{"id":68577,"date":"2020-03-05T10:38:13","date_gmt":"2020-03-05T01:38:13","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=68577"},"modified":"2020-03-09T09:43:59","modified_gmt":"2020-03-09T00:43:59","slug":"%e3%82%b2%e3%83%8e%e3%83%a0dna%e8%bb%a2%e5%86%99%e5%88%b6%e5%be%a1%e6%a9%9f%e8%83%bd%e3%82%92%e8%a7%a3%e6%98%8e","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/68577","title":{"rendered":"\u30b2\u30ce\u30e0DNA\u8ee2\u5199\u5236\u5fa1\u6a5f\u80fd\u3092\u89e3\u660e"},"content":{"rendered":"<h2><strong>\u30b2\u30ce\u30e0<\/strong><strong>DNA<\/strong><strong>\u306e\u69cb\u9020\u3092\u3053\u308f\u308c\u3084\u3059\u304f\u3057\u3066\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308b<\/strong><strong>\u3057\u304f\u307f\u3092\u89e3\u660e<\/strong><\/h2>\n<h4>1. \u6982\u8981<\/h4>\n<p>\u30b2\u30ce\u30e0\u4e2d\u306e\u907a\u4f1d\u5b50\u304c\u30bf\u30a4\u30df\u30f3\u30b0\u3088\u304f\u4f7f\u308f\u308c\u308b\u3001\u3064\u307e\u308a\u201c\u8ee2\u5199\u201d\u3055\u308c\u308b\u3053\u3068\u306f\u3001\u5168\u3066\u306e\u751f\u547d\u6d3b\u52d5\u306b\u91cd\u8981\u3067\u3059\u3002\u3057\u304b\u3057\u771f\u6838\u751f\u7269\u306e\u30b2\u30ce\u30e0DNA \u306f\u3001\u7d30\u80de\u6838\u5185\u3067\u6298\u308a\u305f\u305f\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u6298\u308a\u305f\u305f\u307f\u69cb\u9020\u3067\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8907\u5408\u4f53\u3067\u3042\u308b\u30d2\u30b9\u30c8\u30f3\uff18\u91cf\u4f53\u306bDNA\u304c\u5dfb\u304d\u3064\u304d\u3001\u201c\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u201d\u3068\u547c\u3070\u308c\u308b\u30b3\u30f3\u30d1\u30af\u30c8\u306a\u69cb\u9020\u3092\u3068\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u305d\u306e\u307e\u307e\u3067\u306f\u8ee2\u5199\u304c\u3055\u308c\u306b\u304f\u3044\u72b6\u614b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306a\u3089\u306a\u3044\u30ea\u30dc\u6838\u9178\uff08\u201c\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u201d\u3068\u547c\u3070\u308c\u308b\uff09\u306f\u3001\u8ee2\u5199\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3068\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u6301\u3064\u304b\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-68512 size-full\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/03\/92094c54d27eb7d4c6f269e54a1e5baa.jpg\" alt=\"\" width=\"584\" height=\"407\" \/><\/p>\n<ul>\n<li><a href=\"https:\/\/www.hamadalab.com\/\">\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u6d5c\u7530\u9053\u662d\u6559\u6388<\/a>\u3001\u6771\u4eac\u5927\u5b66\u5b9a\u91cf\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u306e\u80e1\u6843\u5742\u4ec1\u5fd7\u6559\u6388\u3001<a href=\"https:\/\/www.jfcr.or.jp\/laboratory\/news\/7247.html\">\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u304c\u3093\u7814\u7a76\u4f1a\u304c\u3093\u7814\u7a76\u6240<\/a>\u6589\u85e4\u5178\u5b50\u90e8\u9577\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u718a\u672c\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001\u6838\u5185\u306e\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA \u306b\u306f\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3092\u3053\u308f\u308c\u3084\u3059\u304f\u3057\u3066\u8ee2\u5199\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3001\u3068\u3044\u3046\u65b0\u3057\u3044\u306f\u305f\u3089\u304d\u304c\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>\u30a8\u30ec\u30ce\u30a22\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306f\u3001\u518d\u767a\u4e73\u304c\u3093\u30e2\u30c7\u30eb\u7d30\u80de\u3067\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\u5ea7\u306e\u5468\u8fba\u304b\u3089\u3064\u304f\u3089\u308c\u3001\u305d\u3053\u306b\u84c4\u7a4d\u3057\u3066\u8ee2\u5199\u3092\u6d3b\u767a\u306b\u3055\u305b\u307e\u3059\u3002\u3053\u306e\u518d\u767a\u4e73\u304c\u3093\u7d30\u80de\u3067\u306f\u3001\u30a8\u30ec\u30ce\u30a2\uff12\u304c\u3064\u304f\u3089\u308c\u308b\u5468\u8fba\u3067\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u304c\u7de9\u3093\u3067\u304a\u308a\u3001\u30a8\u30ec\u30ce\u30a2\uff12\u3092\u6e1b\u5f31\u3059\u308b\u3068\u3053\u308c\u304c\u89e3\u6d88\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<li>\u8a66\u9a13\u7ba1\u5185\u306e\u5b9f\u9a13\u3067\u306f\u3001\u4eba\u5de5\u7684\u306b\u4f5c\u6210\u3057\u305f\u30a8\u30ec\u30ce\u30a2\uff12 RNA \u65ad\u7247\u304c\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3092\u8457\u3057\u304f\u4e0d\u5b89\u5b9a\u5316\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3092\u4e0d\u5b89\u5b9a\u5316\u3059\u308b\u3001\u3068\u3044\u3046\u6d3b\u6027\u306f\u4ed6\u306eRNA \u306b\u3082\u8a8d\u3081\u3089\u307e\u3057\u305f\u304c\u3001DNA\u306b\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/li>\n<li>\u672c\u7814\u7a76\u306e\u6210\u679c\u306f\u3001Nature Publishing Group\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u8a8c<a href=\"https:\/\/www.nature.com\/articles\/s42003-020-0784-9\"><em>Communications Biology<\/em><\/a>\u306b\u30012020\u5e742\u670811\u65e5\u4ed8\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n<h4>2. \u30dd\u30a4\u30f3\u30c8<\/h4>\n<ul>\n<li>\u518d\u767a\u4e73\u304c\u3093\u30e2\u30c7\u30eb\u7d30\u80de<sup>\uff08\u6ce8\uff11\uff09<\/sup>\u3067\u306f\u3001\u30b2\u30ce\u30e0\u304b\u3089\u30a8\u30ec\u30ce\u30a22\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA<sup>\uff08\u6ce8\uff12\uff09<\/sup>\u304c\u904e\u5270\u306b\u8ee2\u5199<sup>\uff08\u6ce8\uff13\uff09<\/sup>\u3055\u308c\u3064\u304f\u3089\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u8fd1\u304f\u3067\u306f\u30b2\u30ce\u30e0\u304c\u4f5c\u308b\u9ad8\u6b21\u69cb\u9020\u3067\u3042\u308b\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0<sup>\uff08\u6ce8<\/sup><sup>4<\/sup><sup>\uff09<\/sup>\u304c\u7de9\u3093\u3067\u3044\u307e\u3057\u305f<\/li>\n<li>\u4eba\u5de5\u7684\u306a\u8a66\u9a13\u7ba1\u306e\u4e2d\u306e\u5b9f\u9a13\u3067\u3082\u3001\u30a8\u30ec\u30ce\u30a2\uff12 RNA \u65ad\u7247\u304c\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3092\u8457\u3057\u304f\u4e0d\u5b89\u5b9a\u306b\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>\u6838\u5185\u306e\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA \u306b\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u3092\u7de9\u3081\u3066\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308b\u3068\u3044\u3046\u65b0\u3057\u3044\u6a5f\u80fd\u304c\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n<h4>3. \u8ad6\u6587\u540d\u3001\u8457\u8005\u304a\u3088\u3073\u305d\u306e\u6240\u5c5e<\/h4>\n<p><strong>\u25cb\u8ad6\u6587\u540d: <\/strong><a href=\"https:\/\/www.nature.com\/articles\/s42003-020-0784-9\"><strong>Nucleosome destabilization by nuclear non-coding RNAs.<\/strong><\/a><\/p>\n<p><strong>\u25cb\u30b8\u30e3\u30fc\u30ca\u30eb\u540d: <\/strong><a href=\"https:\/\/www.nature.com\/articles\/s42003-020-0784-9\"><strong><em>Communications Biology<\/em><\/strong><\/a> (Nature Publishing Group\u306e\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u8a8c)<\/p>\n<p>\uff08\u203b2020\u5e742\u670811\u65e5\u4ed8\u3067\u30aa\u30f3\u30e9\u30a4\u30f3\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<a href=\"https:\/\/www.nature.com\/articles\/s42003-020-0784-9\">doi: 10.1038\/s42003-020-0784-9<\/a>\uff09<\/p>\n<p><strong>\u00a0<\/strong><strong>\u25cb\u8457\u8005: <\/strong>Risa Fujita<sup>1#<\/sup>, Tatsuro Yamamoto<sup>2,3#<\/sup>, Yasuhiro Arimura<sup>1<\/sup>, Saori Fujiwara<sup>3+<\/sup>, Hiroaki Tachiwana<sup>2<\/sup>, Yuichi Ichikawa<sup>2<\/sup>, Yuka Sakata<sup>2<\/sup>, Liying Yang<sup>2<\/sup>, Reo Maruyama<sup>2<\/sup>, <a href=\"https:\/\/www.hamadalab.com\/\">Michiaki Hamada<\/a><sup>4,5<\/sup>, Mitsuyoshi Nakao<sup>3<\/sup>, Noriko Saitoh<sup>2<\/sup>*, and Hitoshi Kurumizaka<sup>1<\/sup>*<\/p>\n<p><sup># <\/sup>\u5171\u540c\u7b2c\u4e00\u8457\u8005\u3000* \u8cac\u4efb\u8457\u8005<\/p>\n<p><strong>\u25cb\u8457\u8005\u306e\u6240\u5c5e\u6a5f\u95a2<\/strong><\/p>\n<p>1. \u6771\u4eac\u5927\u5b66\u5b9a\u91cf\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240<br \/>\n2. \u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u304c\u3093\u7814\u7a76\u4f1a\u304c\u3093\u7814\u7a76\u6240<br \/>\n3. \u56fd\u7acb\u5927\u5b66\u6cd5\u4eba\u718a\u672c\u5927\u5b66\u767a\u751f\u533b\u5b66\u7814\u7a76\u6240<br \/>\n3<sup>+<\/sup>. \u56fd\u7acb\u5927\u5b66\u6cd5\u4eba\u718a\u672c\u5927\u5b66\u767a\u751f\u533b\u5b66\u7814\u7a76\u6240\uff08\u7814\u7a76\u5f53\u6642\uff09<br \/>\n4. <a href=\"https:\/\/www.ase.sci.waseda.ac.jp\/\">\u65e9\u7a32\u7530\u5927\u5b66\u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1<\/a><br \/>\n5. <a href=\"https:\/\/unit.aist.go.jp\/cbbd-oil\/\">\u7523\u7dcf\u7814\u30fb\u65e9\u5927\u751f\u4f53\u30b7\u30b9\u30c6\u30e0\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u89e3\u6790\u30aa\u30fc\u30d7\u30f3\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u30e9\u30dc\u30e9\u30c8\u30ea<\/a><\/p>\n<h4>4. \u7814\u7a76\u306e\u8a73\u7d30<\/h4>\n<h5><strong>\u80cc\u666f\u3068\u7d4c\u7def<\/strong><\/h5>\n<p>\u30b2\u30ce\u30e0DNA\u306f\u7d30\u80de\u6838\u306e\u4e2d\u3067\u3001\u30af\u30ed\u30de\u30c1\u30f3\u3068\u3088\u3070\u308c\u308b\u30b3\u30f3\u30d1\u30af\u30c8\u306a\u5f62\u3068\u306a\u3063\u3066\u7d0d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30af\u30ed\u30de\u30c1\u30f3\u306e\u57fa\u672c\u69cb\u9020\u306f\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3068\u3088\u3070\u308c\u308b\u3082\u306e\u3067\u3001\u304a\u3088\u305d150 \u5869\u57fa\u5bfe\u306eDNA \u304c2\u3064\u306e\u30d2\u30b9\u30c8\u30f3H2A-H2B\u30682\u3064\u306eH3-H4\u304b\u3089\u306a\u308b\u30d2\u30b9\u30c8\u30f38\u91cf\u4f53\u306b\u5dfb\u304d\u3064\u3044\u305f\u3082\u306e\u3067\u3059\u3002\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306f\u975e\u5e38\u306b\u5b89\u5b9a\u3067\u3001\u8ee2\u5199\u3092\u542b\u3080\u30b2\u30ce\u30e0DNA\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306a\u3089\u306a\u3044RNA\u3067\u3001\u751f\u4f53\u5185\u3067\u591a\u7a2e\u591a\u69d8\u306b\u5b58\u5728\u3057\u3001\u30b2\u30ce\u30e0\u6a5f\u80fd\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002<\/p>\n<p><em>ESR1<\/em>\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001ER\u967d\u6027\u4e73\u304c\u3093\u304c\u3001\u5185\u5206\u6ccc\u7642\u6cd5\u3092\u6a21\u3057\u305f\u30db\u30eb\u30e2\u30f3\u3092\u67af\u6e07\u3057\u305f\u72b6\u6cc1\uff08long-term estrogen deprivation \u3092\u7565\u3057\u3066LTED\u3068\u547c\u3070\u308c\u308b\uff09\u306b\u9069\u5fdc\u3059\u308b\u969b\u306b\u3055\u304b\u3093\u306b\u8ee2\u5199\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u969b\u306b\u30a8\u30ec\u30ce\u30a2\u3068\u3088\u3070\u308c\u308b\u4e00\u7fa4\u306e\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u304c\u3001\u305f\u304f\u3055\u3093\u3064\u304f\u3089\u308c\u307e\u3059\u3002LTED\u7d30\u80de\u6838\u306e\u4e2d\u3067\u3001\u30a8\u30ec\u30ce\u30a2\u306f\u81ea\u8eab\u304c\u8ee2\u5199\u3055\u308c\u308b\u30b2\u30ce\u30e0\u90e8\u4f4d\u306b\u305f\u307e\u308a\u3001\u305d\u306e\u7d50\u679c\u3001<em>ESR1<\/em>\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u30a8\u30ec\u30ce\u30a2\u540c\u69d8\u306b\u3001\u7d30\u80de\u6838\u5185\u306b\u84c4\u7a4d\u3059\u308b\u3088\u3046\u306a\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306f\u591a\u3005\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a8\u30ec\u30ce\u30a2\u3092\u542b\u3081\u6838\u5185\u306e\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u304c\u3069\u306e\u3088\u3046\u306b\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u3057\u304f\u307f\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002<\/p>\n<h5><strong>\u7814\u7a76\u5185\u5bb9<\/strong><\/h5>\n<p>\u672c\u7814\u7a76\u8005\u3089\u306f\u307e\u305a\u3001\u30b2\u30ce\u30e0\u4e2d\u306e\u30af\u30ed\u30de\u30c1\u30f3\u304c\u7de9\u3093\u3067\u3044\u308b\u7b87\u6240\u3092\u691c\u51fa\u3059\u308b\u6280\u8853\u3067\u3042\u308b\u3001FAIRE-Seq (formaldehyde-assisted isolation of regulatory elements, coupled with massively parallel