{"id":61349,"date":"2018-09-28T16:00:34","date_gmt":"2018-09-28T07:00:34","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=61349"},"modified":"2018-09-28T17:06:47","modified_gmt":"2018-09-28T08:06:47","slug":"%e7%a5%9e%e7%b5%8c%e5%b9%b9%e7%b4%b0%e8%83%9e%e3%81%ae%e5%a2%97%e6%ae%96%e3%81%ab%e5%83%8d%e3%81%8f%e9%81%ba%e4%bc%9d%e5%ad%90%e3%82%92%e7%99%ba%e8%a6%8b-%e3%80%80%e7%b4%b0%e8%83%9e%e5%86%85%e5%93%81","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/61349","title":{"rendered":"\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u306b\u50cd\u304f\u907a\u4f1d\u5b50\u3092\u767a\u898b \u3000\u7d30\u80de\u5185\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306e\u65b0\u305f\u306a\u5f79\u5272"},"content":{"rendered":"<h3>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul style=\"list-style-type: 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Rer1\u3092\u30de\u30a6\u30b9\u306e\u8133\u5f62\u6210\u6642\u306b\u6b20\u640d\u3055\u305b\u308b\u3068\u3001\u8133\u5185\u306e\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u306b\u3088\u308aNotch\u30b7\u30b0\u30ca\u30eb\u304c\u4f4e\u4e0b\u3057\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u30de\u30a6\u30b9\u306f\u3001\u8133\u306e\u5f62\u6210\u7570\u5e38\u3084\u69d8\u3005\u306a\u884c\u52d5\u7570\u5e38\u3092\u793a\u3059\u3053\u3068\u304b\u3089\u3001Rer1\u306b\u3088\u308b\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u306e\u54c1\u8cea\u7ba1\u7406\u304c\u3001\u6b63\u5e38\u306a\u8133\u306e\u767a\u9054\u3084\u9ad8\u6b21\u8133\u6a5f\u80fd\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u539f\u56e0\u306e\uff11\u3064\u3067\u3042\u308b\u03b2\u30a2\u30df\u30ed\u30a4\u30c9\u306e\u7523\u751f\u306b\u50cd\u304f\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u500b\u4f53\u767a\u751f\u3084\u5e79\u7d30\u80de\u7dad\u6301\u306b\u6a5f\u80fd\u3059\u308bNotch\u30b7\u30b0\u30ca\u30eb\u306e\u7570\u5e38\u306f\u3001\u795e\u7d4c\u75be\u60a3\u3084\u30ac\u30f3\u3092\u542b\u3081\u305f\u69d8\u3005\u306a\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u4eca\u56de\u306e\u6210\u679c\u306f\u3001\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u3084\u5e79\u7d30\u80de\u306e\u95a2\u4fc2\u3059\u308b\u75be\u60a3\u306e\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e\u3084\u6cbb\u7642\u6cd5\u958b\u767a\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u30012018\u5e749\u670827\u65e5\uff08\u6728\uff09\u5348\u5f8c14\u6642\uff08\u7c73\u56fd\u6642\u9593\uff09\u306b\u7c73\u56fd\u79d1\u5b66\u8a8c\u300c<a href=\"https:\/\/journals.plos.org\/plosgenetics\/\" target=\"_blank\" rel=\"noopener\"><span lang=\"EN-US\">PLOS Genetics<\/span><\/a>\u300dRer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development\uff08PLoS Genet 14(9): e1007647. DOI:10.1371\/journal.pgen.1007647\uff09\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>(1) 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id=\"attachment_61350\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-61350\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/795316b92fc766b0181f6fef074f03fa-1.jpg\" alt=\"\" width=\"1196\" height=\"624\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/795316b92fc766b0181f6fef074f03fa-1.jpg 1196w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/795316b92fc766b0181f6fef074f03fa-1-610x318.