{"id":44256,"date":"2016-08-31T14:00:00","date_gmt":"2016-08-31T05:00:00","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=44256"},"modified":"2016-09-06T16:53:34","modified_gmt":"2016-09-06T07:53:34","slug":"%e3%83%af%e3%83%b3%e3%83%9d%e3%83%83%e3%83%88%e5%90%88%e6%88%90%e3%81%a7%e5%a4%a9%e7%84%b6%e7%89%a9%e3%82%92%e7%a5%9e%e7%b5%8c%e5%88%86%e5%8c%96%e8%aa%bf%e7%af%80%e5%88%86%e5%ad%90%e3%81%b8-%e7%a5%9e","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/44256","title":{"rendered":"\u30ef\u30f3\u30dd\u30c3\u30c8\u5408\u6210\u3067\u5929\u7136\u7269\u3092\u795e\u7d4c\u5206\u5316\u8abf\u7bc0\u5206\u5b50\u3078 \u795e\u7d4c\u75be\u60a3\u306e\u6cbb\u7642\u3084\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u671f\u5f85"},"content":{"rendered":"<p><a href=\"http:\/\/www.riken.jp\/pr\/press\/2016\/20160831_1\/\" target=\"_blank\">\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u7406\u7814\uff09<\/a><a href=\"http:\/\/www.riken.jp\/research\/labs\/associate\/biofunct_synth_chem\/\" target=\"_blank\">\u7530\u4e2d\u751f\u4f53\u6a5f\u80fd\u5408\u6210\u5316\u5b66\u7814\u7a76\u5ba4<\/a>\u306e\u7530\u4e2d\u514b\u5178\u51c6\u4e3b\u4efb\u7814\u7a76\u54e1\u3001\u5ca9\u7530\u9686\u5e78\u7814\u4fee\u751f\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"http:\/\/www.chem.waseda.ac.jp\/nakao\/\" target=\"_blank\">\u4e2d\u5c3e\u6d0b\u4e00\u6559\u6388<\/a>\u3001\u5927\u585a\u609f\u53f2\u52a9\u624b\u3089\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<sup>\u203b<\/sup>\u306f\u3001\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u3067\u3042\u308b\u300c\u30a2\u30b2\u30e9\u30b8\u30f3A<sup>[1]<\/sup>\u300d\u306e\u65b0\u3057\u3044\u8a98\u5c0e\u4f53\u3092\u7c21\u4fbf\u306b\u5408\u6210\u3059\u308b\u624b\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u5408\u6210\u3057\u305f\u8a98\u5c0e\u4f53\u306e\u4e2d\u304b\u3089\u30de\u30a6\u30b9\u795e\u7d4c\u5e79\u7d30\u80de<sup>[2]<\/sup>\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\uff08\u795e\u7d4c\u7d30\u80de\uff09\u3078\u306e\u5206\u5316\u3092\u9078\u629e\u7684\u306b\u4fc3\u9032\u3059\u308b\u8a98\u5c0e\u4f53\u3068\u6291\u5236\u3059\u308b\u8a98\u5c0e\u4f53\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30a2\u30b2\u30e9\u30b8\u30f3A\u306f\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e1\u4eba\u3067\u3042\u308b\u4e2d\u5c3e\u6d0b\u4e00\u6559\u6388\u3089\u306b\u3088\u3063\u3066\u30012003\u5e74\u306b\u767a\u898b\u3055\u308c\u305f\u6d77\u7523\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9<sup>[3]<\/sup>\u3067\u3001\u6297\u304c\u3093\u4f5c\u7528\u3092\u793a\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u3001\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30a2\u30cb\u30ea\u30f3\u307e\u305f\u306f\u30a2\u30eb\u30ae\u30cb\u30f3\u3092\u539f\u6599\u3068\u3057\u3066\u3001\u4e00\u3064\u306e\u30d5\u30e9\u30b9\u30b3\u5185\u306b4\u7a2e\u985e\u306e\u8a66\u85ac\u3092\u9806\u756a\u306b\u52a0\u3048\u308b\u3053\u3068\u3067\u30017\u7a2e\u985e\u306e\u53cd\u5fdc\u3092\u4e00\u6319\u306b\u884c\u3046\u300c\u30ef\u30f3\u30dd\u30c3\u30c8\u5408\u6210<sup>[4]<\/sup>\u300d\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u65b9\u6cd5\u3067\u306f\u4e2d\u9593\u4f53\u3092\u7cbe\u88fd\u3059\u308b\u5fc5\u8981\u304c\u5168\u304f\u306a\u3044\u305f\u3081\u3001\u7c21\u4fbf\u304b\u3064\u77ed\u6642\u9593\u306b\u30a2\u30b2\u30e9\u30b8\u30f3A\u3084\u3001\u3053\u308c\u307e\u3067\u5408\u6210\u3067\u304d\u306a\u304b\u3063\u305f\u65b0\u3057\u3044\u8a98\u5c0e\u4f53\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u65b0\u3057\u304f\u5408\u6210\u3057\u305f\u8a98\u5c0e\u4f53\u306b\u3064\u3044\u3066\u3001\u30de\u30a6\u30b9\u306eES\u7d30\u80de<sup>[5]<\/sup>\u304b\u3089\u5f97\u3089\u308c\u308b\u795e\u7d4c\u5e79\u7d30\u80de\uff08\u5404\u795e\u7d4c\u7d30\u80de\u306e\u3082\u3068\u306b\u306a\u308b\u7d30\u80de\uff09\u306e\u5206\u5316\u8abf\u7bc0\u6d3b\u6027\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u300110\u30ca\u30ce\u30e2\u30eb\uff08nM\u30011nM\u306f10\u5104\u5206\u306e1M\uff09\u3068\u3044\u3046\u6975\u4f4e\u6fc3\u5ea6\u3067\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u3092\u9078\u629e\u7684\u306b\u4fc3\u9032\u3059\u308b\u8a98\u5c0e\u4f53\u3068\u6291\u5236\u3059\u308b\u8a98\u5c0e\u4f53\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u30ef\u30f3\u30dd\u30c3\u30c8\u5408\u6210\u306b\u3088\u308a\u3001\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u3092\u795e\u7d4c\u5206\u5316\u8abf\u7bc0\u5206\u5b50\u3078\u3068\u5909\u63db\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u9078\u629e\u7684\u306b\u5206\u5316\u3055\u305b\u308b\u6280\u8853\u3078\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u795e\u7d4c\u5206\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30c0\u30a6\u30f3\u75c7\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u3068\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306f\u3001<a