sequencing) \u306e\u904e\u53bb\u306e\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\uff08<strong>\u56f3\uff11\u4e0a<\/strong>\uff09\u3002\u305d\u306e\u7d50\u679c\u3001LTED\u7d30\u80de\u3067\u306f<em>ESR1<\/em>\u907a\u4f1d\u5b50\u306e\u4e0a\u6d41\u57df\u3067\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u304c\u8457\u3057\u304f\u6b20\u640d\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u4ed8\u8fd1\u3067\u306f\u3001\u30a8\u30ec\u30ce\u30a2\u306e\u4e2d\u3067\u3082\u6700\u3082\u591a\u3044\u30a8\u30ec\u30ce\u30a2\uff12\u304c\u3055\u304b\u3093\u306b\u3064\u304f\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<strong>\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong><\/p>\n<p>\u305d\u3053\u3067\u7cbe\u7d30\u306a\u8a66\u9a13\u7ba1\u5185\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u30a8\u30ec\u30ce\u30a2\uff12\u306eRNA\u65ad\u7247\u304c\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u5185\u306eH2A-H2B\u3092\u4e0d\u5b89\u5b9a\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3092\u4e0d\u5b89\u5b9a\u306b\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\uff08<strong>\u56f3\uff11\u4e0b<\/strong>\uff09\u3002\u3053\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u4e0d\u5b89\u5b9a\u5316\u6d3b\u6027\u306f\u3001\u4ed6\u306e\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u3067\u3042\u308bMALAT1\u3001DSCAM-AS1\u3001XIST\u306b\u3082\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u4e00\u5b9a\u306e\u69cb\u9020\u3092\u3068\u3089\u306a\u3044poly(U) RNA \u3084DNA\u306b\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306bLTED\u7d30\u80de\u5185\u3067\u30a8\u30ec\u30ce\u30a2\uff12\u306e\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u3066\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306e\u6b20\u640d\u3092\u691c\u51fa\u3059\u308bATAC-Seq (Assay for Transposase-Accessible Chromatin using sequencing)\u3068\u3044\u3046\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30a8\u30ec\u30ce\u30a2\uff12\u306e\u8ee2\u5199\u90e8\u4f4d\u3067\u306f\u30d4\u30fc\u30af\u304c\u5c0f\u3055\u304f\u306a\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u304c\u5b89\u5b9a\u306b\u3082\u3069\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3059\u3082\u306e\u3067\u3057\u305f\uff08<strong>\u56f3\uff11\u4e0a<\/strong>\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-68513 size-full alignnone\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/03\/6bebdce6b8a6e31c72ee060099bb0da6.jpg\" alt=\"\" width=\"796\" height=\"583\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/03\/6bebdce6b8a6e31c72ee060099bb0da6.jpg 796w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/03\/6bebdce6b8a6e31c72ee060099bb0da6-610x447.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2020\/03\/6bebdce6b8a6e31c72ee060099bb0da6-768x562.jpg 768w\" sizes=\"auto, (max-width: 796px) 100vw, 796px\" \/><\/p>\n<h5><strong>\u307e\u3068\u3081<\/strong><\/h5>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30a8\u30ec\u30ce\u30a2\uff12\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u304c\u3001\u8a66\u9a13\u7ba1\u5185\u3068\u7d30\u80de\u5185\u306e\u3069\u3061\u3089\u306b\u304a\u3044\u3066\u3082\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3092\u4e0d\u5b89\u5b9a\u306b\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30a8\u30ec\u30ce\u30a2\uff12\u304c\u518d\u767a\u4e73\u304c\u3093\u3067<em>ESR1<\/em>\u907a\u4f1d\u5b50\u3092\u4f7f\u308f\u308c\u3084\u3059\u304f\u3057\u3066\u3044\u308b\u3057\u304f\u307f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