{"id":82584,"date":"2025-10-24T09:00:08","date_gmt":"2025-10-24T00:00:08","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=82584"},"modified":"2025-10-23T17:17:08","modified_gmt":"2025-10-23T08:17:08","slug":"%e4%b8%96%e4%bb%a3%e3%82%92%e8%b6%85%e3%81%88%e3%81%a6%e3%83%86%e3%83%ad%e3%83%a1%e3%82%a2dna%e3%82%92%e7%b6%ad%e6%8c%81%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e4%bb%95%e7%b5%84%e3%81%bf","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/82584","title":{"rendered":"\u4e16\u4ee3\u3092\u8d85\u3048\u3066\u30c6\u30ed\u30e1\u30a2DNA\u3092\u7dad\u6301\u3059\u308b\u65b0\u305f\u306a\u4ed5\u7d44\u307f"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong><span class=\"TextRun SCXW36494652 BCX8\" lang=\"JA-JP\" xml:lang=\"JA-JP\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW36494652 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href='https:\/\/www.waseda.jp\/inst\/research\/news\/82584\/attachment\/%e3%83%86%e3%83%ad%e3%83%a1%e3%83%ac%e3%83%bc%e3%82%b9'><img loading=\"lazy\" decoding=\"async\" width=\"892\" height=\"268\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/e6b623e928f2cdd3e780b8ad0ddc65c7.png\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-82585\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/e6b623e928f2cdd3e780b8ad0ddc65c7.png 892w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/e6b623e928f2cdd3e780b8ad0ddc65c7-610x183.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/e6b623e928f2cdd3e780b8ad0ddc65c7-768x231.png 768w\" sizes=\"auto, (max-width: 892px) 100vw, 892px\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' 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\/>\n\t\t<\/div>\n\n<h3>\u80cc\u666f<\/h3>\n<p>\u771f\u6838\u751f\u7269\u306e\u67d3\u8272\u4f53\u306f\u7dda\u72b6\u306eDNA\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u304c\u5206\u88c2\u3059\u308b\u3068\u304d\u3001\u67d3\u8272\u4f53DNA\u306fDNA\u5408\u6210\u9175\u7d20\u306e\u50cd\u304d\u306b\u3088\u308a\u8907\u88fd\u3055\u308c\u307e\u3059\u304c\u3001\u9175\u7d20\u53cd\u5fdc\u306e\u4ed5\u7d44\u307f\u4e0a\u3001\u67d3\u8272\u4f53\u672b\u7aef\u306eDNA\uff08\u30c6\u30ed\u30e1\u30a2\uff09\u306b\u306f\u8907\u88fd\u3067\u304d\u306a\u3044\u9818\u57df\u304c\u6b8b\u3055\u308c\u307e\u3059\u3002\u5f93\u3063\u3066\u30c6\u30ed\u30e1\u30a2\u306f\u7d30\u80de\u5206\u88c2\u306e\u305f\u3073\u306b\u77ed\u7e2e\u3055\u308c\u3001\u3053\u308c\u306b\u3088\u308a\u3001\u4f53\u3092\u3064\u304f\u308b\u7d30\u80de\u306e\u5bff\u547d\uff08\u5206\u88c2\u56de\u6570\u306e\u4e0a\u9650\uff09\u304c\u898f\u5b9a\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001\u6b21\u4e16\u4ee3\u3078\u3068\u5f15\u304d\u7d99\u304c\u308c\u308b\u552f\u4e00\u306e\u7d30\u80de\u7cfb\u8b5c\u3067\u3042\u308b\u751f\u6b96\u7d30\u80de\u3067\u306f\u3001\u30c6\u30ed\u30e1\u30a2\u304c\u5341\u5206\u306b\u4f38\u9577\u3055\u308c\u3066\u6b21\u4e16\u4ee3\u306b\u4f1d\u9054\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u7a2e\u306e\u5b58\u7d9a\u304c\u62c5\u4fdd\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u56f31\u5de6\uff09\u3002\u3082\u3057\u30c6\u30ed\u30e1\u30a2\u304c\u751f\u6b96\u7d30\u80de\u3067\u4f38\u9577\u3055\u308c\u306a\u3051\u308c\u3070\u3001\u30c6\u30ed\u30e1\u30a2\u306f\u4e16\u4ee3\u3092\u7d4c\u308b\u3054\u3068\u306b\u5f90\u3005\u306b\u77ed\u7e2e\u3055\u308c\u3001\u6700\u7d42\u7684\u306b\u7a2e\u306f\u7d76\u6ec5\u306b\u81f3\u308a\u307e\u3059\u3002<br \/>\n\u30c6\u30ed\u30e1\u30a2\u306e\u4f38\u9577\u306b\u306f\u3001\u7d30\u80de\u5206\u88c2\u306e\u969b\u306b\u50cd\u304fDNA\u5408\u6210\u9175\u7d20\u3068\u306f\u7570\u306a\u308b\u300c\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u300d\u3068\u547c\u3070\u308c\u308b\u9175\u7d20\u304c\u5fc5\u8981\u306a\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3068RNA\u304b\u3089\u6210\u308b\u30db\u30ed\u9175\u7d20<sup>[4]<\/sup>\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001RNA\u3092\u92f3\u578b\u3068\u3057\u3066\u9006\u8ee2\u5199\u53cd\u5fdc<sup>[5]<\/sup>\u306b\u3088\u308aDNA\u3092\u5408\u6210\u3057\u3001\u30c6\u30ed\u30e1\u30a2\u3092\u4f38\u9577\u3055\u305b\u307e\u3059\uff08\u56f31\u53f3\uff09\u3002\u4f8b\u3048\u3070\u3001\u534a\u6c38\u7d9a\u7684\u306b\u5897\u6b96\u3059\u308b\u591a\u304f\u306e\u304c\u3093\u7d30\u80de\u3067\u306f\u3001\u3053\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u304c\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u30c6\u30ed\u30e1\u30a2\u304c\u7dad\u6301\u3055\u308c\u3001\u5206\u88c2\u9650\u754c\u3092\u8d85\u3048\u3066\u534a\u6c38\u7d9