{"id":64616,"date":"2019-04-23T12:01:02","date_gmt":"2019-04-23T03:01:02","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=64616"},"modified":"2019-04-23T12:12:20","modified_gmt":"2019-04-23T03:12:20","slug":"1%e5%88%86%e3%81%a7%e8%a3%85%e7%9d%80%e5%8f%af%e8%83%bd%e3%80%81%e8%85%b0%e3%81%a0%e3%81%91%e3%81%a7%e3%81%aa%e3%81%8f%e8%85%95%e3%81%ae%e8%b2%a0%e6%8b%85%e3%82%82%e8%bb%bd%e6%b8%9b%e3%81%99-2-3-4-2-4","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/64616","title":{"rendered":"\u4f53\u6e29\u306b\u304a\u3044\u3066\u5fc3\u81d3\u304c\u52b9\u7387\u826f\u304f\u62cd\u52d5\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u89e3\u660e"},"content":{"rendered":"<h3>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul>\n<li>\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5149\u71b1\u5909\u63db\u9855\u5fae\u93e1\u6cd5\u3092\u7528\u3044\u3066\u7b4b\u53ce\u7e2e\u6a5f\u80fd\u306e\u6e29\u5ea6\u7279\u6027\u3092\u8a55\u4fa1\u3059\u308b\u9855\u5fae\u89e3\u6790\u6cd5\u3092\u69cb\u7bc9<\/li>\n<li>\u7b4b\u8089\u304c\u6e29\u307e\u308b\u3068\u53ce\u7e2e\u3059\u308b\u300c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u300d\u3092\uff14\u7a2e\u985e\u306e\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u307f\u3067\u518d\u73fe\u3059\u308b\u3053\u3068\u306b\u6210\u529f<\/li>\n<li>\u5fc3\u81d3\u304c\u4f53\u6e29\u306b\u304a\u3044\u3066\u52b9\u7387\u7684\u306b\u62cd\u52d5\u3067\u304d\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u89e3\u660e<\/li>\n<\/ul>\n<h3>\u6982\u8981<\/h3>\n<p><a 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href=\"https:\/\/www3.chubu.ac.jp\/life_health\/\">\u4e2d\u90e8\u5927\u5b66\u751f\u547d\u5065\u5eb7\u79d1\u5b66\u90e8<\/a>\u52a9\u6559\u306e\u65b0\u8c37\u6b63\u5dba\uff08\u3057\u3093\u305f\u306b\u305b\u3044\u306d\uff09\u3001<a href=\"http:\/\/www.jikei.ac.jp\/univ\/\">\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66<\/a>\u51c6\u6559\u6388\u306e\u798f\u7530\u7d00\u7537\uff08\u3075\u304f\u3060\u306e\u308a\u304a\uff09\u3001\u306a\u3089\u3073\u306b\u65e9\u7a32\u7530\u5927\u5b66\u540d\u8a89\u6559\u6388\u306e<a href=\"http:\/\/www.ishiwata.phys.waseda.ac.jp\/\">\u77f3\u6e21\u4fe1\u4e00\uff08\u3044\u3057\u308f\u305f\u3057\u3093\u3044\u3061\uff09<\/a>\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u79d1\u5b66\u6280\u8853\u7814\u7a76\u5e81\uff08A*STAR\uff09\u3068<a href=\"https:\/\/www.osaka-u.ac.jp\/ja\">\u5927\u962a\u5927\u5b66<\/a>\u306e\u7814\u7a76\u8005\u305f\u3061\u3068\u5171\u540c\u3067\u3001\u7b4b\u53ce\u7e2e\u6a5f\u80fd\u306e\u6e29\u5ea6\u7279\u6027\u3092\u8a55\u4fa1\u3059\u308b\u9855\u5fae\u89e3\u6790\u6cd5\u3092\u69cb\u7bc9\u3057\u3001\u5fc3\u81d3\u304c\u4f53\u6e29\u306b\u304a\u3044\u3066\u52b9\u7387\u7684\u306b\u62cd\u52d5\u3067\u304d\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u6211\u3005\u54fa\u4e73\u985e\u306e\u7b4b\u8089\u306f\u3001\u307e\u305a\u7d30\u80de\u306e\u4e2d\u3067\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u306e\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