href=\"http:\/\/www.jst.go.jp\/presto\/moltech\/index.html\" target=\"_blank\">\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09\u6226\u7565\u7684\u5275\u9020\u7814\u7a76\u63a8\u9032\u4e8b\u696d\u500b\u4eba\u578b\u7814\u7a76\uff08\u3055\u304d\u304c\u3051\uff09\u306e\u7814\u7a76\u9818\u57df\u300c\u5206\u5b50\u6280\u8853\u3068\u65b0\u6a5f\u80fd\u5275\u51fa\u300d\uff08\u7814\u7a76\u7dcf\u62ec\uff1a\u52a0\u85e4\u9686\u53f2\uff09<\/a>\u7814\u7a76\u8ab2\u984c\u540d\u300c\u751f\u4f53\u5185\u5408\u6210\u5316\u5b66\u6cbb\u7642\uff1a\u52d5\u7269\u5185\u3067\u306e\u751f\u7406\u6d3b\u6027\u5206\u5b50\u5408\u6210\u300d\uff08\u7814\u7a76\u8005\uff1a\u7530\u4e2d\u514b\u5178\uff09\u306e\u4e00\u74b0\u3068\u3057\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u6210\u679c\u306f\u3001\u30c9\u30a4\u30c4\u306e\u79d1\u5b66\u96d1\u8a8c\u300e<a href=\"http:\/\/dx.doi.org\/10.1002\/chem.201602651\" target=\"_blank\">Chemistry &#8211; A European Journal<\/a>\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff088\u670825\u65e5\u4ed8\u3051\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>\u203b\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/h4>\n<ul>\n<li>\u7406\u5316\u5b66\u7814\u7a76\u6240\u3000\u7530\u4e2d\u751f\u4f53\u6a5f\u80fd\u5408\u6210\u5316\u5b66\u7814\u7a76\u5ba4<br \/>\n\u51c6\u4e3b\u4efb\u7814\u7a76\u54e1\u3000\u7530\u4e2d\u3000\u514b\u5178\u3000\uff08\u305f\u306a\u304b\u3000\u304b\u3064\u306e\u308a\uff09<br \/>\n\u7814\u4fee\u751f\uff08\u7814\u7a76\u5f53\u6642\uff09 \u5ca9\u7530\u3000\u9686\u5e78\u3000\uff08\u3044\u308f\u305f\u3000\u305f\u304b\u3086\u304d\uff09<br \/>\n\uff08\u73fe \u4e5d\u5dde\u5927\u5b66\u5148\u5c0e\u7269\u8cea\u5316\u5b66\u7814\u7a76\u6240\u3000\u52a9\u6559\uff09<br \/>\n\u7814\u4fee\u751f\u3000\u576a\u5009\u3000\u4e00\u8f1d\u3000\uff08\u3064\u307c\u304f\u3089\u3000\u304b\u305a\u304d\uff09<\/li>\n<li>\u65e9\u7a32\u7530\u5927\u5b66\u3000\u7406\u5de5\u5b66\u8853\u9662<br \/>\n\u6559\u6388\u3000\u4e2d\u5c3e\u3000\u6d0b\u4e00\u3000\uff08\u306a\u304b\u304a\u3000\u3088\u3046\u3044\u3061\uff09<br \/>\n\u6b21\u5e2d\u7814\u7a76\u54e1\u3000\u65b0\u4e95\u3000\u5927\u7950\u3000\uff08\u3042\u3089\u3044\u3000\u3060\u3044\u3059\u3051\uff09<br \/>\n\u52a9\u624b\u3000\u5927\u585a\u3000\u609f\u53f2\u3000\uff08\u304a\u304a\u3064\u304b\u3000\u3055\u3068\u3057\uff09<\/li>\n<li>\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u3000\u7406\u5b66\u7814\u7a76\u79d1<br \/>\n\u6559\u6388\u3000\u6df1\u702c\u3000\u6d69\u4e00\u3000\uff08\u3075\u304b\u305b\u3000\u3053\u3046\u3044\u3061\uff09<\/li>\n<li>\u30ab\u30b6\u30f3\u9023\u90a6\u5927\u5b66\u3000A. Butlerov Institute of Chemistry<br \/>\n\u51c6\u6559\u6388\u3000\u30a2\u30eb\u30df\u30e9\u30fb\u30af\u30eb\u30d0\u30f3\u30ac\u30ea\u30a8\u30d0\uff08Almira Kurbangalieva\uff09<\/li>\n<\/ul>\n<h3>\uff11\uff0e\u80cc\u666f<\/h3>\n<p>\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u306f\u3001\u3053\u308c\u307e\u3067\u4e00\u4e16\u7d00\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u65b0\u305f\u306a\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u307e\u305f\u306f\u533b\u85ac\u54c1\u30ea\u30fc\u30c9\u5316\u5408\u7269<sup>[6]<\/sup>\u306e\u4f9b\u7d66\u6e90\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3001\u65b0\u305f\u306a\u5358\u96e2\u624b\u6cd5\u3084\u751f\u7269\u6d3b\u6027\u306e\u8a55\u4fa1\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u304c\u6301\u3064\u751f\u7269\u6d3b\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u3001\u3042\u308b\u3044\u306f\u5143\u306e\u6d3b\u6027\u3068\u306f\u5168\u304f\u7570\u306a\u308b\u751f\u7269\u6d3b\u6027\u3092\u65b0\u305f\u306b\u898b\u51fa\u3059\u305f\u3081\u306b\u3001\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u