{"id":18533,"date":"2025-04-01T08:00:01","date_gmt":"2025-03-31T23:00:01","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/wias\/?p=18533"},"modified":"2025-03-14T12:05:15","modified_gmt":"2025-03-14T03:05:15","slug":"%e7%a7%8b%e5%b1%b1-%e5%be%b9-2-6-2-5-15-12","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/wias\/other\/2025\/04\/01\/18533\/","title":{"rendered":"\u5fd7\u6751 \u5927\u8f14"},"content":{"rendered":"
\u540d\u524d<\/h5>\n

\u5fd7\u6751 \u5927\u8f14\uff08SHIMURA, Daisuke\uff09<\/p>\n

\u53d6\u5f97\u5b66\u4f4d<\/h5>\n

\u535a\u58eb (\u7406\u5b66)<\/p>\n

HP (URL)<\/h5>\n

https:\/\/researchmap.jp\/daisuke_shimura?lang=ja<\/a><\/p>\n

\u8cc7\u683c<\/h5>\n

\u8b1b\u5e2b<\/p>\n

\u7814\u7a76\u30c6\u30fc\u30de<\/h5>\n

\u7d30\u80de\u306e\u6a5f\u80fd\u3068\u69cb\u9020\u3092\u5305\u62ec\u7684\u306b\u7dad\u6301\u3059\u308b\u65b0\u305f\u306a\u5fc3\u75be\u60a3\u6cbb\u7642\u6226\u7565\u306e\u958b\u767a\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/p>\n

\u751f\u547d\u306e\u8a95\u751f\u304b\u3089\u7d42\u7109\u307e\u3067\u3001\u7d76\u3048\u305a\u62cd\u52d5\u3092\u7d9a\u3051\u308b\u5fc3\u81d3\u3002\u305d\u306e\u6a5f\u80fd\u7dad\u6301\u306b\u306f\u3001\u53ce\u7e2e\u30fb\u5f1b\u7de9\u3092\u62c5\u3046\u7d30\u80de\u9aa8\u683c\u3084\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u7523\u751f\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3001\u7d30\u80de\u9593\u540c\u58eb\u306e\u63a5\u7740\u306a\u3069\u3001\u69d8\u3005\u306a\u8981\u7d20\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u75c5\u614b\u306e\u539f\u56e0\u3084\u75c7\u72b6\u3082\u591a\u7a2e\u591a\u69d8\u3067\u3042\u308b\u3002
\n\u3053\u308c\u3089\u306e\u8907\u96d1\u306a\u7d30\u80de\u5185\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u3001\u307e\u3068\u3081\u3066\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u56e0\u5b50\u306b\u7740\u76ee\u3057\u3001\u8907\u6570\u306e\u5fc3\u75be\u60a3\u306b\u5bfe\u3059\u308b\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6226\u7565\u306e\u958b\u767a\u3092\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u305d\u306e\u4ed5\u7d44\u307f\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u7565\u6b74<\/h5>\n

\u5b66\u6b74<\/strong><\/p>\n\n\n\n\n\n
2013-2016<\/td>\n\u65e9\u7a32\u7530\u5927\u5b66\u5927\u5b66\u9662 \u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1 \u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b \u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b<\/td>\n<\/tr>\n
2011-2013<\/td>\n\u65e9\u7a32\u7530\u5927\u5b66\u5927\u5b66\u9662 \u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1 \u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b \u4fee\u58eb\u8ab2\u7a0b<\/td>\n<\/tr>\n
2007-2011<\/td>\n\u65e9\u7a32\u7530\u5927\u5b66\u3000\u5148\u9032\u7406\u5de5\u5b66\u90e8\u3000\u751f\u547d\u533b\u79d1\u5b66\u79d1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u8077\u6b74<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n
2025-\u73fe\u5728<\/td>\n\u65e9\u7a32\u7530\u5927\u5b66 \u9ad8\u7b49\u7814\u7a76\u6240 (WIAS) \u8b1b\u5e2b<\/td>\n<\/tr>\n
2023-2025<\/td>\n\u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66 \u5927\u5b66\u9662\u533b\u6b6f\u5b66\u7dcf\u5408\u7814\u7a76\u79d1 \u6b6f\u5468\u75c5\u5b66\u5206\u91ce \u7279\u4efb\u8b1b\u5e2b<\/td>\n<\/tr>\n
2022-2025<\/td>\nUniversity of Utah School of Medicine, Department of Surgery, Nora Eccles Harrison Cardiovascular Research and Training Institute Assistant Professor<\/td>\n<\/tr>\n
2021-2022<\/td>\nThe University of Utah Nora Eccles Harrison Cardiovascular Research and Training Institute Associate Instructor (Senior Project Leader)<\/td>\n<\/tr>\n
2019-2021<\/td>\nThe University of Utah Nora Eccles Harrison Cardiovascular Research and Training Institute Postdoctoral Fellow<\/td>\n<\/tr>\n
2017-2019<\/td>\nCedars-Sinai Medical Center Smidt Heart Institute Postdoctoral Scientist<\/td>\n<\/tr>\n
2016-2016<\/td>\n\u6771\u4eac\u5973\u5b50\u533b\u79d1\u5927\u5b66 \u5148\u7aef\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u6240 \u535a\u58eb\u4e3b\u4efb\u7814\u7a76\u54e1<\/td>\n<\/tr>\n
2013-2016<\/td>\n\u65e9\u7a32\u7530\u5927\u5b66 \u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u30fb\u751f\u547d\u533b\u79d1\u5b66\u5c02\u653b \u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u30fb\u7279\u5225\u7814\u7a76\u54e1\uff08DC1\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\u7814\u7a76\u9805\u76ee<\/h5>\n