u6b21\u306b\u7b4b\u8089\u3092\u52d5\u304b\u3059\u30b9\u30a4\u30c3\u30c1\u306e\u5f79\u76ee\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304cON\u306b\u306a\u308b\u3053\u3068\u3067\u3001\u529b\u304c\u751f\u307e\u308c\u3066\u53ce\u7e2e\u3057\u307e\u3059\u3002\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u308c\u307e\u3067\u3001\u77ed\u6642\u9593\u306e\u52a0\u71b1\uff08\u71b1\u30d1\u30eb\u30b9\uff09\u306b\u3088\u3063\u3066\u7b4b\u8089\u306e\u7d30\u80de\u304c\u53ce\u7e2e\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u30fb\u5831\u544a\u3057\u3001\u3053\u306e\u65b0\u3057\u3044\u300c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u300d\u3067\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u306e\u4e0a\u6607\u304c\u4f34\u308f\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u306a\u305c\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u7121\u3057\u3067\u3082\u3001\u71b1\u3060\u3051\u3067\u53ce\u7e2e\u3067\u304d\u308b\u306e\u304b\u3001\u8a73\u7d30\u306a\u4ed5\u7d44\u307f\u3092\u5341\u5206\u306b\u8a3c\u660e\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3067ON\/OFF\u304c\u5236\u5fa1\u3055\u308c\u308b\u7b4b\u8089\u306b\u3068\u3063\u3066\u3001\u300c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u300d\u304c\u512a\u4f4d\u306b\u50cd\u3044\u3066\u3044\u308b\u306e\u304b\u3069\u3046\u304b\u3082\u4e0d\u660e\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u4eca\u56de\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u300c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u300d\u306e\u8d77\u304d\u308b\u4ed5\u7d44\u307f\u3092\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u306e\u50cd\u304d\u304b\u3089\u8a3c\u660e\u3059\u308b\u305f\u3081\u3001\u7b4b\u8089\u306e\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7cbe\u88fd\u3057\u3001\u7b4b\u53ce\u7e2e\u306e\u6e29\u5ea6\u7279\u6027\u3092\u7cbe\u5bc6\u306b\u8a55\u4fa1\u3067\u304d\u308b\u9855\u5fae\u89e3\u6790\u6cd5\u3092\u65b0\u305f\u306b\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\uff14\u7a2e\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u307f\u3092\u7528\u3044\u3066\u300c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u300d\u3092\u518d\u73fe\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u54fa\u4e73\u985e\u306e\u5fc3\u81d3\u306b\u306f\u3001\u4f53\u6e29\u3092\u5229\u7528\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u4e0a\u6607\u306b\u5fdc\u3058\u3066\u52b9\u7387\u3088\u304f\u53ce\u7e2e\u3059\u308b\u4ed5\u7d44\u307f\u304c\u5099\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u77e5\u898b\u3092\u5f97\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306fJSPS\u79d1\u5b66\u7814\u7a76\u8cbb\u3001JST\u3055\u304d\u304c\u3051\u3001\u65e5\u672c\u5fc3\u81d3\u8ca1\u56e3\u306a\u3069\u306e\u52a9\u6210\u3092\u53d7\u3051\u3066\u884c\u308f\u308c\u305f\u3082\u306e\u3067\u3001\u7814\u7a76\u6210\u679c\u306f\u300c<a href=\"http:\/\/jgp.rupress.org\/content\/early\/2019\/04\/19\/jgp.201812243\">Journal of General