{"id":28606,"date":"2015-07-02T20:36:55","date_gmt":"2015-07-02T11:36:55","guid":{"rendered":"http:\/\/www.waseda.jp\/top\/?p=28606"},"modified":"2016-06-06T11:21:51","modified_gmt":"2016-06-06T02:21:51","slug":"%e3%80%8c%e6%97%a9%e7%a8%b2%e7%94%b0%e7%a0%94%e7%a9%b6%e6%9c%80%e5%89%8d%e7%b7%9a%e3%80%8dvol-1%e3%80%80%e3%80%8c%e4%ba%94%e4%bd%93%e4%b8%8d%e6%ba%80%e8%b6%b3%e3%80%8d%e4%b9%99%e6%ad%a6%e6%b4%8b","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/top\/news\/28606","title":{"rendered":"\u300c\u7279\u96c6 Feature\u300dVol.1-1\u3000\u30d2\u30c8\u67d3\u8272\u4f53\u4e2d\u5fc3\u69cb\u9020\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u89e3\u660e\u3057\u305f\u7814\u7a76\u8005\uff08\u51684\u56de\u914d\u4fe1\uff09"},"content":{"rendered":"

\u69cb\u9020\u751f\u7269\u5316\u5b66
\n\u80e1\u6843\u5742\u4ec1\u5fd7\uff08\u304f\u308b\u307f\u3056\u304b\u3072\u3068\u3057\uff09\uff0f\u7406\u5de5\u5b66\u8853\u9662 \u5148\u9032\u7406\u5de5\u5b66\u90e8 \u96fb\u6c17\u30fb\u60c5\u5831\u751f\u547d\u5de5\u5b66\u79d1 \u6559\u6388<\/h3>\n

 <\/p>\n

\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u304c\u62d3\u304f\u65b0\u3057\u3044\u907a\u4f1d\u5b66<\/h2>\n

\"kurumizaka1\"<\/p>\n

\u4eba\u985e\u306f\u4eca\u3001\u65b0\u3057\u3044\u907a\u4f1d\u5b66\u3092\u898b\u3064\u3051\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002
\n<\/i>\u5f93\u6765\u306e\u907a\u4f1d\u5b66\u3067\u306f\u3001\u79c1\u305f\u3061\u306e\u8eab\u4f53\u3092\u69cb\u6210\u3059\u308b\u5168\u3066\u306e\u7d30\u80de\u304c\u6301\u3064DNA\u304c\u3001\u79c1\u305f\u3061\u306e\u8eab\u4f53\u3092\u3064\u304f\u308a\u3001\u5f8c\u4e16\u3078\u3068\u53d7\u3051\u7d99\u3050\u4e0a\u3067\u6700\u3082\u91cd\u8981\u306a\u8a2d\u8a08\u56f3\u3060\u3068\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u65b0\u3057\u3044\u907a\u4f1d\u5b66\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u300d\u306f\u3053\u306e\u8003\u3048\u65b9\u3092\u5927\u304d\u304f\u5909\u3048\u3066\u3044\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002
\n<\/i>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306f\u3001\u79c1\u305f\u3061\u306b\u4f55\u3092\u6559\u3048\u3066\u304f\u308c\u308b\u306e\u3067\u3057\u3087\u3046\uff1f\u3000\u65e9\u7a32\u7530\u5927\u5b66 \u7406\u5de5\u5b66\u8853\u9662 \u5148\u9032\u7406\u5de5\u5b66\u90e8 \u96fb\u6c17\u30fb\u60c5\u5831\u751f\u547d\u5de5\u5b66\u79d1 \u80e1\u6843\u5742\u4ec1\u5fd7\u6559\u6388\u306b\u304a\u805e\u304d\u3057\u307e\u3057\u305f\u3002<\/i><\/p>\n

\u00a0\u3010\u4e16\u754c\u521d\u3001\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u69cb\u9020\u3092\u6c7a\u5b9a\u3011<\/h3>\n
\"kurumizaka2\"

\u80e1\u6843\u5742\u4ec1\u5fd7\u6559\u6388\u3002\u7814\u7a76\u5ba4\u306b\u3066\u3002<\/p><\/div>\n