a\u7684\u306b\u5897\u6b96\u3067\u304d\u307e\u3059\u3002\u4e00\u65b9\u3001\u5065\u5eb7\u306a\u751f\u4f53\u5185\u3067\u306f\u3001\u4f8b\u5916\u7684\u306b\u5e79\u7d30\u80de\u3068\u751f\u6b96\u7d30\u80de\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u304c\u6d3b\u6027\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u751f\u6b96\u7d30\u80de\u3067\u306f\u3001\u305d\u306e\u7279\u5225\u306b\u9577\u3044\u30c6\u30ed\u30e1\u30a2\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u3001\u4f53\u6027\u5e79\u7d30\u80de\u306b\u3082\u5897\u3057\u3066\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8ee2\u5199\u5236\u5fa1\u306a\u3069\u4e00\u90e8\u306e\u8abf\u7bc0\u6a5f\u69cb\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306e\u7d44\u7e54\u7279\u7570\u7684\u306a\u6d3b\u6027\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5168\u4f53\u50cf\u306f\u307e\u3060\u5341\u5206\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-2 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-2 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-2' class='gallery galleryid-82584 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/www.waseda.jp\/inst\/research\/news\/82584\/attachment\/%e3%83%86%e3%83%ad%e3%83%a1%e3%82%a2%e9%95%b7%e3%81%95'><img loading=\"lazy\" decoding=\"async\" width=\"566\" height=\"234\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/95edca16317e270c36156d729d4462c3.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-2-82586\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-2-82586'>\n\t\t\t\t\u56f31\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u306e\u5236\u5fa1\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p style=\"text-align: center;\">\u5de6\uff1a\u30c6\u30ed\u30e1\u30a2\u306f\u7d30\u80de\u5206\u88c2\u306e\u305f\u3073\u306b\u77ed\u7e2e\u3059\u308b\u304c\u3001\u304c\u3093\u5316\u3057\u305f\u7d30\u80de\u3084\u4f53\u6027\u5e79\u7d30\u80de\u3067\u306f\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u304c\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u6bd4\u8f03\u7684\u9577\u3044\u30c6\u30ed\u30e1\u30a2\u304c\u7dad\u6301\u3055\u308c\u308b\u3002\u751f\u6b96\u7d30\u80de\u306f\u4e2d\u3067\u3082\u7279\u6b8a\u3067\u3001\u6b21\u4e16\u4ee3\u3078\u3068\u30c6\u30ed\u30e1\u30a2\u3092\u4f1d\u9054\u3059\u308b\u305f\u3081\u306b\u3001\u975e\u5e38\u306b\u9577\u3044\u30c6\u30ed\u30e1\u30a2\u304c\u7dad\u6301\u3055\u308c\u308b\u304c\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u591a\u304f\u306f\u672a\u89e3\u660e\u3067\u3042\u308b\u3002<br \/>\n\u53f3\uff1a\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306f\u9006\u8ee2\u5199\u9175\u7d20\u3067\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u92f3\u578bRNA\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u3002\u9006\u8ee2\u5199\u53cd\u5fdc\u306b\u3088\u308a\u3001RNA\u3092\u92f3\u578b\u3068\u3057\u3066\u30c6\u30ed\u30e1\u30a2DNA\u3092\u5408\u6210\u3059\u308b\u3002<\/p>\n<p style=\"text-align: left;\">\u6f81\u8c37\u30c1\u30fc\u30e0\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\u306f\u3001\u751f\u6b96\u7d30\u80de\u306b\u304a\u3051\u308b\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u6d3b\u6027\u3084\u30c6\u30ed\u30e1\u30a2\u304c\u4e16\u4ee3\u3092\u8d85\u3048\u3066\u7dad\u6301\u3055\u308c\u308b\u4ed5\u7d44\u307f\u3092\u8abf\u3079\u308b\u305f\u3081\u3001\u4e16\u4ee3\u6642\u9593\u304c3\u65e5\u3068\u77ed\u3044\u7dda\u866b\uff08Caenorhabditis elegans\u3001\u4ee5\u4e0bC. elegans\uff09\u3092\u7528\u3044\u3066\u7814\u7a76\u3057\u3066\u304d\u307e\u3057\u305f\u3002C. elegans\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306e\u69cb\u6210\u5206\u5b50\u306e\u3046\u3061\u3001\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u30bf\u30f3\u30d1\u30af\u8ceaTRT-1\u306f\u3001\u30d2\u30c8\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306e\u76f8\u540c\u6027\u304b\u3089\u30012006\u5e74\u306b\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u9175\u7d20\u6d3b\u6027\u306b\u5fc5\u9808\u306a\u76f8\u65b9\u3068\u306a\u308b\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u306f\u3001\u5148\u884c\u7814\u7a76\u306b\u304a\u3051\u308b\u8a66\u884c\u932f\u8aa4\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001C. elegans\u3084\u305d\u306e\u4ed6\u306e\u7dda\u5f62\u52d5\u7269\u9580\u306b\u5c5e\u3059\u308b\u7dda\u866b\u985e\u3044\u305a\u308c\u306b\u304a\u3044\u3066\u3082\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u56f32\uff09\u3002\u3053\u308c\u306f\u7dda\u866b\u985e\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u304c\u4ed6\u306e\u52d5\u7269\u306e\u3082\u306e\u3068\u306f\u5168\u304f\u7570\u306a\u308b\u914d\u5217\u3084\u69cb\u9020\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u3084\u3001\u3042\u308b\u3044\u306f\u7279\u6b8a\u306a\u30b2\u30ce\u30e0\u4e0a\u306e\u4f4d\u7f6e\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u3067\u3001\u901a\u5e38\u306e\u907a\u4f1d\u5b50\u4e88\u6e2c\u3067\u306f\u767a\u898b\u304c\u96e3\u3057\u3044\u7279\u6b8a\u306aRNA\u3067\u3042\u308b\u3053\u3068\u306b\u8d77\u56e0\u3059\u308b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u8a73\u7d30\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-3 