Physiology<\/a>\u300d\u306b2019\u5e744\u670822\u65e5\uff08\u30a2\u30e1\u30ea\u30ab\u6771\u6d77\u5cb8\u6642\u9593\uff09\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>(1)\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/h4>\n<p>\u79c1\u305f\u3061\u306e\u5fc3\u81d3\u306e\u7b4b\u8089\uff08\u5fc3\u7b4b\uff09\u3084\u624b\u8db3\u3092\u52d5\u304b\u3059\u305f\u3081\u306e\u7b4b\u8089\uff08\u9aa8\u683c\u7b4b\uff09\u306e\u52d5\u304d\uff08\u53ce\u7e2e\uff09\u306f\u3001\u7b4b\u8089\u306e\u7d30\u80de\u306b\u5c4a\u304f\u96fb\u6c17\u7684\u306a\u523a\u6fc0\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\uff08Ca<sup>2+<\/sup>\uff09\u6fc3\u5ea6\u304c\u4e00\u6642\u7684\u306b\u4e0a\u6607\uff08Ca<sup>2+<\/sup>\u30c8\u30e9\u30f3\u30b8\u30a7\u30f3\u30c8\uff09\u3059\u308b\u3053\u3068\u3067\u59cb\u307e\u308a\u307e\u3059\u3002\u3053\u306e\u7b4b\u53ce\u7e2e\u306f\u3001\u7b4b\u8089\u306b\u542b\u307e\u308c\u308b\u30012\u7a2e\u985e\u306e\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u304c\u4e92\u3044\u306b\u6ed1\u308a\u904b\u52d5\u3059\u308b\u3053\u3068\u3067\u8d77\u3053\u308a\u3001\u3053\u308c\u3089\u306e\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306f\u305d\u308c\u305e\u308c\u3001\u30a2\u30af\u30c1\u30f3\u5206\u5b50\u3092\u4e3b\u3068\u3059\u308b\u300c\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u300d\u306b\u300c\u30c8\u30ed\u30dd\u30cb\u30f3\u30fb\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\u8907\u5408\u4f53\u300d\u306a\u3069\u304c\u7d50\u5408\u3057\u305f\u300c\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u300d\u3068\u3001\u30df\u30aa\u30b7\u30f3\u5206\u5b50\u3092\u4e3b\u3068\u3059\u308b\u300c\u592a\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u300d\u3068\u3088\u3070\u308c\u307e\u3059\u3002\u7b4b\u8089\u304c\u5f1b\u7de9\u3057\u3066\u3044\u308b\u3068\u304d\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u6fc3\u5ea6\u306f\u4f4e\u304f\u3001\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u69cb\u6210\u3059\u308b\u30c8\u30ed\u30dd\u30cb\u30f3\u30fb\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\u8907\u5408\u4f53\u304c\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3068\u30df\u30aa\u30b7\u30f3\u5206\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u963b\u5bb3\u3057\u3066\u3044\u307e\u3059\uff08\u30b9\u30a4\u30c3\u30c1\u304cOFF\u306e\u72b6\u614b\uff09\u3002Ca<sup>2+<\/sup>\u30c8\u30e9\u30f3\u30b8\u30a7\u30f3\u30c8\u306f\u3001\u3053\u306e\u7b4b\u53ce\u7e2e\u306e\u30b9\u30a4\u30c3\u30c1\u3092\u62c5\u3046\u30c8\u30ed\u30dd\u30cb\u30f3\u30fb\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\u8907\u5408\u4f53\u306b\u4f5c\u7528\u3057\u3001\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306b\u30df\u30aa\u30b7\u30f3\u5206\u5b50\u304c\u7d50\u5408\u3067\u304d\u308b\u72b6\u614b\uff08\u30b9\u30a4\u30c3\u30c1\u304cON\u306e\u6d3b\u6027\u5316\u72b6\u614b\uff09\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u7b4b\u53ce\u7e2e\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306a\u6559\u79d1\u66f8\u306b\u8a18\