{"id":43235,"date":"2016-07-15T18:00:07","date_gmt":"2016-07-15T09:00:07","guid":{"rendered":"http:\/\/www.waseda.jp\/top\/?p=43235"},"modified":"2016-07-18T18:43:50","modified_gmt":"2016-07-18T09:43:50","slug":"%e7%b2%be%e7%a5%9e%e9%81%85%e6%bb%9e%e5%8e%9f%e5%9b%a0%e9%81%ba%e4%bc%9d%e5%ad%90%e7%94%a3%e7%89%a9%e3%82%bb%e3%83%ac%e3%83%96%e3%83%ad%e3%83%b3%e3%81%ae%e6%8a%97%e9%85%b8%e5%8c%96%e3%82%b9%e3%83%88","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/43235","title":{"rendered":"\u7cbe\u795e\u9045\u6ede\u539f\u56e0\u907a\u4f1d\u5b50\u7523\u7269\u30bb\u30ec\u30d6\u30ed\u30f3\u306e\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u89e3\u660e \u7cbe\u795e\u9045\u6ede\u306b\u6709\u52b9\u306a\u85ac\u5264\u958b\u767a\u306b\u671f\u5f85"},"content":{"rendered":"<p>\u65e9\u7a32\u7530\u5927\u5b66\u30ca\u30ce\u30fb\u30e9\u30a4\u30d5\u5275\u65b0\u7814\u7a76\u6a5f\u69cb\u306e<a href=\"https:\/\/researchers.waseda.jp\/profile\/ja.bdfa14e16506e71cee79f425781edf7c.html\" target=\"_blank\">\u6fa4\u6751\u76f4\u54c9\uff08\u3055\u308f\u3080\u3089\u306a\u304a\u3084\uff09\u4e3b\u4efb\u7814\u7a76\u54e1\uff08\u7814\u7a76\u9662\u51c6\u6559\u6388\uff09<\/a>\u3068\u3001\u7406\u5de5\u5b66\u8853\u9662\u30fb<a href=\"http:\/\/asahi-lab.jp\/\" target=\"_blank\">\u671d\u65e5\u900f\u6559\u6388<\/a>\uff08\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b\u30fb\u5148\u9032\u7406\u5de5\u5b66\u5c02\u653b\uff09\u3001\u540c\u7814\u7a76\u79d1\u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b1\u5e74\u30fb\u7247\u5ca1\u5b5d\u4ecb\u6c0f\u3001\u540c\u7814\u7a76\u79d1\u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b\u4fee\u58eb\u8ab2\u7a0b\u4fee\u4e86\u30fb\u4e2d\u6751\u667a\u83dc\u6c0f\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7cbe\u795e\u9045\u6ede\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30bb\u30ec\u30d6\u30ed\u30f3\uff08Cereblon\u3001\u4ee5\u4e0bCRBN\uff09\u304c\u3001\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>CRBN\u306f\u7cbe\u795e\u9045\u6ede\u3092\u983b\u767a\u3059\u308b\u5bb6\u7cfb\u306e\u89e3\u6790\u304b\u3089\u5f97\u3089\u308c\u3066\u304d\u305f\u907a\u4f1d\u5b50\u7523\u7269\u3067\u3059\u3002CRBN\u306e\u5909\u7570\u306e\u898b\u3089\u308c\u308b\u7cbe\u795e\u9045\u6ede\u306e\u5bb6\u7cfb\u306e\u60a3\u8005\u3067\u306f\u3001CRBN\u304c\u5207\u65ad\u3092\u53d7\u3051\u308b\u3053\u3068\u306b\u3088\u308a\u3001CRBN\u306e\u6a5f\u80fd\u304c\u55aa\u5931\u3057\u3001\u7cbe\u795e\u9045\u6ede\u304c\u767a\u75c7\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002CRBN\u306f\u767a\u898b\u5f53\u521d\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u50cd\u304fLon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u9ad8\u3044\u30a2\u30df\u30ce\u9178\u76f8\u540c\u6027\u3092\u793a\u3059\u3053\u3068\u304b\u3089\u3001Lon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u540c\u69d8\u306b\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3064\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001CRBN \u304c\u69d8\u3005\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u306b\u5b58\u5728\u3059\u308b\u591a\u6a5f\u80fd\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u305f\u3081\u3001\u6a5f\u80fd\u3092\u691c\u8a3c\u3059\u308b\u306e\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001CRBN\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u79fb\u884c\u30b7\u30b0\u30ca\u30eb (Mitochondria targeting sequence; MTS) \u3092\u4ed8\u52a0\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3055\u305b\u3001CRBN \u306eLon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u3068\u3044\u3046\u624b\u6cd5\u3092\u958b\u767a\u3057\u3001\u691c\u8a3c\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001CRBN \u306fLon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u540c\u69d8\u306b\u3001\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u4e8b\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eca\u5f8c\u3001\u672c\u7814\u7a76\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3051\u308bCRBN\u306e\u6a5f\u80fd\u89e3\u660e\u304c\u3001\u7cbe\u795e\u9045\u6ede\u306b\u6709\u52b9\u306a\u85ac\u5264\u306e\u958b\u767a\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001Lon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306f\u69d8\u3005\u306a\u5916\u90e8\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3001\u305d\u306e\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3068\u8001\u5316\u3068\u306e\u95a2\u308f\u308a\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5206\u5b50\u3068\u3057\u3066\u306eCRBN\u306b\u7740\u76ee\u3057\u3001CRBN\u3092\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u305d\u306e\u6fc3\u5ea6\u3092\u8a08\u6e2c\u3067\u304d\u308c\u3070\u3001\u30b9\u30c8\u30ec\u30b9\u3084\u8001\u5316\u306e\u6307\u6a19\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306f\u65e9\u7a32\u7530\u5927\u5b66\u304c\u30b5\u30c6\u30e9\u30a4\u30c8\u3068\u3057\u3066\u5c55\u958b\u3057\u3066\u3044\u308b\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09\u304c\u63a8\u9032\u3059\u308b\u30bb\u30f3\u30bf\u30fc\u30fb\u30aa\u30d6\u30fb\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\uff08COI\uff09\u30d7\u30ed\u30b0\u30e9\u30e0**\u306e<a href=\"http:\/\/www.jst.go.jp\/coi\/site\/vision\/vision01_3.html\" target=\"_blank\">\u300c\u3055\u308a\u3052\u306a\u3044\u30bb\u30f3\u30b7\u30f3\u30b0\u3068\u65e5\u5e38\u4eba\u9593\u30c9\u30c3\u30af\u3067\u5b9f\u73fe\u3059\u308b\u7406\u60f3\u81ea\u5df1\u3068\u5bb6\u65cf\u306e\u7d46\u304c\u5c0e\u304f\u30e2\u30c1\u30d9\u30fc\u30b7\u30e7\u30f3\u5411\u4e0a\u793e\u4f1a\u5275\u751f\u62e0\u70b9\u300d<\/a>\u3067\u5f97\u3089\u308c\u305f\u7814\u7a76\u6210\u679c\u3067\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u82f1\u56fdNature Publishing Group\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u79d1\u5b66\u96d1\u8a8c\u300eScientific Reports\u300f\u306b\u3001\uff17\u670815\u65e510\u6642\uff08\u65e5\u672c\u6642\u9593\uff17\u670815\u65e518\u6642\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u63b2\u8f09\u8ad6\u6587\uff1a<a href=\"http:\/\/www.nature.com\/articles\/srep29986\" target=\"_blank\">Mitochondrial cereblon functions as a Lon-type protease<\/a><\/p>\n<ul>\n<li>**<a href=\"http:\/\/www.jst.go.jp\/coi\/outline\/outline.html\" target=\"_blank\">\u30bb\u30f3\u30bf\u30fc\u30fb\u30aa\u30d6\u30fb\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\uff08COI\uff09\u30d7\u30ed\u30b0\u30e9\u30e0<\/a>\uff1a\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09\u306b\u3088\u308b\u516c\u52df\u578b\u7814\u7a76\u958b\u767a\u30d7\u30ed\u30b0\u30e9\u30e0\u3002\u73fe\u5728\u6f5c\u5728\u3057\u3066\u3044\u308b\u5c06\u6765\u793e\u4f1a\u306e\u30cb\u30fc\u30ba\u304b\u3089\u5c0e\u304d\u51fa\u3055\u308c\u308b\u3042\u308b\u3079\u304d\u793e\u4f1a\u306e\u59ff\u3001\u66ae\u3089\u3057\u306e\u5728\u308a\u65b9\u3092\u898b\u636e\u3048\u305f\u30d3\u30b8\u30e7\u30f3\u306b\u57fa\u3065\u304d\u3001\u4f01\u696d\u3060\u3051\u3067\u306f\u5b9f\u73fe\u3067\u304d\u306a\u3044\u9769\u65b0\u7684\u306a\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u3092\u5275\u51fa\u3059\u308b\u305f\u3081\u3001\u7523\u5b66\u9023\u643a\u306b\u3088\u308b\u7814\u7a76\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<h4>(\uff11)\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/h4>\n<p>Cereblon (CRBN) \u306f\u7cbe\u795e\u9045\u6ede\u3092\u983b\u767a\u3059\u308b\u5bb6\u7cfb\u306e\u89e3\u6790\u304b\u3089\u5f97\u3089\u308c\u3066\u304d\u305f\u907a\u4f1d\u5b50\u7523\u7269\u3067\u3059\u3002\u3053\u306e\u5bb6\u7cfb\u306e\u60a3\u8005\u3067\u306f\u77e5\u80fd\u6307\u6570\u304c\u4f4e\u3044\uff08IQ\u304c 50-70\u306e\u7bc4\u56f2\u3067\u3042\u308b\uff09\u3068\u3044\u3046\u6bd4\u8f03\u7684\u8efd\u5ea6\u306e\u7cbe\u795e\u9045\u6ede\u306e\u75c7\u72b6\u3092\u793a\u3059\u4e8b\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5bb6\u7cfb\u306e\u60a3\u8005\u304b\u3089 CRBN \u306e\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u304c\u767a\u898b\u3055\u308c\u3001CRBN\u306e\u5f8c\u534a\u90e8\u306b\u505c\u6b62\u30b3\u30c9\u30f3\u304c\u5165\u308b\u4e8b\u304b\u3089\u3001 CRBN\u304c\u5207\u65ad\u3092\u53d7\u3051\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u7cbe\u795e\u9045\u6ede\u304c\u767a\u75c7\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059 (Higgins et al. <em>Neurology<\/em> <strong>63<\/strong>, 1927-1931 (2004))\u3002<\/p>\n<p>CRBN \u306f\u69d8\u3005\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u306b\u5b58\u5728\u3059\u308b\u305f\u3081\u3001\u591a\u6a5f\u80fd\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002CRBN\u306f\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3001E3\u30e6\u30d3\u30ad\u30c1\u30f3\u30ea\u30ac\u30fc\u30bc\u8907\u5408\u4f53\u306e\u4e00\u90e8\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u4e8b\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08Ito et al. <em>Science<\/em> <strong>327<\/strong>, 1345-1350 (2010))\u3002\u6211\u3005\u306f\u3053\u306e\u5831\u544a\u306b\u57fa\u3065\u304d\u3001CRBN \u306e\u7d30\u80de\u8cea\u3067\u306e\u6a5f\u80fd\u306b\u7740\u76ee\u3057\u3001CRBN\u304c\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u306b\u3088\u308a\u30a2\u30b0\u30ea\u30bd\u30fc\u30e0\u306b\u84c4\u7a4d\u3057\u3001\u7d30\u80de\u6b7b\u306b\u5bfe\u3059\u308b\u6291\u5236\u52b9\u679c\u3092\u6301\u3064\u4e8b\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f (Sawamura et al. <em>BBRC<\/em> <strong>464<\/strong>, 1054-1059 (2015))\u3002\u307e\u305f\u3001\u6700\u8fd1\u3067\u306fCRBN\u304c\u6838\u306b\u5b58\u5728\u3057\u3001\u8ee2\u5199\u56e0\u5b50Ikaros\u306b\u7d50\u5408\u3059\u308b\u4e8b\u3067\u305d\u306e\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u4e8b\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\uff08Wada et al. <em>BBRC<\/em> <strong>477<\/strong>, 388-394 (2016))\u3002<\/p>\n<p>CRBN\u306f\u3001\u767a\u898b\u5f53\u521d\u306fLon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u9ad8\u3044\u30a2\u30df\u30ce\u9178\u76f8\u540c\u6027\u3092\u793a\u3059\u4e8b\u304b\u3089\u3001CRBN\u306eLon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u306e\u6a5f\u80fd\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3057\u305f\uff08\u56f3\uff11\uff09\u3002Lon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u306b\u5b58\u5728\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u4f34\u3063\u3066\u767a\u73fe\u91cf\u304c\u4e0a\u6607\u3057\u3001\u9178\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6e1b\u5c11\u30fb\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6291\u5236\u3068\u3044\u3063\u305f\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u793a\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u307e\u3067CRBN \u304cLon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u540c\u69d8\u306e\u6a5f\u80fd\u3092\u6301\u3064\u306e\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306f\u3001CRBN \u304c\u69d8\u3005\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u306b\u5b58\u5728\u3059\u308b\u591a\u6a5f\u80fd\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u305f\u3081\u3001\u89e3\u6790\u304c\u56f0\u96e3\u3067\u3042\u308a\u3001\u4e0d\u660e\u306e\u307e\u307e\u3067\u3057\u305f\u3002<\/p>\n<h4>\u00a0(2)\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/h4>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u795e\u7d4c\u7cfb\u306e\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066CRBN\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3044\u3066Lon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001CRBN\u306fLon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u306e\u6d3b\u6027\u3092\u6301\u3061\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h4>\u00a0(3)\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/h4>\n<p>\u524d\u8ff0\u306e\u901a\u308aCRBN \u306f\u69d8\u3005\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u306b\u5b58\u5728\u3057\u3001\u591a\u6a5f\u80fd\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u305f\u3081\u3001\u901a\u5e38\u306e\u72b6\u614b\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3051\u308b\u6a5f\u80fd\u3092\u691c\u8a3c\u3059\u308b\u306e\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002\u305d\u3053\u3067CRBN\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u79fb\u884c\u30b7\u30b0\u30ca\u30eb (Mitochondria targeting sequence; MTS) \u3092\u4ed8\u52a0\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3055\u305b\u3001CRBN \u306eLon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u3068\u3044\u3046\u624b\u6cd5\u3092\u958b\u767a\u3057\u3001\u691c\u8a3c\u3092\u884c\u3044\u307e\u3057\u305f\uff08\u56f3\uff11\uff09\u3002<\/p>\n<div id=\"attachment_43244\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-43244 size-medium\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig1-610x133.png\" alt=\"20160715_fig1\" width=\"610\" height=\"133\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig1-610x133.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig1-768x167.png 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig1.png 1646w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><p class=\"wp-caption-text\">\u56f3\uff11. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308bMTS-CRBN\u306e\u6a21\u5f0f\u56f3 CRBN\u306f442\u30a2\u30df\u30ce\u9178\u304b\u3089\u6210\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001237\u30a2\u30df\u30ce\u9178\u304b\u3089\u6210\u308bLon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u9ad8\u3044\u76f8\u540c\u6027\u3092\u793a\u3059Lon domain\uff0881-317\u30a2\u30df\u30ce\u9178\u306e\u90e8\u5206\uff09\u3092\u542b\u3093\u3067\u3044\u308b (MTS; Mitochondrial targeting signal, Myc; Myc tag.) \u3002 Scientific Reports 6, Article number: 29986, Figure No. 2a, 15 July 2016. \u00a9 Macmillan Publishers Limited.<\/p><\/div>\n<h4>(4)\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/h4>\n<p>CRBN\u3092\u57f9\u990a\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u7279\u7570\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u305f\u3081\u306b\u3001CRBN \u306eN \u672b\u7aef\u306bMTS \u3092\u4ed8\u52a0\u3057\u305fCRBN \u3092\u767a\u73fe\u3059\u308b\u30d9\u30af\u30bf\u30fc(pCMV\/myc\/mito-CRBN) \u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f\uff08\u56f3\uff11\uff09\u3002\u3053\u306e\u30d9\u30af\u30bf\u30fc\u3092\u30d2\u30c8\u795e\u7d4c\u82bd\u7d30\u80de\u816b\u7d30\u80deSH-SY5Y \u306b\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u6052\u5e38\u7684\u306bMTS-CRBN\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u3092\u78ba\u7acb\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067CRBN \u304c\u7279\u7570\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u4e8b\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\uff08\u56f3\uff12\uff09\u3002\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u78ba\u7acb\u3057\u305f\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3051\u308bCRBN \u304c\u3001Lon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u540c\u69d8\u306b\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3064\u304b\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_43245\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-43245 size-medium\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig2-610x240.png\" alt=\"20160715_fig2\" width=\"610\" height=\"240\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig2-610x240.