{"id":16552,"date":"2017-01-20T07:00:16","date_gmt":"2017-01-19T22:00:16","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/weekly\/?p=16552"},"modified":"2016-10-25T10:53:40","modified_gmt":"2016-10-25T01:53:40","slug":"p53%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%8c%e4%bd%9c%e7%94%a8%e3%81%99%e3%82%8b%e9%81%ba%e4%bc%9d%e5%ad%90%e5%80%99%e8%a3%9c%e3%81%ae%e6%95%b0","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/weekly\/academics\/2017\/01\/20\/16552\/","title":{"rendered":"\u3010\u6570\u5b57\u304b\u3089\u8003\u3048\u308b\u672a\u6765\u3011p53\u907a\u4f1d\u5b50\u304c\u4f5c\u7528\u3059\u308b\u907a\u4f1d\u5b50\u5019\u88dc\u306e\u6570"},"content":{"rendered":"

\u7814\u7a76\u8005\u306e\u767a\u60f3\u529b\u304c\u3001\u304c\u3093\u7814\u7a76\u306e\u9032\u5c55\u306e\u30ab\u30ae\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/h3>\n

\"\"<\/p>\n

\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u6240 \u5e0c\u5c11\u304c\u3093\u7814\u7a76\u5206\u91ce\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u3000\u5927\u6728 \u7406\u6075\u5b50\uff08\u304a\u304a\u304d\u30fb\u308a\u3048\u3053\uff09<\/h5>\n

1992 \u5e74\u65e9\u7a32\u7530\u5927\u5b66\u6559\u80b2\u5b66\u90e8\u5352\u696d\u5f8c\u30011997 \u5e74\u6771\u4eac\u5927\u5b66\u7406\u5b66\u7cfb\u7814\u7a76\u79d1\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\u3002\u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u6240\u30fb\u653e\u5c04\u7dda\u7814\u7a76\u90e8\u3001\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u7814\u7a76\u90e8\u3001\u816b\u760d\u751f\u7269\u5b66\u5206\u91ce\u7814\u7a76\u54e1\u3092\u7d4c\u3066\u30012011\u5e74\u3088\u308a\u73fe\u8077\u3002\u7406\u5b66\u535a\u58eb\u3002<\/p>\n

\u591a\u304f\u306e\u304c\u3093\u7d30\u80de\u3067\u5171\u901a\u3057\u3066\u5909\u5316\u304c\u898b\u3089\u308c\u308b\u3001 \u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u300cp53\u300d\u3002\u304c\u3093\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u6a19\u7684\u3068\u3057\u3066 \u6700\u3082\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u306e\u52aa\u529b\u306b\u3088\u3063\u3066\u3001\u3053\u305310 \u5e74\u306e\u9593\u306b235\u500b\u306ep53\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u5019\u88dc\u304c\u898b\u3064\u304b\u3063\u3066\u3044\u308b\u3002<\/h4>\n

235<\/p>\n

\u79c1\u304c\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u6240\u3067\u884c\u3063\u3066\u3044\u308b\u306e\u306f\u3001\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u3067\u3059\u3002\u5b9f\u306f\u3001\u8ab0\u306e\u4f53\u306b\u3082\u304c\u3093\u5316\u3092\u4fc3\u9032\u3059\u308b\u3001\u304c\u3093\u907a\u4f1d\u5b50\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u307e\u3056\u307e\u306a\u8981\u56e0\u3067\u304c\u3093\u907a\u4f1d\u5b50\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u6b63\u5e38\u306a\u7d30\u80de\u304c\u304c\u3093\u5316\u3057\u3066\u3057\u307e\u3044\u3001\u304c\u3093\u5316\u3057\u305f\u7d30\u80de\u304c\u7570\u5e38\u306b\u5897\u5927\u3059\u308b\u3053\u3068\u3067\u7d44\u7e54\u306e\u6a5f\u80fd\u304c\u5931\u308f\u308c\u3066\u751f\u547d\u304c\u304a\u3073\u3084\u304b\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001p53\u3068\u3044\u3046\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u3092\u6291\u5236\u3059\u308b\u907a\u4f1d\u5b50\u3082\u4eba\u306f\u6301\u3063\u3066\u304a\u308a\u3001\u79c1\u306f\u4e3b\u306b\u3053\u306ep53\u306e\u7814\u7a76\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