u8ff0\u3055\u308c\u308b\u751f\u7406\u7684\u30b9\u30c6\u30c3\u30d7\u4ee5\u5916\u306b\u3082\u3001\u7b4b\u53ce\u7e2e\u3092\u8a98\u5c0e\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3042\u308a\u3046\u308b\u3053\u3068\u3092\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u30e9\u30c3\u30c8\u304b\u3089\u8abf\u88fd\u3057\u305f\u5fc3\u7b4b\u7d30\u80de\u304c0.2\uff5e0.5\u79d2\u9593\u3060\u3051\u306e\u52a0\u71b1\uff08\u71b1\u30d1\u30eb\u30b9\uff09\u306b\u5fdc\u7b54\u3057\u3066\u3001Ca<sup>2+<\/sup>\u30c8\u30e9\u30f3\u30b8\u30a7\u30f3\u30c8\u3092\u8d77\u3055\u305a\u306b\u53ce\u7e2e\u3059\u308b\u300c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u300d\u73fe\u8c61\u3092\u767a\u898b\u30fb\u5831\u544a\u3057\u3066\u3044\u307e\u3059\uff08Oyama et al., Biochem. Biophys. Res. Commun. 2012\uff09\u3002Ca<sup>2+<\/sup>\u30c8\u30e9\u30f3\u30b8\u30a7\u30f3\u30c8\u3092\u4ecb\u3055\u306a\u3044\u70b9\u306b\u304a\u3044\u3066\u3001\u52a0\u71b1\u7b4b\u53ce\u7e2e\u306b\u306f\u3001\u96fb\u6c17\u7684\u8208\u596e\u306b\u3088\u308b\u751f\u7406\u7684\u53ce\u7e2e\u3068\u306f\u7570\u306a\u308b\u53ce\u7e2e\u8a98\u5c0e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u52a0\u71b1\u7b4b\u53ce\u7e2e\u306f\u3001\u5fc3\u7b4b\u7d30\u80de\u306b\u9650\u3089\u305a\u3001\u9aa8\u683c\u7b4b\u3067\u3082\u751f\u3058\u3046\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Marino et al., 2017\uff1b<a href=\"https:\/\/www.waseda.jp\/top\/news\/49190\">\u904e\u53bb\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u5149\u3092\u3042\u3066\u305f\u30ca\u30ce\u7c92\u5b50\u304b\u3089\u51fa\u308b\u300c\u71b1\u300d\u3067\u3001\u7b4b\u8089\u3092\u30ef\u30a4\u30e4\u30ec\u30b9\u306b\u6d3b\u6027\u5316\u3059\u308b\u65b0\u624b\u6cd5\u3092\u958b\u767a\u300d<\/a>\uff09\u3002<\/p>\n<p>\u79c1\u305f\u3061\u306e\u4f53\u6e29\u306f1\u65e5\u306e\u4e2d\u3067\u5909\u5316\u3057\u3001\u4f53\u306e\u90e8\u4f4d\u3054\u3068\u306b\u30d0\u30e9\u30c4\u30ad\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u304a\u304a\u3080\u306d\u4e00\u5b9a\u306b\u4fdd\u305f\u308c\u3066\u3044\u307e\u3059\u3002\u4f53\u6e29\u3068\u3001\u52a0\u71b1\u7b4b\u53ce\u7e2e\u73fe\u8c61\u3001\u305d\u3057\u3066Ca<sup>2+<\/sup>\u3067\u8a98\u5c0e\u3055\u308c\u308b\u7b4b\u8089\u306e\u53ce\u7e2e\u3002\u3053\u306e3\u8005\u306b\u3001\u4f55\u304b\u95a2\u4fc2\u306f\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n<h4>(2)\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/h4>\n<p>\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u300c\u52a0\u71b1\u304c\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u6d3b\u6027\u5316\u72b6\u614b\u3078\u30b7\u30d5\u30c8\u3055\u305b\u308b\u300d\u3053\u3068\u304c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u306e\u672c\u8cea\u3067\u3042\u308b\u3068\u63d0\u6848\u3057\u3066\u304d\u305f\u3082\u306e\u306e\u3001\u591a\u7a2e\u591a\u69d8\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5171\u5b58\u3059\u308b\u7d30\u80de\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3053\u308c\u3092\u5b9f\u8a3c\