{"id":69015,"date":"2020-04-16T14:00:33","date_gmt":"2020-04-16T05:00:33","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=69015"},"modified":"2020-04-20T10:39:59","modified_gmt":"2020-04-20T01:39:59","slug":"%e3%82%b3%e3%83%81%e3%83%ac%e3%83%8b%e3%83%b3a-%e4%b8%96%e7%95%8c%e5%88%9d%e5%85%a8%e5%90%88%e6%88%90%e6%88%90%e5%8a%9f","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/69015","title":{"rendered":"\u30b3\u30c1\u30ec\u30cb\u30f3A \u4e16\u754c\u521d\u306e\u5168\u5408\u6210\u306b\u6210\u529f"},"content":{"rendered":"<h2 style=\"text-align: center;\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c01774\"><strong>\u4e16\u754c\u521d\u30fb\u5e02\u8ca9\u306e\u5316\u5408\u7269\u304b\u3089\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5168\u5408\u6210\u306b\u6210\u529f<\/strong><\/a><\/h2>\n<h3 style=\"text-align: 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href=\"http:\/\/www.chem.waseda.ac.jp\/nakada\/\">\u4e2d\u7530\u96c5\u4e45\uff08\u306a\u304b\u3060\u307e\u3055\u3072\u3055\uff09<\/a>\u6559\u6388\u3001\u4e0a\u68ee\u7406\u5f18\uff08\u3046\u308f\u3082\u308a\u307e\u3055\u3072\u308d\uff09\u7814\u7a76\u9662\u8b1b\u5e2b\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u624b\u6cd5\u306b\u3088\u308a\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5168\u5408\u6210<strong>\uff08\u203b\uff11\uff09<\/strong>\u306b\u4e16\u754c\u3067\u521d\u3081\u3066\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-69017 size-full\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1.jpg\" alt=\"\" width=\"1549\" height=\"856\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1.jpg 1549w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1-610x337.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1-768x424.jpg 768w\" sizes=\"auto, (max-width: 1549px) 100vw, 1549px\" \/><\/p>\n<p>\u30b3\u30c1\u30ec\u30cb\u30f3A\u306f\u65b0\u898f\u6297\u304c\u3093\u5264\u5019\u88dc\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u751f\u7523\u83cc\u304c\u5897\u6b96\u80fd\u3092\u5931\u3063\u305f\u305f\u3081\u3001\u57f9\u990a\u306b\u3088\u308b\u751f\u7523\u30fb\u4f9b\u7d66\u306f\u9014\u7d76\u3048\u3001\u5316\u5b66\u5408\u6210\u306b\u3088\u308b\u751f\u7523\u30fb\u4f9b\u7d66\u304c\u5207\u671b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u591a\u304f\u306e\u7814\u7a76\u8005\u304c\u30b3\u30c1\u30ec\u30cb\u30f3\uff21\u306e\u5316\u5b66\u5408\u6210\u306b\u6311\u6226\u3057\u305f\u3082\u306e\u306e\u3001\u30e6\u30cb\u30fc\u30af\u306a\u69cb\u9020\u3086\u3048\u306b\u9054\u6210\u56f0\u96e3\u3067\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u3092\u5927\u304d\u304f\uff13\u3064\u306e\u69cb\u9020\u306b\u5206\u3051\u3066\u5408\u6210\u3057\u3001\u305d\u308c\u3089\u3092\u7e4b\u304e\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u5e02\u8ca9\u306e\u5316\u5408\u7269\u304b\u3089\uff12\uff15\u5de5\u7a0b\u3067\u5168\u5408\u6210\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u3001\uff12\uff10\u307e\u3067\u77ed\u5de5\u7a0b\u5316\u306b\u6210\u529f\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u77ed\u5de5\u7a0b\u5316\u304c\u9032\u3081\u3070\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5316\u5b66\u5408\u6210\u306b\u3088\u308b\u91cf\u7684\u4f9b\u7d66\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306e\u6210\u679c\u306f\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u751f\u7269\u79d1\u5b66\u7814\u7a76\u306e\u3055\u3089\u306a\u308b\u767a\u5c55\u306b\u8ca2\u732e\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5316\u5b66\u4fee\u98fe\u3092