{"id":57153,"date":"2018-02-09T15:04:15","date_gmt":"2018-02-09T06:04:15","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=57153"},"modified":"2018-02-09T15:04:15","modified_gmt":"2018-02-09T06:04:15","slug":"%e3%82%bc%e3%83%96%e3%83%a9%e3%83%95%e3%82%a3%e3%83%83%e3%82%b7%e3%83%a5%e3%82%92%e7%94%a8%e3%81%84%e3%81%9f%e8%84%b3%e6%90%8d%e5%82%b7%e3%83%a2%e3%83%87%e3%83%ab%e3%81%ab%e3%82%88%e3%82%8a%e7%a5%9e","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/57153","title":{"rendered":"\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3092\u7528\u3044\u305f\u8133\u640d\u50b7\u30e2\u30c7\u30eb\u306b\u3088\u308a\u795e\u7d4c\u5e79\u7d30\u80de\u306b\u3088\u308b\u7d44\u7e54\u518d\u751f\u6a5f\u69cb\u306e\u4e00\u7aef\u3092\u89e3\u660e"},"content":{"rendered":"<h3><strong>\u4e8b\u6545\u3084\u75c5\u6c17\u306b\u3088\u308b\u4e2d\u67a2\u795e\u7d4c\u7cfb\u640d\u50b7\u304b\u3089\u306e\u7d44\u7e54\u518d\u751f\u3092\u4fc3\u3059\u4ed5\u7d44\u307f\u767a\u898b\u306b\u671f\u5f85<\/strong><\/h3>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e\u6e05\u6c34\u52c7\u6c17\uff08\u3057\u307f\u305a\u3086\u3046\u304d\uff09\u52a9\u624b\uff08\u540c\u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b3\u5e74\uff09\u3001\u4e0a\u7530\u60a0\u4eba\uff08\u3046\u3048\u3060\u3086\u3046\u3068\uff09\uff08\u540c\u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u4fee\u58eb\u8ab2\u7a0b2\u5e74\uff09\u304a\u3088\u3073\u3001<a 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href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.23311\/full\">\u7c73\u56fdWiley Group\u306e\u79d1\u5b66\u8a8c\u300eGLIA\u300f\u306b2018\u5e742\u67087\u65e5\u4ed8\u306b\u3066\u30aa\u30f3\u30e9\u30a4\u30f3\u7248<\/a>\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h5><strong>\u3010\u7814\u7a76\u5185\u5bb9\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b\u5148\u3011<\/strong><\/h5>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u3000<a href=\"http:\/\/www.ohshima.biomed.sci.waseda.ac.jp\/\">\u5927\u5cf6\u3000\u767b\u5fd7\u7537<\/a><br \/>\nTEL: 03-5369-7321\u3000E-mail: ohshima@waseda.jp<\/p>\n<h4><strong>(1)<\/strong><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/strong><\/h4>\n<p>\u5c0f\u578b\u9b5a\u985e\u306e\u30e2\u30c7\u30eb\u751f\u7269\u3067\u3042\u308b\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306f\u9ad8\u3044\u7d44\u7e54\u518d\u751f\u80fd\u529b\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u54fa\u4e73\u985e\u3067\u306f\u518d\u751f\u80fd\u529b\u304c\u4e4f\u3057\u3044\u4e2d\u67a2\u795e\u7d4c\u7cfb\u304c\u640d\u50b7\u3057\u3066\u3082\u3001\u7d44\u7e54\u3092\u5143\u901a\u308a\u306b\u518d\u751f\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\uff08\u53c2\u8003\u6587\u732e\uff11\uff09\u3002\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u304c\u6301\u3064\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3067\u306e\u9ad8\u3044\u518d\u751f\u80fd\u529b\u306f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u5897\u6b96\u3057\u3001\u65b0\u305f\u306a\u795e\u7d4c\u7d30\u80de\u3092\u4f5c\u308a\u51fa\u3059\u3053\u3068\u3067\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u306e\u3088\u3046\u306b\u3001\u54fa\u4e73\u985e\u3067\u306e\u7d44\u7e54\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3092\u7528\u3044\u305f\u3001\u518d\u751f\u6642\u306b\u304a\u3051\u308b\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u30fb\u5206\u5316\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u6a5f\u69cb\u304c\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306f\u30d2\u30c8\u3084\u30de\u30a6\u30b9\u306b\u5bfe\u3057\u3066\u907a\u4f1d\u5b50\u306e\u76f8\u540c\u6027\uff08\u985e\u4f3c\u6027\uff09\u304c\u9ad8\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u304a\u308a\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3067\u5f97\u3089\u308c\u305f\u6210\u679c\u3092\u30d2\u30c8\u3084\u30de\u30a6\u30b9\u306b\u5fdc\u7528\u3059\u308b\u3053\u3068\u304c\u5341\u5206\u306b\u53ef\u80fd\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>(2)<\/strong><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h4>\n<p>\u4eca\u56de\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u518d\u751f\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u8996\u84cb\u3068\u