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002\u4eca\u56de\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u52a0\u71b1\u7b4b\u53ce\u7e2e\u3092\uff14\u7a2e\u985e\u306e\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u307f\u3067\u518d\u73fe\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u3060\u3051\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u4f53\u6e29\u304c\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u90e8\u5206\u7684\u306b\u6d3b\u6027\u5316\u3059\u308b\u52b9\u679c\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<h4>(3)\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u3067\u30ac\u30e9\u30b9\u57fa\u677f\u4e0a\u306b\u7b4b\u53ce\u7e2e\u3092\u518d\u73fe\u3067\u304d\u308b\u300c<em>in vitro<\/em> \u6ed1\u308a\u904b\u52d5\u7cfb\u300d\u3092\u5229\u7528\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u4eca\u56de\u3001\u30a6\u30b5\u30ae\u9aa8\u683c\u7b4b\u30a2\u30af\u30c1\u30f3\u3001\u30d2\u30c8\u03b1\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\u3001\u30a6\u30b7\u5fc3\u7b4b\u30c8\u30ed\u30dd\u30cb\u30f3\u3067\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u518d\u69cb\u6210\u3057\u3001\u30a6\u30b5\u30ae\u9aa8\u683c\u7b4b\u307e\u305f\u306f\u30d6\u30bf\u5fc3\u7b4b\u7531\u6765\u306e\u30df\u30aa\u30b7\u30f3\u5206\u5b50\u3092\u63a5\u7740\u3055\u305b\u305f\u30ac\u30e9\u30b9\u57fa\u677f\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u518d\u69cb\u6210\u3057\u305f\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306f\u76f4\u5f84\u304c10\u30ca\u30ce\u30e1\u30fc\u30eb\u7a0b\u5ea6\u306e\u305f\u3081\u3001\u305d\u306e\u307e\u307e\u3067\u306f\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\uff081\u30ca\u30ce\u30e1\u30fc\u30c8\u30eb\u306f1\u30df\u30ea\u30e1\u30fc\u30c8\u30eb\u306e\u767e\u4e07\u5206\u306e\u4e00\uff09\u3002\u305d\u3053\u3067\u86cd\u5149\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3067\u304d\u308b\u3088\u3046\u306b\u3001\u86cd\u5149\u8272\u7d20\u3067\u6a19\u8b58\u3057\u3066\u3042\u308a\u307e\u3059\u3002\u4e00\u672c\u4e00\u672c\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u52d5\u304d\uff08\u6ed1\u308a\u904b\u52d5\uff09\u3092\u86cd\u5149\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3057\u3066\u3001\u79fb\u52d5\u901f\u5ea6\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u3053\u3053\u306b\u3001\u6c34\u306b\u5438\u53ce\u3055\u308c\u308b\u6ce2\u9577\u5e2f\u306e\u8d64\u5916\u30ec\u30fc\u30b6\u30fc\u5149\u3092\u5bfe\u7269\u30ec\u30f3\u30ba\u3067\u96c6\u5149\u3059\u308b\u3053\u3068\u3067\u3001\u6c34\u4e2d\u306b\u5fae\u5c0f\u306a\u71b1\u6e90\u3092\u751f\u307f\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3001\u5149\u71b1\u5909\u63db\u9855\u5fae\u93e1\uff08Oyama et al., Lab Chip 2012\uff1b<a