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-3 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-3 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-3 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-3' class='gallery galleryid-82584 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/www.waseda.jp\/inst\/research\/news\/82584\/attachment\/%e5%be%8c%e7%94%9f%e5%8b%95%e7%89%a9'><img loading=\"lazy\" decoding=\"async\" width=\"491\" height=\"411\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/2c442b5ad27505cf065639770a504142.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-3-82588\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-3-82588'>\n\t\t\t\t\u56f32 \u5f8c\u751f\u52d5\u7269\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p style=\"text-align: left;\"><small>\u6d77\u7dbf\u52d5\u7269\u304b\u3089\u30d2\u30c8\u306b\u81f3\u308b\u591a\u304f\u306e\u5f8c\u751f\u52d5\u7269\u3067\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306f\u5168\u3066\u72ec\u81ea\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304b\u3089\u8ee2\u5199\u3055\u308c\u308bnon-coding RNA\u907a\u4f1d\u5b50\u3068\u3057\u3066\u30b3\u30fc\u30c9\u3055\u308c\u3066\u304a\u308a\u3001H\/ACA\u30bf\u30a4\u30d7\u306e\u6838\u5c0f\u4f53\u4f4e\u5206\u5b50RNA\uff08snoRNA\uff09\u306b\u4f3c\u305f\u914d\u5217\u3092\u6301\u3064\u3002\u7dda\u866b\u3092\u542b\u3080\u7dda\u5f62\u52d5\u7269\u9580\u3067\u306f\u3001\u3044\u307e\u3060\u306b\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u306f\u672a\u540c\u5b9a\u3067\u3042\u3063\u305f\u3002\u306a\u304a\u6606\u866b\u985e\u3067\u306f\u4f8b\u5916\u7684\u306b\u3001H\/ACA\u30bf\u30a4\u30d7\u3068\u306f\u7570\u306a\u308b\u6838\u5185\u4f4e\u5206\u5b50RNA\uff08snRNA\uff09\u30bf\u30a4\u30d7\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u3092\u6301\u3064\u3082\u306e\uff08\u30cf\u30c1\u76ee\uff09\u3001small non-coding RNA\u30bf\u30a4\u30d7\u3092\u6301\u3064\u3082\u306e\uff08\u9c57\u7fc5\u76ee\uff08\u308a\u3093\u3057\u3082\u304f\uff09\uff09\u3001\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u8ee2\u79fb\u578b\u306e\u30c6\u30ed\u30e1\u30a2\u3092\u6301\u3064\u3082\u306e\uff08\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\uff09\u304c\u3044\u308b\u3002<\/small><\/p>\n<h3><strong>\u7814\u7a76\u624b\u6cd5\u3068\u6210\u679c\u3000<\/strong><\/h3>\n<p>\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306e\u767a\u73fe\u91cf\u306f\u591a\u304f\u306e\u751f\u7269\u306b\u304a\u3044\u3066\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u7570\u5e38\u306a\u4f38\u9577\u3092\u9632\u3050\u305f\u3081\u306b\u5fc5\u8981\u6700\u5c0f\u9650\u306b\u6291\u3048\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d76\u5bfe\u91cf\u306e\u5c11\u306a\u3055\u304c\u751f\u4f53\u5185\u3067\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u3092\u7814\u7a76\u3059\u308b\u4e0a\u3067\u306e\u5927\u304d\u306a\u969c\u58c1\u306e\u4e00\u3064\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001C. elegans\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u307e\u305a\u907a\u4f1d\u5b50\u6539\u5909\u3057\u305f\u7dda\u866b\u500b\u4f53\u304b\u3089\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u30bf\u30f3\u30d1\u30af\u8ceaTRT-1\u3092\u5927\u91cf\u306b\u3064\u304f\u3089\u305b\u3066\u3001\u7cbe\u88fd\u3057\u3001\u305d\u3053\u306b\u7d50\u5408\u3059\u308bRNA\u3092eCLIP\u6cd5<sup>[6]<\/sup>\u306b\u3088\u308a\u56de\u53ce\u3059\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6cd5\u3092\u8003\u6848\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u898b\u3064\u304b\u3063\u305fRNA\u306f\u3001\u4e88\u60f3\u5916\u306a\u3053\u3068\u306b\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea[7]\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50nmy-2<sup>[7]<\/sup>\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u9818\u57df\u306e\u914d\u5217\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u306eRNA\u914d\u5217\u3092\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u306e\u5019\u88dc\u3068\u3057\u3066\u3001\u300ctelomerase