547c\u3070\u308c\u308b\u8996\u899a\u60c5\u5831\u3092\u51e6\u7406\u3059\u308b\u9818\u57df\u306b\u7740\u76ee\u3057\u3066\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u8996\u84cb\u306b\u306f\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u3068\u547c\u3070\u308c\u308b\u795e\u7d4c\u5e79\u7d30\u80de\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u901a\u5e38\u6642\u306f\u5897\u6b96\u30fb\u5206\u5316\u3092\u307b\u3068\u3093\u3069\u884c\u3063\u3066\u304a\u3089\u305a\u3001\u6210\u4f53\u8996\u84cb\u3067\u306e\u6a5f\u80fd\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u53c2\u8003\u6587\u732e\uff12\uff09\u3002\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u8996\u84cb\u640d\u50b7\u30e2\u30c7\u30eb\u3092\u4f5c\u88fd\u3057\u3001\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u304c\u3069\u306e\u3088\u3046\u306a\u5fdc\u7b54\u3092\u793a\u3059\u306e\u304b\u691c\u8a3c\u3059\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u3001\u8996\u84cb\u640d\u50b7\u306b\u3088\u308a\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u7d30\u80de\u5897\u6b96\u304c\u6d3b\u6027\u5316\u3057\u3001\u65b0\u305f\u306b\u795e\u7d4c\u7d30\u80de\u304c\u751f\u307f\u51fa\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u308c\u3089\u306e\u5fdc\u7b54\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306bWnt\u30b7\u30b0\u30ca\u30eb\uff08\u203b\u6ce8\uff13\uff09\u306e\u6d3b\u6027\u5316\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u3001\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3084\u85ac\u5264\u3092\u7528\u3044\u305f\u89e3\u6790\u306b\u3088\u308a\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>(3)<\/strong><strong>\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h4>\n<p>\u3053\u308c\u307e\u3067\u306b\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306e\u8996\u84cb\u3092\u7528\u3044\u305f\u640d\u50b7\u30e2\u30c7\u30eb\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u70ba\u3001\u65b0\u3057\u3044\u7a7f\u523a\u640d\u50b7\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u8996\u84cb\u640d\u50b7\u30e2\u30c7\u30eb\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002\u640d\u50b7\u306e\u6df1\u3055\u3084\u5834\u6240\u3092\u691c\u8a0e\u3057\u3001\u640d\u50b7\u5f8c\u306e\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u5fdc\u7b54\u304c\u518d\u73fe\u6027\u9ad8\u304f\u78ba\u8a8d\u3067\u304d\u308b\u640d\u50b7\u65b9\u6cd5\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>(4)<\/strong><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/strong><\/h4>\n<p>\u307e\u305a\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306e\u6210\u4f53\uff08\uff13\u30f6\u6708\u9f62\uff09\u306e\u8996\u84cb\u3067\u306f\u5927\u90e8\u5206\u306e\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306f\u5897\u6b96\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u5897\u6b96\u3057\u3066\u3044\u308b\u7d30\u80de\u6570\u306e\u30ab\u30a6\u30f3\u30c8\u306b\u3088\u308a\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u8996\u84cb\u640d\u50b7\u30e2\u30c7\u30eb\u3092\u4f5c\u88fd\u3057\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u7d30\u80de\u5897\u6b96\u3084\u795e\u7d4c\u7d30\u80de\u306e\u5206\u5316\u306a\u3069\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u7d30\u80de\u5897\u6b96\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u30de\u30fc\u30ab\u30fc\uff08BLBP\uff09\u3068\u5897\u6b96\u7d30\u80de\u306e\u30de\u30fc\u30ab\u30fc\uff08PCNA\uff09\u3092\u7528\u3044\u3066\u7d44\u7e54\u306e\u67d3\u8272\u3092\u884c\u3044\u3001\u4e8c\u91cd\u967d\u6027\u306e\u7d30\u80de\u3092\u5897\u6b96\u3057\u3066\u3044\u308b\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u3068\u3057\u3066\u30ab\u30a6\u30f3\u30c8\u3057\u307e\u3057\u305f\u3002\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306f\u640d\u50b7\u306b\u5fdc\u7b54\u3057\u3001\u640d\u50b7\u5f8c3\u65e5\u524d\u5f8c\u3092\u30d4\u30fc\u30af\u306b\u7d30\u80de\u5897\u6b96\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u640d\u50b77\u65e5\u5f8c\u306b\u306f\u975e\u640d\u50b7\u72b6\u614b\u3068\u540c\u3058\u7a0b\u5ea6\u306b\u623b\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f3\uff11\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-57146\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig1_eyecatch.jpg\" alt=\"\" width=\"1040\" height=\"780\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig1_eyecatch.jpg 1040w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig1_eyecatch-360x270.jpg 360w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig1_eyecatch-610x458.