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig2-768x302.png 768w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig2.png 1444w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><p class=\"wp-caption-text\">\u56f32. \u795e\u7d4c\u82bd\u7d30\u80de\u816b\u7d30\u80deSH-SY5Y\u7d30\u80de\u306b\u304a\u3051\u308bCRBN\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7279\u7570\u7684\u767a\u73fe \u5de6\u304b\u3089\u3001MTS-CRBN\u306e\u67d3\u8272\u50cf\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30de\u30fc\u30ab\u30fc\u306e\u67d3\u8272\u50cf\u3001MTS-CRBN\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u5171\u5c40\u5728\u3057\u3066\u3044\u308b\u4e8b\u3092\u793a\u3059\u86cd\u5149\u9855\u5fae\u93e1\u50cf\u3002 Scientific Reports 6, Article number: 29986, Figure No. 2d, 15 July 2016. \u00a9 Macmillan Publishers Limited.<\/p><\/div>\n<p>\u59cb\u3081\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u306eCRBN \u304c\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u306e\u6d3b\u6027\u3092\u6301\u3064\u304b\u3092\u3001\u9175\u7d20\u6d3b\u6027\u6e2c\u5b9a\u6cd5\u306b\u3088\u308a\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001MTS-CRBN \u30d9\u30af\u30bf\u30fc\u3092\u5c0e\u5165\u3057\u305fSH-SY5Y \u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3044\u3066\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u306e\u6709\u610f\u306a\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f (\u56f33)\u3002\u307e\u305f\u3001Lon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u3066\u767a\u73fe\u91cf\u304c\u4e0a\u6607\u3059\u308b\u3068\u3044\u3046\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001CRBN\u3082\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u7b54\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\u3001 CRBN\u306e\u767a\u73fe\u91cf\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u4e00\u904e\u7684\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u3092\u5b9a\u91cf\u3057\u305f\u7d50\u679c\u3001CRBN \u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7279\u7570\u7684\u767a\u73fe\u306b\u3088\u3063\u3066\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u6700\u5f8c\u306bCRBN \u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3064\u3053\u3068\u3092\u691c\u8a3c\u3057\u305f\u3068\u3053\u308d\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7279\u7570\u7684\u306aCRBN \u306e\u767a\u73fe\u306b\u3088\u3063\u3066\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u7d30\u80de\u6b7b\u304c\u6291\u5236\u3055\u308c\u308b\u4e8b\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f (\u56f3\uff14)\u3002<\/p>\n<div id=\"attachment_43246\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-43246\" src=\"http:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig3-610x707.png\" alt=\"20160715_fig3\" width=\"500\" height=\"580\" srcset=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig3-610x707.png 610w, https:\/\/www.waseda.jp\/top\/assets\/uploads\/2016\/07\/20160715_fig3.png 758w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><p class=\"wp-caption-text\">\u56f33. 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