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/795316b92fc766b0181f6fef074f03fa-1-768x401.jpg 768w\" sizes=\"auto, (max-width: 1196px) 100vw, 1196px\" \/><p class=\"wp-caption-text\">\u56f31\uff1a\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb<\/p><\/div>\n<h3>(2) 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\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/h3>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u52d5\u7269\u500b\u4f53\u306b\u304a\u3051\u308bRer1\u306e\u751f\u7406\u7684\u91cd\u8981\u6027\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u306b\u3001\u5168\u8eab\u6027\u306bRer\uff11\u3092\u6b20\u640d\u3059\u308b\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30de\u30a6\u30b9\u306f\u7740\u5e8a\u76f4\u5f8c\u306b\u81f4\u6b7b\u3068\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u795e\u7d4c\u767a\u751f\u3084\u51fa\u751f\u5f8c\u306eRer1\u306e\u8133\u6a5f\u80fd\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u3001\u5927\u8133\u8208\u596e\u6027\u7d30\u80de\u3067\u7279\u7570\u7684\u306bRer1\u306e\u6a5f\u80fd\u3092\u306f\u305f\u3089\u304b\u306a\u304f\u3055\u305b\u308b\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f \u3002<\/p>\n<h3>(4) \u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/h3>\n<p>Rer1\u306b\u3088\u308b\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306e\u54fa\u4e73\u52d5\u7269\u500b\u4f53\u306b\u304a\u3051\u308b\u751f\u7406\u7684\u5f79\u5272\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u5168\u8eab\u6027\u306bRer1\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30de\u30a6\u30b9\u306f\u7740\u5e8a\u76f4\u5f8c\u306b\u81f4\u6b7b\u3068\u306a\u308b\u3053\u3068\u304b\u3089\u3001Rer1\u304c\u500b\u4f53\u767a\u751f\u306b\u304a\u3044\u3066\u5fc5\u9808\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u3053\u3067\u3001\u5927\u8133\u8208\u596e\u6027\u795e\u7d4c\u7d30\u80de\u7279\u7570\u7684\u306bRer1\u306e\u6a5f\u80fd\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u3001\u5927\u8133\u5f62\u6210\u3084\u6a5f\u80fd\u7dad\u6301\u306b\u304a\u3051\u308bRer1\u306e\u5f79\u5272\u3092\u8abf\u3079\u307e\u3057\u305f\u3002Rer1\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u6210\u4f53\u306b\u304a\u3044\u3066\u8133\u306e\u5f62\u6210\u7570\u5e38\u3068\u69d8\u3005\u306a\u884c\u52d5\u7570\u5e38\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08\u56f3\uff12 \uff09\u3002\u307e\u305f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u8131\u843d\u3068\u30b0\u30ea\u30aa\u30fc\u30b7\u30b9\uff08\u795e\u7d4c\u8131\u843d\u306b\u3088\u308b\u8133\u708e\u75c7\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\uff09\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_61352\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-61352\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/2b530e80c7d0de90885e285c5d798063-1.jpg\" alt=\"\" width=\"1165\" height=\"544\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/2b530e80c7d0de90885e285c5d798063-1.jpg 1165w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/2b530e80c7d0de90885e285c5d798063-1-610x285.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/2b530e80c7d0de90885e285c5d798063-1-768x359.jpg 768w\" sizes=\"auto, (max-width: 1165px) 100vw, 1165px\" \/><p class=\"wp-caption-text\">\u56f3\uff12\uff1a\u5927\u8133\u7279\u7570\u7684Rer1\u6b20\u640d\u30de\u30a6\u30b9\uff08\u5f15\u7528\uff1aHara T <i>et al<\/i>., Plos Genetics. ,2018, 14(9), e1007647, DOI: 10.1371\/journal.pgen.1007647\uff09<\/p><\/div>\n<p>\u6b21\u306bRer1\u6b20\u640d\u306e\u8133\u5f62\u6210\u7570\u5e38\u306e\u539f\u56e0\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u795e\u7d4c\u767a\u751f\u306b\u304a\u3051\u308bRer1\u306e\u5f79\u5272\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001Rer1\u6b20\u640d\u5927\u8133\u3067\u306f\u3001\u8133\u5f62\u6210\u306e\u5f8c\u671f\u306b\u7523\u751f\u3055\u308c\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u8457\u3057\u304f\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u795e\u7d4c\u7d30\u80de\u306e\u5206