{"id":57043,"date":"2018-02-06T19:59:40","date_gmt":"2018-02-06T10:59:40","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=57043"},"modified":"2018-02-07T10:19:09","modified_gmt":"2018-02-07T01:19:09","slug":"%e3%82%b5%e3%83%aa%e3%83%89%e3%83%9e%e3%82%a4%e3%83%89%e3%81%ae%e8%84%b3%e6%a2%97%e5%a1%9e%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e8%96%ac%e5%8a%b9%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0%e3%82%92","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/57043","title":{"rendered":"\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u8133\u6897\u585e\u306b\u5bfe\u3059\u308b\u85ac\u52b9\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b"},"content":{"rendered":"<h3><strong>\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506<\/strong><\/h3>\n<p><a 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Publishing Group\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u79d1\u5b66\u96d1\u8a8c\u300e<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-20911-2\">Scientific 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[1,2]\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u8a73\u7d30\u306a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3068\u306e\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u3068\u3057\u3066\u3001\u7cbe\u795e\u9045\u6ede\u539f\u56e0\u907a\u4f1d\u5b50\u7523\u7269\u3067\u3082\u3042\u308b\u30bb\u30ec\u30d6\u30ed\u30f3\uff08Cereblon; CRBN\uff09\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3057\u305f [3]\u3002\u6211\u3005\u306f\u5148\u884c\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5206\u5b50\u3068\u3057\u3066\u306eCRBN\u306e\u6a5f\u80fd\u306b\u7740\u76ee\u3057\u3001CRBN\u304c\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u306b\u3088\u308a\u30a2\u30b0\u30ea\u30bd\u30fc\u30e0\u306b\u84c4\u7a4d\u3057\u3001\u7d30\u80de\u6b7b\u306b\u5bfe\u3059\u308b\u6291\u5236\u52b9\u679c\u3092\u6301\u3064\u4e8b\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f [4]\u3002\u3055\u3089\u306b\u3001\u30bb\u30ec\u30d6\u30ed\u30f3\u3092\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u4e8b\u3067\u3001\u30bb\u30ec\u30d6\u30ed\u30f3\u304c\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u4e8b\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f [5]\u3002\u4e00\u65b9\u3001CRBN\u306b\u76f4\u63a5\u7684\u306b\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3001AMP\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08AMP-activated protein kinase; AMPK\uff09\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3057\u305f [6]\u3002AMPK\u306f\u3001\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3067\u3042\u308b\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff08Adenosine triphosphate; ATP\uff09\u304c\u67af\u6e07\u3059\u308b\u3068\u6d3b\u6027\u5316(\u30ea\u30f3\u9178\u5316)\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185ATP\u91cf\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u91cd\u8981\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u3067\u3042\u308a\u3001\u8133\u865a\u8840\u4e0b\u3067\u30ea\u30f3\u9178\u5316\u5897\u5e45\u304c\u8d77\u304d\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u3001AMPK\u306e\u8131\u30ea\u30f3\u9178\u5316\u304c\u795e\u7d4c\u4fdd\u8b77\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f [7, 