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig1_eyecatch-768x576.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig1_eyecatch-720x540.jpg 720w\" sizes=\"auto, (max-width: 1040px) 100vw, 1040px\" 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loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-57147\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig2_eyecatch.jpg\" alt=\"\" width=\"1040\" height=\"780\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig2_eyecatch.jpg 1040w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig2_eyecatch-360x270.jpg 360w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig2_eyecatch-610x458.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig2_eyecatch-768x576.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig2_eyecatch-720x540.jpg 720w\" sizes=\"auto, (max-width: 1040px) 100vw, 1040px\" \/><\/p>\n<p>\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u8996\u84cb\u306e\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306f\u640d\u50b7\u306b\u5fdc\u7b54\u3057\u3001\u5897\u6b96\u3092\u6d3b\u6027\u5316\u3055\u305b\u795e\u7d4c\u7d30\u80de\u3092\u751f\u307f\u51fa\u3059\u6a5f\u80fd\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306b\u3001\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u30fb\u5206\u5316\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066Wnt\u30b7\u30b0\u30ca\u30eb\u306b\u7740\u76ee\u3057\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002Wnt\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u3092\u53ef\u8996\u5316\u3059\u308b\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3092\u7528\u3044\u3066\u640d\u50b7\u5b9f\u9a13\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306b\u304a\u3044\u3066Wnt\u30b7\u30b0\u30ca\u30eb\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\uff08\u56f3\uff13\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-57149\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig3_eyecatch.jpg\" alt=\"\" width=\"1040\" height=\"780\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig3_eyecatch.jpg 1040w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig3_eyecatch-360x270.jpg 360w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig3_eyecatch-610x458.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig3_eyecatch-768x576.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig3_eyecatch-720x540.jpg 720w\" sizes=\"auto, (max-width: 1040px) 100vw, 1040px\" \/><\/p>\n<p>\u307e\u305f\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u3092\u5236\u5fa1\u3059\u308b\u85ac\u5264\u6295\u4e0e\u306e\u5b9f\u9a13\u3092\u884c\u3044\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u6291\u5236\u304c\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u30fb\u5206\u5316\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u307e\u305a\u3001\u5897\u6b96\u3078\u306e\u5f71\u97ff\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u640d\u50b7\u5f8c\uff12\u65e5\u9593\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u963b\u5bb3\u5264\u3092\u6295\u4e0e\u3057\u5897\u6b96\u3057\u3066\u3044\u308b\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u6570\u3092\u30ab\u30a6\u30f3\u30c8\u3057\u305f\u7d50\u679c\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u6291\u5236\u304c\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f3\uff14\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-57150\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig4_eyecatch.jpg\" alt=\"\" width=\"1040\" height=\"780\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig4_eyecatch.jpg 1040w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig4_eyecatch-360x270.jpg 360w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig4_eyecatch-610x458.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig4_eyecatch-768x576.