GJA1-20k \u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2 \u3001\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3001\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3 \u3001\u30ae\u30e3\u30c3\u30d7\u7d50\u5408 \u3001\u4e0d\u6574\u8108\u3001\u5206\u5b50\u7d30\u80de\u751f\u7269\u5b66 \u3001\u751f\u7406\u5b66<\/p>\n

\u4e3b\u306a\u7814\u7a76\u696d\u7e3e<\/h5>\n
    \n
  • Baum R, Nguyen VD, Maalouf M, Shimura D, Waghalter M, Srapyan S, Jin Q, Kuzmanovich L, Gaffney AT, Bell BR, Xiao S, Palatinus JA, Kl\u00e9ber AG, Grintsevich EE, Hong T, Shaw RM. A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43. J Cell Biol. (2025), 224 (3): e202402112.
    \nDOI: 10.1083\/jcb.202402112<\/li>\n
  • Hoshina Y, Delic A, Wong KH, Lyden S, Kadish R, Smith TL, Wright MA, Shimura D, Clardy SL. Vasculitis in the Central Nervous System: Etiology, Characteristics, and Outcomes in a Large Single-Center Cohort. Neurohospitalist. (2024), 14(2), 129-139
    \nDOI: 10.1177\/19418744231223283<\/li>\n
  • Jin Q, Lee KY, Selimi Z, Shimura D, Wang E, Zimmerman JF, Shaw RM, Kucera JP, Parker KK, Saffitz JE, Kleber AG. Determinants of electrical propagation and propagation block in Arrhythmogenic cardiomyopathy. J Mol Cell Cardiol. (2024), 186, 71-80
    \nDOI: 10.1016\/j.yjmcc.2023.11.003<\/li>\n
  • Shimura D* and Shaw RM. Live-cell imaging and analysis of actin-mediated mitochondrial fission. STAR Protoc. (2023), 4(1), 101958, *Technical Corresponding Author
    \nDOI: 10.1016\/j.xpro.2022.101958<\/li>\n
  • Shimura D and Shaw RM. GJA1-20k and Mitochondrial Dynamics. [Review]. Front Physiol. (2022), 13, 867358.
    \nDOI: 10.3389\/fphys.2022.867358<\/li>\n
  • Shimura D, Hunter J, Katsumata M, Shaw RM. Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein. J Vis Exp. (2022), (181).
    \nDOI: 10.3791\/63405<\/li>\n
  • Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw RM. Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. eLife (2021), 10.
    \nDOI: 10.7554\/eLife.69207<\/li>\n
  • Xiao S*, Shimura D*, Baum R, Hernandez DM, Agvanian S, Nagaoka Y, Katsumata M, Lampe PD, Kleber AG, Hong T, Shaw RM. Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias. J Clin Invest. (2020), 130(9), 4858-4870.
    \n*Co-First Author
    \nDOI: 10.1172\/JCI134682<\/li>\n
  • Sjoqvist S, Kasai Y, Shimura D, Ishikawa T, Ali N, Iwata T, Kanai N. Oral keratinocyte-derived exosomes regulate proliferation of fibroblasts and epithelial cells. Biochem Biophys Res Commun. (2019), 514(3), 706-712.
    \nDOI: 10.1016\/j.bbrc.2019.04.202<\/li>\n
  • Nakai G, Shimura D, Uesugi K, Kajimura I, Jiao Q, Kusakari Y, Soga T, Goda N, Minamisawa S. Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice. Heart Vessels. (2019), 34(3), 545-555.
    \nDOI: 10.1007\/s00380-018-1293-3<\/li>\n
  • Sj\u00f6qvist S, Ishikawa T, Shimura D, Kasai Y, Imafuku A, Bou-Ghannam S, Iwata T, Kanai N. Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing. J Extracell Vesicles. (2019), 8(1), 1565264.
    \nDOI: 10.1080\/20013078.2019.1565264<\/li>\n
  • Basheer WA, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez DM, Hitzeman TC, Hong T, Shaw RM. Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia\/reperfusion injury. JCI Insight. (2018), 3(20).
    \nDOI: 10.1172\/jci.insight.121900<\/li>\n
  • L\u00fc P, Jiao Q, Shimura D, Kusakari Y, Liu F, Minamisawa S. Distinct Vascular Remodeling Pattern of Adult Rats with Carotid-Jugular Shunt. Ann Vasc Surg. (2018), 49, 168-178.
    \nDOI: 10.1016\/j.avsg.2017.12.011<\/li>\n
  • Kusakari Y, Urashima T, Shimura D, Amemiya E, Miyasaka G, Yokota S, Fujimoto Y, Akaike T, Inoue T, Minamisawa S. Impairment of Excitation-Contraction Coupling in Right Ventricular Hypertrophied Muscle with Fibrosis Induced by Pulmonary Artery Banding. PLoS One. (2017), 12(1), e0169564.
    \nDOI: 10.1371\/journal.pone.0169564<\/li>\n
  • Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S. Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats. PLoS One. (2016), 11(2), e0148666.
    \nDOI: 10.1371\/journal.pone.0148666<\/li>\n
  • Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. (2016), 310(1), H92-103.
    \nDOI: 10.1152\/ajpheart.00411.2015<\/li>\n
  • Shimura D, Nakai G, Jiao Q, Osanai K, Kashikura K, Endo K, Soga T, Goda N, Minamisawa S. Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart. Am J Physiol Heart Circ Physiol. (2013), 305(4), H494-505.
    \nDOI: 10.1152\/ajpheart.00867.2012<\/li>\n<\/ul>\n
    \u8da3\u5473 \u95a2\u5fc3<\/h5>\n