8]\u3002<\/p>\n<h4><strong>\u00a0(2) \u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u8133\u6897\u585e\u306b\u5bfe\u3059\u308b\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u3067\u3042\u308bCRBN\u3068\u3001\u305d\u306e\u7d50\u5408\u30bf\u30f3\u30d1\u30afAMPK\u306e\u6d3b\u6027\u8abf\u7bc0\u306b\u7740\u76ee\u3057\u3066\u691c\u8a0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306f\u305d\u306e\u6a19\u7684\u5206\u5b50\u3067\u3042\u308bCRBN\u3092\u4ecb\u3057\u3066AMPK-CRBN\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u3067AMPK\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001\u8133\u865a\u8840\u306b\u3088\u308b\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>\u00a0(3)\u00a0<\/strong><strong>\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u8133\u6897\u585e\u3078\u306e\u6709\u52b9\u6027\u3068\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u30d2\u30c8\u8133\u6897\u585e\u306e\u6a21\u5023\u30e2\u30c7\u30eb\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u30e9\u30c3\u30c8\u4e2d\u5927\u8133\u52d5\u8108\u9589\u585e\uff0f\u518d\u704c\u6d41\u30e2\u30c7\u30eb\u3092\u4f5c\u88fd\u3057\u3066\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u8133\u6897\u585e\u3092\u5f15\u304d\u8d77\u3053\u3059\u8840\u6813\u5f62\u6210\u306e\u7d0480%\u304c\u4e2d\u5927\u8133\u52d5\u8108\u3067\u8d77\u3053\u308b\u4e8b\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30e2\u30c7\u30eb\u3067\u306f\u30e9\u30c3\u30c8\u306e\u4e2d\u5927\u8133\u52d5\u8108\u3092\u9589\u585e\u3059\u308b\u3053\u3068(=\u4e2d\u5927\u8133\u52d5\u8108\u9589\u585e\uff0f\u518d\u704c\u6d41\u8853\uff1aMiddle Cerebral Artery Occlusion \/ Reperfusion; MCAO\/R)\u306b\u3088\u308a\u3001\u9589\u585e\u5074\u306e\u8133\u306b\u5bfe\u3057\u3001\u4e2d\u5927\u8133\u52d5\u8108\u652f\u914d\u9818\u57df\u3067\u3042\u308b\u7dda\u6761\u4f53\u3068\u5927\u8133\u76ae\u8cea\u306b\u6897\u585e\u5de3\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306e\u8179\u8154\u5185\u306b\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u8133\u6897\u585e\u3078\u306e\u6709\u52b9\u6027\u3068\u95a2\u9023\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306b\u3088\u308b\u795e\u7d4c\u7d30\u80de\u6b7b\u6291\u5236\u306e\u8a73\u7d30\u306a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u904e\u9178\u5316\u6c34\u7d20\u3092\u795e\u7d4c\u82bd\u7d30\u80de\u816b\u3067\u3042\u308bSH-SY5Y\u306b\u6dfb\u52a0\u3057\u3066\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u4e0e\u3048\u3001\u8133\u865a\u8840\u30e2\u30c7\u30eb\u7d30\u80de\u3068\u3057\u3066\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>(4)\u00a0<\/strong><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/strong><\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u30e9\u30c3\u30c8\u306bMCAO\/R\u3092\u884c\u3044\u3001\u8133\u6897\u585e\u30e2\u30c7\u30eb\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002MCAO\/R\u51e6\u7406\u306e\u969b\u306b\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3092\u8179\u8154\u5185\u6295\u4e0e\u3057\u3066\u304a\u304f\u3068\u6897\u585e\u9818\u57df\u306e\u6e1b\u5c11\u304c\u898b\u3089\u308c\u3001\u795e\u7d4c\u6b20\u640d\u75c7\u72b6\u3082\u8efd\u6e1b\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u8133\u865a\u8840\u306b\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u56f3\uff11\uff09<\/p>\n<div id=\"attachment_57045\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-57045\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/sawamura1-1.jpg\" alt=\"\" width=\"436\" height=\"528\" \/><p