RNA component-1\uff08terc-1\uff09\u300d\u3068\u547d\u540d\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-4 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-4 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-4 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-4 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-4' class='gallery galleryid-82584 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/www.waseda.jp\/inst\/research\/news\/82584\/attachment\/terc-1'><img loading=\"lazy\" decoding=\"async\" width=\"563\" height=\"311\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/terc-1.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-4-82590\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-4-82590'>\n\t\t\t\t\u56f33 C. elegans\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u300cterc-1\u300d\u306e\u767a\u898b\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p style=\"text-align: left;\"><small>\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u30bf\u30f3\u30d1\u30af\u8ceaTRT-1\u306b\u7d50\u5408\u3059\u308bRNA\u3092\u56de\u53ce\u3057\u3001\u305d\u306e\u914d\u5217\u3092\u89e3\u8aad\u3057\u305f\u3002\u3055\u307e\u3056\u307e\u306a\u9577\u3055\u306eRNA\u304c\u56de\u53ce\u3055\u308c\u305f\u304c\u3001\u305d\u308c\u3089\u3068\u4e00\u81f4\u3059\u308b\u30b2\u30ce\u30e0\u914d\u5217\u3092\u691c\u7d22\u3057\u305f\u3068\u3053\u308d\u3001\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50nmy-2\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u9818\u57df\u306e\u30bb\u30f3\u30b9\u9396\uff08\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306b\u76f4\u63a5\u95a2\u308f\u308b\u60c5\u5831\u3092\u542b\u3080\u9396\uff09\u306b\u96c6\u4e2d\u3057\u3066\u3044\u305f\u3002\u3053\u306e\u9818\u57df\u306b\u306f\u3001C.elegans\u306e\u30c6\u30ed\u30e1\u30a2DNA\u914d\u5217\u306b\u898b\u3089\u308c\u308b\u7e70\u308a\u8fd4\u3057\u914d\u52175\u2019-\uff08TTAGGC\uff09-3\u2019\u306b\u76f8\u88dc\u7684\u306a\u300c\u92f3\u578b\u914d\u5217\uff085\u2019-UAAGCCUAAG-3\u2019\uff09\u300d\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002\u4e00\u65b9\u3001TRT-1\u306a\u3057\u306bRNA\u3092\u56de\u53ce\u3057\u305f\u5834\u5408\u306b\u306f\u3001nmy-2\u907a\u4f1d\u5b50\u306b\u5bfe\u5fdc\u3059\u308b\u914d\u5217\u306f\u898b\u3044\u3060\u3055\u308c\u306a\u304b\u3063\u305f\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff09\u3002<\/small><\/p>\n<p style=\"text-align: left;\">\u30a4\u30f3\u30c8\u30ed\u30f3\u306f\u3001\u907a\u4f1d\u5b50\u5185\u306b\u3042\u308b\u3044\u308f\u3086\u308b\u300c\u30b8\u30e3\u30f3\u30af\u914d\u5217[3]\u300d\u3067\u3042\u308a\u3001\u901a\u5e38\u306f\u907a\u4f1d\u5b50\u304c\u8ee2\u5199\u3055\u308c\u305f\u5f8c\u306b\u5207\u308a\u6368\u3066\u3089\u308c\u3066\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u5b58\u5728\u3059\u308b\u9577\u9396\u975e\u30b3\u30fc\u30c9RNA[3]\uff08intronic long non-coding RNA\uff09\u304c\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u3092\u751f\u6210\u3059\u308b\u4f8b\u306f\u3001\u83cc\u3084\u690d\u7269\u3092\u542b\u3081\u305f\u5168\u771f\u6838\u751f\u7269\u3067\u3053\u308c\u307e\u3067\u5831\u544a\u304c\u306a\u304f\u3001\u3053\u306e\u5b9f\u9a13\u7d50\u679c\u306f\u306b\u308f\u304b\u306b\u306f\u4fe1\u3058\u96e3\u3044\u3082\u306e\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001C. elegans\u306b\u8fd1\u7e01\u306a\u4ed6\u306e\u7dda\u866b\u985e\u306b\u304a\u3044\u3066\u3082\u3001nmy-2\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u9818\u57df\u306b\u985e\u4f3c\u3057\u305f\u914d\u5217\u304c\u78ba\u8a8d\u3055\u308c\u3001\u3053\u308c\u3089\u306f2\u6b21\u69cb\u9020\u306e\u9762\u3067\u3082\u9ad8\u3044\u985e\u4f3c\u6027\u3092\u793a\u3057\u305f\u3053\u3068\u304b\u3089\u3001terc-1\u304c\u7dda\u866b\u985e\u306b\u4fdd\u5b58\u3055\u308c\u305f\u914d\u5217\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u2460terc-1\u306e\u914d\u5217\u306b\u306f\u3001C. elegans\u30c6\u30ed\u30e1\u30a2DNA\u306b\u76f8\u88dc\u7684\u306a\u300c\u92f3\u578b\u914d\u5217<sup>[8]<\/sup>\u300d\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u2461terc-1\u914d\u5217\u3092\u6b20\u5931\u3055\u305b\u305f\u907a\u4f1d\u5b50\u6539\u5909\u7dda\u866b\u306f\u4e16\u4ee3\u3092\u7d4c\u308b\u3054\u3068\u306b\u5f90\u3005\u306b\u7523\u4ed4\uff08\u3055\u3093\u3057\uff1a\u51fa\u7523\uff09\u306e\u6570\u304c\u6e1b\u5c11\u3057\u3001\u6700\u7d42\u7684\u306b\u7d0415\u4