\u79c1\u306e\u5c02\u9580\u306f\u3001\u300c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08epigenetics\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u65b0\u3057\u3044\u907a\u4f1d\u5b66\u306e\u9818\u57df\u3067\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30d2\u30c8\u67d3\u8272\u4f53\u306e\u4e2d\u5fc3\u69cb\u9020\u3067\u3042\u308b\u300c\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u300d\u3092\u72ec\u81ea\u306e\u6280\u8853\u3067\u89e3\u6790\u3057\u3001\u4e16\u754c\u3067\u521d\u3081\u3066\u305d\u306e\u69cb\u9020\u3092\u6c7a\u5b9a\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u304c\u79d1\u5b66\u8a8c\u300eNature\u300f\uff08\u56f31\uff09\u306b\u63b2\u8f09\u3055\u308c\u305f\u300eCrystal structure of the human centromeric nucleosome containing CENP-A\u300f\uff08\u56f31\u53ca\u3073\u56f32\uff09\u3067\u3059\u3002<\/p>\n

\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306f\u300cX\u300d\u306e\u5f62\u3092\u3057\u305f\u67d3\u8272\u4f53\u306e\u304f\u3073\u308c\u305f\u9023\u7d50\u90e8\u5206\u306b\u3042\u305f\u308a\uff08\u56f33\uff09\u3001\u5206\u88c2\u671f\u306b\u907a\u4f1d\u5b50\u672c\u4f53\u3067\u3042\u308bDNA\uff08\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u6838\u9178,deoxyribonucleic acid\uff09\u3092\u5a18\u7d30\u80de\u306b\u5747\u7b49\u914d\u5206\u3059\u308b\u4e0a\u3067\u3001\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u3053\u306e\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u90e8\u54c1\u3092\u907a\u4f1d\u5b50\u5de5\u5b66\u7684\u306b\u4eba\u5de5\u5408\u6210\u3057\u3001\u8a66\u9a13\u7ba1\u306e\u4e2d\u3067\u7d44\u307f\u7acb\u3066\u305f\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u57fa\u76e4\u3068\u306a\u308b\u69cb\u9020\u4f53\u3092\u7d50\u6676\u5316\u3055\u305b\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u305d\u306e\u69cb\u9020\u306e\u6c7a\u5b9a\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u69cb\u9020\u6c7a\u5b9a\u306f\u3001\u30c0\u30a6\u30f3\u75c7\u306a\u3069\u306e\u67d3\u8272\u4f53\u5206\u914d\u7570\u5e38\u306b\u8d77\u56e0\u3059\u308b\u75be\u60a3\u306e\u539f\u56e0\u7a76\u660e\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3068\u3068\u3082\u306b\u3001\u907a\u4f1d\u5b50\u304c\u3069\u306e\u3088\u3046\u306b\u300c\u5206\u96e2\u30fb\u7d99\u627f\u300d\u3059\u308b\u304b\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3001\u3055\u3089\u306b\u306f\u304c\u3093\u6cbb\u7642\u306b\u9769\u547d\u3092\u8d77\u3053\u3059\u53ef\u80fd\u6027\u3082\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"kurumizaka3\"<\/p>\n

\u56f31\uff1a\u69cb\u9020\u751f\u7269\u5b66\uff1a\u300c\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u300dReprinted by permission from Macmillan Publishers Ltd.Nature\u3000Vol.476, 11 August 2011 , copyright 2011\u3000\u65e9\u7a32\u7530\u5927\u5b66\u56f3\u66f8\u9928\u6240\u8535<\/p>\n

\"kurumizaka4\"<\/p>\n

\u56f32 \uff1a\u4e16\u754c\u3067\u521d\u3081\u3066\u69cb\u9020\u304c\u6c7a\u5b9a\u3055\u308c\u305f\u3001\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u5206\u5b50\u69cb\u9020\u3002\u666e\u901a\u306e\u67d3\u8272\u4f53\u306e\u57fa\u76e4\u69cb\u9020\u3092\u6301\u3061\u306a\u304c\u3089\u3001DNA\u304c\u5916\u5074\u306b\u958b\u3044\u305f\u3088\u3046\u306a\u69cb\u9020\uff08\u56f3\u5185\u306e\u300cmobile\uff08\u53ef\u52d5\u90e8\uff09\u300d\u90e8\u5206\uff09\u3092\u3068\u3063\u3066\u3044\u308b\u306e\u304c\u7279\u5fb4\u3002<\/p>\n

