{"id":64897,"date":"2019-05-14T14:00:10","date_gmt":"2019-05-14T05:00:10","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=64897"},"modified":"2019-05-22T11:07:53","modified_gmt":"2019-05-22T02:07:53","slug":"%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%ae%e3%83%aa%e3%83%b3%e9%85%b8%e5%8c%96%e3%82%92%e6%8a%91%e5%88%b6%e3%81%99%e3%82%8b%e3%81%93%e3%81%a8%e3%81%a7%e6%90%8d%e5%82%b7%e3%81%97%e3%81%9f","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/64897","title":{"rendered":"\u640d\u50b7\u3057\u305f\u8996\u795e\u7d4c\u518d\u751f\u4fc3\u9032"},"content":{"rendered":"<h1>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u640d\u50b7\u3057\u305f\u8996\u795e\u7d4c\u306e\u518d\u751f\u3092\u4fc3\u9032<\/h1>\n<h2>\u5916\u529b\u306b\u3088\u308b\u640d\u50b7\u4ee5\u5916\u306e\u7dd1\u5185\u969c\u306a\u3069\u306e\u75be\u60a3\u3078\u306e\u6709\u52b9\u6027\u691c\u8a3c\u306b\u671f\u5f85<\/h2>\n<h3>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul>\n<li>\u8133\u3084\u810a\u9ac4\u306a\u3069\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306f\u3001\u4e00\u5ea6\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u308b\u3068\u518d\u751f\u3057\u306b\u304f\u304f\u3001\u6cbb\u7642\u304c\u96e3\u3057\u3044\u3002<\/li>\n<li>\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u795e\u7d4c\u306e\u8ef8\u7d22\u306e\u5f62\u614b\u3092\u652f\u3048\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u3064\u3067\u3042\u308bCRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u4e2d\u67a2\u795e\u7d4c\u306e\u4e00\u90e8\u3067\u3042\u308b\u8996\u795e\u7d4c\u306e\u518d\u751f\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/li>\n<li>\u60a3\u8005\u6570\u306e\u591a\u3044\u7dd1\u5185\u969c\u306a\u3069\u3067\u3082\u5916\u529b\u306b\u3088\u308b\u8996\u795e\u7d4c\u640d\u50b7\u3068\u540c\u69d8\u306e\u75c5\u614b\u304c\u8d77\u304d\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u4eca\u5f8c\u306e\u691c\u8a3c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"http:\/\/researchers.waseda.jp\/profile\/ja.3b5d5a3cf7672492cec044182f40ef29.html\" target=\"_blank\" rel=\"noopener\">\u5927\u5cf6\u767b\u5fd7\u7537\uff08\u304a\u304a\u3057\u307e\u3068\u3057\u304a\uff09\u6559\u6388<\/a>\u3001<a href=\"https:\/\/www.ncnp.go.jp\/press\/release.html?no=450\" target=\"_blank\" rel=\"noopener\">\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u56fd\u7acb\u7cbe\u795e\u30fb\u795e\u7d4c\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc<\/a>\u795e\u7d4c\u7814\u7a76\u6240\u306e\u8352\u6728\u654f\u4e4b\uff08\u3042\u3089\u304d\u3068\u3057\u3086\u304d\uff09\u90e8\u9577\u3001<a href=\"https:\/\/www.yokohama-cu.ac.jp\/amedrc\/news\/20190514_goshima.html\" target=\"_blank\" rel=\"noopener\">\u516c\u7acb\u5927\u5b66\u6cd5\u4eba\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66<\/a>\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u306e\u4e94\u5d8b\u826f\u90ce\uff08\u3054\u3057\u307e\u3088\u3057\u304a\uff09\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5916\u529b\u306b\u3088\u3063\u3066\u640d\u50b7\u3057\u305f\u8996\u795e\u7d4c\u306e\u518d\u751f\u304c\u3001CRMP2 (collapsin response mediator