p53\u306e\u5b58\u5728\u304c\u5206\u304b\u3063\u305f\u306e\u306f\u3001\u4eca\u304b\u308937\u5e74\u524d\u306e\u3053\u3068\u3067\u3059\u3002p53\u306e\u6a5f\u80fd\u304c\u4e0d\u5168\u306b\u306a\u308b\u3068\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u304c\u4fc3\u9032\u3057\u307e\u3059\u3002\u6a5f\u80fd\u4e0d\u5168\u3068\u306a\u308b\u304d\u3063\u304b\u3051\u306f\u3001\u4f8b\u3048\u3070\u3001\u80ba\u304c\u3093\u3067\u3042\u308c\u3070\u55ab\u7159\u3001\u76ae\u819a\u304c\u3093\u3067\u3042\u308c\u3070\u7d2b\u5916\u7dda\u306a\u3069\u304c\u8981\u56e0\u3067\u3001\u304c\u3093\u60a3\u8005\u306e\u304a\u3088\u305d\u534a\u6570\u304cp53\u81ea\u4f53\u306b\u7570\u5e38\u304c\u3042\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001p53\u304c\u3069\u306e\u3088\u3046\u306b\u304c\u3093\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u306e\u304b\u306f\u3001\u307e\u3060\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u5206\u304b\u3063\u3066\u3044\u308b\u306e\u306f\u3001p53\u304c\u67d3\u8272\u4f53\u306e\u3042\u308b\u90e8\u5206\u306b\u50cd\u304d\u304b\u3051\u308b\u3068\u3001\u305d\u306e\u5468\u8fba\u306b\u3042\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u52d5\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u3044\u3046\u3053\u3068\u3002\u3064\u307e\u308a\u3001p53\u306f\u3001\u5468\u56f2\u306e\u907a\u4f1d\u5b50\u306b\u547d\u4ee4\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002\"\"<\/p>\n