class=\"wp-caption-text\">\u56f3\uff11. \u8133\u865a\u8840\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306e\u6897\u585e\u5de3\u306e\u5b9a\u91cf<\/p><\/div>\n<h6>\u203bTTC\u67d3\u8272\u753b\u50cf\u306e\u975e\u67d3\u8272\u90e8\u4f4d\u3059\u306a\u308f\u3061\u6897\u585e\u9818\u57df\u3092\u5b9a\u91cf\u3057\u305f\u3002MCAO\/R\u306b\u3088\u308a\u751f\u3058\u305f\u6897\u585e\u9818\u57df\u306e\u7dcf\u4f53\u7a4d\u3092\u7b97\u51fa\u3057\u305f\u7d50\u679c\u3001MCAO\/R\u306b\u3088\u308a\u751f\u3058\u305f\u6897\u585e\u5de3\u304c\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u6295\u4e0e\u306b\u3088\u308a\u6709\u610f\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f(*p&lt;0.05)\u3002Scientific Reports 8, Article\u00a0number:\u00a02459, Figure No. 1bc, 6 February 2018 \u00a9 Macmillan Publishers Limited.<\/h6>\n<p>\u6b21\u306b\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u306b\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u306e\u63a2\u7d22\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u795e\u7d4c\u4fdd\u8b77\u306b\u50cd\u304f\u30b7\u30b0\u30ca\u30eb\u3067\u3042\u308bAMPK\u3001ERK1\/2\u3001AKT\u306b\u3064\u3044\u3066\u3001\u8133\u865a\u8840\u53ca\u3073\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u6295\u4e0e\u306b\u3088\u308a\u3069\u306e\u3088\u3046\u306a\u5909\u5316\u304c\u3042\u308b\u306e\u304b\u3092\u8abf\u3079\u305f\u7d50\u679c\u3001AMPK\u306e\u30ea\u30f3\u9178\u5316\u306e\u307f\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u6295\u4e0e\u306b\u3088\u308a\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f3\uff12\uff09\u3002<\/p>\n<div id=\"attachment_57046\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-57046 size-full\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/sawamura2.jpg\" alt=\"\" width=\"603\" height=\"562\" \/><p class=\"wp-caption-text\">\u56f3\uff12. \u8133\u865a\u8840\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u795e\u7d4c\u4fdd\u8b77\u30b7\u30b0\u30ca\u30eb\u306e\u691c\u51fa<\/p><\/div>\n<h6>\u203b\u795e\u7d4c\u4fdd\u8b77\u306b\u50cd\u304f\u30b7\u30b0\u30ca\u30eb\u3067\u3042\u308bAMPK\u3001ERK1\/2\u3001AKT\u306e\u3046\u3061\u3001AMPK\u306b\u95a2\u3057\u3066\u306e\u307f\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\uff08Thalidomide\uff09\u6295\u4e0e\u30e9\u30c3\u30c8\u306e\u5927\u8133\u76ae\u8cea\u6897\u585e\u9818\u57df (C) \u53ca\u3073\u7dda\u6761\u4f53 (S) \u306b\u3064\u3044\u3066\u3001\u5de6\u534a\u7403 (Left) \u3068\u53f3\u534a\u7403 (Right) \u3092\u6bd4\u8f03\u3059\u308b\u3068\u30ea\u30f3\u9178\u5316\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u305f\u3002Scientific Reports 8, Article\u00a0number:\u00a02459, Figure No. 3ab, 6 February 2018. \u00a9 Macmillan Publishers Limited.<\/h6>\n<p>\u3055\u3089\u306b\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306b\u3088\u308b\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\u304c\u8d77\u3053\u308b\u969b\u306bAMPK-CRBN\u76f8\u4e92\u4f5c\u7528\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3001\u8133\u865a\u8840\u30e2\u30c7\u30eb\u7d30\u80de\u3067\u306e\u691c\u8a3c\u3092\u884c\u3044\u307e\u3057\u305f\u3002SH-SY5Y\u7d30\u80de\u306b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u52a0\u3048\u305f\u969b\u3001\u307e\u305f\u305d\u308c\u3068\u540c\u6642\u306b\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3092\u6295\u4e0e\u3057\u305f\u969b\u306eAMPK\u3068CRBN\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u514d\u75ab\u6c88\u964d\u6cd5\u306b\u3088\u308a\u691c\u8a3c\u3057\u305f\u7d50\u679c\u3001\u901a\u5e38\u306eSH-SY5Y\u7d30\u80de\u306b\u304a\u3