u306a\u304a\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3092\u3053\u308f\u3059\u6d3b\u6027\u306f\u4ed6\u306e\u69d8\u3005\u306aRNA\u306b\u3082\u3042\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u3001RNA\u304c\u5171\u901a\u3057\u3066\u3082\u3064\u56fa\u6709\u306e\u6027\u8cea\u3068\u3044\u3048\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4>5. \u672c\u7814\u7a76\u3078\u306e\u652f\u63f4<\/h4>\n<p>\u672c\u7814\u7a76\u306f\u3001\u4e0b\u8a18\u6a5f\u95a2\u3088\u308a\u8cc7\u91d1\u7684\u652f\u63f4\u7b49\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<ul>\n<li>\u6587\u90e8\u79d1\u5b66\u7701\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\uff65\u65b0\u5b66\u8853\u9818\u57df\u7814\u7a76\u300c\u907a\u4f1d\u5b50\u5236\u5fa1\u306e\u57fa\u76e4\u3068\u306a\u308b\u30af\u30ed\u30de\u30c1\u30f3\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u300d<\/li>\n<li>\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\u57fa\u76e4\u7814\u7a76\u3001\u6311\u6226\u7684\u7814\u7a76\u3001\u82e5\u624b\u7814\u7a76<\/li>\n<li>JST (\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb) CREST<\/li>\n<li>AMED (\u9769\u65b0\u7684\u5148\u7aef\u7814\u7a76\u958b\u767a\u652f\u63f4\u4e8b\u696d) CREST<\/li>\n<li>JST (\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb) ERATO<\/li>\n<li>\u6b66\u7530\u5831\u5f70\u533b\u5b66\u7814\u7a76\u52a9\u6210<\/li>\n<li>\u4e09\u83f1\u8ca1\u56e3\u81ea\u7136\u79d1\u5b66\u7814\u7a76\u52a9\u6210<\/li>\n<\/ul>\n<h4>6. \u7528\u8a9e\u89e3\u8aac<\/h4>\n<h6>\uff08\u6ce8\uff11\uff09\u518d\u767a\u4e73\u304c\u3093\u30e2\u30c7\u30eb\u7d30\u80de<\/h6>\n<ul>\n<li>\u30d2\u30c8ER\u967d\u6027\u4e73\u304c\u3093\u7d30\u80de\u682aMCF7\u3092\u30013\u30f6\u6708\u4ee5\u4e0a\u306e\u9577\u671f\u306b\u308f\u305f\u3063\u3066\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3092\u67af\u6e07\u3057\u305f\u72b6\u614b\u3067\u57f9\u990a\u3057\u3066\u3001\u751f\u304d\u6b8b\u308b\u7d30\u80de\u3002LTED\uff08long-term estrogen deprivation\uff09\u7d30\u80de\u3068\u3088\u3070\u308c\u308b\u3002\u3082\u3068\u306eMCF7 \u7d30\u80de\u3068\u306f\u7570\u306a\u308a\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304c\u306a\u304f\u3066\u3082\u5897\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n<h6>\uff08\u6ce8\uff12\uff09\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA<\/h6>\n<ul>\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7ffb\u8a33\u3055\u308c\u306a\u3044\u7a2e\u985e\u306eRNA\uff08\u30ea\u30dc\u6838\u9178\uff09\u3002\u7d30\u80de\u8cea\u3067\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u3088\u308a\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306a\u308b\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u3068\u306f\u7570\u306a\u308a\u3001\u7d30\u80de\u3084\u751f\u547d\u306e\u5236\u5fa1\u56e0\u5b50\u3068\u63a8\u5b9a\u3055\u308c\u308b\u3002\u30d2\u30c8\u306b\u306f10\u4e07\u7a2e\u985e\u307b\u3069\u306e\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u304c\u5b58\u5728\u3059\u308b\u3068\u898b\u7a4d\u3082\u3089\u308c\u3066\u304a\u308a\u3001\u591a\u304f\u304c\u7d30\u80de\u6838\u5185\