{"id":83031,"date":"2025-12-12T10:00:58","date_gmt":"2025-12-12T01:00:58","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=83031"},"modified":"2025-12-11T15:03:09","modified_gmt":"2025-12-11T06:03:09","slug":"%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e6%88%90%e4%bd%93%e7%a5%9e%e7%b5%8c%e6%96%b0%e7%94%9f%e3%81%8c%e6%b8%9b%e5%b0%91%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/83031","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3044\u3066\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u304c\u6e1b\u5c11\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u65b0\u305f\u306a\u77e5\u898b"},"content":{"rendered":"<h2 style=\"text-align: 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href=\"https:\/\/w-rdb.waseda.jp\/html\/100000839_ja.html\">\u5927\u5cf6\u767b\u5fd7\u7537\uff08\u304a\u304a\u3057\u307e\u3068\u3057\u304a\uff09\u6559\u6388<\/a>\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9APPNL-G-F\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u6027\u5dee\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76\u3092\u884c\u306a\u3044\u3001\u5973\u6027\u30db\u30eb\u30e2\u30f3\u304c\u95a2\u9023\u3057\u3066\u3001BMP\u30b7\u30b0\u30ca\u30eb\u306e\u4e0a\u6607\u304c\u8d77\u3053\u308a\u3001\u8a18\u61b6\u306b\u95a2\u4fc2\u3059\u308b\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u307e\u3057\u305f\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f2025\u5e7412\u670812\u65e5\u306b\u300cBiology of Sex Differences\u300d\u306b\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u52a0\u9f62\u3068\u3068\u3082\u306b\u6d77\u99ac\u306b\u304a\u3051\u308bBMP\u30b7\u30b0\u30ca\u30eb\u306e\u4e0a\u6607\u304c\u8d77\u304d\u3001\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u306e\u4f4e\u4e0b\u3068\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u3055\u3089\u306b\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u8133\u3067\u306fBMP\u30b7\u30b0\u30ca\u30eb\u306e\u4e0a\u6607\u3068\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u306e\u4f4e\u4e0b\u304c\u95a2\u9023\u3059\u308b\u3053\u3068\u306f\u5206\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001BMP\u30b7\u30b0\u30ca\u30eb\u3068\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3001\u6027\u5dee\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76\u306f\u3053\u308c\u307e\u3067\u884c\u308f\u308c\u3066\u304a\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u75ab\u5b66\u7684\u306b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u5973\u6027\u3067\u7f79\u60a3\u7387\u304c\u9ad8\u3044\u3053\u3068\u306f\u5206\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u539f\u56e0\u3068\u3057\u3066\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306e\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u6027\u5dee\u306b\u7740\u76ee\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u614b\u89e3\u660e\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3><strong>\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u3001\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u5171\u8457\u8005\u306e\u4e00\u4eba\u3067\u3042\u308b\u897f\u9053\u5143\u7406\u7814\u30c1\u30fc\u30e0\u30ea\u2015\u30c0\u30fc\u3089\u304c\u958b\u767a\u3057\u305f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u203b1\u306eAPPNL-G-F\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u3002APPNL-G-F\u30de\u30a6\u30b9\u306f\u3001\u30d2\u30c8\u5316\u3057\u305fAPP\uff08\u30a2\u30df\u30ed\u30a4\u30c9\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u907a\u4f1d\u5b50\u306bSwedish\u5909\u7570\uff0cIberian\u5909\u7570\uff0cArctic\u5909\u7570\uff08\u907a\u4f1d\u6027\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u907a\u4f1d\u5b50\u5909\u7570\uff09\u3092\u30ce\u30c3\u30af\u30a4\u30f3\u6cd5\u306b\u3088\u308a\u5c0e\u5165\u3057\u305f\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30de\u30a6\u30b9\u3067\u30012\uff5e3\u30ab\u6708\u3067\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u7279\u5fb4\u7684\u306a\u30a2\u30df\u30ed\u30a4\u30c9\u75c5\u7406\u304c\u51fa\u73fe\u3057\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u89e3\u6790\u3092\u884c\u306a\u3063\u305f6\u30ab\u6708\u9f62\u3067\u306f\u9855\u8457\u306a\u30a2\u30df\u30ed\u30a4\u30c9\u75c5\u7406\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u5b9f\u9a13\u306b\u3088\u308a\u4ee5\u4e0b\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<br \/>\n1\uff0e\u6d77\u99ac\u306b\u304a\u3044\u3066\u3001BMP4,5,6\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u91ce\u751f\u578b\u306b\u6bd4\u3079\u2640\u512a\u4f4d\u306bAPPNL-G-F\u30de\u30a6\u30b9\u3067\u4e0a\u6607\u3057\u3066\u3044\u305f\u3002<br \/>\n2. \u6d77\u99ac\u6b6f\u72b6\u56de\u306b\u304a\u3051\u308b\u795e\u7d4c\u5e79\u7d30\u80de\u5897\u6b96\u3092\u7d30\u80de\u5897\u6b96\u306e\u30de\u30fc\u30ab\u30fc\u306ePCNA\u3092\u7528\u3044\u3066\u8abf\u3079\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u91ce\u751f\u578b\u306b\u6bd4\u3079\u2640\u512a\u4f4d\u306bAPPNL-G-F\u30de\u30a6\u30b9\u3067\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3002<br \/>\n\uff13. A\u30da\u30d7\u30c1\u30c9\u3092\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306e\u8133\u5ba4\u5185\u3078\u6ce8\u5165\u3059\u308b\u3068\u3001BMP\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u4e0a\u6607\u3068\u6d77\u99ac\u6b6f\u72b6\u56de\u306e\u795e\u7d4c\u65b0\u751f\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002<br \/>\n4. BMP\u963b\u5bb3\u5264\u306b\u3088\u308a\u2640APPNL-G-F\u30de\u30a6\u30b9\u3067\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u795e\u7d4c\u65b0\u751f\u304c\u56de\u5fa9\u3057\u305f\u3002<br \/>\n5. \u57f9\u990a\u7d30\u80deNeuro2a\u306e\u57f9\u990a\u6db2\u306b\u30a8\u30b9\u30c8\u30ed\u30b8\u30a7\u30f3\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u3067\u3001Neuro2a\u7d30\u80de\u306eBMP\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u4e0a\u6607\u3057\u305f\u3002<br \/>\n\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001\u2640\u512a\u4f4d\u306aBMP\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u4e0a\u6607\u304cAPPNL-G-F\u30de\u30a6\u30b9\u306e\u6d77\u99ac\u3067\u8a8d\u3081\u3089\u308c\u3001\u2640\u3067\u512a\u4f4d\u306a\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u306e\u6d77\u99ac\u6b6f\u72b6\u56de\u3067\u306e\u4f4e\u4e0b\u304c\u3042\u308a\u3001BMP\u963b\u5bb3\u5264\u3067\u56de\u5fa9\u3057\u305f\u3053\u3068\u304b\u3089\u3001BMP\u30b7\u30b0\u30ca\u30eb\u306e\u4e0a\u6607\u304c\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3001\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306e\u30a8\u30b9\u30c8\u30ed\u30b8\u30a7\u30f3\u304cBMP\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u4e0a\u6607\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u3001\u57f9\u990a\u7d30\u80de\u306e\u5b9f\u9a13\u304b\u3089\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-1 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-1 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-1' class='gallery galleryid-83031 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/www.waseda.jp\/inst\/research\/news\/83031\/attachment\/%e7%94%bb%e5%83%8f1-126'><img loading=\"lazy\" decoding=\"async\" width=\"1299\" height=\"505\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/29d3bc99193cb0b837fb8cc53f050ae5-3.png\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-83032\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/29d3bc99193cb0b837fb8cc53f050ae5-3.png 1299w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/29d3bc99193cb0b837fb8cc53f050ae5-3-610x237.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/29d3bc99193cb0b837fb8cc53f050ae5-3-940x365.