\"kurumizaka5\"<\/p>\n

\u56f33\u3000\u67d3\u8272\u4f53\u306b\u304a\u3051\u308b\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u4f4d\u7f6e\u3068\u50cd\u304d<\/p>\n

\u56f3\u4e0a\u90e8\u306e\u8d64\u3044\u70b9\u7dda\u3067\u56f2\u307e\u308c\u305f\u90e8\u5206\u304c\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u3002\u67d3\u8272\u4f53\u4e2d\u5fc3\u90e8\u306b\u3042\u308b\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306f\u4e21\u5074\u304b\u3089\u7d21\u9318\u7cf8\u3067\u5f15\u3063\u5f35\u3089\u308c\u3001\u7d30\u80de\u306f\uff12\u3064\u306e\u5a18\u7d30\u80de\u306b\u5747\u7b49\u5206\u914d\u3055\u308c\u3066\u3044\u304f\uff08\u56f3\u4e0a\u90e8\u53f3\uff09\u3002<\/p>\n

 <\/p>\n

\u00a0\u3010\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u89e3\u8aad\u304c\u6559\u3048\u3066\u304f\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u3011<\/h3>\n

\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306f\u3001\u300c\u907a\u4f1d\u5b50(gene)\u300d\u306e\u300c\u767a\u73fe\u300d\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u3001\u751f\u547d\u4f53\u3092\u69cb\u6210\u3059\u308b\u3001\u3044\u308f\u3070\u201c\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u201d\u3092\u89e3\u660e\u3057\u3088\u3046\u3068\u3059\u308b\u7814\u7a76\u9818\u57df\u3067\u3059\u3002\u3053\u306e\u8996\u70b9\u306f\u3001\u5f93\u6765\u306e\u907a\u4f1d\u5b66\u3084\u5206\u5b50\u751f\u7269\u5b66\u306b\u5927\u304d\u306a\u6b74\u53f2\u7684\u8ee2\u63db\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002<\/p>\n

\u907a\u4f1d\u5b50\u3068\u805e\u3044\u3066\u591a\u304f\u306e\u4eba\u304c\u601d\u3044\u51fa\u3059\u306e\u306f\u30012003\u5e74\u306b\u5b8c\u4e86\u3057\u305f\u300c\u30d2\u30c8\u30b2\u30ce\u30e0\u8a08\u753b\u300d\u3067\u3059\u3002\u5f53\u6642\u306e\u79d1\u5b66\u8005\u305f\u3061\u306f\u3001\u30d2\u30c8\u306e\u8a2d\u8a08\u56f3\u3067\u3042\u308b\u30d2\u30c8\u30b2\u30ce\u30e0\u304c\u3059\u3079\u3066\u89e3\u8aad\u3067\u304d\u308c\u3070\u3001\u30d2\u30c8\u3092\u5b8c\u5168\u306b\u7406\u89e3\u3067\u304d\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3068\u3053\u308d\u304c\u3053\u306e\u8a2d\u8a08\u56f3\u306f\u3001\u30d2\u30c8\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5b8c\u5168\u306b\u89e3\u304d\u660e\u304b\u3059\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u79c1\u305f\u3061\u306f\u305f\u3063\u305f\u4e00\u3064\u306e\u5375\u7d30\u80de\u304b\u3089\u767a\u751f\u3057\u3001\u5206\u88c2\u3092\u7e70\u308a\u8fd4\u3057\u3066\u7d0440\u5146\u500b\u3082\u306e\u7d30\u80de\u3092\u6301\u3064\u751f\u547d\u4f53\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u7d30\u80de\u5168\u3066\u304c\u540c\u3058\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306f\u300c\u5206\u5316\u300d\u3092\u3057\u3001\u624b\u3084\u8db3\u3001\u5fc3\u81d3\u3084\u809d\u81d3\u306a\u3069\u3001\u9055\u3046\u50cd\u304d\u3092\u6301\u3064\u7d44\u7e54\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u3068\u304d\u3001\u624b\u3067\u3042\u308c\u3070\u624b\u3092\u69cb\u6210\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u3060\u3051\u304c\u30b9\u30a4\u30c3\u30c1\u30fb\u30aa\u30f3\u3055\u308c\u3066\u767a\u73fe\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u9006\u306b\u8a00\u3048\u3070\u3001\u624b\u3067\u306f\u3001\u624b\u3092\u69cb\u6210\u3059\u308b\u305f\u3081\u4ee5\u5916\u306e\u907a\u4f1d\u5b50\u306f\u30b9\u30a4\u30c3\u30c1\u304c\u30aa\u30d5\u306e\u72b6\u614b\u3067\u3059\u3002
\n\u3053\u306e\u30b9\u30a4\u30c3\u30c1\u306e\u30aa\u30f3\u30fb\u30aa\u30d5\u3092\u884c\u306a\u3063\u3066\u3044\u308b\u306e\u306f\u3001\u4e00\u4f53\u3069\u306e\u3088\u3046\u306a\u50cd\u304d\u306b\u3088\u308b\u3082\u306e\u306a\u306e\u304b\u3092\u89e3\u660e\u3059\u308b\u306e\u304c\u79c1\u306e\u7814\u7a76\u306a\u306e\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u00a0\u3010\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u3092\u8ffd\u3044\u304b\u3051\u3066\u3011<\/h3>\n