\u884c\u3044\u3001\u751f\u7269\u6d3b\u6027\u8a66\u9a13\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3088\u308a\u5f37\u529b\u306a\u6297\u304c\u3093\u6d3b\u6027\u3092\u793a\u3057\u3001\u526f\u4f5c\u7528\u306e\u306a\u3044\u65b0\u898f\u6297\u304c\u3093\u5264\u5019\u88dc\u3092\u767a\u898b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u4eca\u56de\u958b\u767a\u3057\u305f\u8a66\u85ac\u30fb\u53cd\u5fdc\u30fb\u624b\u6cd5\u306f\u3001\u4eca\u5f8c\u3001\u69d8\u3005\u306a\u5316\u5408\u7269\u306e\u5408\u6210\u306b\u304a\u3044\u3066\u6d3b\u7528\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u901f\u5831\u3068\u3057\u3066\u30a2\u30e1\u30ea\u30ab\u5316\u5b66\u4f1a\u8a8c\u300e<a href=\"https:\/\/pubs.acs.org\/journal\/jacsat\">Journal of the American Chemical Society<\/a>\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b\uff12\uff10\uff12\uff10\u5e74\uff13\u6708\uff11\uff16\u65e5\uff08\u73fe\u5730\u6642\u9593\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><strong>\u8ad6\u6587\u540d\uff1a<\/strong> <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c01774\">Enantioselective Total Synthesis of Cotylenin A<\/a><br \/>\n<strong>\u63b2\u8f09URL\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c01774\">https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c01774<\/a><\/p>\n<h4><strong>(1)<\/strong><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/strong><\/h4>\n<p>\u30b3\u30c1\u30ec\u30cb\u30f3A\u306f\u5f53\u521d\u3001\u690d\u7269\u6210\u9577\u8abf\u7bc0\u7269\u8cea\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u5f8c\u306e\u7814\u7a76\u306b\u3088\u308a\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff0d\u03b1<strong>\uff08<\/strong><strong>\u203b\uff12<\/strong><strong>\uff09<\/strong>\u3068\u4f75\u7528\u3059\u308b\u3068\u3001\u30d2\u30c8\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u5206\u5316\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3001\u5e45\u5e83\u3044\u7a2e\u985e\u306e\u30d2\u30c8\u304c\u3093\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<strong>\uff08<\/strong><strong>\u203b3<\/strong><strong>\uff09<\/strong>\u3092\u5f15\u304d\u304a\u3053\u3059\u3053\u3068\u306a\u3069\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u300114-3-3\u30bf\u30f3\u30d1\u30af\u3068\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u306e\u30bf\u30f3\u30d1\u30af\uff0d\u30bf\u30f3\u30d1\u30af\u76f8\u4e92\u4f5c\u7528\u3092\u30b3\u30c1\u30ec\u30cb\u30f3A\u304c\u4e09\u8005\u4f1a\u5408\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u5b89\u5b9a\u5316\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u4f5c\u7528\u6a5f\u5e8f\u3092\u3082\u3064\u5316\u5408\u7269\u306f\u73cd\u3057\u3044\u3053\u3068\u306b\u52a0\u3048\u3066\u3001\u52d5\u7269\u5b9f\u9a13\u3067\u3082\u6297\u304c\u3093\u5264\u3068\u3057\u3066\u306e\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u305f\u305f\u3081\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306f\u65b0\u898f\u6297\u304c\u3093\u5264\u5019\u88dc\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u751f\u7523\u83cc\u304c\u5897\u6b96\u80fd\u3092\u5931\u3063\u305f\u305f\u3081\u306b\u3001\u57f9\u990a\u306b\u3088\u308b\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u751f\u7523\u30fb\u4f9b\u7d66\u306f\u9014\u7d76\u3048\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u30b3\u30c1\u30ec\u30cb\u30f3A\u306f\u30b8\u30c6\u30eb\u30da\u30f3<strong>\uff08\u203b\uff14\uff09<\/strong>\u306b\u5206\u985e\u3055\u308c\u3001\u4e8c\u3064\u306e5\u54e1\u70ad\u7d20\u74b0<strong>\uff08\u203b\uff15