protein)\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306f\u3001\u4e00\u5ea6\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u308b\u3068\u518d\u751f\u3057\u306b\u304f\u304f\u3001\u3053\u308c\u304c\u795e\u7d4c\u75be\u60a3\u306e\u6cbb\u7642\u3092\u96e3\u3057\u304f\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u304c\u640d\u50b7\u3092\u53d7\u3051\u305f\u969b\u306b\u795e\u7d4c\u7d30\u80de\u5074\u3067\u30ea\u30f3\u9178\u5316\u3059\u308bCRMP2\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7740\u76ee\u3057\u3001\u3053\u308c\u307e\u3067\u3082\u810a\u9ac4\u306e\u640d\u50b7\u30e2\u30c7\u30eb\u3067\u3001\u72ec\u81ea\u306b\u958b\u767a\u3057\u305fCRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3057\u305f\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u306f\u3001\u91ce\u751f\u578b\u306e\u30de\u30a6\u30b9\u3088\u308a\u3082\u904b\u52d5\u6a5f\u80fd\u56de\u5fa9\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u8996\u795e\u7d4c\u306e\u640d\u50b7\u30e2\u30c7\u30eb\u3067\u3053\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001CRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u304c\u640d\u50b7\u5f8c\u306e\u795e\u7d4c\u8ef8\u7d22\u518d\u751f\u306b\u6709\u52b9\u304b\u3092\u691c\u8a0e\u3057\u3001\u795e\u7d4c\u518d\u751f\u304c\u9855\u8457\u306b\u4fc3\u9032\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eca\u5f8c\u3001\u7dd1\u5185\u969c\u306a\u3069\u306e\u75be\u60a3\u306b\u5bfe\u3057\u3066\u3082\u3001CRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u304c\u75c5\u6c17\u306e\u9032\u884c\u3092\u6291\u5236\u3067\u304d\u308b\u304b\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u691c\u8a3c\u3059\u308b\u3068\u3068\u3082\u306b\u3001CRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u306e\u540c\u75be\u60a3\u3078\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u82f1\u56fd\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u79d1\u5b66\u96d1\u8a8c\u300e<a href=\"https:\/\/www.nature.com\/articles\/s41598-019-43658-w\" target=\"_blank\" rel=\"noopener\">Scientific Reports<\/a>\u300f\u306b2019\u5e745\u670810\u65e5\u5348\u524d10\u6642\uff08\u73fe\u5730\u6642\u9593\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/strong><\/h4>\n<p>\u8133\u3084\u810a\u9ac4\u306a\u3069\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306f\u3001\u4e00\u5ea6\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u308b\u3068\u518d\u751f\u304c\u8d77\u3053\u3089\u305a\u3001\u3053\u308c\u304c\u795e\u7d4c\u75be\u60a3\u306e\u6cbb\u7642\u3092\u96e3\u3057\u304f\u3057\u3066\u3044\u308b\u3002\u518d\u751f\u306b\u306f\u3001\u795e\u7d4c\u7d30\u80de\u304c\u65b0\u305f\u306b\u4f5c\u3089\u308c\u308b\u795e\u7d4c\u65b0\u751f\u3068\u3001\u4e00\u5ea6\u5207\u65ad\u3042\u308b\u3044\u306f\u640d\u50b7\u3092\u53d7\u3051\u305f\u795e\u7d4c\u306e\u8ef8\u7d22\u304c\u518d\u3073\u4f38\u9577\u3059\u308b\u795e\u7d4c\u8ef8\u7d22\u518d\u751f\u304c\u3042\u308b\u3002\u5927\u4eba\u306e\u8133\u3067\u306e\u795e\u7d4c\u65b0\u751f\uff08\u6210\u4f53\u795e\u7d4c\u65b0\u751f\uff09\u306f\u30d2\u30c8\u306a\u3069\u54fa\u4e73\u985e\u3067\u306f\u8133\u306e\u9650\u3089\u308c\u305f\u90e8\u4f4d\u3067\u306e\u307f\u8d77\u304d\u3066\u3044\u3066\u3001\u8133\u306e\u4e00\u90e8\u306e\u969c\u5bb3\u306e\u56de\u5fa9\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u5897\u6b96\u3084\u5206\u5316\u306e\u5236\u5fa1\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u3002\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u306e\u7814\u7a76\u304c\u76db\u3093\u306b\u884c\u306a\u308f\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u305d\u306e\u5897\u6b96\u3084\u795e\u7d4c\u7d30\u80de\u3078\u306e\u5206\u5316\u3092\u5236\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5229\u7528\u3057\u3066\u3001\u795e\u7d4c\u518d\u751f\u3092\u4fc3\u3059\u3053\u3068\u304c\u51fa\u6765\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