\u30d2\u30c8\u306e\u907a\u4f1d\u5b50\u304c\u523b\u307e\u308c\u305fDNA\u306e\u9577\u3055\u306f2\u30e1\u30fc\u30c8\u30eb\u3001\u6587\u5b57\u306b\u3057\u306660\u5104\u6587\u5b57\u5206\uff08\u7236\u3001\u6bcd\u304b\u308930\u5104\u6587\u5b57\u305a\u3064\uff09\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3060\u3051\u306e\u9577\u3055\u306e\u3082\u306e\u304c10\u30de\u30a4\u30af\u30ed\u30e1\u30fc\u30c8\u30eb\u306e\u3001\u7d30\u80de\u5185\u306b\u3042\u308b\u300c\u6838\u300d\u306b\u62bc\u3057\u8fbc\u3081\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u304d\u3061\u3093\u3068\u6298\u308a\u305f\u305f\u307e\u306a\u3051\u308c\u3070\u3001\u3053\u3093\u304c\u3089\u304c\u3063\u3066\u5207\u308c\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u305d\u3093\u306aDNA\u3092\u53ce\u7d0d\u3057\u3066\u3044\u308b\u306e\u304c\u300c\u30af\u30ed\u30de\u30c1\u30f3\u300d\u3068\u547c\u3070\u308c\u308b\u69cb\u9020\u3067\u3059\u3002<\/p>\n

\u300c\u30d2\u30b9\u30c8\u30f3\u300d\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\uff18\u91cf\u4f53\u3067\u69cb\u6210\u3055\u308c\u308b\u30af\u30ed\u30de\u30c1\u30f3\u306f\u7cf8\u5dfb\u304d\u306e\u3088\u3046\u306bDNA\u3092\u5dfb\u304d\u3068\u308b\u300c\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u300d\u306e\u9023\u306a\u308a\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u56f34\uff09<\/p>\n

\u304b\u3064\u3066\u30af\u30ed\u30de\u30c1\u30f3\u306fDNA\u3092\u9069\u5207\u306b\u53ce\u7d0d\u3057\u3066\u304a\u304f\u305f\u3081\u3060\u3051\u306e\u3057\u304f\u307f\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u6700\u65b0\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u7814\u7a76\u3067\u306f\u3001\u30af\u30ed\u30de\u30c1\u30f3\u306f\u3001\u7d30\u80de\u306e\u5206\u5316\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u4e0a\u3067\u975e\u5e38\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u79c1\u304c\u6700\u3082\u7740\u76ee\u3057\u3066\u3044\u308b\u306e\u304c\u3001\u30af\u30ed\u30de\u30c1\u30f3\u306e\u300c\u904b\u52d5\u6027\u300d\u3067\u3059\u3002<\/p>\n

\"kurumizaka6\"<\/p>\n

\u56f34\u3000\u771f\u6838\u751f\u7269\u306eDNA<\/p>\n

DNA\u306f4\u7a2e\u985e\u306e\u30d2\u30b9\u30c8\u30f3\u304b\u3089\u5f62\u6210\u3055\u308c\u308b\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u3068\u3057\u3066\u5dfb\u304d\u3064\u304d\u3001\u9023\u306a\u3063\u3066\u30af\u30ed\u30de\u30c1\u30f3\u306e\u69cb\u9020\u3092\u3068\u308a\u306a\u304c\u3089\u3001\u7d30\u80de\u6838\u5185\u306b\u53ce\u7d0d\u3055\u308c\u3066\u3044\u308b<\/p>\n

