{"id":15155,"date":"2024-02-13T15:07:07","date_gmt":"2024-02-13T06:07:07","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/wias\/?p=15155"},"modified":"2024-02-13T15:07:07","modified_gmt":"2024-02-13T06:07:07","slug":"%e9%87%8f%e7%9a%84%e3%83%86%e3%82%ad%e3%82%b9%e3%83%88%e5%88%86%e6%9e%90%e3%81%ab%e3%82%88%e3%82%8b%e5%9b%bd%e9%9a%9b%e6%94%bf%e6%b2%bb%e7%a0%94%e7%a9%b6%e3%80%80%e6%b8%a1%e8%be%ba%e8%80%95-12-2-2-50","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/wias\/news\/2024\/02\/13\/15155\/","title":{"rendered":"\u8133\u306b\u304a\u3051\u308b\u30b7\u30ca\u30d7\u30b9\u63a5\u7740\u5206\u5b50\u306e\u6a5f\u80fd\u7684\u5f79\u5272\u3068\u7cbe\u795e\u30fb\u795e\u7d4c\u75be\u60a3\u3078\u306e\u95a2\u4e0e<br \/>\u661f\u540d \u76f4\u7950 \u8b1b\u5e2b"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-15161\" src=\"https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly-360x270.jpg\" alt=\"\" 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id=\"attachment_15157\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-15157\" src=\"https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_2-610x514.jpg\" alt=\"\" width=\"500\" height=\"421\" srcset=\"https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_2-610x514.jpg 610w, https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_2-940x792.jpg 940w, https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_2-768x647.jpg 768w, https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_2.jpg 1013w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><p class=\"wp-caption-text\">\u56f32. \u30de\u30a6\u30b9\u306e\u8133\u5185\u306b\u304a\u3051\u308bPCDH17\u306e\u767a\u73fe\u5206\u5e03\u3002\u5927\u8133\u76ae\u8cea\u306e\u4e00\u90e8\u3068\u3001\u5927\u8133\u57fa\u5e95\u6838\u306e\u7dda\u6761\u4f53\u3001\u6de1\u84bc\u7403\u3001\u9ed2\u8cea\u7db2\u69d8\u90e8\u306e\u4e00\u90e8\u306e\u9818\u57df\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3057\u3001\u4e26\u5217\u795e\u7d4c\u56de\u8def\u3092\u69cb\u7bc9\u3057\u3066\u3044\u308b\u3002<\/p><\/div>\n<p>\u3055\u3089\u306b\u3001PCDH17\u304c\u767a\u73fe\u3059\u308b\u795e\u7d4c\u56de\u8def\u304c\u8133\u5185\u3067\u3069\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3001PCDH17\u3092\u3082\u3064\u30de\u30a6\u30b9\u3068\u3082\u305f\u306a\u3044\u30de\u30a6\u30b9\u3092\u4f5c\u308a\u3001\u96fb\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305f\u89e3\u6790\u3084\u96fb\u6c17\u751f\u7406\u5b66\u7684\u306a\u89e3\u6790\u306b\u3088\u308a\u30b7\u30ca\u30d7\u30b9\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3092\u8abf\u3079\u3001\u884c\u52d5\u5b66\u7684\u89e3\u6790\u306b\u3088\u308a\u69d8\u3005\u306a\u8133\u6a5f\u80fd\u306b\u3064\u3044\u3066\u8abf\u3079\u307e\u3057\u305f\u3002\u5b9f\u9a13\u306e\u7d50\u679c\u3001PCDH17\u3092\u3082\u305f\u306a\u3044\u30de\u30a6\u30b9\u306f\u3082\u3064\u30de\u30a6\u30b9\u306b\u6bd4\u3079\u3066\u3001\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3092\u8caf\u8535\u3059\u308b\u30b7\u30ca\u30