3089\u3067\u3042\u308b\u3002\u4e00\u65b9\u306e\u795e\u7d4c\u8ef8\u7d22\u518d\u751f\u304c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3067\u8d77\u3053\u308a\u3065\u3089\u3044\u306e\u306f\u3001\u305d\u308c\u3092\u963b\u5bb3\u3059\u308b\u4ed5\u7d44\u307f\u304c\u3042\u308b\u304b\u3089\u3067\u3042\u308b\u3002\u810a\u9ac4\u640d\u50b7\u3067\u306f\u52a0\u3048\u3066\u640d\u50b7\u90e8\u306e\u7622\u75d5\u5f62\u6210\u306a\u3069\u306e\u7269\u7406\u7684\u969c\u5bb3\u304c\u554f\u984c\u3068\u306a\u308b\u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u4e00\u90e8\u3067\u3042\u308b\u8996\u795e\u7d4c\u3082\u640d\u50b7\u3092\u53d7\u3051\u308b\u3068\u3001\u7622\u75d5\u5f62\u6210\u306f\u9855\u8457\u3067\u306a\u3044\u3082\u306e\u306e\u3001\u518d\u751f\u304c\u96e3\u3057\u3044\u304c\u3001\u305d\u306e\u539f\u56e0\u306b\u306f\u518d\u751f\u3092\u963b\u5bb3\u3059\u308b\u56e0\u5b50\u306e\u5b58\u5728\u3068\u305d\u306e\u963b\u5bb3\u56e0\u5b50\u306b\u5bfe\u3059\u308b\u795e\u7d4c\u7d30\u80de\u5074\u306e\u53cd\u5fdc\u304c\u3042\u308b\u3002\u3053\u3046\u3057\u305f\u963b\u5bb3\u56e0\u5b50\u3084\u305d\u306e\u795e\u7d4c\u7d30\u80de\u5074\u306e\u53cd\u5fdc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u6b21\u7b2c\u306b\u660e\u3089\u306a\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u3001\u305d\u308c\u3092\u5229\u7528\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<h4><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h4>\n<p>\u795e\u7d4c\u7d30\u80de\u5074\u306e\u963b\u5bb3\u56e0\u5b50\u306b\u53cd\u5fdc\u3057\u3066\u8ef8\u7d22\u306e\u4f38\u9577\u304c\u6291\u5236\u3055\u308c\u308b\u4ed5\u7d44\u307f\u306e\u4e2d\u3067\u3001\u8ef8\u7d22\u306e\u5f62\u614b\u3092\u652f\u3048\u308b\u9aa8\u683c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5fae\u5c0f\u7ba1\u306e\u4e0d\u5b89\u5b9a\u5316\u304c\u3042\u308b\u3002\u5fae\u5c0f\u7ba1\u306fa-\u30c1\u30e5\u2015\u30d6\u30ea\u30f3\u3068b-\u30c1\u30e5\u30fc\u30d6\u30ea\u30f3\u304c\uff12\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3066\u3001\u305d\u308c\u304c\u91cd\u5408\u3057\u3066\u9023\u306a\u3063\u305f\u69cb\u9020\u3092\u3057\u3066\u304a\u308a\u3001\u91cd\u5408\u3068\u8131\u91cd\u5408\u306b\u3088\u308a\u5fae\u5c0f\u7ba1\u306e\u4f38\u9577\u3068\u9000\u7e2e\u304c\u8d77\u3053\u308b\u3002\u3053\u3046\u3057\u305f\u69cb\u9020\u3092\u5b89\u5b9a\u5316\u3059\u308b\u3082\u306e\u306b\u3001\u5fae\u5c0f\u7ba1\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3042\u308b\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u7740\u76ee\u3057\u3066\u3044\u308bCRMP2 (collapsin response mediator protein)\u306f\u3001\u5fae\u5c0f\u7ba1\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u3064\u3067\u3001\u975e\u30ea\u30f3\u9178\u5316\u72b6\u614b\u3067\u5fae\u5c0f\u7ba1\u306b\u7d50\u5408\u3057\u3066\u5fae\u5c0f\u7ba1\u3092\u5b89\u5b9a\u5316\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u305d\u306e\u91cd\u5408\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u308c\u307e\u3067\u306bCRMP2\u304c\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u308b\u3068\u5fae\u5c0f\u7ba1\u3068\u306e\u7d50\u5408\u80fd\u304c\u5931\u308f\u308c\u3001\u7d50\u679c\u3068\u3057\u3066\u5fae\u5c0f\u7ba1\u304c\u4e0d\u5b89\u5b9a\u5316\u3057\u3066\u8ef8\u7d22\u306e\u9000\u7e2e\u304c\u8d77\u304d\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u308b\uff08Uchida et al., 