href=\"https:\/\/www.waseda.jp\/top\/news\/6275\">\u904e\u53bb\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u7d30\u80de\u5185\u3092\u6b69\u304f\u30ca\u30ce\u6e29\u5ea6\u8a08\u3092\u958b\u767a\u3000\u30df\u30af\u30ed\u30f3\u30b5\u30a4\u30ba\u306e\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u5185\u90e8\u306e\u6e29\u5ea6\u5909\u5316\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u6e2c\u5b9a\u300d<\/a>\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u3046\u3057\u3066\u3001\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u3066\u7b4b\u53ce\u7e2e\u6a5f\u80fd\u306e\u6e29\u5ea6\u7279\u6027\u3092\u8a55\u4fa1\u3067\u304d\u308b\u9855\u5fae\u89e3\u6790\u6cd5\u3092\u65b0\u305f\u306b\u69cb\u7bc9\u3057\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u3053\u306e\u5c40\u6240\u5149\u52a0\u71b1\u6cd5\u306e\u7279\u5fb4\u306f\u3001\u30ec\u30fc\u30b6\u30fc\u96c6\u5149\u70b9\u3092\u4e2d\u5fc3\u306b100\u30de\u30a4\u30af\u30ed\u30e1\u30fc\u30c8\u30eb\u7a0b\u5ea6\u306e\u7bc4\u56f2\u3078\u3001\u6700\u9ad8\u7d0420\u2103\u306e\u540c\u5fc3\u5186\u72b6\u306e\u6e29\u5ea6\u52fe\u914d\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306b\u3088\u3063\u3066\u3001\u5149\u5b66\u9855\u5fae\u93e1\u306e\u540c\u4e00\u8996\u91ce\u5185\u3067\u3001\u69d8\u3005\u306a\u6e29\u5ea6\u306e\u3082\u3068\u3067\u52d5\u304d\u56de\u308b\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u4e00\u5ea6\u306b\u89b3\u5bdf\u3067\u304d\u307e\u3059\u3002\u3082\u3046\u4e00\u3064\u306e\u7279\u5fb4\u306f\u3001\u52a0\u71b1\u7528\u30ec\u30fc\u30b6\u30fc\u5149\u7167\u5c04\u4e2d\u306e\u5c40\u6240\u7684\u306a\u6e29\u5ea6\u52fe\u914d\u306e\u5f62\u6210\u3068\u3001\u7167\u5c04\u7d42\u4e86\u5f8c\u306b\u6e29\u5ea6\u52fe\u914d\u304c\u6d88\u5931\u3059\u308b\u904e\u7a0b\u304c\u7d041\u79d2\u3067\u5b8c\u4e86\u3059\u308b\u70b9\u3067\u3059\u3002\u52a0\u71b1\u7528\u30ec\u30fc\u30b6\u30fc\u5149\u306e\u7167\u5c04\u3092\u7d20\u65e9\u304f\u5207\u308a\u66ff\u3048\u308b\u3053\u3068\u3067\u3001\u540c\u3058\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306b\u7740\u76ee\u3057\u305f\u307e\u307e\u3001\u6e29\u5ea6\u7279\u6027\u3092\u9023\u7d9a\u7684\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_64617\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-64617 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/04\/1d79c337dad85aa7501c486f90676eee-610x213.png\" alt=\"\" width=\"610\" height=\"213\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/04\/1d79c337dad85aa7501c486f90676eee-610x213.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/04\/1d79c337dad85aa7501c486f90676eee-768x268.png 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/04\/1d79c337dad85aa7501c486f90676eee.png 773w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><p 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id=\"attachment_64618\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-64618 size-medium\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/04\/7b718104927add4d548440243103accc-610x229.png\" alt=\"\" width=\"610\" height=\"229\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/04\/7b718104927add4d548440243103accc-610x229.