\u3053\u306e\u904b\u52d5\u6027\u306b\u3064\u3044\u3066\u3001\u79c1\u305f\u3061\u306f\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u304c\u8aad\u307e\u308c\u308b\u90e8\u5206\u3068\u3001\u8aad\u307e\u308c\u306a\u3044\u90e8\u5206\u306b\u3069\u3093\u306a\u9055\u3044\u304c\u3042\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u3088\u3046\u3068\u7814\u7a76\u3092\u9032\u3081\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u6d6e\u304b\u3073\u4e0a\u304c\u3063\u3066\u304d\u305f\u3082\u306e\u304c\u300c\u30af\u30ed\u30de\u30c1\u30f3\u52d5\u7684\u69cb\u9020\u300d\u306e\u5b58\u5728\u3067\u3059\u3002<\/p>\n

\u7d30\u80de\u306e\u6838\u306b\u3042\u308b\u30af\u30ed\u30de\u30c1\u30f3\u3092\u7d30\u304b\u304f\u89b3\u5bdf\u3059\u308b\u3068\u3001DNA\u304c\u304d\u3064\u304f\u6298\u308a\u305f\u305f\u307e\u308c\u3066\u9589\u3058\u3066\u3044\u308b\u5834\u6240\uff08\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\uff09\u3068\u3001\u7de9\u3093\u3067\u958b\u3044\u3066\u3044\u308b\u5834\u6240\uff08\u30e6\u30fc\u30af\u30ed\u30de\u30c1\u30f3\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u304c\u300cRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u300d\u306b\u3088\u3063\u3066\u8aad\u307f\u53d6\u3089\u308c\u308b\u306e\u306f\u3001\u30af\u30ed\u30de\u30c1\u30f3\u304c\u7de9\u3093\u3067\u3044\u308b\u90e8\u5206\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u306a\u3069\u3092\u4f7f\u3063\u305f\u8a73\u7d30\u306a\u30b2\u30ce\u30df\u30af\u30b9\u89e3\u6790\u306b\u3088\u3063\u3066\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u7d30\u80de\u306e\u5206\u5316\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u300c\u30aa\u30f3\u300d\u306b\u306a\u308b\u306e\u304b\u3001\u3059\u306a\u308f\u3061\u3069\u306e\u3088\u3046\u306b\u30af\u30ed\u30de\u30c1\u30f3\u304c\u7de9\u3080\u306e\u304b\u3001\u305d\u306e\u8a3c\u62e0\u306b\u4eca\u3001\u8feb\u308d\u3046\u3068\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u3053\u3046\u3057\u305f\u7814\u7a76\u306b\u306f\u30af\u30ed\u30de\u30c1\u30f3\u306e\u69cb\u9020\u89e3\u6790\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u69cb\u9020\u89e3\u6790\u306f\u3001\u5b9f\u969b\u306e\u751f\u7269\u304b\u3089\u3068\u308c\u308b\u30b5\u30f3\u30d7\u30eb\u3067\u306f\u3068\u3066\u3082\u56f0\u96e3\u3067\u3059\u3002\u6210\u5206\u304c\u4e0d\u5747\u4e00\u306a\u305f\u3081\u3001\u826f\u597d\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u306e\u3067\u3059\u3002\u7269\u7406\u5316\u5b66\u7684\u306b\u69cb\u9020\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u975e\u5e38\u306b\u9ad8\u6fc3\u5ea6\u3067\u9ad8\u7d14\u5ea6\u306a\u30af\u30ed\u30de\u30c1\u30f3\u304c\u5fc5\u8981\u3067\u3059\u3002\u305d\u3053\u3067\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u3084\u57f9\u990a\u7d30\u80de\u306b\u3088\u3063\u3066\u30af\u30ed\u30de\u30c1\u30f3\u306e\u90e8\u54c1\u3067\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3084DNA\u3092\u5408\u6210\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u305d\u308c\u3092\u30d5\u30ea\u30fc\u30ba\u30c9\u30e9\u30a4\u306b\u3057\u305f\u30d1\u30a6\u30c0\u30fc\u72b6\u306e\u5b89\u5b9a\u7684\u306a\u7269\u8cea\u306b\u3057\u3066\u4fdd\u7ba1\u30fb\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5148\u7aef\u6280\u8853\u306f\u3001\u4e16\u754c\u7684\u306b\u898b\u3066\u3082\u30c8\u30c3\u30d7\u30af\u30e9\u30b9\u306e\u8a55\u4fa1\u3092\u5f97\u3066\u3044\u307e\u3059\u3002\uff08\u51684\u56de\u914d\u4fe1\uff09<\/p>\n