    \u7a7a\u624b\u3001\u6c34\u6cf3\u3001\u30b4\u30eb\u30d5\u3001\u30b5\u30fc\u30d5\u30a3\u30f3\u3001\u91e3\u308a<\/p>\n

    \u6240\u5c5e\u5b66\u4f1a<\/h5>\n

    \u56fd\u969b\u5fc3\u81d3\u7814\u7a76\u5b66\u4f1a
    \n\u65e5\u672c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5b66\u4f1a
    \n\u65e5\u672c\u5faa\u74b0\u5668\u5b66\u4f1a
    \n\u7c73\u56fd\u5fc3\u81d3\u5b66\u4f1a
    \n\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a
    \n\u65e5\u672c\u751f\u7406\u5b66\u4f1a<\/p>\n

    \u53d7\u8cde\u6b74<\/h5>\n

    2023<\/strong> \u6700\u512a\u79c0\u767a\u8868\u8cde \u65e5\u672c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5b66\u4f1a
    \n2023<\/strong> Star Research Achievement Award GJA1-20K REDUCES RESUSCITATION REQUIREMENTS AND RENAL INJURY POST-REBOA ISCHEMIA-REPERFUSION INJURY Critical Care Medicine
    \n2023<\/strong> Nominated Sigma-Xi full membership
    \n2022<\/strong> Abstract Presentation Award \u7b2c6\u56de\u65e5\u672c\u5faa\u74b0\u5668\u5b66\u4f1a\u57fa\u790e\u7814\u7a76\u30d5\u30a9\u30fc\u30e9\u30e0
    \n2021<\/strong> \u5353\u8d8a\u7814\u7a76\u54e1\u5019\u88dc\u8005 \u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\uff09
    \n2018<\/strong> New Investigator Travel Award Basic Cardiovascular Sciences Scientific Sessions
    \n2014<\/strong> The best team presentation award, 6th-HOPE meeting \u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u540d\u524d \u5fd7\u6751 \u5927\u8f14\uff08SHIMURA, Daisuke\uff09 \u53d6\u5f97\u5b66\u4f4d \u535a\u58eb (\u7406\u5b66) HP (URL) https:\/\/researchmap.jp\/daisuke_shimura?lang=ja \u8cc7\u683c \u8b1b\u5e2b \u7814\u7a76\u30c6\u30fc\u30de \u7d30\u80de […]<\/p>\n","protected":false},"author":6,"featured_media":18402,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[96],"tags":[],"class_list":["post-18533","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/posts\/18533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/comments?post=18533"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/posts\/18533\/revisions"}],"predecessor-version":[{"id":18536,"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/posts\/18533\/revisions\/18536"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/media\/18402"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/media?parent=18533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/categories?post=18533"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/wias\/wp-json\/wp\/v2\/tags?post=18533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}