e16\u4ee3\u4ee5\u5185\u306b\u6b7b\u6ec5\u3057\u307e\u3057\u305f\u3002\u2462\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u6539\u5909\u7dda\u866b\u306e\u30c6\u30ed\u30e1\u30a2DNA\u306e\u9577\u3055\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u4e16\u4ee3\u3092\u7d4c\u308b\u3054\u3068\u306b\u5f90\u3005\u306b\u30c6\u30ed\u30e1\u30a2\u304c\u77ed\u7e2e\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f34\uff09\u3002\u3053\u308c\u3089\u306e\u89b3\u5bdf\u7d50\u679c\u306a\u3069\u304b\u3089\u3001terc-1\u304c\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u4e16\u4ee3\u3092\u8d85\u3048\u305f\u30c6\u30ed\u30e1\u30a2\u306e\u7dad\u6301\u3084\u500b\u4f53\u7fa4\u306e\u5b58\u7d9a\u306b\u5fc5\u9808\u306a\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-5 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-5 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-5 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-5 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-5' class='gallery galleryid-82584 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/www.waseda.jp\/inst\/research\/news\/82584\/attachment\/terc-1%e5%a4%89%e7%95%b0%e4%bd%93'><img loading=\"lazy\" decoding=\"async\" width=\"370\" height=\"411\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/02b8d5f9d08b0d5d1e6a00850c1b578e.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-5-82600\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-5-82600'>\n\t\t\t\t\u56f34 terc-1\u5909\u7570\u4f53\u3067\u898b\u3089\u308c\u308b\u30c6\u30ed\u30e1\u30a2\u306e\u7d4c\u4e16\u4ee3\u7684\u306a\u77ed\u7e2e\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p style=\"text-align: left;\"><small>C. elegans\u306e\u5168\u7d30\u80de\u304b\u3089DNA\u3092\u56de\u53ce\u3057\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u3092\u53ef\u8996\u5316\u3057\u305f\u96fb\u6c17\u6cf3\u52d5\u50cf\u3002\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u306f\u7d30\u80de\u306b\u3088\u3063\u3066\u3055\u307e\u3056\u307e\u3060\u304c\u3001\u91ce\u751f\u578bC. elegans\u306e\u6cf3\u52d5\u50cf\u3068\u6bd4\u8f03\u3057\u3001terc-1\u306e\u5168\u9577\u3092\u6b20\u640d\u3055\u305b\u305f\u500b\u4f53\u3084\u92f3\u578b\u914d\u5217\u3092\u6b20\u640d\u3057\u305f\u500b\u4f53\u3001\u304a\u3088\u3073\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u30bf\u30f3\u30d1\u30af\u8ceaTRT-1\u3092\u6b20\u640d\u3055\u305b\u305f\u500b\u4f53\u3067\u306f\u3001\u30c6\u30ed\u30e1\u30a2\u304c\u4e16\u4ee3\u3092\u7d4c\u308b\u3054\u3068\u306b\u5f90\u3005\u306b\u77ed\u7e2e\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308b\u3002\u3053\u308c\u3089\u306e\u6b20\u640d\u500b\u4f53\u7fa4\u306f\u3001\u6700\u7d42\u7684\u306b\u7d0415\u4e16\u4ee3\u3067\u6b7b\u6ec5\u3057\u305f\u3002kbp\uff08k=1,000\u3001bp\uff1d\u5869\u57fa\u6570\uff09\uff1a\u6838\u9178\u306e\u9577\u3055\u3092\u8868\u3059\u5358\u4f4d\u3002<\/small><\/p>\n<p>\u6b21\u306b\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001C. elegans\u306e\u7d30\u80de\u5185\u3067terc-1\u304c\u751f\u6210\u3055\u308c\u308b\u4ed5\u7d44\u307f\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u3084\u30d2\u30c8\u306e\u5834\u5408\u306f\u3001\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u3092\u3064\u304f\u308b\u305f\u3081\u306e\u5c02\u7528\u306e\u907a\u4f1d\u5b50\u304c\u5b58\u5728\u3057\u3001\u305d\u306e\u907a\u4f1d\u5b50\u304b\u3089\u307e\u305a\u524d\u99c6\u4f53RNA\u304c\u8ee2\u5199\u3055\u308c\u305f\u5f8c\u3001\u4e0d\u8981\u306a\u914d\u5217\u304c\u524a\u3089\u308c\u3066\u6210\u719f\u3057\u305f\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u306b\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001C. elegans\u3067\u306f\u3001nmy-2\u907a\u4f1d\u5b50\u304c\u8ee2\u5199\u3055\u308c\u305f\u5f8c\u306b\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u5207\u308a\u96e2\u3055\u308c\u308b\u904e\u7a0b\u3067\u3042\u308b\u300c\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0<sup>[9]<\/sup>\u300d\u304cterc-1\u306e\u767a\u73fe\u306b\u5fc5\u9808\u3067\u3042\u308a\u3001\u3053\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u963b\u5bb3\u3059\u308b\u3088\u3046\u306a\u5909\u7570\u3092\u5165\u308c\u305f\u7dda\u866b\u682a\u3067\u306fterc-1\u304c\u5168\u304f\u767a\u73fe\u305b\u305a\u3001terc-1\u6b20\u640d\u500b\u4f53\u540c\u69d8\u306b\u30c6\u30ed\u30e1\u30a2\u306e\u7d4c\u4e16\u4ee3\u7684\u306a\u77ed\u7e2e\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u524d\u99c6\u4f53RNA\uff08\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u305f\u30a4\u30f3\u30c8