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/29d3bc99193cb0b837fb8cc53f050ae5-3-768x299.png 768w\" sizes=\"auto, (max-width: 1299px) 100vw, 1299px\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-83032'>\n\t\t\t\t\u56f3\uff11\u3000\u4e3b\u306aBMP\u907a\u4f1d\u5b50\u767a\u73fe\u306eTg-female(APPNL-G-F\u2640)\u3067\u306e\u4e0a\u6607\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p style=\"text-align: center;\"><small>6\u6708\u9f62\u306e\u6d77\u99ac\u306b\u304a\u3051\u308bBMP4-6\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5b9a\u91cfPCR\u6cd5\u3067\u8abf\u3079\u305f\u3068\u3053\u308d\u3001WT(\u91ce\u751f\u578b)\u306b\u6bd4\u3079\u3001Tg(APPNL-G-F)\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u50be\u5411\u306f\u2640\u3067\u9855\u8457\u3060\u3063\u305f\u3002<\/small><\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-2 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-2 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-2' class='gallery galleryid-83031 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/www.waseda.jp\/inst\/research\/news\/83031\/attachment\/%e7%94%bb%e5%83%8f2-83'><img loading=\"lazy\" decoding=\"async\" width=\"1299\" height=\"990\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/cbf5b9f60da99bf791c0aa12a770f429-3.png\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-2-83033\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/cbf5b9f60da99bf791c0aa12a770f429-3.png 1299w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/cbf5b9f60da99bf791c0aa12a770f429-3-610x465.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/cbf5b9f60da99bf791c0aa12a770f429-3-940x716.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/12\/cbf5b9f60da99bf791c0aa12a770f429-3-768x585.png 768w\" sizes=\"auto, (max-width: 1299px) 100vw, 1299px\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-2-83033'>\n\t\t\t\t\u56f32 BMP\u963b\u5bb3\u5264(LDN)\u3092\u7528\u3044\u3066BNP\u30b7\u30b0\u30ca\u30eb\u963b\u5bb3\u3092\u884c\u306a\u3063\u305f\u7d50\u679c\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p style=\"text-align: center;\"><small>3\u9031\u9593BMP\u963b\u5bb3\u5264\u3092\u4e0e\u3048\u305f1\u9031\u9593\u5f8c\u306b(A)\u3001\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u3092\u8abf\u3079\u305f(B)\u3002\u5897\u6b96\u7d30\u80de\u306e\u30de\u30fc\u30ab\u30fc\u306ePCNA\u967d\u6027\u7d30\u80de\u6570\u304cBMP\u963b\u5bb3\u5264\u6295\u4e0e\u306b\u3088\u308aTg(APPNL-G-F)\u3067WT(\u91ce\u751f\u578b)\u306b\u6bd4\u3079\u3001\u540c\u7a0b\u5ea6\u306b\u56de\u5fa9\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f(C)\u3002<\/small><\/p>\n<h3><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h3>\n<p>\u307e\u3060\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u614b\u3092\u3001\u6027\u5dee\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u884c\u306a\u3063\u305f\u7814\u7a76\u6210\u679c\u3067\u3059\u3002<\/p>\n<h3><strong>\u8ab2\u984c\u3001\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u3067BMP\u963b\u5bb3\u5264\u304c\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u304c\u3001\u30de\u30a6\u30b9\u306e\u5b66\u7fd2\u30fb\u8a18\u61b6\u306a\u3069\u306b\u5bfe\u3057\u3066\u306e\u5177\u4f53\u7684\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u306b\u5bfe\u3059\u308b\u6297\u4f53\u533b\u85ac\u304c\u81e8\u5e8a\u3067\u4f7f\u7528\u3055\u308c\u59cb\u3081\u3066\u3044\u308b\u304c\u3001\u75c5\u6c17\u306e\u9032\u884c\u3092\u7de9\u3081\u308b\u3068\u3053\u308d\u3067\u6b62\u3081\u308b\u3068\u3053\u308d\u306b\u306f\u81f3\u3063\u3066\u304a\u3089\u305a\u3001\u66f4\u306a\u308b\u75c5\u614b\u89e3\u660e\u304c\u5fc5\u8981\u3067\u3059\u3002\u4eca\u56de\u3001\u7814\u7a76\u306b\u7528\u3044\u305fAPPNL-G-F\u30de\u30a6\u30b9\u306f\u3001\u65e9\u671f\u306b\u30a2\u30df\u30ed\u30a4\u30c9\u75c5\u7406\u304c\u518d\u73fe\u51fa\u6765\u308b\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u3042\u308a\u3001APPNL-G-F\u30de\u30a6\u30b9\u3067\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u8133\u3067\u3082\u8d77\u304d\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304b\u3089\u3001\u540c\u30de\u30a6\u30b9\u3092\u6d3b\u7528\u3057\u305f\u4eca\u5f8c\u306e\u66f4\u306a\u308b\u7814\u7a76\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3><strong>\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u3067\u306f\u3001\u30d2\u30c8\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