\uff09<\/strong>\u304c\u7d50\u5408\u3057\u305f8\u54e1\u70ad\u7d20\u74b0\u306b\u30b0\u30eb\u30b3\u30fc\u30b9\u7531\u6765\u306e\u73cd\u3057\u3044\u69cb\u9020\u306e\u7cd6\u304c\u7d50\u5408\u3057\u305f\u30e6\u30cb\u30fc\u30af\u306a\u69cb\u9020\u3092\u3082\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u305d\u306e\u70ad\u7d20\u74b0\u4e0a\u306b\u306f\u591a\u304f\u306e\u5b98\u80fd\u57fa<strong>\uff08\u203b\uff16\uff09<\/strong>\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u30018\u54e1\u70ad\u7d20\u74b0\u306f\u5316\u5b66\u5408\u6210\u3059\u308b\u306e\u304c\u56f0\u96e3\u3067\u3042\u308b\u3053\u3068\u3082\u76f8\u307e\u3063\u3066\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5168\u5408\u6210\u306f\u591a\u304f\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u8208\u5473\u3092\u60f9\u3044\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u30011970\u5e74\u306b\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u767a\u898b\u304c\u5831\u544a\u3055\u308c\u3066\u4ee5\u6765\u3001\u5168\u5408\u6210\u306f\u9054\u6210\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h4><strong>(2)<\/strong><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068<\/strong><strong>\u3057\u305f\u3053\u3068<\/strong><\/h4>\n<p>\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u751f\u7269\u79d1\u5b66\u7814\u7a76\u306e\u3055\u3089\u306a\u308b\u767a\u5c55\u306e\u305f\u3081\u306b\u306f\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5316\u5b66\u5408\u6210\u306b\u3088\u308b\u751f\u7523\u30fb\u4f9b\u7d66\u304c\u5207\u671b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u65e9\u7a32\u7530\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\uff08\u7406\u5de5\u5b66\u8853\u9662 \u4e0a\u68ee\u7406\u5f18 \u7814\u7a76\u9662\u8b1b\u5e2b\u3001\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u4fee\u58eb\u8ab2\u7a0b2019\u5e74\u5352\u696d \u9577\u7530\u9f8d\u4e4b\u4ecb\u3001\u540c\u4fee\u58eb\u8ab2\u7a0b\uff12\u5e74 \u6749\u5c71\u4eae\u53f8\u3001\u540c\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b2017\u5e74\u5352\u696d \u6c38\u8c37\u5e78\u592a\u90ce\u3001\u7406\u5de5\u5b66\u8853\u9662 \u4e2d\u7530\u96c5\u4e45 \u6559\u6388\uff09\u306f\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u4e16\u754c\u521d\u306e\u5168\u5408\u6210\u306b\u6311\u6226\u3057\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>(3)<\/strong><strong>\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-69017 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1-610x337.jpg\" alt=\"\" width=\"610\" height=\"337\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1-610x337.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1-768x424.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-1.jpg 1549w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p>\u30b3\u30c1\u30ec\u30cb\u30f3A\u3092\u52b9\u7387\u7684\u306b\u5408\u6210\u3059\u308b\u305f\u3081\u306b\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u3092A\u74b0\u3001C\u74b0\u3001\u7cd6\u90e8\u4f4d\u306e\u4e09\u3064\u306e\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306b\u5206\u3051\u3066\u5408\u6210\u3057\uff08\u30ad\u30e9\u30eb\u30d3\u30eb\u30c7\u30a3\u30f3\u30b0\u30d6\u30ed\u30c3\u30af\u6cd5\uff09\u3001\u305d\u308c\u3089\u3092\u7e4b\u304e\u5408\u308f\u305b\u308b\u5408\u6210\u8a08\u753b\uff08\u53ce\u675f\u7684\u5168\u5408\u6210\uff09\u3092\u7acb\u3066\u307e\u3057\u305f\u3002A\u74b0\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306e\u5408\u6210\u306f\u5f53\u7814\u7a76\u5ba4\u3067\u958b\u767a\u3057\u305f\u300c\u89e6