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2019\/04\/7b718104927add4d548440243103accc.png 750w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><p 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vitro \u6ed1\u308a\u904b\u52d5\u7cfb<\/p>\n<p>\u5236\u5fa1\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u542b\u3081\u3066\u3001\u30a2\u30af\u30c8\u30df\u30aa\u30b7\u30f3\u306e\u904b\u52d5\u30fb\u5236\u5fa1\u7279\u6027\u3092\u8abf\u3079\u308b\u305f\u3081\u306e\u624b\u6bb5\u3068\u3057\u3066\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u5b9f\u9a13\u7cfb\u3067\u3059\u3002\u30ac\u30e9\u30b9\u57fa\u677f\u4e0a\u3067\u30a2\u30af\u30c8\u30df\u30aa\u30b7\u30f3\u53ce\u7e2e\u30b7\u30b9\u30c6\u30e0\u3092\u518d\u69cb\u6210\u3057\u3001\u5149\u5b66\u9855\u5fae\u93e1\u3092\u7528\u3044\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u4e00\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u6ed1\u308a\u904b\u52d5\u306e\u69d8\u5b50\u3092\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u6700\u3082\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u6ed1\u308a\u904b\u52d5\u306e\u901f\u3055\u304b\u3089\u5404\u6761\u4ef6\u306b\u304a\u3051\u308b\u30a2\u30af\u30c8\u30df\u30aa\u30b7\u30f3\u306e\u6d3b\u6027\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3059\u3002\u307e\u305f\u3001\u4ed6\u306e\u6280\u8853\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u672c\u7814\u7a76\u3067\u306f\u8d64\u5916\uff08IR\uff09\u30ec\u30fc\u30b6\u30fc\u3092\u5229\u7528\u3059\u308b\u5c40\u6240\u71b1\u30d1\u30eb\u30b9\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u307e\u3057\u305f\u3002<\/p>\n<h4>(8)\u8ad6\u6587\u60c5\u5831<\/h4>\n<p>\u96d1\u8a8c\u540d\uff1aJournal of General Physiology<br \/>\n\u8ad6\u6587\u540d\uff1a<a href=\"http:\/\/jgp.rupress.org\/content\/early\/2019\/04\/19\/jgp.201812243\">Microscopic heat pulses activate cardiac thin filaments<\/a><br \/>\n\u57f7\u7b46\u8005\u540d\uff1aShuya Ishii (\u77f3\u4e95\u79c0\u5f25) *1, Kotaro Oyama (\u5927\u5c71\u5ee3\u592a\u90ce) *1, *2, *3, *4, Tomomi Arai (\u65b0\u4e95\u667a\u5b9f) *1, *2, Hideki Itoh (\u4f0a\u85e4\u79c0\u57ce) *1, *5, Seine A. Shintani (\u65b0\u8c37\u6b63\u5dba) *6, Madoka Suzuki (\u9234\u6728\u56e3) *4,7, Fuyu Kobirumaki -Shimozawa (\u5c0f\u6bd4\u985e\u5dfb\u751f) *2, Takako Terui (\u7167\u4e95\u8cb4\u5b50) *2; Norio Fukuda (\u798f\u7530\u7d00\u7537) *2, Shin&#8217;ichi Ishiwata (\u77f3\u6e21\u4fe1\u4e00) *1<br \/>\n\u8457\u8005\u6240\u5c5e\uff08\u7814\u7a76\u5f53\u6642\uff09\uff1a*1:\u65e9\u7a32\u7530\u5927\u5b66\u3001*2:\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u3001*3:\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u91cf\u5b50\u79d1\u5b66\u6280\u8853\u7814\u7a76\u958b\u767a\u6a5f\u69cb\u3001*4:JST\u3055\u304d\u304c\u3051\u3001*5:\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u79d1\u5b66\u6280\u8853\u7814\u7a76\u5e81(A*STAR)\u3001*6:\u4e2d\u90e8\u5927\u5b66\u3001*7:\u5927\u962a\u5927\u5b66<\/p>\n<p><a href=\"http:\/\/jgp.rupress.org\/content\/early\/2019\/04\/19\/jgp.201812243\"><span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"><span class=\"metadata-label\">DOI:<\/span> 