u3001\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u306b\u4f34\u3044\u3001\u5927\u304d\u306a\u793e\u4f1a\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u8a8d\u77e5\u75c7\u306e\u75c5\u614b\u89e3\u660e\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u65b0\u305f\u306a\u77e5\u898b\u3092\u5f97\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u5411\u3051\u305f\u4e00\u6b69\u76ee\u3067\u3042\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u7814\u7a76\u3092\u767a\u5c55\u3055\u305b\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n<p>\u203b1\u3000\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9<br \/>\n\u5bb6\u65cf\u6027\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u5bb6\u7cfb\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u3082\u3064APP\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u75c5\u7406\u3092\u518d\u73fe\u3057\u305f\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u304c\u958b\u767a\u3055\u308c\u3066\u304d\u305f\u304c\u3001\u904e\u5270\u767a\u73fe\u304c\u3082\u305f\u3089\u3059\u526f\u6b21\u7684\u306a\u52b9\u679c\u304c\u3042\u3063\u305f\u3002\u305d\u306e\u554f\u984c\u3092\u89e3\u6c7a\u3057\u305f\u306e\u304cAPPNL-G-F\u30de\u30a6\u30b9\u3067\u3042\u308b\u3002<\/p>\n<p>\u203b2\u3000\u6210\u4f53\u795e\u7d4c\u65b0\u751f<br \/>\n\u6210\u4f53\u8133\u3067\u65b0\u3057\u304f\u795e\u7d4c\u7d30\u80de\u304c\u795e\u7d4c\u5e79\u7d30\u80de\u304b\u3089\u4f5c\u3089\u308c\u308b\u73fe\u8c61\u3067\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u306e2\u3064\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u306b\u95a2\u308f\u308b\u5206\u5b50\u3084\u30b7\u30b0\u30ca\u30eb\u7cfb\u306e\u7814\u7a76\u304c\u884c\u306a\u308f\u308c\u3066\u3044\u308b\u3002\u6d77\u99ac\u6b6f\u72b6\u56de\u306b\u304a\u3051\u308b\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u304c\u59a8\u3052\u3089\u308c\u308b\u3068\u3001\u5b66\u7fd2\u3084\u8a18\u61b6\u304c\u59a8\u3052\u3089\u308c\u308b\u3002<\/p>\n<p>\u203b3\u3000BMP\u30b7\u30b0\u30ca\u30eb<br \/>\n\u9aa8\u5f62\u6210\u30bf\u30f3\u30d1\u30af\u8cea\uff08Bone Morphogenetic Protein\uff09\u304c\u7d30\u80de\u306e\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u3066\u3001\u7d30\u80de\u5185\u3067\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u9054\u3059\u308b\u7d4c\u8def\u3067\u3059\u3002\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u3001\u767a\u751f\u521d\u671f\u306e\u7d30\u80de\u306e\u5206\u5316\u3084\u3001\u9aa8\u3001\u8840\u7ba1\u3001\u9854\u9762\u3001\u795e\u7d4c\u306a\u3069\u306e\u5f62\u6210\u3001\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002<\/p>\n<h3>\u30ad\u30fc\u30ef\u30fc\u30c9<\/h3>\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9 APPNL-G-F\u3001\u6210\u4f53\u795e\u7d4c\u65b0\u751f\u3001BMP\u30b7\u30b0\u30ca\u30eb\u3001\u6027\u5dee\u3001\u5b9a\u91cfPCR\u3001\u30a8\u30b9\u30c8\u30ed\u30b8\u30a7\u30f3<\/p>\n<h3><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h3>\n<p>\u96d1\u8a8c\u540d\uff1aBiology of Sex Differences<br \/>\n\u8ad6\u6587\u540d\uff1aSex-related upregulation of bone morphogenetic protein signaling inhibits adult neurogenesis in APP NL-G-F Alzheimer&#8217;s disease model mice<br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1aXingyu Su\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09, Rina Takayanagi\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09, Hiroki Maeda\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09, Toshio Ohshima\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09*\u3001Takaomi C Saido\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\uff09<br \/>\n\u63b2\u8f09\u65e5\u6642\uff1a2025\u5e7412\u670812\u65e5<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/doi.org\/10.1186\/s13293-025-00799-0\">https:\/\/doi.org\/10.1186\/s13293-025-00799-0<\/a><br \/>\nDOI\uff1a <a href=\"https:\/\/doi.org\/10.1186\/s13293-025-00799-0\">https:\/\/doi.org\/10.1186\/s13293-025-00799-0<\/a><br 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