044\u3066AMPK\u3068CRBN\u306f\u5f37\u304f\u7d50\u5408\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u904e\u9178\u5316\u6c34\u7d20\u6dfb\u52a0\u306b\u3088\u308aAMPK\u3068CRBN\u306e\u7d50\u5408\u304c\u5f31\u307e\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u904e\u9178\u5316\u6c34\u7d20\u3068\u540c\u6642\u306b\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3092\u6295\u4e0e\u3059\u308b\u3068AMPK\u3068CRBN\u306e\u7d50\u5408\u304c\u56de\u5fa9\u3057\u307e\u3057\u305f\uff08\u56f3\uff13\uff09\u3002<\/p>\n<div id=\"attachment_57047\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-57047\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/sawamura3.jpg\" alt=\"\" width=\"383\" height=\"418\" \/><p class=\"wp-caption-text\">\u56f3\uff13. \u8133\u865a\u8840\u30e2\u30c7\u30eb\u7d30\u80de\u3078\u306e\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u6295\u4e0e\u306b\u3088\u308bAMPK\u3068CRBN\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u5909\u5316<\/p><\/div>\n<h6>\u203b\u904e\u9178\u5316\u6c34\u7d20\u3092\u6295\u4e0e\u3057\u305f\u8133\u865a\u8840\u30e2\u30c7\u30eb\u7d30\u80de\u3067AMPK\u306e\u30ea\u30f3\u9178\u5316\u5897\u5e45\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u3057\u304b\u3057\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3092\u540c\u6642\u306b\u6295\u4e0e\u3059\u308b\u3068\u3001AMPK\u306e\u30ea\u30f3\u9178\u5316\u5897\u5e45\u304c\u6291\u5236\u3055\u308c\u305f\u3002\u307e\u305fAMPK-CRBN\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u3001\u904e\u9178\u5316\u6c34\u7d20\u306e\u6295\u4e0e\u306b\u3088\u308aAMPK-CRBN\u306e\u7d50\u5408\u304c\u5f31\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3092\u540c\u6642\u306b\u6295\u4e0e\u3059\u308b\u3068\u3001AMPK-CRBN\u306e\u7d50\u5408\u304c\u56de\u5fa9\u3057\u305f\u3002Scientific Reports 8, Article\u00a0number:\u00a02459, Figure No. 4c, 6 February 2018. \u00a9 Macmillan Publishers Limited.<\/h6>\n<p>\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u304cCRBN\u3092\u4ecb\u3057\u3066AMPK\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>(5)\u00a0<\/strong><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h4>\n<p>\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u8133\u6897\u585e\u306b\u5bfe\u3059\u308b\u85ac\u52b9\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bCRBN\u3092\u4ecb\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u3067\u3042\u308bAMPK\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u3088\u308a\u5b89\u5168\u3067\u5b89\u5b9a\u306a\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u8a98\u5c0e\u4f53\u3084\u3001AMPK-CRBN\u306e\u7d50\u5408\u3092\u5f37\u3081\u308b\u3088\u3046\u306a\u85ac\u5264\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8133\u6897\u585e\u306b\u6709\u52b9\u306a\u85ac\u5264\u306e\u958b\u767a\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4><strong>(6) \u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n<p>\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306f\u6c34\u6eb6\u6db2\u4e2d\u306b\u304a\u3044\u3066\u81ea\u767a\u7684\u304b\u3064\u901f\u3084\u304b\u306b\u52a0\u6c34\u5206\u89e3\u3092\u53d7\u3051\u308b\u305f\u3081\u4e0d\u5b89\u5b9a\u306a\u85ac\u5264\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u8a98\u5c0e\u4f53\u3067\u3042\u308a\u3001\u69cb\u9020\u304c\u5b89\u5b9a\u306a\u4ee3\u8b1d\u7523\u7269\u3084\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u52a0\u6c34\u5206\u89e3\u7523\u7269\u3092\u7528\u3044\u3066\u3001\u3088