\u5316\u306f\u6b63\u5e38\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u7570\u5e38\u306b\u3088\u308a\u8133\u5f62\u6210\u306b\u5fc5\u8981\u306a\u795e\u7d4c\u7d30\u80de\u304c\u7523\u751f\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u7591\u308f\u308c\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001Rer1\u6b20\u640d\u5927\u8133\u306e\u8133\u5207\u7247\u3092\u69d8\u3005\u306a\u795e\u7d4c\u5e79\u7d30\u80de\u30de\u30fc\u30ab\u30fc\u3067\u67d3\u8272\u3057\u305f\u7d50\u679c\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5206\u88c2\u3059\u308b\u9818\u57df\u306b\u304a\u3044\u3066\u8457\u3057\u304f\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001Rer1\u3092\u6b20\u5931\u3055\u305b\u305f\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u57f9\u990a\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3082\u3001Rer1\u306e\u6b20\u640d\u304c\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3092\u8457\u3057\u304f\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f<sup>\uff08\u56f3\uff13\uff09<\/sup>\u3002<\/p>\n<div id=\"attachment_61353\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-61353\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/c8856789ec11ab8b1013037cef6929f9-1.jpg\" alt=\"\" width=\"1176\" height=\"926\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/c8856789ec11ab8b1013037cef6929f9-1.jpg 1176w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/c8856789ec11ab8b1013037cef6929f9-1-610x480.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/c8856789ec11ab8b1013037cef6929f9-1-768x605.jpg 768w\" sizes=\"auto, (max-width: 1176px) 100vw, 1176px\" \/><p class=\"wp-caption-text\">\u56f3\uff13\uff1a\u5927\u8133\u5f62\u6210\u306b\u304a\u3051\u308bRer1\u306e\u5f79\u5272<\/p><\/div>\n<p>\u3055\u3089\u306b\u3001Rer1\u3092\u6b20\u640d\u3057\u305f\u5927\u8133\u3067\u306f\u3001\u8133\u5185\u306e\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u306e\u91cf\u3068\u6d3b\u6027\u304c\u6e1b\u5c11\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u7d50\u679c\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u672a\u5206\u5316\u6027\u3092\u5236\u5fa1\u3059\u308bNotch\u30b7\u30b0\u30ca\u30eb\u304c\u4f4e\u4e0b\u3057\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u30fb\u7dad\u6301\u306b\u7570\u5e38\u3092\u751f\u3058\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001Rer1\u6b20\u640d\u7d30\u80de\u3092\u7528\u3044\u305f\u89e3\u6790\u304b\u3089\u3001Rer1\u907a\u4f1d\u5b50\u3092\u6b20\u640d\u3059\u308b\u3068\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u306e\u4e00\u90e8\u304c\u7d44\u307f\u7acb\u3066\u5b8c\u4e86\u524d\u306b\u5c0f\u80de\u4f53\u4ee5\u964d\u306b\u642c\u51fa\u3055\u308c\u3066\u3057\u307e\u3044\u3001\u30ea\u30bd\u30bd\u30fc\u30e0\u3078\u904b\u3070\u308c\u5206\u89e3\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f<sup>\uff08\u56f3\uff14\uff09<\/sup>\u3002<\/p>\n<div id=\"attachment_61354\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-61354\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/3a4f695a458cb0ac0aceaa2eb13ac2dd-1.jpg\" alt=\"\" width=\"1311\" height=\"748\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/3a4f695a458cb0ac0aceaa2eb13ac2dd-1.jpg 1311w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/3a4f695a458cb0ac0aceaa2eb13ac2dd-1-610x348.