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig4_eyecatch-720x540.jpg 720w\" sizes=\"auto, (max-width: 1040px) 100vw, 1040px\" \/><\/p>\n<p>\u6b21\u306b\u3001\u5206\u5316\u3078\u306e\u5f71\u97ff\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u640d\u50b7\u5f8c\uff12\u65e5\u9593\u3067\u5897\u6b96\u7d30\u80de\u3092\u6a19\u8b58\u3057\u305f\u306e\u3061Wnt\u30b7\u30b0\u30ca\u30eb\u963b\u5bb3\u5264\u3092\u6295\u4e0e\u3057\u65b0\u305f\u306b\u7523\u307f\u51fa\u3055\u308c\u305f\u795e\u7d4c\u7d30\u80de\u3092\u30ab\u30a6\u30f3\u30c8\u3057\u305f\u7d50\u679c\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u6291\u5236\u304c\u795e\u7d4c\u7d30\u80de\u306e\u7523\u751f\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f3\uff15\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-57151\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig5_eyecatch.jpg\" alt=\"\" width=\"1040\" height=\"780\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig5_eyecatch.jpg 1040w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig5_eyecatch-360x270.jpg 360w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig5_eyecatch-610x458.jpg 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig5_eyecatch-768x576.jpg 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/oshima_fig5_eyecatch-720x540.jpg 720w\" sizes=\"auto, (max-width: 1040px) 100vw, 1040px\" \/><\/p>\n<p>\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u640d\u50b7\u5f8c\u306eWnt\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u304c\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u304a\u3088\u3073\u795e\u7d4c\u7d30\u80de\u306e\u7523\u751f\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>(5)<\/strong><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h4>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u8996\u84cb\u3067\u306e\u7d44\u7e54\u518d\u751f\u6a5f\u69cb\u306e\u4e00\u7aef\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3067\u306f\u591a\u69d8\u306a\u795e\u7d4c\u640d\u50b7\u30e2\u30c7\u30eb\u304c\u4f5c\u88fd\u3055\u308c\u3066\u304a\u308a\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u30fb\u5206\u5316\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u6a5f\u69cb\u304c\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u69d8\u3005\u306a\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u89e3\u6790\u3057\u3001\u30e2\u30c7\u30eb\u9593\u3067\u6bd4\u8f03\u691c\u8a0e\u3059\u308b\u3053\u3068\u3067\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u304c\u6301\u3064\u9ad8\u3044\u518d\u751f\u80fd\u529b\u3092\u5236\u5fa1\u3059\u308b\u4ed5\u7d44\u307f\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u4e8b\u6545\u3084\u75c5\u6c17\u306b\u3088\u308b\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u640d\u50b7\u306f\u751f\u6d3b\u306e\u8cea\u3092\u8457\u3057\u304f\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3001\u518d\u751f\u80fd\u529b\u304c\u4f4e\u3044\u30de\u30a6\u30b9\u3067\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5fdc\u7b54\u3068\u518d\u751f\u80fd\u529b\u304c\u9ad8\u3044\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3067\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5fdc\u7b54\u306e\u9055\u3044\u3092\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u7db2\u7f85\u7684\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u54fa\u4e73\u985e\u3067\u306e\u795e\u7d4c\u7d44\u7e54\u518d\u751f\u3092\u4fc3\u3059\u4ed5\u7d44\u307f\u304c\u767a\u898b\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4><strong>\u00a0<\/strong><strong>(6)<\/strong><strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u640d\u50b7\u5f8c\u306b\u65b0\u3057\u304f\u4f5c\u3089\u308c\u305f\u795e\u7d4c\u7d30\u80de\u306e\u7a2e\u985e\u3084\u6a5f\u80fd\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2\u304b\u3089\u4f5c\u3089\u308c\u308b\u7d30\u80de\u3092\u6a19\u8b58\u3059\u308b\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u65b0\u3057\u304f\u4f5c\u3089\u308c\u305f\u795e\u7d4c\u7d30\u80de\u304c\u795e\u7d4c\u7d44\u7e54\u306e\u6a5f\u80fd\u56de\u5fa9\u306b\u8ca2\u732e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306e\u518d\u751f\u80fd\u529b\u3092\u5236\u5fa1\u3059\u308b\u4ed5\u7d44\u307f\u304c\u30de\u30a6\u30b9\u3067\u3082\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u304c\u3001\u73fe\u72b6\u3067\u306f\u305d\u306e\u52b9\u679c\u306f\u9650\u5b9a\u7684\u306a\