\u3008\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u3009<\/span><\/h5>\n

\"kurumizaka2\"\u80e1\u6843\u5742\u4ec1\u5fd7\uff08\u304f\u308b\u307f\u3056\u304b\u3000\u3072\u3068\u3057\uff09<\/span><\/p>\n

1989\u5e74\u3000\u6771\u4eac\u85ac\u79d1\u5927\u5b66\u85ac\u5b66\u90e8\u5352\u696d\u3000\u85ac\u5264\u5e2b\u30011995\u5e74\u3000\u57fc\u7389\u5927\u5b66\u5927\u5b66\u9662\u3000\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b\u4fee\u4e86\u3000\u535a\u58eb\uff08\u5b66\u8853\uff09\u30011995\uff5e97\u5e74\u3000\u30a2\u30e1\u30ea\u30ab\u5408\u8846\u56fd\u3000\u56fd\u7acb\u4fdd\u5065\u7814\u7a76\u6240\uff08\uff2e\uff29\uff28\uff09\u3000\u535a\u58eb\u7814\u7a76\u54e1\u30011997\uff5e2003\u5e74\u3000\u7406\u5316\u5b66\u7814\u7a76\u6240\u3000\u7814\u7a76\u54e1\u30012003\uff5e07\u5e74\u3000\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u90e8\u3000\u96fb\u6c17\u30fb\u60c5\u5831\u751f\u547d\u5de5\u5b66\u79d1\u3000\u52a9\u6559\u6388\u30012001\uff5e07\u5e74\u3000\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u7dcf\u5408\u7406\u5b66\u7814\u7a76\u79d1\u3000\u751f\u4f53\u8d85\u5206\u5b50\u30b7\u30b9\u30c6\u30e0\u79d1\u5b66\u5c02\u653b\u3000\u5ba2\u54e1\u51c6\u6559\u6388\u30012007\uff5e08\u5e74\u3000\u65e9\u7a32\u7530\u5927\u5b66\u3000\u5148\u9032\u7406\u5de5\u5b66\u90e8\u3000\u96fb\u6c17\u30fb\u60c5\u5831\u751f\u547d\u5de5\u5b66\u79d1\u3000\u51c6\u6559\u6388\u30012008\uff5e12\u5e74\u3000\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u3000\u7dcf\u5408\u7406\u5b66\u7814\u7a76\u79d1\u3000\u5ba2\u54e1\u6559\u6388\u30012003\u5e74\uff5e15\u5e74\u3000\u7406\u5316\u5b66\u7814\u7a76\u6240\u3000\u5ba2\u54e1\u7814\u7a76\u54e1\u30012012\u5e74\uff5e\u73fe\u5728\u3000\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u3000\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1\u3000\u5ba2\u54e1\u6559\u6388\u30012008\u5e74\u3088\u308a\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u3000\u5148\u9032\u7406\u5de5\u5b66\u90e8\u3000\u96fb\u6c17\u30fb\u60c5\u5831\u751f\u547d\u5de5\u5b66\u79d1\u3000\u6559\u6388<\/p>\n

 <\/p>\n

\u3008\u4e3b\u306a\u696d\u7e3e\u3009<\/span><\/h5>\n

2013, \u30b2\u30ce\u30e0DNA\u306e\u8ee2\u5199\u30fb\u8907\u88fd\u30fb\u4fee\u5fa9\u306b\u50cd\u304f\u30d2\u30c8\u67d3\u8272\u4f53\u69cb\u9020\u4f53\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u89e3\u660e \u751f\u6b96\u533b\u7642\u306e\u767a\u5c55\u3078\u306e\u5bc4\u4e0e\u3082\u671f\u5f85<\/a>
\n\u2015\u7406\u5de5\u30fb\u80e1\u6843\u5742\u7814\u3001\u962a\u5927\u306a\u3069\u3068\u5171\u540c\u7814\u7a76\u30fb\u30fb\u30fb<\/a>
\n\u300cScientific Reports\u300d\uff08Nature Publishing Group\uff09\u306b\u3066\u8ad6\u6587\u300cStructural basis of a<\/a>
\nnucleosome containing histone H2A.B\/H2A.Bbd that transiently associates<\/a>
\nwith reorganized chromatin\u300d\u304c\u63b2\u8f09<\/a><\/p>\n