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/3a4f695a458cb0ac0aceaa2eb13ac2dd-1-768x438.jpg 768w\" sizes=\"auto, (max-width: 1311px) 100vw, 1311px\" \/><p class=\"wp-caption-text\">\u56f3\uff14\uff1aRer1\u6b20\u640d\u7d30\u80de\u3067\u306f\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u91cf\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b<\/p><\/div>\n<p>\u4ee5\u4e0a\u306e\u7d50\u679c\u3088\u308a\u3001\u5927\u8133\u306b\u304a\u3044\u3066Rer1\u306e\u6a5f\u80fd\u3092\u6b20\u640d\u3055\u305b\u308b\u3068\u3001\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u306e\u7d30\u80de\u819c\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u30fb\u7dad\u6301\u306b\u95a2\u308f\u308bNotch\u30b7\u30b0\u30ca\u30eb\u306e\u4e0d\u5168\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u5927\u8133\u5f62\u6210\u7570\u5e38\u3084\u884c\u52d5\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>(5) \u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/h3>\n<p>\u5f27\u767a\u6027\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u91cd\u5ea6\u306e\u7cbe\u795e\u767a\u9054\u9045\u5ef6\u306e\u75c7\u72b6\u3092\u6765\u30591p36\u75c7\u5019\u7fa4\u306b\u304a\u3044\u3066\u3001Rer1\u306e\u767a\u73fe\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u500b\u4f53\u767a\u751f\u3084\u5e79\u7d30\u80de\u7dad\u6301\u306b\u6a5f\u80fd\u3059\u308bNotch\u30b7\u30b0\u30ca\u30eb\u306e\u7570\u5e38\u306f\u3001\u795e\u7d4c\u75be\u60a3\u3084\u30ac\u30f3\u3092\u542b\u3081\u305f\u69d8\u3005\u306a\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u6210\u679c\u306f\u3001\u96e3\u75c5\u306e\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e\u3084\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<h3>(6) \u4eca\u5f8c\u306e\u8ab2\u984c<\/h3>\n<p>\u4eca\u56de\u3001\u5927\u8133\u5f62\u6210\u306b\u304a\u3051\u308bRer1\u306e\u5f79\u5272\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u4ed6\u306e\u7d44\u7e54\u306b\u304a\u3051\u308b\u5f79\u5272\u3084Rer1\u306e\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u75be\u60a3\u3068\u306e\u95a2\u9023\u306b\u95a2\u3057\u3066\u306f\u4e0d\u660e\u306a\u70b9\u3092\u591a\u304f\u6b8b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8b0e\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u306e\u91cd\u8981\u306a\u8ab2\u984c\u3068\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\u7528\u8a9e\u89e3\u8aac<\/h4>\n<ul>\n<li>\uff08\u6ce8\uff11\uff09\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc<br \/>\nPresenilin1, Nicastrin, APH-1, Pen2\u306e\u69cb\u6210\u56e0\u5b50\u304b\u3089\u306a\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7d30\u80de\u819c\u306e\u4e2d\u3067\u5207\u65ad\u3059\u308b\u9175\u7d20\u3002<\/li>\n<li>\uff08\u6ce8\uff12\uff09<br \/>\nNotch\u30b7\u30b0\u30ca\u30eb\uff1a\u767a\u751f\u904e\u7a0b\u3084\u6210\u4f53\u306e\u7d44\u7e54\u5e79\u7d30\u80de\u306e\u7d30\u80de\u5897\u6b96\u3084\u5206\u5316\u306b\u6a5f\u80fd\u3057\u3001\u7d44\u7e54\u69cb\u7bc9\u3084\u6052\u5e38\u6027\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8ceaNotch\u304c\u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u306b\u3088\u308a\u7d30\u80de\u819c\u4e0a\u3067\u5207\u308a\u51fa\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u4e0b\u6d41\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<li>\uff08\u6ce8\uff13\uff09Rer1<br \/>\n\u9175\u6bcd\u304b\u3089\u30d2\u30c8\u306b\u307e\u3067\u9ad8\u5ea6\u306b\u4fdd\u5b58\u3055\u308c\u305f\u30b4\u30eb\u30b8\u4f53\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3002\u54fa\u4e73\u985e\u306b\u304a\u3044\u3066\u306f\u3001\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3066\u3044\u306a\u3044\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u819c\u8cab\u901a\u9818\u57df\u306b\u5909\u7570\u3092\u3082\u3064\u75be\u60a3\u95a2\u9023\u7570\u5e38\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c0f\u80de\u4f53\u5c40\u5728\u5316\u306b\u306f\u305f\u3089\u304f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<li>\uff08\u6ce8\uff14\uff09\u30ea\u30bd\u30bd\u30fc\u30e0<br \/>\n\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u306e\u4e00\u3064\u3002\u30ea\u30bd\u30bd\u30fc\u30e0\u5185\u306b\u306f\u5404\u7a2e\u52a0\u6c34\u5206\u89e3\u9175\u7d20\u304c\u5b58\u5728\u3057\u57fa\u8cea\u3092\u6d88\u5316\u3059\u308b\u3002<\/li>\n<\/ul>\n<h4>\u8ad6\u6587\u60c5\u5831<\/h4>\n<ul>\n<li>\u30bf\u30a4\u30c8\u30eb\uff1aRer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development<\/li>\n<li>\u96d1\u8a8c\uff1a<a href=\"https:\/\/journals.plos.org\/plosgenetics\/\" target=\"_blank\" rel=\"noopener\"><span lang=\"EN-US\">PLOS Genetics<\/span><\/a>. 14(9): e1007647, DOI: 10.1371\/journal.pgen.1007647<\/li>\n<li>\u8457\u8005\u540d\uff1aTaichi Hara1, 2, Ikuko Maejima1, Tomoko Akuzawa1, Rika Hirai1, Hisae Kobayashi1, Satoshi Tsukamoto3, Mika Tsunoda1, Aguri Ono2, Shota Yamakoshi2, Satoshi Oikawa2 and Ken Sato1<\/li>\n<li>\u8ad6\u6587\u8457\u8005\uff1a\u539f\u592a\u4e00\uff081\uff0c2\uff09\uff0c\u524d\u5cf6\u90c1\u5b50\uff081\uff09\u3001\u963f\u4e45\u6fa4\u5171\u5b50\uff081\uff09\u3001\u5e73\u4e95\u91cc\u9999\uff081\uff09\u3001\u5c0f\u6797\u4e45\u6c5f\uff081\uff09\u3001\u585a\u672c\u667a\u53f2\uff083\uff09\u3001\u89d2\u7530\u7f8e\u9999\uff081\uff09\u3001\u5927\u91ce\u3042\u3050\u308a\uff082\uff09\u3001\u5c71\u8d8a\u6b63\u6c70\uff082\uff09\u3001\u53ca\u5ddd\u54f2\u5fd7\uff082\uff09\u3001\u4f50\u85e4\u5065\uff081\uff09<\/li>\n<li>\u6240\u5c5e<\/li>\n<li>1) \u7fa4\u99ac\u5927\u5b66 \u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u3000\u7d30\u80de\u69cb\u9020\u5206\u91ce<br \/>\n2) \u65e9\u7a32\u7530\u5927\u5b66\u3000\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662\u3000\u5065\u5eb7\u798f\u7949\u79d1\u5b66\u79d1<br \/>\n3) \u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u91cf\u5b50\u79d1\u5b66\u6280\u8853\u7814\u7a76\u958b\u767a\u6a5f\u69cb \u91cf\u5b50\u79d1\u5b66\u6280\u8853\u7814\u7a76\u958b\u767a\u6a5f\u69cb\u653e\u5c04\u7dda\u533b\u5b66\u7dcf\u5408\u7814\u7a76\u6240 \u6280\u8853\u5b89\u5168\u90e8<\/li>\n<\/ul>\n<h4>\u7814\u7a76\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b\u5148<\/h4>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662\u5065\u5eb7\u798f\u7949\u79d1\u5b66\u79d1<br \/>\n\u6559\u6388\uff1a\u539f\u592a\u4e00\uff08\u306f\u3089\u305f\u3044\u3061\uff09<br \/>\nTel\uff1a04-2947-6763\u3000Fax\uff1a04-2947-6816 \u3000E-mail\uff1aharata1@waseda.jp<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u5927\u8133\u5f62\u6210\u306b\u304a\u3051\u308b\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306e\u5f79\u5272\u306f\u4e0d\u660e\u3060\u3063\u305f \u03b3-\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u91cf\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3084\u7dad\u6301\u306b\u306f\u305f\u3089\u304f\u3053\u3068\u3092\u767a\u898b \u767a\u751f\u3084\u5e79\u7d30\u80de\u7dad\u6301\u306b\u95a2\u4fc2\u3059\u308b\u75be\u60a3\u306e\u767a\u75c7\u6a5f\u69cb\u3084\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u306b\u671f\u5f85 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":61381,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[5],"class_list":["post-61349","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/61349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=61349"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/61349\/revisions"}],"predecessor-version":[{"id":61382,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/61349\/revisions\/61382"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/61381"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=61349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=61349"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=61349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}