2005\uff09\u3002\u3053\u306eCRMP2\u306e\u30ea\u30f3\u9178\u5316\u306b\u3088\u308b\u8ef8\u7d22\u306e\u9000\u7e2e\u306f\u8ef8\u7d22\u4f38\u9577\u3092\u963b\u5bb3\u3059\u308b\u56e0\u5b50\u3067\u3042\u308bSema3A<sup>*1<\/sup>\u3067\u8d77\u304d\u308b\u304c\u3001CRMP2\u306f\u3053\u306e\u53cd\u5fdc\u3092\u4f1d\u3048\u308b\u3053\u3068\u304b\u3089\u547d\u540d\u3055\u308c\u3066\u3044\u308b\uff08collapsin\u306f\u30cb\u30ef\u30c8\u30ea\u306eSema3A\u306e\u65e7\u540d\uff09\u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u304c\u640d\u50b7\u3092\u53d7\u3051\u305f\u969b\u306b\u306f\u3001\u3053\u306eSema3A\u306b\u52a0\u3048\u3066\u3001\u8ef8\u7d22\u3092\u53d6\u308a\u5dfb\u304f\u30df\u30a8\u30ea\u30f3\u7531\u6765\u306e\u30df\u30a8\u30ea\u30f3\u95a2\u9023\u963b\u5bb3\u56e0\u5b50\u3068\u547c\u3070\u308c\u308b\u4e00\u9023\u306e\u963b\u5bb3\u56e0\u5b50\u304c\u8ef8\u7d22\u518d\u751f\u3092\u6291\u5236\u3059\u308b\u304c\u3001\u8ef8\u7d22\u5074\u3067\u306fCRMP2\u306e\u30ea\u30f3\u9178\u5316\u304c\u8d77\u304d\u3066\u304a\u308a\u3001\u305d\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u518d\u751f\u3092\u4fc3\u305d\u3046\u3068\u3044\u3046\u306e\u304c\u4eca\u56de\u306e\u7814\u7a76\u306e\u76ee\u7684\u3067\u3042\u308b\u3002\u3053\u3046\u3057\u305f\u76ee\u7684\u306e\u305f\u3081\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u308c\u307e\u3067\u306bCRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3057\u305f\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u958b\u767a\u3057\u3066\u3044\u308b\uff08Yamashita et al., 2012\uff09\u3002CRMP2\u306f\u4f55\u7a2e\u985e\u304b\u306e\u30ad\u30ca\u30fc\u30bc\u306b\u3088\u308a\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u304c\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u7740\u76ee\u3057\u3066\u3044\u308b\u306e\u306fSer522\u306e\u30b5\u30a4\u30af\u30ea\u30f3\u4f9d\u5b58\u6027\u30ad\u30ca\u30fc\u30bc\uff15(Cdk5)\u306b\u3088\u308b\u30ea\u30f3\u9178\u5316\u3067\u3001\u3053\u306e\u30ea\u30f3\u9178\u5316\u4f9d\u5b58\u7684\u306b\u3055\u3089\u306b\u5225\u306e\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308bGSK3b\u306b\u3088\u308aThr509, Thr514, Ser518\u306e\uff13\u3064\u306e\u90e8\u4f4d\u304c\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u308b\u304c\uff08Uchida et al., 2005\uff09\u3001\u3053\u306e522\u756a\u76ee\u306eSer\u3092Ala\u306b\u7f6e\u63db\u3057\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u306a\u304f\u3057\u305f\u306e\u304c\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u958b\u767a\u3057\u305fCRMP2KI (\u30ce\u30c3\u30af\u30a4\u30f3 (knock-in, KI))\u30de\u30a6\u30b9\u3067\u3042\u308b\uff08Yamashita et al., 2012\uff09\u3002\u3053\u306e\u30de\u30a6\u30b9\u3067\u306f\u3001\uff14\u7b87\u6240\u306e\u30ea\u30f3\u9178\u5316\u304c\u963b\u5bb3\u3055\u308c\u308b\u3053\u3068\u3068\u306a\u308a\u3001Sema3A\u306a\u3069\u306e\u963b\u5bb3\u56e0\u5b50\u306b\u3088\u308b\u8ef8\u7d22\u518d\u751f\u963b\u5bb3\u3092\u53d7\u3051\u306a\u3044\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u308b\u3002\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u308c\u307e\u3067\u306b\u3001\u810a\u9ac4\u640d\u50b7\u306e\u30e2\u30c7\u30eb\u7cfb\u3067\u3001CRMP2KI\u30de\u30a6\u30b9\u304c\u91ce\u751f\u578b\u306b\u6bd4\u3079\u3066\u640d\u50b7\u304b\u3089\u306e\u904b\u52d5\u6a5f\u80fd\u56de\u5fa9\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u308b\uff08Nagai et al., 