\u5a92\u7684\u4e0d\u6589\u5206\u5b50\u5185\u30b7\u30af\u30ed\u30d7\u30ed\u30d1\u30f3\u5316\u300d\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u77ed\u5de5\u7a0b\u3067\u5408\u6210\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5408\u6210\u306e\u904e\u7a0b\u3067\u306f\u3001\u81ed\u7d20\u539f\u5b50\u3092\u5c0e\u5165\u3059\u308b\u65b0\u3057\u3044\u53cd\u5fdc\u3082\u898b\u51fa\u3057\u307e\u3057\u305f\u3002C\u74b0\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306f\u30a2\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\u74b0\u5316<strong>\uff08\u203b\uff17\uff09<\/strong>\u3092\u6d3b\u7528\u3057\u3001\u65e2\u77e5\u5316\u5408\u7269\u304b\u3089\u77ed\u5de5\u7a0b\u3067\u5408\u6210\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u30a2\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\u74b0\u5316\u306b\u304a\u3044\u3066\u306f\u3001\u53ce\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u65b0\u898f\u53cd\u5fdc\u6761\u4ef6\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-69018 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-2-610x338.jpg\" alt=\"\" width=\"610\" height=\"338\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-2-610x338.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-2-768x426.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-2.jpg 1350w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p>\u5f62\u6210\u56f0\u96e3\u306a\u516b\u54e1\u70ad\u7d20\u74b0\u306f\u3001\u5f53\u7814\u7a76\u5ba4\u304c\u30bf\u30ad\u30bd\u30fc\u30eb\u306e\u5168\u5408\u6210\u306b\u304a\u3044\u3066\u898b\u51fa\u3057\u305f\u30d1\u30e9\u30b8\u30a6\u30e0\u89e6\u5a92\u53cd\u5fdc\u3067\u69cb\u7bc9\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u9a5a\u3044\u305f\u3053\u3068\u306b\u540c\u3058\u53cd\u5fdc\u6761\u4ef6\u3067\u306f\u3001\u516b\u54e1\u70ad\u7d20\u74b0\u306e\u5f62\u6210\u306f\u5168\u304f\u9032\u884c\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u7570\u306a\u308b\u914d\u4f4d\u5b50<strong>\uff08\u203b\uff18\uff09<\/strong>PCy<sub>3<\/sub>\u3092\u3082\u3064\u30d1\u30e9\u30b8\u30a6\u30e0\u89e6\u5a92\u3092\u7528\u3044\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u516b\u54e1\u70ad\u7d20\u74b0\u304c\u9ad8\u53ce\u7387\u3067\u751f\u6210\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u65b0\u3057\u3044\u53cd\u5fdc\u6761\u4ef6\u3067\u306e\u30d2\u30c9\u30ed\u30ad\u30b7\u57fa\u306e\u5c0e\u5165\u3001\u65b0\u305f\u306b\u958b\u767a\u3057\u305f\u8a66\u85ac\u306b\u3088\u308b\u30b1\u30c8\u30f3\u306e\u9084\u5143\u3092\u7acb\u4f53\u9078\u629e\u7684\u306b\u884c\u3044\u3001\u30b3\u30c1\u30ec\u30ce\u30fc\u30eb\u306e\u5408\u6210\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-69019 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-3-610x166.jpg\" alt=\"\" width=\"610\" height=\"166\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-3-610x166.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-3-768x209.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-3.jpg 1359w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p>\u7cd6\u90e8\u4f4d\u306f\u3001\u4e8c\u3064\u306e\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306e\u9023\u7d9a\u53cd\u5fdc\u306b\u3088\u308b\u5408\u6210\u3092\u8a08\u753b\u3057\u307e\u3057\u305f\u3002\u53cd\u5fdc\u306e\u9032\u884c\u306e\u78ba\u8a8d\u306f\u3001\u53cd\u5fdc\u6eb6\u6db2\u306e\u6838\u78c1\u6c17\u5171\u9cf4<strong>\uff08\u203b\uff19\uff09<\/strong>\u306b\u3088\u308b\u89e3\u6790\u306b\u3088\u308a\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u3001\u671f\u5f85\u3057\u305f\u9023\u7d9a\u53cd\u5fdc\u304c\u9014\u4e2d\u307e\u3067\u9032\u884c\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u9023\u7d9a\u53cd\u5fdc\u3092\u5b8c\u7d50\u3055\u305b\u308b\u3079\u304f\u53cd\u5fdc\u6761\u4ef6\u3092\u6700\u9069\u5316\u3057\u305f\u3068\u3053\u308d\u3001\u4e09\u3064\u306e\u53cd\u5fdc\u3092\u9023\u7d9a\u7684\u306b\u9032\u884c\u3055\u305b\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u7cd6\u90e8\u4f4d\u306e\u5408\u6210\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-69020 