\u30ed\u30f3RNA\uff09\u304b\u3089\u4e0d\u8981\u306a\u914d\u5217\u3092\u524a\u308a\u300c\u6210\u719f\u578b\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\uff08terc-1\uff09\u300d\u3092\u5f62\u6210\u3059\u308b\u904e\u7a0b\u306fC. elegans\u306b\u3082\u5b58\u5728\u3057\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u904e\u7a0b\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u54fa\u4e73\u985e\u306e\u3082\u306e\u3068\u306f\u7570\u306a\u308a\u3001RNA\u5206\u89e3\u9175\u7d20\u306b\u8fd1\u3044\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n\u6700\u5f8c\u306b\u3001\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u300c\u306a\u305cterc-1\u306fnmy-2\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u5b58\u5728\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u306e\u304b\u300d\u3068\u3044\u3046\u6700\u5927\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u691c\u8a3c\u5b9f\u9a13\u3092\u8003\u6848\u3057\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001terc-1\u3092\u672c\u6765\u306enmy-2\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u304b\u3089\u3001\u7d44\u7e54\u7279\u7570\u7684\u306a\u767a\u73fe\u3092\u793a\u3059\u5225\u306e\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u79fb\u690d\u3057\u305f\u907a\u4f1d\u5b50\u6539\u5909C. elegans\u3092\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306b\u3088\u308a\u4f5c\u88fd\u3057\u3001\u7d4c\u4e16\u4ee3\u7684\u306b\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3067\u305d\u306e\u500b\u4f53\u7fa4\u304c\u5b58\u7d9a\u53ef\u80fd\u304b\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<br \/>\n\u305d\u306e\u7d50\u679c\u3001\u751f\u6b96\u7d30\u80de\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u3084\u3001\u751f\u6b96\u7d30\u80de\u3092\u542b\u3080\u5168\u8eab\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306bterc-1\u3092\u79fb\u690d\u3057\u305f\u500b\u4f53\u7fa4\u3067\u306f\u30c6\u30ed\u30e1\u30a2\u304c\u4e16\u4ee3\u3092\u8d85\u3048\u3066\u7dad\u6301\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f35\uff09\u3002\u307e\u305f\u3053\u308c\u3089\u306e\u500b\u4f53\u7fa4\u306f\u5b9f\u9a13\u5ba4\u3067\u534a\u6c38\u4e45\u7684\u306b\u7d99\u4ee3\u98fc\u80b2\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3057\u305f\u3002\u305d\u308c\u306b\u5bfe\u3057\u3066\u3001\u751f\u6b96\u7d30\u80de\u3067\u306f\u767a\u73fe\u3057\u306a\u3044\u907a\u4f1d\u5b50\uff08\u4f8b\u3048\u3070\u76ae\u4e0b\u7d44\u7e54\u3001\u7b4b\u7d44\u7e54\u3001\u795e\u7d4c\u7d30\u80de\u3001\u54bd\u982d\u7d44\u7e54\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\uff09\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306bterc-1\u3092\u79fb\u690d\u3057\u305f\u500b\u4f53\u7fa4\u306f\u3001terc-1\u6b20\u640d\u500b\u4f53\u540c\u69d8\u306b\u30c6\u30ed\u30e1\u30a2\u306e\u6975\u5ea6\u306a\u77ed\u7e2e\u306b\u3088\u308a\u7d0415\u4e16\u4ee3\u4ee5\u5185\u3067\u7d76\u6ec5\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f35\uff09\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-6 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-6 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-6 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-6 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-6' class='gallery galleryid-82584 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/www.waseda.jp\/inst\/research\/news\/82584\/attachment\/%e7%a7%bb%e6%a4%8d%e5%ae%9f%e9%a8%93'><img loading=\"lazy\" decoding=\"async\" width=\"476\" height=\"271\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/e65ea653249dd5a2abb9fc198893c20e.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-6-82603\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-6-82603'>\n\t\t\t\t\u56f35 terc-1\u306e\u79fb\u690d\u5b9f\u9a13\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p style=\"text-align: left;\"><small>terc-1\u3092nmy-2\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u304b\u3089\u3001\u7d44\u7e54\u7279\u7570\u7684\u306a\u767a\u73fe\u3092\u793a\u3059\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u3078\u3068\u79fb\u690d\u3057\u305f\uff08\u5de6\u56f3\uff09\u3002\u751f\u6b96\u7d30\u80de\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\uff08pgl-1\uff09\u3084\u3001\u751f\u6b96\u7d30\u80de\u3092\u542b\u3080\u5168\u8eab\u3067\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\uff08eft-3\uff09\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u79fb\u690d\u3057\u305f\u5834\u5408\u306e\u307f\u3001\u5f8c\u671f\u4e16\u4ee3\u306b\u304a\u3044\u3066\u3082\u30c6\u30ed\