2016\uff09\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u8996\u795e\u7d4c\u306e\u640d\u50b7\u30e2\u30c7\u30eb\u3067CRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u304c\u640d\u50b7\u5f8c\u306e\u795e\u7d4c\u8ef8\u7d22\u518d\u751f\u306b\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u3001\u4ee5\u4e0b\u306e\u70b9\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n<ol>\n<li>CRMP\uff12KI\u30de\u30a6\u30b9\u3067\u306f\u8996\u795e\u7d4c\u640d\u50b7\u76f4\u5f8c\u306b\u8d77\u304d\u308b\u5fae\u5c0f\u7ba1\u306e\u8131\u91cd\u5408\u304c\u8efd\u5ea6\u3067\u3042\u308b\u3053\u3068\u3002<\/li>\n<li>CRMP2KI\u30de\u30a6\u30b9\u3067\u306f\u7db2\u819c\u306b\u3042\u308b\u8996\u795e\u7d4c\u306e\u5143\u306b\u306a\u308b\u7d30\u80de(\u7db2\u819c\u795e\u7d4c\u7bc0\u7d30\u80de)\u306e\u8131\u843d\u304c\u5c11\u306a\u3044\u3053\u3068\uff08\u56f3\uff11\uff09\u3002<\/li>\n<li>\u8996\u795e\u7d4c\u640d\u50b7\uff14\u9031\u9593\u5f8c\u306b\u6bd4\u8f03\u3059\u308b\u3068CRMP2KI\u3067\u306f\u795e\u7d4c\u518d\u751f\u30de\u30fc\u30ab\u30fc\u306eGAP43\u306e\u767a\u73fe\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\uff08\u56f3\uff12\uff09\u3002<\/li>\n<li>\u8996\u795e\u7d4c\u518d\u751f\u3092\u30c8\u30ec\u30fc\u30b5\u30fc\u3092\u7528\u3044\u3066\u8abf\u3079\u308b\u3068<sup>*2<\/sup>\u3001CRMP2KI\u3067\u306f\u795e\u7d4c\u518d\u751f\u304c\u9855\u8457\u306b\u4fc3\u9032\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\uff08\u56f33\uff09\u3002<\/li>\n<\/ol>\n<h4><strong>\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h4>\n<p>\u524d\u8ff0\u306e\u901a\u308a\u3001\u907a\u4f1d\u5b50\u6539\u5909\u306b\u3088\u308aCRMP2KI\u30de\u30a6\u30b9\u3092\u958b\u767a\u3057\u3066\u3044\u308b\uff08Yamashita et al., 2012\uff09\u3002\u958b\u767a\u306f\u3001\u4eca\u56de\u306e\u5171\u540c\u7814\u7a76\u8005\u3067\u3042\u308b\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u306e\u4e94\u5d8b\u826f\u90ce\u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u884c\u306a\u3063\u305f\u3002<\/p>\n<h4><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h4>\n<p>\u8996\u795e\u7d4c\u640d\u50b7\u306f\u3001\u7269\u7406\u7684\u5916\u529b\u306b\u3088\u308b\u30c0\u30e1\u30fc\u30b8\u3067\u8d77\u304d\u308b\u3082\u306e\u3067\u3042\u308b\u304c\u3001\u3088\u308a\u60a3\u8005\u6570\u306e\u591a\u3044\u773c\u79d1\u75be\u60a3\u3067\u3042\u308b\u7dd1\u5185\u969c\u306a\u3069\u306e\u75c5\u614b\u3067\u3082\u540c\u69d8\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u795e\u7d4c\u518d\u751f\u963b\u5bb3\u304c\u8d77\u304d\u3066\u3044\u308b\u53ef\u80fd\u304c\u3042\u308b\u3002\u672c\u7814\u7a76\u306b\u52a0\u3048\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u810a\u9ac4\u640d\u50b7\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308bCRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u7d50\u679c\uff08Nagai et al., 2016\uff09\u3084\u3001CRMP2KI\u3067\u306fALS\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u75c7\u72b6\u306e\u9032\u884c\u304c\u6291\u3048\u3089\u308c\u308b\uff08Numata-Uematsu et al., 2019\uff09\u3068\u3044\u3063\u305f\u7814\u7a76\u6210\u679c\u306f\u3001CRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u85ac\u5264\u304c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u795e\u7d4c\u518d\u751f\u4fc3\u9032\u306b\u6709\u7528\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u5f37\u304f\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u5b9f\u969b\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306fCRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3057\u3001CRMP2\u3068\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306e\u7d50\u5408\u3092\u5909\u5316\u3055\u305b\u308b\u85ac\u5264\u3067\u3042\u308bLKE\u304c\u810a\u9ac4\u640d\u50b7\u30e2\u30c7\u30eb\u306e\u6a5f\u80fd\u56de\u5fa9\u306b\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u308b\uff08Kotaka