10.1085\/jgp.201812243<\/span><\/a><\/p>\n<p>\u6ce8\uff1a3\u670828-31\u65e5\u306b\u795e\u6238\u56fd\u969b\u4f1a\u8b70\u5834\u3067\u958b\u50ac\u3055\u308c\u305f\u7b2c9\u56deFAOPS\u4f1a\u8b70\uff08\u30a2\u30b8\u30a2\u30fb\u30aa\u30bb\u30a2\u30cb\u30a2\u751f\u7406\u5b66\u4f1a\u9023\u5408\u5927\u4f1a\uff09\u3067\u3001\u77f3\u4e95\u79c0\u5f25\u304cJGP\u30dd\u30b9\u30bf\u30fc\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\u3002<br \/>\nJournal of General Physiology\u306eSNS\u30a2\u30ab\u30a6\u30f3\u30c8\u3067\u3082\u5199\u771f\u4ed8\u304d\u3067\u5831\u3058\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\nJGP Twitter\u30a2\u30ab\u30a6\u30f3\u30c8: <a href=\"https:\/\/twitter.com\/jgenphysiol\">https:\/\/twitter.com\/jgenphysiol<\/a><br \/>\nJGP Facebook\u30a2\u30ab\u30a6\u30f3\u30c8: <a href=\"https:\/\/www.facebook.com\/JGenPhysiol\/\">https:\/\/www.facebook.com\/JGenPhysiol\/<\/a><\/p>\n<h4>(9)\u5f15\u7528\u6587\u732e<\/h4>\n<ul>\n<li>Marino, A.*, Arai, S., Hou, Y., Degl\u2019Innocenti, A., Cappello, V., Mazzolai, B., Chang, Y.T., Mattoli, V., Suzuki, M.*, and Ciofani, G.* (*Corresponding authors), ACS Nano, 11(3), 2494\u20132508 (2017), <em>Gold Nanoshell-Mediated Remote Myotube Activation<\/em>.<\/li>\n<li>Oyama, K., Mizuno, A., Shintani, S.A., Itoh, H., Serizawa, T., Fukuda, N., Suzuki, M.* and Ishiwata, S.* (*Corresponding authors), Biochem. Biophys. Res. Commun., 417, 607-612 (2012), <em>Microscopic heat pulses induce contraction of cardiomyocytes without calcium transients.<\/em><\/li>\n<li>Oyama K, Takabayashi M, Takei Y, Arai S, Takeoka S, Ishiwata S.* Suzuki M.* (*Corresponding authors), Lab Chip. 12(9):1591-1593 (2012), <em>Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells.<\/em><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5149\u71b1\u5909\u63db\u9855\u5fae\u93e1\u6cd5\u3092\u7528\u3044\u3066\u7b4b\u53ce\u7e2e\u6a5f\u80fd\u306e\u6e29\u5ea6\u7279\u6027\u3092\u8a55\u4fa1\u3059\u308b\u9855\u5fae\u89e3\u6790\u6cd5\u3092\u69cb\u7bc9 \u7b4b\u8089\u304c\u6e29\u307e\u308b\u3068\u53ce\u7e2e\u3059\u308b\u300c\u52a0\u71b1\u7b4b\u53ce\u7e2e\u300d\u3092\uff14\u7a2e\u985e\u306e\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u307f\u3067\u518d\u73fe\u3059\u308b\u3053\u3068\u306b\u6210\u529f \u5fc3\u81d3\u304c\u4f53\u6e29\u306b\u304a\u3044\u3066\u52b9\u7387\u7684\u306b\u62cd\u52d5 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":64667,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,5],"class_list":["post-64616","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/64616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=64616"}],"version-history":[{"count":0,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/64616\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/64667"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=64616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=64616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=64616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}