u30e1\u30a2\u304c\u91ce\u751f\u578b\u3068\u540c\u3058\u30ec\u30d9\u30eb\u306e\u9577\u3055\u306b\u7dad\u6301\u3055\u308c\u3066\u3044\u305f\uff08\u53f3\u56f3\uff09\u3002Chr\uff1aChromosome\u306e\u7565\u3067\u67d3\u8272\u4f53\u3002<\/small><\/p>\n<p>nmy-2\u907a\u4f1d\u5b50\u3082\u3001\u751f\u6b96\u7d30\u80de\u3067\u767a\u73fe\u304c\u4ea2\u9032\uff08\u3053\u3046\u3057\u3093\uff09\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u5b9f\u9a13\u7d50\u679c\u3092\u4f75\u305b\u3066\u8003\u3048\u308b\u3068\u3001terc-1\u304c\u751f\u6b96\u7cfb\u5217\u3067\u6d3b\u6027\u5316\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u300c\u30d2\u30c3\u30c1\u30cf\u30a4\u30af\u300d\u3059\u308b\u3053\u3068\u3067\u3001\u30db\u30b9\u30c8\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc<sup>[10]<\/sup>\u4f9d\u5b58\u7684\u306b\u767a\u73fe\u3057\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u904e\u7a0b\u3092\u7d4c\u3066\u6210\u719f\u3057\u3001\u751f\u6b96\u7d30\u80de\u306b\u304a\u3051\u308b\u30c6\u30ed\u30e1\u30a2\u306e\u4f38\u9577\u3092\u62c5\u4fdd\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3001\u5927\u5909\u5de7\u5999\u306a\u7a2e\u306e\u751f\u5b58\u6226\u7565\u304c\u6d6e\u304b\u3073\u4e0a\u304c\u3063\u3066\u304d\u307e\u3057\u305f\u3002<br \/>\n\u307e\u305f\u3001\u751f\u6b96\u817a\u3060\u3051\u3067\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308bpgl-1\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u79fb\u690d\u3057\u305f\u5834\u5408\u3067\u3082\u30c6\u30ed\u30e1\u30a2\u304c\u7d4c\u4e16\u4ee3\u7684\u306b\u7dad\u6301\u3055\u308c\u305f\u3053\u3068\u304b\u3089\uff08\u56f35\uff09\u3001C. elegans\u3067\u306f\u751f\u6b96\u7d30\u80de\u4ee5\u5916\u306e\u5168\u8eab\u306e\u7d30\u80de\u306e\u30c6\u30ed\u30e1\u30a2\u3092\u7dad\u6301\u3059\u308b\u4e0a\u3067\u3001\u751f\u6b96\u817a\u306b\u304a\u3051\u308b\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306e\u6d3b\u6027\u5316\u304c\u5fc5\u8981\u5341\u5206\u3067\u3042\u308b\u3053\u3068\u3082\u540c\u6642\u306b\u8a3c\u660e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>\u4eca\u5f8c\u306e\u671f\u5f85<\/h3>\n<p>\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u6d3b\u6027\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3053\u308c\u307e\u3067\u7d30\u80de\u306e\u304c\u3093\u5316\u3068\u306e\u95a2\u9023\u3067\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u672c\u7814\u7a76\u3092\u76ae\u5207\u308a\u306b\u3001\u6b63\u5e38\u306a\u751f\u4f53\u5185\u306b\u304a\u3051\u308b\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u6d3b\u6027\u5316\u5236\u5fa1\u306e\u7814\u7a76\u304c\u9032\u5c55\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306e\u6d3b\u6027\u5316\u306f\u5e79\u7d30\u80de\u306e\u7dad\u6301\u3084\u7a2e\u306e\u5b58\u7d9a\u306b\u5fc5\u9808\u3067\u3042\u308a\u3001\u305d\u306e\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306f\u57fa\u790e\u751f\u7269\u5b66\u304a\u3088\u3073\u533b\u5b66\u7684\u306a\u89b3\u70b9\u304b\u3089\u4eca\u5f8c\u91cd\u8981\u306a\u8ab2\u984c\u3068\u3044\u3048\u307e\u3059\u3002<br \/>\n\u672c\u7814\u7a76\u3067\u898b\u3064\u304b\u3063\u305fnmy-2\u907a\u4f1d\u5b50\u30a4\u30f3\u30c8\u30ed\u30f3\u4e2d\u306e\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u69d8\u306e\u914d\u5217\u306f\u3001C. elegans\u306e\u307f\u306a\u3089\u305a\u3001\u8fd1\u7e01\u7a2e\u306eC. briggsae\u3084C. japonica\u306b\u304a\u3044\u3066\u3082\u5b58\u5728\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u30fb\u30d2\u30c3\u30c1\u30cf\u30a4\u30af\u306b\u3088\u308b\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u767a\u73fe\u5236\u5fa1\u306f\u7dda\u866b\u985e\u306b\u5e83\u304f\u4fdd\u5b58\u3055\u308c\u305f\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4e00\u3064\u306e\u4eee\u8aac\u3068\u3057\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u306a\u3044\u6a5f\u80fd\u7684RNA\u3092\u7d44\u7e54\u7279\u7570\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u4ed5\u7d44\u307f\u3068\u3057\u3066\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u30fb\u30d2\u30c3\u30c1\u30cf\u30a4\u30af\u306f\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9RNA\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u7d4c\u4e16\u4ee3\u7684\u306a\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5f62\u8cea\u306e\u907a\u4f1d\u3084\u751f\u6b96\u7d30\u80de\u306e\u767a\u751f\u306b\u6a5f\u80fd\u3059\u308b\u975e\u30b3\u30fc\u30c9RNA\u3084small