{"id":85261,"date":"2026-07-15T15:11:00","date_gmt":"2026-07-15T06:11:00","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=85261"},"modified":"2026-07-15T15:11:00","modified_gmt":"2026-07-15T06:11:00","slug":"%ce%b42-protocadherins-organize-parallel-indirect-basal-ganglia-circuits-%ef%bc%88published-in-science-advances-july-2026%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/85261","title":{"rendered":"\u03b42-Protocadherins organize parallel indirect basal ganglia circuits \uff08Published in Science Advances, July, 2026\uff09"},"content":{"rendered":"<table class=\"table table-bordered table-colored-tbhd\" style=\"height: 636px; width: 100%; border-collapse: collapse; border-style: solid;\" border=\"1\">\n<tbody>\n<tr style=\"height: 78px;\">\n<td style=\"width: 18.9673%; height: 78px;\">Journal Title<br \/>\n\/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d<\/td>\n<td style=\"width: 80.934%; height: 78px;\">Science Advances<\/td>\n<\/tr>\n<tr style=\"height: 65px;\">\n<td style=\"width: 18.9673%; height: 80px;\">Publication Year and Month<br \/>\n\/\u63b2\u8f09\u5e74\u6708<\/td>\n<td style=\"width: 80.934%; height: 80px;\">July, 2026<\/td>\n<\/tr>\n<tr style=\"height: 55px;\">\n<td style=\"width: 18.9673%; height: 79px;\">Paper Title<br \/>\n\/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/td>\n<td style=\"width: 80.934%; height: 79px;\">\u03b42-Protocadherins organize parallel indirect basal ganglia circuits<\/td>\n<\/tr>\n<tr style=\"height: 85px;\">\n<td style=\"width: 18.9673%; height: 85px;\">DOI<br \/>\n\/\u8ad6\u6587DOI<\/td>\n<td style=\"width: 80.934%; height: 85px;\"><a href=\"https:\/\/doi.org\/10.64898\/2025.12.13.694147\">10.64898\/2025.12.13.694147\u00a0<\/a><\/td>\n<\/tr>\n<tr style=\"height: 59px;\">\n<td style=\"width: 18.9673%; height: 80px;\">\u00a0Author of Waseda University<br \/>\n\/\u672c\u5b66\u306e\u8457\u8005<\/td>\n<td style=\"width: 80.934%; height: 80px;\"><span style=\"font-family: inherit; font-size: inherit;\"><span style=\"font-family: inherit; font-size: inherit;\">HOSHINA, Naosuke(Assistant Professor(non-tenure-track), Affiliated organization, Waseda Institute for Advanced Study):Lead Author<\/span><\/span><\/td>\n<\/tr>\n<tr style=\"height: 68px;\">\n<td style=\"width: 18.9673%; height: 86px;\">Related Websites<br \/>\n\/\u95a2\u9023Web<\/td>\n<td style=\"width: 80.934%; height: 86px;\">&#8211;<\/td>\n<\/tr>\n<tr style=\"height: 138px;\">\n<td style=\"width: 18.9673%; height: 148px;\">Abstract<br \/>\n\/\u6284\u9332<\/td>\n<td style=\"width: 80.934%; height: 148px;\">\n<div id=\"abstractBox\">\n<p data-test=\"abstract-sub-heading\">The basal ganglia (BG) contain multiple parallel neural circuits, each of which may control different behaviors. However, how the distinct parallel BG circuits are molecularly organized is not known. Here we show that two \u03b42-protocadherins (PCDHs), PCDH17 and PCDH10, which are homophilic cell-adhesion molecules, establish and define two distinct indirect BG circuits that regulate different behaviors. PCDH17 and PCDH10 are expressed in a complementary expression pattern in the BG, anatomically defining two parallel indirect BG connections. Indirect pathway-specific\u00a0<em>Pcdh17<\/em>\u00a0and\u00a0<em>Pcdh10<\/em>\u00a0conditional knockout (cKO) mice show impaired establishment of the indirect BG circuits in a region-preferential manner. Finally, the\u00a0<em>Pcdh17<\/em>-cKO mice show defects in task learning, while the\u00a0<em>Pcdh10<\/em>-cKO mice show defects in motor\/sensory habituation. These results identify PCDH17 and PCDH10 as the molecular organizers for two distinct indirect BG circuits regulating different behaviors and reveal the molecular mechanisms for organizing parallel BG circuits.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Journal Title \/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d Science Advances Publication Year and Month \/\u63b2\u8f09\u5e74\u6708 July, 2026 Paper Title \/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb \u03b42-Pr [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[218,217],"class_list":["post-85261","post","type-post","status-publish","format-standard","hentry","tag-impact-en","tag-impact"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/85261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=85261"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/85261\/revisions"}],"predecessor-version":[{"id":85263,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/85261\/revisions\/85263"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=85261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=85261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=85261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}