2012,\u304c\u3093\u6291\u5236\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u6a5f\u80fd\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u89e3\u660e \u7406\u5de5\u30fb\u80e1\u6843\u5742\u7814\u306a\u3069\u3001\u907a\u4f1d\u75c5\u3084\u767a\u304c\u3093\u306e\u539f\u56e0\u89e3\u660e\u306b\u91cd\u8981\u306a\u4e00\u6b69\u30fb\u30fb\u30fb<\/a>
\n\u300cThe EMBO Journal(\u6b27\u5dde\u5206\u5b50\u751f\u7269\u5b66\u6a5f\u69cb\u8a8c)\u300d\u96fb\u5b50\u7248\u306b\u3066\u8ad6\u6587 \u300cHistone chaperone activity of<\/a>
\nFanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink<\/a>
\nrepair\u300d \u304c\u63b2\u8f09<\/a>
\n2011,<\/span>\u30d2\u30c8\u67d3\u8272\u4f53\u306e\u4e2d\u5fc3\u9818\u57df\u306e\u7acb\u4f53\u69cb\u9020\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u539f\u5b50\u5206\u89e3\u80fd\u3067\u89e3\u660e \u7406\u5de5\u30fb\u80e1\u6843\u5742\u7814\u3001\u907a\u4f1d\u75c5\u3084\u767a\u304c\u3093\u306e\u539f\u56e0\u89e3\u660e\u3078\u3064\u306a\u304c\u308b\u4e00\u6b69\u30fb\u30fb\u30fb<\/a><\/p>\n

\u300c\u30cd\u30a4\u30c1\u30e3\u30fc(Nature)\u300d\u96fb\u5b50\u7248\u306b\u3066\u8ad6\u6587\u300cCrystal structure of the human centromeric<\/a>
\nnucleosome containing CENP-A\u300d\u3068\u3057\u3066\u63b2\u8f09<\/a><\/p>\n

2010,<\/span>\u30d2\u30c8\u7cbe\u5de3\u67d3\u8272\u4f53\u306e\u69cb\u9020\u57fa\u76e4\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u89e3\u660e \u7406\u5de5\u5b66\u8853\u9662\u30fb\u80e1\u6843\u5742\u6559\u6388\u3001\u7c73\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u7d00\u8981\u3067\u767a\u8868\u30fb\u30fb\u30fb<\/a><\/p>\n

\u300c\u7c73\u56fd\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u7d00\u8981(\uff30\uff2e\uff21\uff33)\u300d\u96fb\u5b50\u7248\u306b\u3066\u8ad6\u6587\u300cStructural basis of instability of the<\/a>
\nnucleosome containing a testis-specific histone variant, human H3T\u300d\u304c\u63b2\u8f09<\/a><\/p>\n