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-4-610x217.jpg\" alt=\"\" width=\"610\" height=\"217\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-4-610x217.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-4-768x273.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-4.jpg 1360w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p>\u30b3\u30c1\u30ec\u30ce\u30fc\u30eb\u3068\u7cd6\u90e8\u4f4d\u306e\u7d50\u5408\uff08\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\uff09\u306f\u3001\u53cd\u5fdc\u70b9\u304c\u6df7\u307f\u3042\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u308c\u307e\u3067\u306b\u4f7f\u308f\u308c\u3066\u3044\u305f\u65b9\u6cd5\u3067\u306f\u6210\u529f\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u30012019\u5e74\u306bWan\u3089\u304c\u5831\u544a\u3057\u305f\u30ed\u30b8\u30a6\u30e0\u89e6\u5a92\u3092\u7528\u3044\u308b\u53cd\u5fdc\uff08<em>J. Am. Chem. Soc. <\/em><strong>2019<\/strong>, <em>141<\/em>, 11775\uff09\u304c\u3053\u306e\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u5f8c\u3001\u3044\u304f\u3064\u304b\u306e\u5909\u63db\u3092\u7d4c\u3066\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u4e16\u754c\u521d\u306e\u5168\u5408\u6210\u3092\u9054\u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-69021 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-5-610x258.jpg\" alt=\"\" width=\"610\" height=\"258\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-5-610x258.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-5-768x325.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/04\/nakada-5.jpg 1362w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<h4><strong>(4)<\/strong><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h4>\n<p>\u4eca\u56de\u306e\u5168\u5408\u6210\u9054\u6210\u306b\u3088\u308a\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u3092\u5316\u5b66\u5408\u6210\u306b\u3088\u308a\u4f9b\u7d66\u3059\u308b\u9053\u3092\u62d3\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u751f\u7269\u79d1\u5b66\u7814\u7a76\u306e\u3055\u3089\u306a\u308b\u767a\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u4eca\u56de\u306e\u5408\u6210\u65b9\u6cd5\u3092\u3082\u3068\u306b\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5316\u5b66\u4fee\u98fe\u3092\u884c\u3044\u3001\u751f\u7269\u6d3b\u6027\u8a66\u9a13\u3092\u884c\u3046\u3053\u3068\u306b\u3088\u308a\u3001\u3088\u308a\u5f37\u529b\u306a\u6297\u304c\u3093\u6d3b\u6027\u3092\u793a\u3057\u3001\u526f\u4f5c\u7528\u306e\u306a\u3044\u65b0\u898f\u6297\u304c\u3093\u5264\u5019\u88dc\u3092\u767a\u898b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u958b\u767a\u3057\u305f\u8a66\u85ac\u30fb\u53cd\u5fdc\u30fb\u624b\u6cd5\u306f\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5168\u5408\u6210\u306e\u904e\u7a0b\u3067\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u69d8\u3005\u306a\u5316\u5408\u7269\u306e\u5408\u6210\u306b\u304a\u3044\u3066\u6d3b\u7528\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4><strong>(5)<\/strong><strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n<p>\u5e02\u8ca9\u306e\u5316\u5408\u7269\u304b\u308925\u5de5\u7a0b\u3067\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5168\u5408\u6210\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u300120\u5de5\u7a0b\u307e\u3067\u77ed\u5de5\u7a0b\u5316\u306b\u6210\u529f\u3057\u3066\u304a\u308a\u3001\u3055\u3089\u306a\u308b\u77ed\u5de5\u7a0b\u5316\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u306e\u53ce\u7387\u5411\u4e0a\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3067\u3059\u3002\u3053\u306e\u554f\u984c\u304c\u89e3\u6c7a\u3059\u308c\u3070\u3001\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u91cf\u7684\u4f9b\u7d66\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h4><strong>(6)<\/strong><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h4>\n<h5>\u203b1\u3000\u5168\u5408\u6210<\/h5>\n<p>\u7802\u7cd6\u3084\u30a2\u30df\u30ce\u9178\u306a\u3069\u306e\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u5316\u5408\u7269\u304b\u3089\u5316\u5b66\u53cd\u5fdc\u306b\u3088\u308a\u591a\u6bb5\u968e\u306e\u69cb\u9020\u5909\u63db\u3092\u884c\u3044\u3001\u6297\u751f\u7269\u8cea\u306a\u3069\u3092\u5408\u6210\u3059\u308b\u3053\u3068\u3002<\/p>\n<h5>\u203b2\u3000\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff0d\u03b1<\/h5>\n<p>\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3092\u6291\u5236\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u307e\u3067\u306b\u3001\u5897\u6b96\u6291\u5236\u3001\u514d\u75ab\u8abf\u7bc0\u304a\u3088\u3073\u4ed6\u306e\u591a\u304f\u306e\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h5>\u203b3\u3000\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<\/h5>\n<p>\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3002<\/p>\n<h5>\u203b4\u3000\u30b8\u30c6\u30eb\u30da\u30f3<\/h5>\n<p>\u30b2\u30e9\u30cb\u30eb\u30b2\u30e9\u30cb\u30eb\u4e8c\u30ea\u30f3\u9178\u304b\u3089\u751f\u4f53\u3067\u5408\u6210\u3055\u308c\u308b\u70ad\u7d20\u657020\u306e\u6709\u6a5f\u5316\u5408\u7269\u3002<\/p>\n<h5>\u203b5\u3000\uff15\u54e1\u70ad\u7d20\u74b0<\/h5>\n<p>\uff15\u3064\u306e\u70ad\u7d20\u539f\u5b50\u304c\u74b0\u72b6\u306b\u7d50\u5408\u3057\u305f\u69cb\u9020\u3002<\/p>\n<h5>\u203b6\u3000\u5b98\u80fd\u57fa<\/h5>\n<p>\u6709\u6a5f\u5316\u5408\u7269\u306e\u6027\u8cea\u3092\u7279\u5fb4\u3065\u3051\u308b\u539f\u5b50\u56e3\u307e\u305f\u306f\u7d50\u5408\u69d8\u5f0f\u3002<\/p>\n<h5>\u203b7\u3000\u30a2\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\u74b0\u5316<\/h5>\n<p>\u74b0\u5f0f\u69cb\u9020\u3092\u5f62\u6210\u3059\u308b\u30a2\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\u306e\u53cd\u5fdc\u3002\u30a2\u30b7\u30eb\u306f\u3001\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57faR-COOH\u304b\u3089\u30d2\u30c9\u30ed\u30ad\u30b7\u57fa\u3092\u9664\u3044\u305fR-CO\u3002\u30e9\u30b8\u30ab\u30eb\u306f\u3001\u4e0d\u5bfe\u96fb\u5b50\u3092\u3082\u3064\u539f\u5b50\u30fb\u5206\u5b50\u3002<\/p>\n<h5>\u203b8\u3000\u914d\u4f4d\u5b50<\/h5>\n<p>\u91d1\u5c5e\u306b\u914d\u4f4d\u3059\u308b\u5316\u5408\u7269\u3002<\/p>\n<h5>\u203b9\u3000\u6838\u78c1\u6c17\u5171\u9cf4<\/h5>\n<p>\u539f\u5b50\u6838\u306e\u30b9\u30d4\u30f3\u3092\u5229\u7528\u3057\u3066\u7269\u8cea\u306e\u69cb\u9020\u60c5\u5831\u3092\u5f97\u308b\u6a5f\u5668\u5206\u6790\u65b9\u6cd5\u3002<\/p>\n<h4><strong>(7)<\/strong><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h4>\n<p><strong>\u96d1\u8a8c\u540d\uff1a<\/strong>Journal of the American Chemical Society<br \/>\n<strong>\u8ad6\u6587\u540d\uff1a<\/strong>Enantioselective Total