d7\u30b9\u5c0f\u80de\u306e\u84c4\u7a4d\u304c\u7570\u5e38\u306b\u5897\u3048\u3001\u795e\u7d4c\u4f1d\u9054\u52b9\u7387\u304c\u5909\u5316\u3057\u3001\u3055\u3089\u306b\u3001\u3046\u3064\u75c5\u306b\u95a2\u9023\u3059\u308b\u884c\u52d5\u306b\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001PCDH17\u306f\u5927\u8133\u76ae\u8cea\u3068\u5927\u8133\u57fa\u5e95\u6838\u3092\u7d50\u3076\u4e26\u5217\u795e\u7d4c\u56de\u8def\u306e\u30b7\u30ca\u30d7\u30b9\u63a5\u7740\u5206\u5b50\u3068\u3057\u3066\u50cd\u304d\u3001\u305d\u306e\u7570\u5e38\u306f\u3046\u3064\u75c5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h3><em>PCDH19<\/em>\u306e\u5909\u7570\u306b\u3088\u308a\u751f\u3058\u308b\u5973\u6027\u306e\u307f\u306b\u767a\u75c7\u3059\u308b\u75be\u60a3<\/h3>\n<p>\uff38\u67d3\u8272\u4f53\u907a\u4f1d\u5b50<em>PCDH19<\/em>\uff08\u30d2\u30c8\u907a\u4f1d\u5b50\uff09\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308b\u300cPCDH19\u95a2\u9023\u75c7\u5019\u7fa4\u300d\u306f\u3001\u5973\u6027\u306e\u307f\u306b\u767a\u75c7\u3059\u308b\u907a\u4f1d\u6027\u795e\u7d4c\u75be\u60a3\u3067\u3059\u3002\u3066\u3093\u304b\u3093\u3084\u77e5\u7684\u969c\u5bb3\u306a\u3069\u306e\u75c7\u72b6\u3092\u4f34\u3044\u307e\u3059\u304c\u3001\u306a\u305c\u5973\u6027\u3060\u3051\u306b\u767a\u75c7\u3059\u308b\u304b\u306f\u308f\u304b\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u8a66\u307f\u307e\u3057\u305f\u3002<\/p>\n<p>PCDH19\u3092\u3082\u3064\u30aa\u30b9\u3068\u30e1\u30b9\u306e\u30de\u30a6\u30b9\uff08\u4ee5\u5f8c<em>Pcdh19<\/em>\uff08\u30de\u30a6\u30b9\u907a\u4f1d\u5b50\uff09\u6b63\u5e38\u578b\uff09\u3068\u3001PCDH19\u3092\u3082\u305f\u306a\u3044\u30aa\u30b9\u30de\u30a6\u30b9\uff08\u4ee5\u5f8c<em>Pcdh19<\/em>\u3078\u30df\u5909\u7570\u4f53\uff09\u3001PCDH19\u3092\u3082\u3064\u7d30\u80de\u3068\u3082\u305f\u306a\u3044\u7d30\u80de\u304c\u6df7\u5408\u3059\u308b\u30e1\u30b9\u30de\u30a6\u30b9\uff08\u4ee5\u5f8c<em>Pcdh19<\/em>\u30d8\u30c6\u30ed\u5909\u7570\u4f53\uff09\u306b\u3064\u3044\u3066\u3001\u96fb\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305f\u89e3\u6790\u3084\u96fb\u6c17\u751f\u7406\u5b66\u7684\u306a\u89e3\u6790\u306b\u3088\u308a\u30b7\u30ca\u30d7\u30b9\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3092\u8abf\u3079\u3001\u884c\u52d5\u5b66\u7684\u89e3\u6790\u306b\u3088\u308a\u8a8d\u77e5\u6a5f\u80fd\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30e1\u30b9\u306e<em>Pcdh19<\/em>\u30d8\u30c6\u30ed\u5909\u7570\u4f53\u306f\u3001\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u7570\u5e38\u3068\u305d\u308c\u306b\u4f34\u3046\u8a8d\u77e5\u969c\u5bb3\u304c\u8d77\u304d\u308b\u304c\u3001\u30aa\u30b9\u306e<em>Pcdh19<\/em>\u30d8\u30df\u5909\u7570\u4f53\u306f\u6b63\u5e38\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u3053\u306e\u30e1\u30b9\u306e\u307f\u3067\u898b\u3089\u308c\u308b\u7570\u5e38\u3092\u8aac\u660e\u3059\u308b\u305f\u3081\u3001PCDH19\u3068N\u30ab\u30c9\u30d8\u30ea\u30f3\u306e\u30b7\u30ca\u30d7\u30b9\u63a5\u7740\u5206\u5b50\u3068\u3057\u3066\u306