306e\u69cb\u9020\u306e\u4e00\u90e8\u3092\u5408\u6210\u5316\u5b66\u7684\u306b\u5909\u63db\u3059\u308b\u624b\u6cd5\u3082\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u300c\u30a2\u30b2\u30e9\u30b8\u30f3A\u300d\u306f\u30012003\u5e74\u306b\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\uff11\u4eba\u3067\u3042\u308b\u4e2d\u5c3e\u6d0b\u4e00\u6559\u6388\u3089\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u305f\u6d77\u7523\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u3067\u3059\uff08\u56f3\uff11\uff09\u3002\u7d30\u80de\u5916\u57fa\u8cea\u306e\u5206\u89e3\u30fb\u4ee3\u8b1d\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u9175\u7d20\u3067\u3042\u308b\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMPs\uff09\u306e\u963b\u5bb3\u5264\u3068\u3057\u3066\u5358\u96e2\u3055\u308c\u305f\u5206\u5b50\u3067\u3001\u6297\u304c\u3093\u4f5c\u7528\u3092\u793a\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001MMPs\u306e\u963b\u5bb3\u6d3b\u6027\u3084\u6297\u304c\u3093\u4f5c\u7528\u306e\u5411\u4e0a\u3092\u76ee\u6307\u3057\u3066\u3001\u30a2\u30b2\u30e9\u30b8\u30f3A\u306e\u8a98\u5c0e\u4f53\u304c\u5408\u6210\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u307e\u3067\u306e\u65b9\u6cd5\u3067\u306f\u3001\u591a\u304f\u306e\u53cd\u5fdc\u30b9\u30c6\u30c3\u30d7\u3084\u4e2d\u9593\u4f53\u306e\u7cbe\u88fd\u904e\u7a0b\u3092\u7d4c\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u305f\u3081\u3001\u4f5c\u308b\u3053\u3068\u306e\u3067\u304d\u308b\u5316\u5408\u7269\u306f\u3054\u304f\u4e00\u90e8\u306b\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u30a2\u30b2\u30e9\u30b8\u30f3A\u3084\u65b0\u3057\u3044\u8a98\u5c0e\u4f53\u3092\u77ed\u6642\u9593\u3067\u7c21\u4fbf\u306b\u5408\u6210\u3059\u308b\u65b0\u305f\u306a\u65b9\u6cd5\u3092\u958b\u767a\u3057\u3001\u3053\u308c\u307e\u3067\u306eMMPs\u963b\u5bb3\u6d3b\u6027\u3084\u6297\u304c\u3093\u6d3b\u6027\u3068\u306f\u5168\u304f\u9055\u3046\u6d3b\u6027\u3092\u6301\u3064\u8a98\u5c0e\u4f53\u3092\u898b\u51fa\u3059\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-44257\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig1-610x261.png\" alt=\"20160831_fig1\" width=\"610\" height=\"261\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig1-610x261.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig1-768x329.png 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig1-940x400.png 940w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig1.png 1016w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<h3>\uff12\uff0e\u7814\u7a76\u624b\u6cd5\u3068\u6210\u679c<\/h3>\n<p>\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u307e\u305a\u3001\u30a2\u30b2\u30e9\u30b8\u30f3A\u304c\u6301\u3064\u300c2-\u30a2\u30df\u30ce\u30a4\u30df\u30c0\u30be\u30fc\u30eb<sup>[7]<\/sup>\u90e8\u4f4d\u300d\u3092\u5408\u6210\u3059\u308b\u65b9\u6cd5\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u81ea\u7136\u754c\u3067\u306f\u3001\u7ffb\u8a33\u5f8c\u4fee\u98fe<sup>[8]<\/sup>\u3068\u3044\u3046\u73fe\u8c61\u306b\u3088\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30eb\u30ae\u30cb\u30f3\u5074\u9396\u306e\u300c\u30b0\u30a2\u30cb\u30b8\u30f3\uff08HN=C(NH2)2\uff09\u300d\u304c\u3001\u8102\u8cea\u4ee3\u8b1d\u7269\u3067\u3042\u308b\u300c\u5171\u5f79\u30a2\u30eb\u30c7\u30d2\u30c9\uff08\u30a2\u30eb\u30c7\u30d2\u30c9\u57fa\u306eC=O\u306e\u4e8c\u91cd\u7d50\u5408\u3068\u5171\u5f79\u3059\u308b\u4e8c\u91cd\u7d50\u5408\u3092\u3082\u3064\u5316\u5408\u7269\uff09\u300d\u3068\u53cd\u5fdc\u3057\u3066\u30012-\u30a2\u30df\u30ce\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u304c\u751f\u6210\u3055\u308c\u307e\u3059\uff08\u56f32\u4e0a\u6bb5\uff09\u3002\u3053\u306e\u53cd\u5fdc\u306b\u6ce8\u76ee\u306b\u3057\u3066\u3001\u30a2\u30eb\u30ae\u30cb\u30f3\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u30b0\u30a2\u30cb\u30b8\u30f3\u3068\u5171\u5f79\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u53cd\u5fdc\u6027\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30a2\u30eb\u30ae\u30cb\u30f3\u3068\u5171\u5f79\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u53cd\u5fdc\u3067\u306f\u53ce\u7387\u304c65\uff05\u3001N-\u30a2\u30ea\u30fc\u30eb\u30b0\u30a2\u30cb\u30b8\u30f3\u3068\u5171\u5f79\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u53cd\u5fdc\u3067\u306f86\uff05\u306e\u9ad8\u53ce\u7387\u30672-\u30a2\u30df\u30ce\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u304c\u751f\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f32\u4e0b\u6bb5\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-44258\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig2-610x512.png\" alt=\"20160831_fig2\" width=\"610\" height=\"512\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig2-610x512.