Synthesis of Cotylenin A<br \/>\n<strong>\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong>Masahiro Uwamori, Ryunosuke Osada, Ryoji Sugiyama, Kotaro Nagatani, and <a href=\"http:\/\/www.chem.waseda.ac.jp\/nakada\/\">Masahisa Nakada<\/a>\uff08\u4e0a\u68ee\u7406\u5f18\u3001\u9577\u7530\u9f8d\u4e4b\u4ecb\u3001\u6749\u5c71\u4eae\u53f8\u3001\u6c38\u8c37\u5e78\u592a\u90ce\u3001<a href=\"http:\/\/www.chem.waseda.ac.jp\/nakada\/\">\u4e2d\u7530\u96c5\u4e45<\/a>\uff09\uff08\u3059\u3079\u3066\u65e9\u7a32\u7530\u5927\u5b66\uff09<br \/>\n<strong>\u63b2\u8f09\u65e5\u6642\uff08\u73fe\u5730\u6642\u9593\uff09\uff1a<\/strong>2020\u5e743\u670816\u65e5\uff08Just Accepted Manuscripts\uff09<br \/>\n<strong>\u63b2\u8f09URL\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c01774\">https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c01774<\/a><br \/>\n<strong>DOI\uff1a<\/strong>jacs.0c01774<\/p>\n<h4><strong>(8)<\/strong><strong>\u7814\u7a76\u52a9\u6210<\/strong><\/h4>\n<p><strong>\u7814\u7a76\u8cbb\u540d\uff1a<\/strong>\u79d1\u5b66\u7814\u7a76\u8cbb\uff1a\u65b0\u5b66\u8853\u9818\u57df\u7814\u7a76<br \/>\n<strong>\u7814\u7a76\u8ab2\u984c\u540d\uff1a<\/strong>\u6709\u7528\u306a\u751f\u7269\u6a5f\u80fd\u591a\u74b0\u5f0f\u4e2d\u5206\u5b50\u306e\u9ad8\u52b9\u7387\u5408\u6210<br \/>\n<strong>\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong><a href=\"http:\/\/www.chem.waseda.ac.jp\/nakada\/\">\u4e2d\u7530\u96c5\u4e45\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/a><\/p>\n<p><strong>\u7814\u7a76\u8cbb\u540d\uff1a<\/strong>\u5185\u85e4\u8a18\u5ff5\u79d1\u5b66\u5968\u52b1\u91d1\uff08\u7814\u7a76\u52a9\u6210\uff09<br \/>\n<strong>\u7814\u7a76\u8ab2\u984c\u540d\uff1a<\/strong>\u30d5\u30b7\u30b3\u30c3\u30ab\u30f3\u985e\u306e\u7db2\u7f85\u7684\u4e0d\u6589\u5168\u5408\u6210\u3092\u5ff5\u982d\u306b\u7f6e\u3044\u305f\u30b3\u30c1\u30ec\u30cb\u30f3A\u3068\u30d5\u30b7\u30b3\u30af\u30b7\u30f3A\u306e\u4e0d\u6589\u5168\u5408\u6210\u7814\u7a76<br \/>\n<strong>\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<\/strong><a href=\"http:\/\/www.chem.waseda.ac.jp\/nakada\/\">\u4e2d\u7530\u96c5\u4e45\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e16\u754c\u521d\u30fb\u5e02\u8ca9\u306e\u5316\u5408\u7269\u304b\u3089\u30b3\u30c1\u30ec\u30cb\u30f3A\u306e\u5168\u5408\u6210\u306b\u6210\u529f \u3088\u308a\u5f37\u529b\u3067\u526f\u4f5c\u7528\u306e\u306a\u3044\u65b0\u898f\u6297\u304c\u3093\u5264\u5019\u88dc\u767a\u898b\u306b\u671f\u5f85 \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u30b3\u30c1\u30ec\u30cb\u30f3A\u306f\u65b0\u898f\u6297\u304c\u3093\u5264\u5019\u88dc\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u305f\u304c\u3001\u57f9\u990a\u306b\u3088\u308b\u751f\u7523\u30fb\u4f9b\u7d66\u306f\u9014\u7d76\u3048\u3066\u3044\u305f\u3002 \u672c\u7814\u7a76\u30b0\u30eb [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":69054,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,204,5],"class_list":["post-69015","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-highlight","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/69015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=69015"}],"version-history":[{"count":0,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/69015\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/69054"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=69015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=69015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=69015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}