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30a6\u30b9\u3068\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306b\u304a\u3051\u308b\u518d\u751f\u80fd\u529b\u3092\u5236\u5fa1\u3059\u308b\u4ed5\u7d44\u307f\u306e\u9055\u3044\u3092\u3088\u308a\u8a73\u7d30\u306b\u63a2\u7d22\u3057\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u54fa\u4e73\u985e\u306e\u518d\u751f\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u660e\u304a\u3088\u3073\u5236\u5fa1\u65b9\u6cd5\u306e\u958b\u767a\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>(7)100<\/strong><strong>\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/strong><\/h4>\n<p>\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3092\u7528\u3044\u305f\u65b0\u305f\u306a\u8133\u640d\u50b7\u30e2\u30c7\u30eb\u3092\u4f5c\u88fd\u3057\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u7d44\u7e54\u518d\u751f\u306e\u4e00\u7aef\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u640d\u50b7\u5f8c\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3067Wnt\u30b7\u30b0\u30ca\u30eb\u304c\u6d3b\u6027\u5316\u3057\u3001\u5897\u6b96\u304a\u3088\u3073\u795e\u7d4c\u7d30\u80de\u3078\u306e\u5206\u5316\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002<\/p>\n<h5><strong>\u00a0<\/strong><strong>\u3010\u7528\u8a9e\u8aac\u660e\u3011<\/strong><\/h5>\n<ul>\n<li>\u6ce8\uff11\uff1a\u8996\u84cb \u2013 \u4e2d\u8133\u306b\u4f4d\u7f6e\u3057\u3001\u8996\u899a\u60c5\u5831\u3092\u51e6\u7406\u3059\u308b\u8133\u90e8\u4f4d\u3002<\/li>\n<li>\u6ce8\uff12\uff1a\u30e9\u30b8\u30a2\u30eb\u30b0\u30ea\u30a2 \u2013 \u795e\u7d4c\u7d30\u80de\u3084\u30b0\u30ea\u30a2\u7d30\u80de\u3092\u751f\u307f\u51fa\u3059\u795e\u7d4c\u5e79\u7d30\u80de\u306e\uff11\u3064\u3002<\/li>\n<li>\u6ce8\uff13\uff1aWnt\u30b7\u30b0\u30ca\u30eb \u2013 \u7d30\u80de\u306e\u5897\u6b96\u3084\u5206\u5316\u306b\u95a2\u308f\u308b\u30b7\u30b0\u30ca\u30eb\u3002\u751f\u7269\u7a2e\u3092\u8d85\u3048\u3066\u5e83\u304f\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<h5><strong>\u00a0<\/strong><strong>\u3010\u53c2\u8003\u6587\u732e\u3011<\/strong><\/h5>\n<ol>\n<li>Kroehne et al., Development, 2011. DOI: 10.1242\/dev.072587<\/li>\n<li>Ito et al., Developmental Biology, 2010. DOI: 10.1016\/j.ydbio.2010.03.008<\/li>\n<\/ol>\n<h5><strong>\u3010\u8ad6\u6587\u60c5\u5831\u3011<\/strong><\/h5>\n<ul>\n<li>\u63b2\u8f09\u8a8c\uff1a<em>GLIA<\/em><\/li>\n<li>\u8ad6\u6587\u540d\uff1a<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.23311\/full\">Wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish.<\/a><\/li>\n<li>\u8457\u8005\uff1a\u6e05\u6c34\u52c7\u6c17\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001\u4e0a\u7530\u60a0\u4eba\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001<a href=\"http:\/\/www.ohshima.biomed.sci.waseda.ac.jp\/\">\u5927\u5cf6\u767b\u5fd7\u7537\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/a><\/li>\n<li><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.23311\/full\">DOI: 10.1002\/glia.23311<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u4e8b\u6545\u3084\u75c5\u6c17\u306b\u3088\u308b\u4e2d\u67a2\u795e\u7d4c\u7cfb\u640d\u50b7\u304b\u3089\u306e\u7d44\u7e54\u518d\u751f\u3092\u4fc3\u3059\u4ed5\u7d44\u307f\u767a\u898b\u306b\u671f\u5f85 \u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e\u6e05\u6c34\u52c7\u6c17\uff08\u3057\u307f\u305a\u3086\u3046\u304d\uff09\u52a9\u624b\uff08\u540c\u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b3\u5e74\uff09\u3001\u4e0a\u7530\u60a0\u4eba\uff08\u3046\u3048\u3060\u3086\u3046\u3068\uff09\uff08\u540c\u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u4fee\u58eb\u8ab2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":57148,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,5],"class_list":["post-57153","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/57153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=57153"}],"version-history":[{"count":0,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/57153\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/57148"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=57153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=57153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=57153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}