\u305d\u306e\u4ed6\u306e\u696d\u7e3e\u2192and more<\/a><\/span>
\n<\/a><\/p>\n

\u3008\u7528\u8a9e\u89e3\u8aac\u3009<\/span><\/h5>\n

\u25cf\u30d2\u30c8\u30b2\u30ce\u30e0\u3000\u2192\u3000\u30d2\u30c8\u306e\u6301\u3064\u5168\u3066\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3002\u7d0430\u5104\u500b\u304b\u3089\u306a\u308bDNA\u306e\u5869\u57fa\u914d\u5217\u306b\u8a18\u9332\u3055\u308c\u308b\u3002
\n\u25cfDNA\uff08\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u6838\u9178,deoxyribonucleic acid\uff09\u2192\u3000\u4e8c\u672c\u9396\u306e\u3089\u305b\u3093\u69cb\u9020\u3092\u5f62\u6210\u3057\u3001\u30a2\u30c7\u30cb\u30f3\u3001\u30b0\u30a2\u30cb\u30f3\u3001\u30c1\u30df\u30f3\u3001\u30b7\u30c8\u30b7\u30f3\u306e4\u3064\u306e\u5869\u57fa\u306b\u3088\u3063\u3066\u907a\u4f1d\u60c5\u5831\u3092\u69cb\u6210\u3059\u308b\u7269\u8cea\u3002
\n\u25cf\u907a\u4f1d\u5b50(gene)\u3000 \u2192\u3000DNA\u306b\u8a18\u9332\u3055\u308c\u3066\u3044\u308b\u3001\u5b9f\u969b\u306e\u751f\u547d\u4f53\u3092\u69cb\u6210\u3059\u308b\u4e0a\u3067\u5fc5\u8981\u306a\u3001\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3064\u304f\u308b\u50cd\u304d\u3092\u6301\u3064\u90e8\u4f4d\u3002
\n\u25cf\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3000\u2192\u3000\u907a\u4f1d\u5b50\u306e\u60c5\u5831\u304c\u3001\u591a\u7a2e\u591a\u69d8\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u308b\u3053\u3068\u3092\u901a\u3057\u3066\u3001\u305d\u306e\u6a5f\u80fd\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3002
\n\u25cf\u30d2\u30c8\u30b2\u30ce\u30e0\u89e3\u8aad\u8a08\u753b\u3000\u2192\u3000\u56fd\u969b\u7684\u306a\u53d6\u308a\u7d44\u307f\u3068\u3057\u3066\u3001\u30d2\u30c8\u306e\u5168DNA\u914d\u5217\uff0830\u5104\u6587\u5b57\uff09\u3092\u89e3\u8aad\u3059\u308b\u8a66\u307f\u30022001\u5e74\u306b\u6982\u8981\u914d\u5217\u304c\u3001 2003\u5e74\u306b\u306f\u5168\u5869\u57fa\u914d\u5217\u304c\u6c7a\u5b9a\u3057\u3066\u3044\u308b\u3002
\n\u25cf\u5206\u5316\u3000\u2192\u3000\u5e79\u7d30\u80de\u304c\u7279\u5b9a\u306e\u6a5f\u80fd\u306b\u7279\u5316\u3057\u3001\u4e0d\u53ef\u9006\u7684\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u901a\u3057\u3001\u751f\u7269\u306e\u767a\u751f\u30d7\u30ed\u30bb\u30b9\u304c\u9032\u884c\u3059\u308b\u3053\u3068\u3002
\n\u25cfRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3000\u2192\u3000\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u308b\u969b\u306b\u3001\u907a\u4f1d\u5b50\u304b\u3089mRNA(\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA)\u3078\u60c5\u5831\u3092\u8ee2\u5199\u3059\u308b\u5f79\u5272\u3092\u62c5\u3046\u3002\u3053\u306e\u8ee2\u5199\u306e\u5f8c\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u304c\u30a2\u30df\u30ce\u9178\u3078\u7ffb\u8a33\u3057\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u51fa\u6765\u4e0a\u304c\u308b<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u69cb\u9020\u751f\u7269\u5316\u5b66 \u80e1\u6843\u5742\u4ec1\u5fd7\uff08\u304f\u308b\u307f\u3056\u304b\u3072\u3068\u3057\uff09\uff0f\u7406\u5de5\u5b66\u8853\u9662 \u5148\u9032\u7406\u5de5\u5b66\u90e8 \u96fb\u6c17\u30fb\u60c5\u5831\u751f\u547d\u5de5\u5b66\u79d1 \u6559\u6388   \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u304c\u62d3\u304f\u65b0\u3057\u3044\u907a\u4f1d\u5b66 \u4eba\u985e\u306f\u4eca\u3001\u65b0\u3057\u3044\u907a\u4f1d\u5b66\u3092\u898b\u3064\u3051\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002 \u5f93\u6765\u306e\u907a\u4f1d\u5b66\u3067\u306f\u3001 […]<\/p>\n","protected":false},"author":1,"featured_media":29580,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40,1],"tags":[5,305],"class_list":["post-28606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-topic","category-news","tag-research","tag-feature"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/28606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/comments?post=28606"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/28606\/revisions"}],"predecessor-version":[{"id":42147,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/posts\/28606\/revisions\/42147"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media\/29580"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/media?parent=28606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/categories?post=28606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/top\/wp-json\/wp\/v2\/tags?post=28606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}