{"id":5096,"date":"2018-04-02T08:10:06","date_gmt":"2018-04-01T23:10:06","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/wias\/?p=5096"},"modified":"2021-05-17T18:15:30","modified_gmt":"2021-05-17T09:15:30","slug":"maruyama-takeshi","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/wias\/other-en\/2018\/04\/02\/5096\/","title":{"rendered":"MARUYAMA, Takeshi"},"content":{"rendered":"
Name<\/h5>\n

MARUYAMA, Takeshi<\/p>\n

Degree<\/h5>\n

Ph.D.<\/p>\n

Status<\/h5>\n

Associate Professor<\/p>\n

HP\uff08URL\uff09<\/h5>\n

–<\/p>\n

Monthly Spotlight<\/h5>\n

[Monthly Spotlight] is focusing on a researcher to introduce his\/her research.
\nProphylactic treatment for combating cancers: applying the mechanism of cell competition<\/a><\/p>\n

Research Topic<\/h5>\n

Antigen presentation of transformed cells and recognition by normal epithelial cells<\/p>\n

In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition that was originally discovered in Drosophila. Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium.<\/p>\n

In the process, cell competition signals are non-cell autonomously induced in both normal and transformed cells after surrounding normal cells first recognize the transformed cells. The first process is, however, still unclear. We are attempting to reveal triggers of the cell competition signals; how the normal and transformed cells recognize each other? To this question, we study antigen presentation of epithelial cells and its recognition by \u2018epithelial cells\u2019.<\/p>\n

Education and Academic Employment<\/h5>\n

-2011 Tokyo Medical and Dental university (JSPS-Research fellowship for young scientist, DC)
\n2011-2013 Tokyo University, Graduate School of Pharmaceutical Sciences (Project researcher)
\n2013-2015 MIT, Whitehead institute for biomedical research \uff08Overseas Research Fellowships, Postdoctoral fellow\uff09
\n2015-2018 Hokkaido University, Institute for Genetic Medicine \uff08Assistant Professor\uff09
\n2016-\u00a0\u00a0\u00a0 \u3000 \u00a0JST PRESTO researcher (concurrent)<\/p>\n

Fields of Research Interests<\/h5>\n

Genome editing, CRISPR\/Cas9, Signal transduction, Caner, Cell competition, Apoptosis<\/p>\n