et al., 2016\uff09\u3002<\/p>\n<h4><strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u907a\u4f1d\u5b50\u6539\u5909\u3057\u305f\u30de\u30a6\u30b9\u3067\u306e\u7d50\u679c\u3067\u3042\u308a\u3001\u524d\u8ff0\u306eLKE\u306a\u3069CRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u304c\u795e\u7d4c\u518d\u751f\u306b\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u307e\u305f\u3001\u3088\u308a\u60a3\u8005\u6570\u306e\u591a\u3044\u7dd1\u5185\u969c\u306a\u3069\u3067\u3082\u5916\u529b\u306b\u3088\u308b\u8996\u795e\u7d4c\u640d\u50b7\u3068\u540c\u69d8\u306e\u75c5\u614b\u304c\u8d77\u304d\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u7dd1\u5185\u969c\u306a\u3069\u306e\u773c\u79d1\u75be\u60a3\u306b\u305f\u3044\u3057\u3066\u3082CRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u304c\u75c5\u6c17\u306e\u9032\u884c\u3092\u6291\u5236\u3067\u304d\u308b\u304b\u3001CRMP2KI\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u691c\u8a3c\u3059\u308b\u3068\u3068\u3082\u306b\u3001CRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u306e\u540c\u75be\u60a3\u3078\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002ALS\u306a\u3069\u306e\u795e\u7d4c\u7cfb\u5909\u6027\u75be\u60a3\u306b\u5bfe\u3057\u3066\u3082CRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u304c\u6709\u52b9\u3067\u3042\u308b\u304b\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u6700\u8fd1\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001MPTP\u3068\u3044\u3046\u85ac\u5264\u3067\u30c9\u30fc\u30d1\u30df\u30f3\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3057\u305f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001\u8ef8\u7d22\u5909\u6027\u304cCRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u306b\u3088\u308a\u8efd\u6e1b\u3055\u308c\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u308b\uff08Togashi et al., 2019\uff09\u3002\u5f93\u3063\u3066\u3001CRMP2\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u304c\u795e\u7d4c\u640d\u50b7\u53ca\u3073\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3001\u4eca\u5f8c\u306e\u691c\u8a3c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n<h4><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h4>\n<ul>\n<li><strong>*1 Sema3A<\/strong><\/li>\n<\/ul>\n<p>Semaphorin 3A\u306e\u7565\u3067\u3001\u795e\u7d4c\u8ef8\u7d22\u306e\u9000\u7e2e\u3092\u5f15\u304d\u8d77\u3053\u3059\u5178\u578b\u7684\u306a\u5206\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u795e\u7d4c\u7d30\u80de\u306e\u30cb\u30e5\u30fc\u30ed\u30d4\u30ea\u30f3\u3068\u30d7\u30ec\u30ad\u30b7\u30f3\u3068\u3044\u3046\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u305d\u306e\u53cd\u5fdc\u304c\u7d30\u80de\u3067\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002\u767a\u898b\u5f53\u521d\u306f\u7a2e\u306b\u3088\u308a\u69d8\u3005\u306a\u540d\u79f0\u3001\u4f8b\u3048\u3070\u30cb\u30ef\u30c8\u30ea\u3067\u306fcollapsin\u3068\u547c\u3070\u308c\u3066\u3044\u305f\u3002\u3053\u306e\u53cd\u5fdc\u3092\u4f1d\u3048\u308b\u7d30\u80de\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066collapsin response mediator protein (CRMP)\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\uff08Goshima et al., 1996\uff09\u3002<\/p>\n<ul>\n<li><strong>*2 <\/strong><strong>\u30c8\u30ec\u30fc\u30b5\u30fc\u306b\u3088\u308b\u6a19\u8b58<\/strong><\/li>\n<\/ul>\n<p>\u785d\u5b50\u4f53\u4e2d\u306b\u30c8\u30ec\u30fc\u30b5\u30fc\u3092\u6ce8\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30c8\u30ec\u30fc\u30b5\u30fc\u304c\u7db2\u819c\u306e\u795e\u7d4c\u7bc0\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u9806\u884c\u6027\u8f38\u9001\u306b\u3088\u308a\u305d\u306e\u8ef8\u7d22\u3067\u3042\u308b\u8996\u795e\u7d4c\u306e\u672b\u7aef\u307e\u3067\u904b\u642c\u3055\u308c\u308b\u305f\u3081\u3001\u8ef8\u7d22\u3092\u542b\u3081\u305f\u795e\u7d4c\u7d30\u80de\u5168\u4f53\u3092\u6a19\u8b58\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n<h4><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h4>\n<ul>\n<li><strong>\u96d1\u8a8c\u540d\uff1a<\/strong>Scientific Reports<\/li>\n<li><strong>\u8ad6\u6587\u540d\uff1a<\/strong>Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury<\/li>\n<li><strong>\u57f7\u7b46\u8005\u540d\uff1a<\/strong>Shunsuke Kondo<sup>1<\/sup>, Kazuya Takahashi<sup>1<\/sup>, Yuki Kinoshita<sup>1<\/sup>, Jun Nagai<sup>1<\/sup>, Shuji Wakatsuki<sup>2<\/sup>, Toshiyuki Araki<sup>2<\/sup>, Yoshio Goshima<sup>3<\/sup>, Toshio Ohshima<sup>1<\/sup><\/li>\n<\/ul>\n<p>\u203b\uff11\u6240\u5c5e\uff1a\u65e9\u7a32\u7530\u5927\u5b66\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b<br \/>\n\u203b\uff12\u6240\u5c5e\uff1a\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u56fd\u7acb\u7cbe\u795e\u30fb\u795e\u7d4c\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u75be\u75c5\u7814\u7a76\u7b2c\uff15\u90e8<br \/>\n\u203b\uff13\u6240\u5c5e\uff1a\u516c\u7acb\u5927\u5b66\u6cd5\u4eba\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66 \u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1 \u5206\u5b50\u85ac\u7406\u795e\u7d4c\u751f\u7269\u5b66<\/p>\n<ul>\n<li><strong>\u63b2\u8f09\u65e5\u6642\uff1a<\/strong>2019\u5e745\u670810\u65e5\u5348\u524d10\u6642\uff08\u30a4\u30ae\u30ea\u30b9\u73fe\u5730\u6642\u9593\uff09<\/li>\n<li><strong>\u63b2\u8f09URL\uff1a<\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-019-43658-w\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41598-019-43658-w<\/a><\/li>\n<li><strong>DOI<\/strong><strong>\uff1a<\/strong>10.1038\/s41598-019-43658-w<\/li>\n<\/ul>\n<h4><strong>\u00a0<\/strong><strong>\u7814\u7a76\u52a9\u6210<\/strong><\/h4>\n<ul>\n<li>\u79d1\u7814\u8cbb\u57fa\u76e4\u7814\u7a76C\u300c\uff23\uff32\uff2d\uff30\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u795e\u7d4c\u640d\u50b7\u30fb\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6cbb\u7642\u6226\u7565\u958b\u767a\u300d\uff08\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5927\u5cf6\u767b\u5fd7\u7537\uff09<\/li>\n<li>\u305d\u306e\u4ed6\u3001JST\u30fbCREST\u3001\u6587\u90e8\u79d1\u5b66\u7701\u300c\u5148\u7aef\u878d\u5408\u9818\u57df\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u5275\u51fa\u62e0\u70b9\u5f62\u6210\u30d7\u30ed\u30b0\u30e9\u30e0\u300d<\/li>\n<\/ul>\n<h4><strong>\u53c2\u8003\u56f3<\/strong><\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-64909 aligncenter\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig1-610x288.jpg\" alt=\"\" width=\"610\" height=\"288\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig1-610x288.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig1-768x362.