u306b\u5b58\u5728\u3059\u308b\u3002\u3044\u304f\u3064\u304b\u306e\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306b\u3064\u3044\u3066\u306f\u3001\u304c\u3093\u3092\u542b\u3080\u75be\u60a3\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<h6>\uff08\u6ce8\uff13\uff09\u8ee2\u5199<\/h6>\n<ul>\n<li>\u907a\u4f1d\u60c5\u5831\u306e\u672c\u4f53\u3067\u3042\u308bDNA\uff08\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u6838\u9178\uff09\u306e\u5869\u57fa\u914d\u5217\u304c\u3001RNA\u5408\u6210\u9175\u7d20\u306b\u3088\u3063\u3066\u30b3\u30d4\u30fc\u3055\u308c\u3066\u3001RNA\u304c\u5408\u6210\u3055\u308c\u308b\u3053\u3068\u3002\u4e00\u822c\u7684\u306b\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u306f\u3001DNA\u304c\u8ee2\u5199\u3055\u308c\u3066RNA\u306b\u306a\u308a\u3001\u305d\u308c\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7ffb\u8a33\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u767a\u73fe\u3059\u308b\u3002<\/li>\n<\/ul>\n<h6>\uff08\u6ce8\uff14\uff09\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0<\/h6>\n<ul>\n<li>\u771f\u6838\u751f\u7269\u306e\u30b2\u30ce\u30e0DNA\u304c\u7d30\u80de\u6838\u5185\u3067\u3068\u308b\u30af\u30ed\u30de\u30c1\u30f3\u306e\u57fa\u672c\u69cb\u9020\u5358\u4f4d\u30024\u7a2e\u985e\u306e\u30d2\u30b9\u30c8\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\uff08H2A\u3001H2B\u3001H3\u3001H4\uff09\u304c2\u5206\u5b50\u305a\u3064\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u30d2\u30b9\u30c8\u30f38\u91cf\u4f53\u306e\u5468\u56f2\u306bDNA\u4e8c\u91cd\u3089\u305b\u3093\u304c\u7d041.5\u56de\u307b\u3069\u3001\u5dfb\u304d\u3064\u3044\u305f\u3082\u306e\u3002<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u30b2\u30ce\u30e0DNA\u306e\u69cb\u9020\u3092\u3053\u308f\u308c\u3084\u3059\u304f\u3057\u3066\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308b\u3057\u304f\u307f\u3092\u89e3\u660e 1. \u6982\u8981 \u30b2\u30ce\u30e0\u4e2d\u306e\u907a\u4f1d\u5b50\u304c\u30bf\u30a4\u30df\u30f3\u30b0\u3088\u304f\u4f7f\u308f\u308c\u308b\u3001\u3064\u307e\u308a\u201c\u8ee2\u5199\u201d\u3055\u308c\u308b\u3053\u3068\u306f\u3001\u5168\u3066\u306e\u751f\u547d\u6d3b\u52d5\u306b\u91cd\u8981\u3067\u3059\u3002\u3057\u304b\u3057\u771f\u6838\u751f\u7269\u306e\u30b2\u30ce\u30e0DNA \u306f\u3001\u7d30\u80de\u6838 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":68578,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,204,5],"class_list":["post-68577","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-highlight","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/68577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=68577"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/68577\/revisions"}],"predecessor-version":[{"id":68580,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/68577\/revisions\/68580"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/68578"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=68577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=68577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=68577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}