Academic Publications<\/h5>\n
    \n
  • Kasai N, Kadeer A, Kajita M, Saitoh S, Ishikawa S, Maruyama T<\/u><\/strong>\u2020<\/sup>, Fujita Y\u2020 <\/sup>(\u2020<\/sup>: corresponding author)
    \nThe paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation. Sci Rep.<\/em><\/strong> (2018)<\/li>\n
  • Maruyama T<\/u><\/strong>, Fujita Y
    \nCell competition in mammals –novel homestatic machinery for embryonic development and cancer prevention
    \nCurr Opin Cell Biol<\/em><\/strong>. (2017)<\/li>\n
  • Kon S, Ishibashi K, Katoh H, Kitamoto S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T<\/u><\/strong>, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki J, Sato T, Duchen M, Shirai T, Tanaka S, Narumi R, Morita T, Nam J, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y and Fujita Y
    \nCell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
    \nNat Cell Biol.,<\/em><\/strong> (2017)<\/li>\n
  • Saitoh S#<\/sup><\/strong>, Maruyama T<\/u><\/strong>#<\/sup>, <\/strong>Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, Hayashi T, Yamazaki T, Tada M and Fujita Y (#<\/sup>: equally contributed)
    \nRab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.
    \nProc Natl Acad Sci USA.<\/em><\/strong> (2017)<\/li>\n
  • Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Dhesycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T<\/u><\/strong>, Lodish HF and Ploegh HL.
    \nEngineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
    \nProc Natl Acad Sci USA.<\/em><\/strong> (2017)<\/li>\n
  • Kadeer A, Maruyama T<\/u><\/strong>, Kajita M, Morita T, Sasaki A, Ohoka A, Ishikawa S, Ikegawa M, Shimada T and Fujita Y
    \nPlectin is a novel regulator for apical extrusion of RasV12-transformed cells.
    \nSci Rep.<\/em><\/strong> (2017)<\/li>\n
  • Maruyama T<\/u><\/strong>, Dougan SK, Truttmann M, Bilate AM, Ingram J and Ploegh HL
    \nIncreasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.
    \nNat Biotechnol.<\/em><\/strong> (2015)<\/li>\n
  • Kadowaki H, Nagai A, Maruyama T<\/u><\/strong>, Takami Y, Fitrah PS, Kato H, Honda A, Natsume T, Sato T, Kai H, Ichijo H and Nishitoh H
    \nPreemptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP.
    \nCell Rep.<\/em><\/strong> (2015)<\/li>\n
  • Chen GY, Li Z, Theile CS, Kumar PV, Nardhan NM, Duarte JN, Maruyama T<\/u><\/strong>, Grossman JC, Belcher AM
    \nand Ploegh HL
    \nGraphene oxide nanosheets modified with single domain antibodies for rapid and efficient capture of cells.
    \nChemistry<\/em><\/strong>.<\/em><\/strong> (2015)<\/li>\n
  • Tafesse F, Rashidfarrokhi A, Frein KM, Dougan S, Schmidt F, Dougan ML, Alest BF,
    \nMaruyama T<\/u><\/strong>, Strijbis K and Ploegh HL
    \nDisruption of sphingolipid biosynthesis blocks phagocytosis of Candida albicans.
    \nPLoS Pathog.<\/em><\/strong> (2015)<\/li>\n
  • Maruyama T<\/u><\/strong>, Araki T, Kawarazaki Y, Naguro I, Heynen S, Aza-Blanc P, Ronai Z, Matsuzawa A and Ichijo H
    \nRoquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.
    \nSci Signal.<\/em><\/strong> (2014)<\/li>\n
  • Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T<\/u><\/strong>, Dougan SK, Ploegh HL and Lodish HF.
    \nEngineered red blood cells as carriers for systemic delivery of a wide array of functional probes.
    \nProc Natl Acad Sci USA.<\/em><\/strong> (2014)<\/li>\n
  • Tafesse FG, Guimaraes CP, Maruyama T<\/u><\/strong>, Carette JE, Lory S, Brummelkamp TR and Ploegh HL
    \nGPR107, a GPCR Essential for Intoxication by P. aeruginosa Exotoxin A, Localizes to the Golgi and is Cleaved by Furin.
    \nJ Biol Chem.<\/em><\/strong> (2014)<\/li>\n
  • Koenig PA, Nicholls PK, Schmidt FI, Hagiwara M, Maruyama T<\/u><\/strong>, Frydman GH, Watson N, Page DC and Ploegh HL
    \nThe E2 Ubiquitin Conjugating Enzyme UBE2J1 is Required for Spermiogenesis in Mice.
    \nJ Biol Chem.<\/em><\/strong> (2014)<\/li>\n
  • Sanyal S, Ashour J, Maruyama T<\/u><\/strong>, Altenburg AF, Cragnolini JJ, Bilate A, Avalos AM, Kundrat L, Garc\u00eda-Sastre A and Ploegh HL
    \nType I interferon imposes a TSG101\/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection.
    \nCell Host Microbe.<\/em><\/strong> (2013)<\/li>\n
  • Maruyama T<\/u><\/strong>, Kadowaki H, Okamoto N, Nagai A, Naguro I, Matsuzawa A, Shibuya H, Tanaka K, Murata S, Takeda K, Nishitoh H and Ichijo H
    \nCHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
    \nEMBO J.<\/em><\/strong> (2010)<\/li>\n
  • Nishitoh H, Kadowaki H, Nagai A, Maruyama T<\/u><\/strong>, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K and Ichijo H
    \nALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
    \nGenes Dev.<\/em><\/strong> (2008)<\/li>\n
  • Nagai A, Kadowaki H, Maruyama T<\/u><\/strong>, Takeda K, Nishitoh H and Ichijo H
    \nUSP14 inhibits ER-associated degradation via interaction with IRE1alpha
    \nBiochem Biophys Res Commun<\/em><\/strong>.<\/em><\/strong> (2009)<\/li>\n<\/ul>\n
    Other Interests<\/h5>\n

    Go for a drive, Fishing, Animal loving<\/p>\n

    Affiliated Academic Organizations<\/h5>\n

    The Molecular Biology Society of Japan
    \nThe Japan Biochemical Society<\/p>\n

    Awards<\/h5>\n

    –<\/p>\n","protected":false},"excerpt":{"rendered":"

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