\u308a\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u304c\u5927\u304d\u304f\u526f\u4f5c\u7528\u304c\u5c11\u306a\u3044\u3082\u306e\u3092\u540c\u5b9a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u6211\u3005\u306f\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5206\u5b50\u3068\u3057\u3066\u306eCRBN\u306e\u6a5f\u80fd\u306b\u7740\u76ee\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u6025\u6027\u306e\u30b9\u30c8\u30ec\u30b9\u3067\u3042\u308b\u8133\u6897\u585e\u30e2\u30c7\u30eb\u3078\u306e\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u6295\u4e0e\u306b\u3088\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5206\u5b50\u3068\u3057\u3066\u306eCRBN\u306e\u50cd\u304d\u304c\u5f37\u304f\u306a\u3063\u3066\u7d30\u80de\u6b7b\u306e\u6291\u5236\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5206\u5b50\u3068\u3057\u3066\u306eCRBN\u306b\u7740\u76ee\u3057\u3001CRBN\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u30b9\u30c8\u30ec\u30b9\u3084\u8001\u5316\u306e\u6307\u6a19\uff08\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff09\u306b\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3001\u8001\u5316\u30fb\u30b9\u30c8\u30ec\u30b9\u30e2\u30c7\u30eb\u3067\u306e\u30bb\u30ec\u30d6\u30ed\u30f3\u306e\u5fdc\u7b54\u306b\u7740\u76ee\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>(7) 100\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/strong><\/h4>\n<p>\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u8133\u6897\u585e\u306b\u5bfe\u3059\u308b\u85ac\u52b9\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30bb\u30ec\u30d6\u30ed\u30f3\u3092\u4ecb\u3057\u3066\u751f\u4f53\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u3067\u3042\u308bAMPK\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>\u7528\u8a9e\u8aac\u660e<\/strong><\/h4>\n<ul>\n<li>AMPK &#8211; AMP\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08AMP-activated protein kinase; AMPK\uff09\u3002\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3067\u3042\u308b\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff08Adenosine triphosphate; ATP\uff09\u304c\u67af\u6e07\u3059\u308b\u3068\u6d3b\u6027\u5316(\u30ea\u30f3\u9178\u5316)\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185ATP\u91cf\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u91cd\u8981\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u3002<\/li>\n<li>ATP &#8211; \u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff08Adenosine triphosphate; ATP\uff09\u3002\u751f\u4f53\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u308b\u5206\u5b50\u3002<\/li>\n<li>SH-SY5Y &#8211; \u30d2\u30c8\u7531\u6765\u306e\u795e\u7d4c\u82bd\u7d30\u80de\u816b\u3002\u795e\u7d4c\u7d30\u80de\u306e\u30e2\u30c7\u30eb\u306e\u57f9\u990a\u7d30\u80de\u3068\u3057\u3066\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u308b\u3002<\/li>\n<li>ERK1\/2 &#8211; Extracellular signal-regulated kinase 1\/2\u3002\u7d30\u80de\u5916\u306e\u69d8\u3005\u306a\u523a\u6fc0\u306b\u5fdc\u7b54\u3059\u308b\u30ea\u30f3\u9178\u5316\u9175\u7d20\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u306b\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u306e\u4e00\u3064\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<li>AKT &#8211; \u7d30\u80de\u5916\u306e\u69d8\u3005\u306a\u523a\u6fc0\u306b\u5fdc\u7b54\u3059\u308b\u30ea\u30f3\u9178\u5316\u9175\u7d20\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u306b\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u306e\u4e00\u3064\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ol>\n<li>Hyakkoku