e\u6a5f\u80fd\u306b\u7740\u76ee\u3057\u305f\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002<em>Pcdh19<\/em>\u6b63\u5e38\u578b\u3068\u30aa\u30b9\u306e<em>Pcdh19<\/em>\u30d8\u30df\u5909\u7570\u4f53\u3067\u306f\u3001\u7d30\u80de\u9593\u306e\u300c\u30de\u30c3\u30c1\u30f3\u30b0\u300d\u306b\u3088\u308a\u6b63\u5e38\u306a\u30b7\u30ca\u30d7\u30b9\u5236\u5fa1\u3092\u884c\u3046\u304c\u3001\u30e1\u30b9\u306e<em>Pcdh19<\/em>\u30d8\u30c6\u30ed\u5909\u7570\u4f53\u3067\u306f\u7d30\u80de\u9593\u306e\u300c\u30df\u30b9\u30de\u30c3\u30c1\u30f3\u30b0\u300d\u306b\u3088\u308a\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u7570\u5e38\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u305d\u3057\u3066\u3001\u3053\u306e\u30df\u30b9\u30de\u30c3\u30c1\u30f3\u30b0\u304c\u30b7\u30ca\u30d7\u30b9\u306e\u4f1d\u9054\u52b9\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u306e\u7570\u5e38\u3001\u3055\u3089\u306b\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5973\u6027\u306e\u307f\u306b\u767a\u75c7\u3059\u308b\u907a\u4f1d\u6027\u795e\u7d4c\u75be\u60a3\u306e\u539f\u56e0\u3092\u89e3\u660e\u3057\u3001\u3055\u3089\u306b\u75be\u60a3\u306e\u6cbb\u7642\u6226\u7565\u306e\u9053\u7b4b\u3092\u793a\u3059\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_15159\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-15159\" src=\"https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_3-610x515.jpg\" alt=\"\" width=\"500\" height=\"422\" srcset=\"https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_3-610x515.jpg 610w, https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_3-940x794.jpg 940w, https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_3-768x649.jpg 768w, https:\/\/www.waseda.jp\/inst\/wias\/assets\/uploads\/2024\/02\/hoshina_monthly_3.jpg 1019w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><p class=\"wp-caption-text\">\u56f33. <em>Pcdh19<\/em>\u6b63\u5e38\u578b\u306e\u30aa\u30b9\u3068\u30e1\u30b9\u3001<em>Pcdh19<\/em>\u3078\u30df\u5909\u7570\u4f53\u306e\u30aa\u30b9\u3001<em>Pcdh19<\/em>\u30d8\u30c6\u30ed\u5909\u7570\u4f53\u306e\u30e1\u30b9\u306e\u8a8d\u77e5\u6a5f\u80fd\u3068\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u3092\u8abf\u3079\u305f\u3002\u305d\u306e\u7d50\u679c\u3001<em>Pcdh19<\/em>\u30d8\u30c6\u30ed\u5909\u7570\u4f53\u306e\u30e1\u30b9\u306e\u307f\u3001\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u3068\u8a8d\u77e5\u6a5f\u80fd\u306b\u7570\u5e38\u304c\u898b\u3089\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u30e1\u30b9\u306e\u307f\u3067\u898b\u3089\u308c\u308b\u7570\u5e38\u306e\u57fa\u76e4\u3068\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63d0\u5531\u3057\u305f\u3002 <br \/>\u51fa\u5178\u5143\uff1aHoshina et al.,\u202f<em>Science\u202f<\/em>372, eaaz3893 (2021)<\/p><\/div>\n<h3>\u7cbe\u795e\u75be\u60a3\u95a2\u9023\u5206\u5b50PCDH10\u306e\u8133\u5185\u306b\u304a\u3051\u308b\u6a5f\u80fd\u7684\u5f79\u5272<\/h3>\n<p style=\"text-align: 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