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig2-768x645.png 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig2.png 772w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p>\u6b21\u306b\u3001\u3053\u306e\u81ea\u7136\u754c\u306e\u53cd\u5fdc\u3092\u5229\u7528\u3057\u3066\u3001\u4e00\u3064\u306e\u30d5\u30e9\u30b9\u30b3\u5185\u3067\u8a66\u85ac\u3092\u9806\u306b\u52a0\u3048\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4e2d\u9593\u4f53\u3092\u5168\u304f\u7cbe\u88fd\u3059\u308b\u3053\u3068\u306a\u304f\u3001\u30a2\u30b2\u30e9\u30b8\u30f3A\u3084\u305d\u306e\u8a98\u5c0e\u4f53\u3092\u4e00\u6319\u306b\u77ed\u6642\u9593\u3067\u5408\u6210\u3059\u308b\u300c\u30ef\u30f3\u30dd\u30c3\u30c8\u5408\u6210\u300d\u3092\u8a08\u753b\u3057\u307e\u3057\u305f\u3002\u3055\u307e\u3056\u307e\u306a\u691c\u8a0e\u306e\u7d50\u679c\u3001\u30d5\u30e9\u30b9\u30b3\u5185\u306b\u30a2\u30b2\u30e9\u30b8\u30f3A\u306e\u539f\u6599\u3068\u306a\u308b\u30a2\u30cb\u30ea\u30f3\u3001\u307e\u305f\u306f\u30a2\u30eb\u30ae\u30cb\u30f3\u3092\u52a0\u3048\u3001\u9806\u756a\u306b4\u7a2e\u985e\u306e\u8a66\u85ac\uff08\u30b7\u30a2\u30ca\u30df\u30c9\u3001\u5171\u5f79\u30a2\u30eb\u30c7\u30d2\u30c9\u3001\u30a2\u30f3\u30e2\u30cb\u30a2\u3001\u30a2\u30ea\u30fc\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\uff09\u3092\u4f5c\u7528\u3055\u305b\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001(1)\u30b0\u30a2\u30cb\u30b8\u30f3\u5316\u3001(2)\u30a4\u30df\u30f3\u306e\u5f62\u6210\u3001(3)\u74b0\u5316\u306b\u3088\u308b2-\u30a2\u30df\u30ce\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u306e\u5f62\u6210\u3001(4)\u30a2\u30f3\u30e2\u30cb\u30a2\u3068\u306e\u30a8\u30ca\u30df\u30f3\u306e\u5f62\u6210\u3001(5)\u30a2\u30ea\u30fc\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u3068\u306e\u30a2\u30b6\u30c8\u30ea\u30a8\u30f3\u306e\u5f62\u6210\u3001(6)\u30a2\u30b6\u96fb\u5b50\u74b0\u72b6\u53cd\u5fdc\u3001(7)\u81ea\u7136\u9178\u5316\u306b\u3088\u308b\u82b3\u9999\u65cf\u5316\u306e7\u7a2e\u985e\u306e\u53cd\u5fdc\u304c\u30d5\u30e9\u30b9\u30b3\u306e\u4e2d\u3067\u4e00\u6319\u306b\u9032\u884c\u3057\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u3053\u306e\u30ef\u30f3\u30dd\u30c3\u30c8\u5408\u6210\u306b\u3088\u308a\u3001\u30a2\u30b2\u30e9\u30b8\u30f3A\u306e\u307b\u304b\u306b\u3001\u3053\u308c\u307e\u3067\u5408\u6210\u3067\u304d\u306a\u304b\u3063\u305f\u3055\u307e\u3056\u307e\u306a\u30a2\u30b2\u30e9\u30b8\u30f3A\u306e\u8a98\u5c0e\u4f53\uff0816\u7a2e\uff09\u304c\u5408\u6210\u3067\u304d\u307e\u3057\u305f\u3002\u4e2d\u3067\u3082\u8a98\u5c0e\u4f53c\u306f34\uff05\u3068\u3044\u3046\u9ad8\u53ce\u7387\u3067\u5408\u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\uff08\u56f34\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-44259\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160813_fig3-610x356.png\" alt=\"20160813_fig3\" width=\"610\" height=\"356\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160813_fig3-610x356.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160813_fig3-768x448.png 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160813_fig3.png 823w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-44260\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig4-610x700.png\" alt=\"20160831_fig4\" width=\"610\" height=\"700\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig4-610x700.