p53\u306e\u547d\u4ee4\u3092\u53d7\u3051\u308b\u907a\u4f1d\u5b50\u306f\u300cp53\u6a19\u7684\u907a\u4f1d\u5b50\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u304c\u535a\u58eb\u7814\u7a76\u54e1\u6642\u4ee3\u306b\u767a\u898b\u3057\u305f\u4e8c\u3064\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3092\u542b\u3081\u300110\u5e74\u307b\u3069\u524d\u307e\u3067\u306f\u300120\uff5e 30\u500b\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3057\u304b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f100\u500b\u307b\u3069\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u3082\u3001\u672a\u78ba\u8a8d\u3082\u8db3\u3057\u52a0\u3048\u305f\u6a19\u7684\u907a\u4f1d\u5b50\u5019\u88dc\u3068\u3057\u3066\u3001235\u500b\u3092\u540c\u5b9a\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u306f\u3001\u305d\u306e\u4e2d\u304b\u308910\u500b\u7a0b\u5ea6\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002p53\u306e\u304c\u3093\u6291\u5236\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u89e3\u660e\u3055\u308c\u308c\u3070\u3001\u304c\u3093\u6cbb\u7642\u3082\u5927\u304d\u304f\u524d\u9032\u3059\u308b\u3053\u3068\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u3053\u306e\u3088\u3046\u306a\u65e5\u9032\u6708\u6b69\u306e\u304c\u3093\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u6b20\u304b\u305b\u306a\u3044\u306e\u304c\u3001\u65b0\u3057\u3044\u7814\u7a76\u6a5f\u5668\u306e\u958b\u767a\u3067\u3042\u308a\u3001\u305d\u306e\u4ee3\u8868\u4f8b\u304c\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\uff08DNA\u89e3\u6790\u88c5\u7f6e\uff09\u3067\u3059\u30021990\u5e74\u306b\u958b\u59cb\u3055\u308c\u305f\u300c\u30d2\u30c8\u30b2\u30ce\u30e0\u8a08\u753b\u300d\u3067\u3001\u4eba\u985e\u306f\u521d\u3081\u3066\u30d2\u30c8\uff11\u4eba\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u89e3\u8aad\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u3068\u304d\u306f\u5f93\u6765\u578b\u306e\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u3092\u4f7f\u7528\u3057\u305f\u306e\u3067\u3059\u304c\u3001\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u304c\u5354\u529b\u3057\u306613\u5e74\u304b\u304b\u308a\u3001\u4f55\u5343\u5104\u5186\u3068\u3044\u3046\u83ab\u5927\uff08\u3070\u304f\u3060\u3044\uff09\u306a\u8cc7\u91d1\u304c\u3064\u304e\u8fbc\u307e\u308c\u307e\u3057\u305f\u3002\u5bfe\u3057\u3066\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u3067\u306f\u3001\u308f\u305a\u304b1\u65e5\u7a0b\u5ea6\u3067\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u89e3\u8aad\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u305d\u3046\u3057\u3066\u96c6\u3081\u305f\u5927\u91cf\u306e\u30c7\u30fc\u30bf\u306b\u3088\u3063\u3066\u3001\u5358\u306bDNA\u3092\u8aad\u3080\u306e\u3067\u306f\u306a\u3044\u9ad8\u6b21\u306e\u60c5\u5831\u3092\u5f97\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u3059\u307e\u3059\u9ad8\u9f62\u5316\u304c\u9032\u3080\u65e5\u672c\u793e\u4f1a\u306b\u304a\u3044\u3066\u306f\u3001\u304c\u3093\u306e\u65e9\u671f\u767a\u898b\u30fb\u6cbb\u7642\u3001\u305d\u3057\u3066\u518d\u767a\u9632\u6b62\u3084\u75c7\u72b6\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u5927\u304d\u306a\u8ab2\u984c\u3002\u3053\u308c\u304b\u3089\u306e\u304c\u3093\u7814\u7a76\u306f\u3001\u9ad8\u6027\u80fd\u5316\u3057\u305f\u6a5f\u5668\u306e\u6027\u80fd\u306b\u983c\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u308c\u3089\u3092\u3069\u306e\u3088\u3046\u306b\u7528\u3044\u308b\u304b\u3068\u3044\u3046\u7814\u7a76\u8005\u306e\u30af\u30ea\u30a8\u30fc\u30c6\u30a3\u30d3\u30c6\u30a3\u304c\u6c42\u3081\u3089\u308c\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\uff08\u300e\u65b0\u9418\u300fNo.82\u63b2\u8f09\u8a18\u4e8b\u3088\u308a\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7814\u7a76\u8005\u306e\u767a\u60f3\u529b\u304c\u3001\u304c\u3093\u7814\u7a76\u306e\u9032\u5c55\u306e\u30ab\u30ae\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002 \u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u6240 \u5e0c\u5c11\u304c\u3093\u7814\u7a76\u5206\u91ce\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u3000\u5927\u6728 \u7406\u6075\u5b50\uff08\u304a\u304a\u304d\u30fb\u308a\u3048\u3053\uff09 1992 \u5e74\u65e9\u7a32\u7530\u5927\u5b66\u6559\u80b2\u5b66\u90e8\u5352\u696d\u5f8c\u30011997 \u5e74\u6771\u4eac\u5927\u5b66\u7406\u5b66\u7cfb\u7814\u7a76\u79d1 […]<\/p>\n","protected":false},"author":3614,"featured_media":16553,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[181],"tags":[105],"class_list":["post-16552","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-academics","tag-shinsho"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/posts\/16552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/users\/3614"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/comments?post=16552"}],"version-history":[{"count":4,"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/posts\/16552\/revisions"}],"predecessor-version":[{"id":20184,"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/posts\/16552\/revisions\/20184"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/media\/16553"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/media?parent=16552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/categories?post=16552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/weekly\/wp-json\/wp\/v2\/tags?post=16552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}