et al. <em>Neuroscience<\/em> <strong>159<\/strong>, 760\u2013769 (2009)<\/li>\n<li>Palencia et al. <em>J Neurol Sci <\/em><strong>351<\/strong>, 78\u201387 (2015)<\/li>\n<li>Ito et al. <em>Science<\/em> <strong>327<\/strong>, 1345-1350 (2010)<\/li>\n<li>Sawamura et al. <em>BBRC<\/em> <strong>464<\/strong>, 1054-1059 (2015)<\/li>\n<li>Kataoka et al. <em>Scientific reports<\/em> <strong>6<\/strong>, 29986 (2016)<\/li>\n<li>Lee et al. <em>Biochimica et biophysica acta<\/em> <strong>1813<\/strong>, 448\u2013455 (2011)<\/li>\n<li>McCullough et al. <em>Journal of biological chemistry<\/em> <strong>280<\/strong>, 20493\u201320502 (2005)<\/li>\n<li>Li et al. <em>Stroke<\/em> <strong>38<\/strong>, 2992\u20132999 (2007)<\/li>\n<\/ol>\n<h4><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h4>\n<ul>\n<li>\u63b2\u8f09\u8a8c\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-20911-2\">Scientific Reports 8, Article\u00a0number:\u00a02459 (2018)<\/a><\/li>\n<li>\u8ad6\u6587\u540d\uff1aThe Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon -mediated Repression of AMPK Activity<\/li>\n<li>\u8457\u3000\u8005\uff1a\u6fa4\u6751\u76f4\u54c9\uff08\u65e9\u7a32\u7530\u5927\uff09, \u5c71\u7530\u307e\u308a\u3053\uff08\u6771\u4eac\u85ac\u79d1\u5927\uff09, \u85e4\u539f\u7f8e\u7d05\uff08\u65e9\u7a32\u7530\u5927\uff09, \u5c71\u7530\u6625\u4f73\uff08\u65e9\u7a32\u7530\u5927\uff09, \u6797\u79c0\u6a39\uff08\u6771\u4eac\u85ac\u79d1\u5927\uff09, \u9ad8\u6728\u6559\u592b\uff08\u6771\u4eac\u85ac\u79d1\u5927\uff09, \u671d\u65e5\u900f\uff08\u65e9\u7a32\u7530\u5927\uff09<\/li>\n<li>DOI: <a href=\"https:\/\/www.nature.com\/articles\/s41598-018-20911-2\">10.1038\/s41598-018-20911-2<\/a><\/li>\n<\/ul>\n<h4><strong>\u7814\u7a76\u5185\u5bb9\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b\u5148<\/strong><\/h4>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u30ca\u30ce\u30fb\u30e9\u30a4\u30d5\u5275\u65b0\u7814\u7a76\u6a5f\u69cb\u3000\u6fa4\u6751 \u76f4\u54c9<br \/>\nTEL: 03-5369-7327\u3000E-mail: naoya@aoni.waseda.jp<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506 \u65e9\u7a32\u7530\u5927\u5b66\u30ca\u30ce\u30fb\u30e9\u30a4\u30d5\u5275\u65b0\u7814\u7a76\u6a5f\u69cb\u306e\u6fa4\u6751\u76f4\u54c9\uff08\u3055\u308f\u3080\u3089\u306a\u304a\u3084\uff09\u7814\u7a76\u9662\u51c6\u6559\u6388\u3068\u3001\u540c\u5927\u5b66\u9662\u4fee\u4e86\u30fb\u85e4\u539f\u7f8e\u7d05\uff08\u3075\u3058\u308f\u3089\u307f\u304f\uff09\u6c0f\u3001\u540c\u5927\u5b66\u9662\u4fee\u4e86\u30fb\u5c71\u7530\u6625\u4f73\uff08\u3084\u307e\u3060\u306f\u308b\u304b\uff09\u6c0f\u3001\u540c\u7406\u5de5\u5b66\u8853\u9662\u306e\u671d\u65e5\u900f [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":57077,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[357,5],"class_list":["post-57043","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/57043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=57043"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/57043\/revisions"}],"predecessor-version":[{"id":57071,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/57043\/revisions\/57071"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/57077"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=57043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=57043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=57043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}