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig4.png 652w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p>\u7d9a\u3044\u3066\u3001\u5408\u6210\u3057\u305f\u30a2\u30b2\u30e9\u30b8\u30f3A\u306e\u8a98\u5c0e\u4f53\u3092\u30de\u30a6\u30b9\u306eES\u7d30\u80de\u304b\u3089\u8abf\u88fd\u3057\u305f\u795e\u7d4c\u5e79\u7d30\u80de\uff08\u5404\u795e\u7d4c\u7d30\u80de\u306e\u3082\u3068\u306b\u306a\u308b\u7d30\u80de\uff09\u306b\u4f5c\u7528\u3055\u305b\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\uff08\u795e\u7d4c\u7d30\u80de\uff09\u3078\u306e\u5206\u5316\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001\u56f34\u306b\u793a\u3057\u305f2\u7a2e\u985e\u306e\u8a98\u5c0e\u4f53b\u304a\u3088\u3073l\u3067\u306f\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u304c\u8457\u3057\u304f\u9032\u307f\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u795e\u7d4c\u7d30\u80de\u3078\u306e\u5206\u5316\u3092\u4fc3\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u5316\u5408\u7269\u300c\u30cf\u30eb\u30df\u30f3\uff08Dyrk1A\u963b\u5bb3\u5264\uff09<sup>[9]<\/sup>\u300d\u3092\u4e0a\u56de\u308b\u5206\u5316\u4fc3\u9032\u6d3b\u6027\u3067\u3042\u308a\u300110\u30ca\u30ce\u30e2\u30eb\uff08nM\u30011nM\u306f10\u5104\u5206\u306e1M\uff09\u3068\u3044\u3046\u6975\u4f4e\u6fc3\u5ea6\u306b\u304a\u3044\u3066\u3082\u6d3b\u6027\u3092\u4fdd\u6301\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u5225\u306e\u8a98\u5c0e\u4f53i\u306f\u3001\u9006\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u309210nM\u3067\u6291\u5236\u3059\u308b\u3053\u3068\u3082\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u4e00\u822c\u7684\u306b\u795e\u7d4c\u5e79\u7d30\u80de\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u3060\u3051\u3067\u306a\u304f\u3001\u30b0\u30ea\u30a2\u7d30\u80de\uff08\u795e\u7d4c\u7cfb\u3092\u69cb\u7bc9\u3059\u308b\u7d30\u80de\u306e\u3046\u3061\u795e\u7d4c\u7d30\u80de\u3067\u306f\u306a\u3044\u7d30\u80de\u306e\u7dcf\u79f0\uff09\u306e\u4e00\u3064\u3067\u3042\u308b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306a\u3069\u306b\u3082\u5206\u5316\u3057\u307e\u3059\u304c\u3001\u4eca\u56de\u898b\u51fa\u3057\u305f\u4e09\u3064\u306e\u8a98\u5c0e\u4f53\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u306e\u5206\u5316\u306b\u306f\u5168\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u30a2\u30b2\u30e9\u30b8\u30f3A\u306e\u8a98\u5c0e\u4f53\u306f\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u3060\u3051\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f35\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-44261\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig5-610x656.png\" alt=\"20160831_fig5\" width=\"610\" height=\"656\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig5-610x656.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig5.png 642w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p>\u3055\u3089\u306b\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u6d3b\u6027\u767a\u73fe\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u8a98\u5c0e\u4f53b\u306b\u3064\u3044\u3066\u3001\u907a\u4f1d\u5b50\u30aa\u30f3\u30c8\u30ed\u30b8\u30fc[10]\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u3082\u3068\u306b\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u306b\u95a2\u308f\u308b\u8a0826\u7a2e\u306e\u30ad\u30ca\u30fc\u30bc\uff08\u30ea\u30f3\u9178\u5316\u9175\u7d20\uff09\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u8a98\u5c0e\u4f53b\u3092\u795e\u7d4c\u5e79\u7d30\u80de\u306b\u4f5c\u7528\u3055\u305b\u305f\u3068\u304d\u306b\u306f\u3001\u975e\u7279\u7570\u7684\u306a\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u304c\u306a\u304f\u306a\u308a\u3001\u3053\u306e\u305f\u3081\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u9078\u629e\u7684\u306a\u5206\u5316\u4fc3\u9032\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>\uff13\uff0e\u4eca\u5f8c\u306e\u671f\u5f85<\/h3>\n<p>\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306b\u3088\u3063\u3066\u5e79\u7d30\u80de\u304b\u3089\u7279\u5b9a\u306e\u7d30\u80de\u3001\u4f8b\u3048\u3070\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3001\u3042\u308b\u3044\u306f\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u3078\u3068\u5206\u5316\u3055\u305b\u308b\u65b9\u6cd5\u306f\u307e\u3060\u5341\u5206\u306b\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3042\u308b\u7d30\u80de\u3078\u306e\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u5206\u5b50\u306f\u3001\u5225\u306e\u7d30\u80de\u3078\u306e\u5206\u5316\u3092\u6291\u5236\u3059\u308b\u306a\u3069\u3001\u8907\u96d1\u306a\u56e0\u679c\u95a2\u4fc2\u306e\u3082\u3068\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306b\u3088\u3063\u3066\u898b\u51fa\u3055\u308c\u305f\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u306e\u8a98\u5c0e\u4f53\u306f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u306e\u307f\u3092\u9078\u629e\u7684\u306b\u4fc3\u9032\u307e\u305f\u306f\u6291\u5236\u3067\u304d\u307e\u3059\u3002\u672c\u6210\u679c\u306f\u3001\u4eca\u5f8c\u3001\u8907\u96d1\u306a\u795e\u7d4c\u5206\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3084\u3001\u3055\u3089\u306b\u306f\u30c0\u30a6\u30f3\u75c7\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u795e\u7d4c\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u3068\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<h3>\uff14\uff0e\u8ad6\u6587\u60c5\u5831<\/h3>\n<h5>\u30bf\u30a4\u30c8\u30eb<\/h5>\n<p><a