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig1.jpg 943w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56f3\uff11\u3000<\/strong><strong>\u91ce\u751f\u578b(WT)\u3068CRMP2KI\u30de\u30a6\u30b9\u306e\u8996\u795e\u7d4c\u640d\u50b72\u9031\u9593\u5f8c(ONC 2W)\u306e\u7db2\u819c\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001CRMP2KI\u30de\u30a6\u30b9\u3067\u8d64\u304f\u67d3\u8272\u3055\u308c\u305f\u795e\u7d4c\u7bc0\u7d30\u80de\u306e\u6570\u304c\u591a\u3044\u3053\u3068\u304c\u5206\u304b\u308b\u3002\u30b0\u30e9\u30d5\u306f\u3001\u975e\u640d\u50b7\u5074(intact side)\u306b\u6bd4\u3079\u305f\u640d\u50b7\u5074(ONC side)\u306e\u7d30\u80de\u306e\u30d1\u30fc\u30bb\u30f3\u30c8\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-64912 aligncenter\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig2.png\" alt=\"\" width=\"350\" height=\"403\" \/><\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u56f3\uff12\u3000<\/strong><strong>\u91ce\u751f\u578b(WT)\u3068CRMP2KI\u30de\u30a6\u30b9\u306e\u8996\u795e\u7d4c\u306e\u640d\u50b7\u524d(int)\u3001\u640d\u50b7\uff11\u9031\u9593\u5f8c(1W)\u30014\u9031\u9593\u5f8c(4W)\u306e\u5404\u7a2e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cf\u3092\u6bd4\u8f03\u3057\u305f\u3082\u306e\u3002\u518d\u751f\u3057\u305f\u795e\u7d4c\u306e\u30de\u30fc\u30ab\u30fcGAP43\u304cCRMP2KI\u30de\u30a6\u30b9\u306e\u640d\u50b7\u5f8c\u306e\u8996\u795e\u7d4c\u3067\u591a\u3044\u3053\u3068\u304c\u5206\u304b\u308b\u3002<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-64913 aligncenter\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig3-610x280.jpg\" alt=\"\" width=\"610\" height=\"280\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig3-610x280.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig3-768x353.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/05\/20190514_fig3.jpg 908w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u56f33\u3000<\/strong><strong>\u30c8\u30ec\u30fc\u30b5\u30fc\u306b\u3088\u308b\u6a19\u8b58\u306e\u7d50\u679c\u3001CRMP2KI\u306e\u640d\u50b7\uff14\u9031\u9593\u5f8c(4W)\u3067\u6a19\u8b58\u3055\u308c\u305f\u8ef8\u7d22\u304c\u591a\u304f\u89b3\u5bdf\u3055\u308c\u308b\u3002\u640d\u50b7\u90e8\u4f4d\u304b\u3089\u306e\u4e00\u70b9\u8ddd\u96e2\u3067\u6a19\u8b58\u3055\u308c\u305f\u8ef8\u7d22\u306e\u6570\u3092\u6570\u5024\u5316\u3057\u305f\u30b0\u30e9\u30d5\u304b\u3089\u3082\u3001CRMP2KI\u3067\u306f\u640d\u50b7\u5f8c\u306e\u8996\u795e\u7d4c\u518d\u751f\u304c\u9855\u8457\u306b\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308b\u3002<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u640d\u50b7\u3057\u305f\u8996\u795e\u7d4c\u306e\u518d\u751f\u3092\u4fc3\u9032 \u5916\u529b\u306b\u3088\u308b\u640d\u50b7\u4ee5\u5916\u306e\u7dd1\u5185\u969c\u306a\u3069\u306e\u75be\u60a3\u3078\u306e\u6709\u52b9\u6027\u691c\u8a3c\u306b\u671f\u5f85 \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u8133\u3084\u810a\u9ac4\u306a\u3069\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306f\u3001\u4e00\u5ea6\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u308b\u3068\u518d\u751f\u3057\u306b\u304f\u304f\u3001\u6cbb\u7642\u304c\u96e3\u3057\u3044\u3002 \u7814 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":64922,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,5],"class_list":["post-64897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/64897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=64897"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/64897\/revisions"}],"predecessor-version":[{"id":64955,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/64897\/revisions\/64955"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/64922"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=64897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=64897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=64897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}