u3068\u5e38\u6e29\u6d3b\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6301\u3064\u9175\u7d20\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3055\u3089\u306b\u591a\u304f\u306e\u7956\u5148\u914d\u5217\u3092\u518d\u69cb\u6210\u3057\u3001\u5de5\u696d\u5229\u7528\u306b\u6700\u9069\u306a\u7279\u6027\u3092\u6301\u3064\u9175\u7d20\u306e\u958b\u767a\u3092\u8a66\u307f\u3066\u3044\u304f\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n<h4>6.\u8ad6\u6587\u60c5\u5831<\/h4>\n<p>\u96d1\u8a8c\u540d\uff1a<a href=\"https:\/\/www.nature.com\/srep\/\" target=\"_blank\" rel=\"noopener\">Scientific Reports<\/a><br \/>\n\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-72418-4\" target=\"_blank\" rel=\"noopener\">Ancestral sequence reconstruction produces thermally stable enzymes with mesophilic enzyme\u2011like catalytic properties<\/a><br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u53e4\u5ddd\u9f8d\u592a\u90ce\u3001\u7576\u9ebb\u548c\u9999\u5b50\u3001\u5c71\u5d0e\u6d69\u53f8\u3001\u8d64\u6cbc\u54f2\u53f2\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<br \/>\nDOI\uff1a10.1038\/s41598-020-72418-4<br \/>\n\u672c\u7814\u7a76\u306e\u4e00\u90e8\u306f\u3001\u65e9\u7a32\u7530\u5927\u5b66\u7279\u5b9a\u8ab2\u984c\u7814\u7a76\u300c\u8010\u71b1\u6027\u3068\u4f4e\u6e29\u6d3b\u6027\u3092\u4e21\u7acb\u3057\u305f\u9175\u7d20\u306e\u5275\u6210\u300d\uff08\u4ee3\u8868\uff1a\u8d64\u6cbc\u54f2\u53f2\uff1a2017K-291\uff09\u306e\u7814\u7a76\u8cbb\u52a9\u6210\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n<h5>\u3010\u7528\u8a9e\u8aac\u660e\u3011<\/h5>\n<p>(\u6ce81) \u9175\u7d20\u306e\u534a\u6e1b\u671f\uff1a\u9175\u7d20\u5206\u5b50\u306e\u534a\u5206\u304c\u9175\u7d20\u6d3b\u6027\u3092\u5931\u3046\u306e\u306b\u8981\u3059\u308b\u6642\u9593\u3002\u9175\u7d20\u306e\u5b89\u5b9a\u6027\uff08\u8010\u4e45\u6027\uff09\u306e\u6307\u6a19\u306e\u4e00\u3064\u3068\u3057\u3066\u4f7f\u308f\u308c\u308b\u3002<br \/>\n(\u6ce82) \u597d\u71b1\u83cc\uff1a50\u2103\u4ee5\u4e0a\u306e\u9ad8\u6e29\u3067\u751f\u80b2\u3059\u308b\u5fae\u751f\u7269\u3002\u597d\u71b1\u83cc\u306e\u4e2d\u3067\u3082\u751f\u80b2\u4e0a\u9650\u6e29\u5ea6\u304c70\u2103\u3092\u8d85\u3048\u308b\u5fae\u751f\u7269\u3092\u9ad8\u5ea6\u597d\u71b1\u83cc\u3001\u6700\u9069\u306a\u751f\u80b2\u6e29\u5ea6\u304c80\u2103\u4ee5\u4e0a\u306e\u5fae\u751f\u7269\u3092\u8d85\u597d\u71b1\u83cc\u3068\u547c\u3076\u3002<br \/>\n(\u6ce83) 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\/>\n(\u6ce84) \u9032\u5316\u7cfb\u7d71\u6a39\uff1a\u751f\u7269\u3084\u907a\u4f1d\u5b50\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u9032\u5316\u3057\u3066\u304d\u305f\u9053\u7b4b\u3092\u3001\u6a39\u6728\u304c\u6839\u304b\u3089\u5e79\u3001\u305d\u3057\u3066\u679d\u3078\u3068\u5206\u5c90\u3057\u3066\u3044\u304f\u69d8\u5b50\u306b\u306a\u305e\u3089\u3048\u3066\u63cf\u3044\u305f\u3082\u306e\u3002\u6839\u306e\u4f4d\u7f6e\u304c\u8d77\u6e90\u306b\u76f8\u5f53\u3057\u3001\u679d\u306e\u7aef\u304c\u73fe\u5728\u306b\u76f8\u5f53\u3059\u308b\u3002<br \/>\n(\u6ce85) 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\/>\n(\u6ce86) 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\/>\n(\u6ce87) 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