href=\"http:\/\/dx.doi.org\/10.1002\/chem.201602651\" target=\"_blank\">One-pot evolution of ageladine A via bio-inspired cascade towards selective modulators of neuronal differentiation<\/a><\/p>\n<h5>\u8457\u8005\u540d<\/h5>\n<p>Takayuki Iwata, Satoshi Otsuka, Kazuki Tsubokura, Almira Kurbangalieva, Daisuke Arai, Koichi Fukase, Yoichi Nakao, Katsunori Tanaka<\/p>\n<h5>\u96d1\u8a8c<\/h5>\n<p>Chemistry &#8211; A European Journal<\/p>\n<h5>DOI<\/h5>\n<p>10.1002\/chem.201602651<\/p>\n<h3>\uff15\uff0e\u88dc\u8db3\u8aac\u660e<\/h3>\n<ul>\n<li>[1] \u30a2\u30b2\u30e9\u30b8\u30f3A<br \/>\n\u6d77\u7dbf\u52d5\u7269Agelas nakamurai\u3088\u308a\u5358\u96e2\u3055\u308c\u305f\u6d77\u7523\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u3002\u7d30\u80de\u5916\u57fa\u8cea\u306e\u5206\u89e3\u30fb\u4ee3\u8b1d\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u9175\u7d20\u306e\u4e00\u7fa4\u3067\u3042\u308b\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMPs\uff09\u306e\u963b\u5bb3\u6d3b\u6027\u3068\u3001\u3053\u308c\u306b\u4f34\u3046\u8840\u7ba1\u65b0\u751f\uff08\u65e2\u5b58\u306e\u8840\u7ba1\u304b\u3089\u65b0\u3057\u3044\u8840\u7ba1\u3092\u4f5c\u308b\u751f\u7406\u73fe\u8c61\uff09\u306e\u963b\u5bb3\u6d3b\u6027\u3092\u6301\u3064\u3002<\/li>\n<li>[2] \u795e\u7d4c\u5e79\u7d30\u80de<br \/>\n\u30cb\u30e5\u30fc\u30ed\u30f3\uff08\u795e\u7d4c\u7d30\u80de\uff09\u304a\u3088\u3073\u30b0\u30ea\u30a2\u7d30\u80de\uff08\u795e\u7d4c\u7cfb\u3092\u69cb\u7bc9\u3059\u308b\u7d30\u80de\u306e\u3046\u3061\u795e\u7d4c\u7d30\u80de\u3067\u306f\u306a\u3044\u7d30\u80de\u306e\u7dcf\u79f0\uff09\u3078\u3068\u5206\u5316\u3059\u308b\u80fd\u529b\u3092\u6301\u3064\u5e79\u7d30\u80de\u3002\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3001\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306a\u3069\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u4ee5\u5916\u306e\u795e\u7d4c\u7cfb\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u304c\u3042\u308b\u3002<\/li>\n<li>[3] \u6d77\u7523\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9<br \/>\n\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306f\u3001\u4e3b\u306b\u7a92\u7d20\u539f\u5b50\u3092\u6301\u3064\u690d\u7269\u7531\u6765\u306e\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u306e\u7dcf\u79f0\u3002\u6d77\u7dbf\u52d5\u7269\u7531\u6765\u306e\u5316\u5408\u7269\u306b\u3082\u7a92\u7d20\u3092\u542b\u3080\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u304c\u591a\u6570\u5b58\u5728\u3057\u3001\u4e00\u822c\u7684\u306b\u3053\u308c\u3089\u3092\u307e\u3068\u3081\u3066\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u3068\u547c\u3076\u3002\u6d77\u7523\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306f\u591a\u7a2e\u591a\u69d8\u306a\u751f\u7406\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u5275\u85ac\u306e\u30ea\u30fc\u30c9\u5316\u5408\u7269\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u308b\u3053\u3068\u3082\u591a\u3044\u3002<\/li>\n<li>[4] \u30ef\u30f3\u30dd\u30c3\u30c8\u5408\u6210<br \/>\n\u30d5\u30e9\u30b9\u30b3\u306b\u5165\u308c\u305f\u539f\u6599\u5316\u5408\u7269\u306b\u5bfe\u3057\u3066\u3001\u53cd\u5fdc\u8a66\u85ac\u3092\u9806\u6b21\u4f5c\u7528\u3055\u305b\u308b\u3053\u3068\u3067\u591a\u6bb5\u968e\u306e\u53cd\u5fdc\u3092\u4e00\u6319\u306b\u884c\u3046\u624b\u6cd5\u3002\u901a\u5e38\u306e\u6709\u6a5f\u5408\u6210\u3067\u306f\u4e00\u6bb5\u968e\u305a\u3064\u53cd\u5fdc\u3092\u505c\u6b62\u3055\u305b\u3001\u7cbe\u88fd\u4f5c\u696d\u3092\u884c\u3063\u305f\u5f8c\u3001\u6b21\u306e\u53cd\u5fdc\u3092\u884c\u3046\u304c\u3001\u30ef\u30f3\u30dd\u30c3\u30c8\u5408\u6210\u3067\u306f\u591a\u6bb5\u968e\u306e\u53cd\u5fdc\u3092\u505c\u6b62\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u884c\u3046\u3002\u305d\u306e\u305f\u3081\u3001\u901a\u5e38\u306e\u5408\u6210\u6cd5\u3088\u308a\u3082\u53cd\u5fdc\u306e\u5236\u5fa1\u306f\u96e3\u3057\u304f\u306a\u308b\u304c\u3001\u4e00\u65b9\u3067\u6642\u9593\u3092\u8981\u3059\u308b\u7cbe\u88fd\u4f5c\u696d\u3092\u7701\u7565\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u77ed\u6642\u9593\u306b\u76ee\u7684\u306e\u5316\u5408\u7269\u3092\u5408\u6210\u3067\u304d\u308b\u3002<\/li>\n<li>[5] ES\u7d30\u80de\u3001iPS\u7d30\u80de<br \/>\nES\u7d30\u80de\u306f\u53d7\u7cbe\u5375\u304c\u5206\u5316\u3057\u3066\u3067\u304d\u305f\u767a\u751f\u521d\u671f\u306e\u80da\u306e\u7d30\u80de\u304b\u3089\u4f5c\u3089\u308c\u3001\u3059\u3079\u3066\u306e\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u80fd\u529b\u3092\u6301\u3064\u3002iPS\u7d30\u80de\u306f\u7dda\u7dad\u82bd\u7d30\u80de\u306a\u3069\u306e\u5206\u5316\u7d30\u80de\u306b\u30013\uff5e4\u500b\u306e\u8ee2\u5199\u56e0\u5b50\u3092\u5c0e\u5165\u3059\u308b\u306a\u3069\u3057\u3066\u4f5c\u3089\u308c\u305f\u591a\u5206\u5316\u80fd\u3092\u6301\u3064\u7d30\u80de\u3002ES\u7d30\u80de\u306e\u3088\u3046\u306b\u3001\u3042\u3089\u3086\u308b\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u3002ES\u7d30\u80de\u304c\u62b1\u3048\u308b\u502b\u7406\u7684\u554f\u984c\u3092\u89e3\u6c7a\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u307e\u305f\u60a3\u8005\u81ea\u8eab\u306e\u7d30\u80de\u304b\u3089\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3001iPS\u7d30\u80de\u304b\u3089\u5206\u5316\u3057\u305f\u7d30\u80de\u3092\u60a3\u8005\u306b\u79fb\u690d\u3057\u3066\u3082\u62d2\u7d76\u53cd\u5fdc\u304c\u8d77\u304d\u306b\u304f\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<li>[6] \u533b\u85ac\u54c1\u30ea\u30fc\u30c9\u5316\u5408\u7269<br \/>\n\u671b\u307e\u3057\u3044\u751f\u7406\u6d3b\u6027\u3092\u793a\u3059\u5316\u5408\u7269\u3092\u533b\u85ac\u54c1\u3068\u3057\u3066\u4f7f\u3046\u305f\u3081\u306b\u306f\u3001\u4f53\u5185\u3067\u306e\u5b89\u5b9a\u6027\u3084\u52d5\u614b\u3001\u3042\u308b\u3044\u306f\u6bd2\u6027\u3084\u526f\u4f5c\u7528\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u6761\u4ef6\u3092\u6e80\u305f\u3055\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u305d\u306e\u305f\u3081\u306b\u5316\u5408\u7269\u306e\u69cb\u9020\u3092\u9806\u6b21\u5909\u5316\u3055\u305b\u3066\u3044\u304f\u304c\u3001\u305d\u306e\u5143\u3068\u306a\u308b\u6700\u521d\u306e\u5316\u5408\u7269\u3092\u30ea\u30fc\u30c9\u5316\u5408\u7269\u3068\u547c\u3076\u3002<\/li>\n<li>[7] 2-\u30a2\u30df\u30ce\u30a4\u30df\u30c0\u30be\u30fc\u30eb<br \/>\n\u4e0b\u8a18\u306e\u69cb\u9020\u3067\u793a\u3055\u308c\u308b\u6709\u6a5f\u5316\u5408\u7269\u3002\u591a\u304f\u306e\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u306b\u542b\u307e\u308c\u3001\u305d\u306e\u5408\u6210\u6cd5\u306f\u6709\u6a5f\u5316\u5b66\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-44262\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/09\/20160831_fig6.png\" alt=\"20160831_fig6\" width=\"203\" height=\"126\" \/><\/p>\n<ul>\n<li>[8] \u7ffb\u8a33\u5f8c\u4fee\u98fe<br \/>\n\u30bf\u30f3\u30d1\u30af\u8cea\u304cDNA\u60c5\u5831\u3092\u3082\u3068\u306b\u4f5c\u3089\u308c\u308b\u904e\u7a0b\u3092\u7ffb\u8a33\u3068\u547c\u3073\u3001\u7ffb\u8a33\u5f8c\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5316\u5b66\u7684\u306a\u4fee\u98fe\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3068\u547c\u3076\u3002\u4e00\u822c\u7684\u306b\u306f\u3001\u9175\u7d20\u306b\u3088\u3063\u3066\u7cd6\u3084\u30ea\u30f3\u9178\u306a\u3069\u304c\u4ed8\u52a0\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u305d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u672c\u6765\u306e\u6a5f\u80fd\u3092\u793a\u3059\u3088\u3046\u306b\u306a\u308b\u3002\u4eca\u56de\u7740\u76ee\u3057\u305f2-\u30a2\u30df\u30ce\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u3092\u4e0e\u3048\u308b\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3067\u306f\u3001\u9175\u7d20\u3092\u4ecb\u3055\u305a\u8102\u8cea\u4ee3\u8b1d\u7269\u3067\u3042\u308b\u5171\u5f79\u30a2\u30eb\u30c7\u30d2\u30c9\u3068\u53cd\u5fdc\u3059\u308b\u3002<\/li>\n<li>[9] \u30cf\u30eb\u30df\u30f3\uff08Dyrk1A\u963b\u5bb3\u5264\uff09<br \/>\nDyrk1A\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u5897\u6b96\u3084\u5206\u5316\u3092\u6291\u5236\u3059\u308b\u30bb\u30ea\u30f3\u30fb\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u3001\u30c0\u30a6\u30f3\u75c7\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002Dyrk1A\u3092\u963b\u5bb3\u3059\u308b\u5316\u5408\u7269\u306f\u3053\u308c\u3089\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002\u30cf\u30eb\u30df\u30f3\u306fDyrk1A\u3092\u963b\u5bb3\u3059\u308b\u5178\u578b\u7684\u306a\u5316\u5408\u7269\u3067\u3042\u308a\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u3092\u4fc3\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002Dyrk1A \u306fDual Specificity Tyrosine-Phosphorylation-Regulated Kinase1A\u306e\u7565\u3002<\/li>\n<li>[10] \u907a\u4f1d\u5b50\u30aa\u30f3\u30c8\u30ed\u30b8\u30fc<br \/>\n\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u7528\u8a9e\u3092\u5206\u5b50\u6a5f\u80fd\u3001\u7d30\u80de\u306e\u69cb\u6210\u8981\u7d20\u3001\u751f\u7269\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u5206\u985e\u3057\u305f\u751f\u7269\u5b66\u5206\u91ce\u306b\u304a\u3051\u308b\u5171\u901a\u8a9e\u5f59\u96c6\u3002\u3053\u308c\u3092\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u5316\u3057\u305f\u3082\u306e\u3092\u907a\u4f1d\u5b50\u30aa\u30f3\u30c8\u30ed\u30b8\u30fc\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3068\u547c\u3073\u3001\u4f8b\u3048\u3070\u3001\u3042\u308b\u7528\u8a9e\u3067\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u691c\u7d22\u3059\u308b\u3068\u3001\u305d\u306e\u7528\u8a9e\u3092\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\uff08\u6ce8\u91c8\uff09\u306b\u6301\u3064\u907a\u4f1d\u5b50\u306e\u4e00\u89a7\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u795e\u7d4c\u5206\u5316\u306b\u95a2\u308f\u308b\u30ad\u30ca\u30fc\u30bc\u3092\u9078\u629e\u3057\u305f\u3002<\/li>\n<\/ul>\n<h3>\uff16\uff0e\u767a\u8868\u8005<\/h3>\n<ul>\n<li>\u7406\u5316\u5b66\u7814\u7a76\u6240\u3000\u7530\u4e2d\u751f\u4f53\u6a5f\u80fd\u5408\u6210\u5316\u5b66\u7814\u7a76\u5ba4<br \/>\n\u51c6\u4e3b\u4efb\u7814\u7a76\u54e1\u3000\u7530\u4e2d\u3000\u514b\u5178\uff08\u305f\u306a\u304b\u3000\u304b\u3064\u306e\u308a\uff09<br \/>\n\u7814\u4fee\u751f\uff08\u7814\u7a76\u5f53\u6642\uff09\u3000\u5ca9\u7530\u3000\u9686\u5e78\uff08\u3044\u308f\u305f\u3000\u305f\u304b\u3086\u304d\uff09<br \/>\n\uff08\u73fe\u3000\u4e5d\u5dde\u5927\u5b66\u5148\u5c0e\u7269\u8cea\u5316\u5b66\u7814\u7a76\u6240\u3000\u52a9\u6559\uff09<br \/>\nTEL\uff1a048-467-9405\u3000FAX\uff1a048-467-9379<br \/>\nE-mail\uff1akotzenori@riken.jp\uff08\u7530\u4e2d\uff09<\/li>\n<li>\u65e9\u7a32\u7530\u5927\u5b66\u3000\u7406\u5de5\u5b66\u8853\u9662<br \/>\n\u6559\u6388\u3000\u4e2d\u5c3e\u3000\u6d0b\u4e00\uff08\u306a\u304b\u304a\u3000\u3088\u3046\u3044\u3061\uff09<br \/>\n\u52a9\u624b\u3000\u5927\u585a\u3000\u609f\u53f2\uff08\u304a\u304a\u3064\u304b\u3000\u3055\u3068\u3057\uff09<br \/>\nTEL\uff1a03-5286-3100\uff08\u4e2d\u5c3e\uff09<br \/>\nE-mail\uff1aayocha@waseda.jp\uff08\u4e2d\u5c3e\uff09otsuka3104@aoni.waseda.jp\uff08\u5927\u585a\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u7406\u7814\uff09\u7530\u4e2d\u751f\u4f53\u6a5f\u80fd\u5408\u6210\u5316\u5b66\u7814\u7a76\u5ba4\u306e\u7530\u4e2d\u514b\u5178\u51c6\u4e3b\u4efb\u7814\u7a76\u54e1\u3001\u5ca9\u7530\u9686\u5e78\u7814\u4fee\u751f\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e\u4e2d\u5c3e\u6d0b\u4e00\u6559\u6388\u3001\u5927\u585a\u609f\u53f2\u52a9\u624b\u3089\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u203b\u306f\u3001\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u3067\u3042\u308b\u300c\u30a2\u30b2\u30e9\u30b8\u30f3A[1]\u300d\u306e [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":44259,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[5],"class_list":["post-44256","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/44256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=44256"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/44256\/revisions"}],"predecessor-version":[{"id":44418,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/44256\/revisions\/44418"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/44259"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=44256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=44256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=44256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}