RNA[3]\u306a\u3069\u306b\u3082\u540c\u69d8\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u304b\u3089\u6d6e\u304b\u3073\u4e0a\u304c\u3063\u305f\u3053\u306e\u65b0\u305f\u306a\u554f\u3044\u3092\u8ffd\u7a76\u3059\u308b\u3053\u3068\u3067\u3001\u4e16\u4ee3\u3092\u8d85\u3048\u3066\uff08\u9032\u5316\u306e\u30ec\u30d9\u30eb\u3067\u306f\u7a2e\u3092\u8d85\u3048\u3066\uff09\u751f\u7269\u304c\u5b58\u7d9a\u3059\u308b\u300c\u9023\u7d9a\u6027\u300d\u306e\u79d8\u5bc6\u304c\u89e3\u304d\u660e\u304b\u3055\u308c\u3066\u3044\u304f\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>\u8ad6\u6587\u60c5\u5831<\/h3>\n<p>\uff1c\u30bf\u30a4\u30c8\u30eb\uff1e<br \/>\nNematode telomerase RNA hitchhikes on introns of germline-up-regulated genes<br \/>\n\uff1c\u8457\u8005\u540d\uff1e<br \/>\nYutaka Takeda, Masahiro Onoguchi, Fumiya Ito, Io Yamamoto, Shunsuke Sumi, Tatsuyuki Yoshii, Mori\u00e9 Ishida, Eriko Kajikawa, Jingjing Zhang, Osamu Nishimura, Mitsutaka Kadota, Shunsuke Tagami, Takefumi Kondo, Hirohide Saito, Michiaki Hamada, and Hiroki Shibuya<br \/>\n\uff1c\u96d1\u8a8c\uff1e<br \/>\nScience<br \/>\n\uff1cDOI\uff1e<br \/>\n<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ads7778\">10.1126\/science.ads7778<\/a><\/p>\n<h3><strong>\u88dc\u8db3\u8aac\u660e<\/strong><\/h3>\n<p>[1] \u7dda\u866b<br \/>\n\u7dda\u5f62\u52d5\u7269\u9580\u306b\u5c5e\u3059\u308b\u4f53\u95771mm\u307b\u3069\u306e\u591a\u7d30\u80de\u751f\u7269\u3002\u7dcf\u7d30\u80de\u6570\u304c\u308f\u305a\u304b1,000\u500b\u3068\u5c11\u6570\u306a\u304c\u3089\u3001\u6d88\u5316\u5668\u5b98\u30fb\u795e\u7d4c\u30fb\u7b4b\u8089\u30fb\u751f\u6b96\u7d44\u7e54\u306a\u3069\u3001\u52d5\u7269\u306e\u57fa\u672c\u7684\u306a\u69cb\u9020\u3092\u5099\u3048\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u4e16\u4ee3\u6642\u9593\u304c3\u65e5\u3068\u77ed\u3044\u3053\u3068\u304b\u3089\u3001\u5bff\u547d\u7814\u7a76\u306e\u30e2\u30c7\u30eb\u52d5\u7269\u3068\u3057\u3066\u3082\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>[2] \u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u3001\u30c6\u30ed\u30e1\u30a2<br \/>\nDNA\u5408\u6210\u9175\u7d20\u306f\u92f3\u578b\u9396\u306e\u672b\u7aef\u307e\u3067DNA\u3092\u8907\u88fd\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u305f\u3081\u3001DNA\u306f\u8907\u88fd\u306e\u305f\u3073\u306b\u5c11\u3057\u305a\u3064\u77ed\u304f\u306a\u3063\u3066\u3044\u304f\u3002\u3057\u304b\u3057\u3001\u771f\u6838\u7d30\u80de\u306e\u30b2\u30ce\u30e0DNA\u672b\u7aef\u306b\u306f\u7279\u5fb4\u7684\u306a\u7e70\u308a\u8fd4\u3057\u914d\u5217\u304c\u5b58\u5728\u3057\u3001\u3053\u3046\u3057\u305f\u672b\u7aef\u306e\u77ed\u7e2e\u304c\u76f4\u3061\u306b\u907a\u4f1d\u60c5\u5831\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u3053\u306e\u672b\u7aef\u914d\u5217\u3068\u3001\u67d3\u8272\u4f53\u672b\u7aef\u3092\u4fdd\u8b77\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u6210\u308b\u69cb\u9020\u3092\u30c6\u30ed\u30e1\u30a2\u3068\u547c\u3076\u3002\u307e\u305f\u3001\u30c6\u30ed\u30e1\u30a2DNA\u3092\u4f38\u9577\u3059\u308b\u9175\u7d20\u3092\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\uff08\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\uff09\u3068\u547c\u3076\u3002<\/p>\n<p>[3] \u30a4\u30f3\u30c8\u30ed\u30f3\u3001\u30b8\u30e3\u30f3\u30af\u914d\u5217\u3001\u9577\u9396\u975e\u30b3\u30fc\u30c9RNA\u3001small RNA<br \/>\n\u30b2\u30ce\u30e0DNA\u306e\u914d\u5217\u306e\u3046\u3061\u3001\u907a\u4f1d\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u4ee5\u5916\u306e\u6a5f\u80fd\u4e0d\u660e\u306a\u914d\u5217\u306f\u3057\u3070\u3057\u3070\u30b8\u30e3\u30f3\u30af\uff08\u304c\u3089\u304f\u305f\uff09\u3068\u547c\u3070\u308c\u308b\u3002\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u5834\u5408\u3001\u5168\u30b2\u30ce\u30e0\u306e3\u5206\u306e2\u306f\u8ee2\u5199\u3055\u308c\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u3046\u3061\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u914d\u5217\u60c5\u5831\u304c\u30b3\u30fc\u30c9\u3055\u308c\u305f\u9818\u57df\uff08\u30a8\u30ad\u30bd\u30f3\u3068\u547c\u3070\u308c\u308b\uff09\u306f\u3054\u304f\u308f\u305a\u304b\u3067\u3042\u308a\u3001mRNA\u304c\u6210\u719f\u3059\u308b\u904e\u7a0b\u3067\u5207\u308a\u96e2\u3055\u308c\u5206\u89e3\u3055\u308c\u308b\u914d\u5217\uff08\u30a4\u30f3\u30c8\u30ed\u30f3\uff09\u306a\u3069\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u60c5\u5831\u3092\u6301\u305f\u306a\u3044\u300c\u975e\u30b3\u30fc\u30c9RNA\u300d\u304c\u5927\u534a\u3092\u5360\u3081\u308b\u3002\u9577\u9396\u975e\u30b3\u30fc\u30c9RNA\u306f\u3001\u975e\u30b3\u30fc\u30c9RNA\u306e\u3046\u3061200\u5869\u57fa\u3088\u308a\u3082\u9577\u3044\u3082\u306e\u3092\u6307\u3057\u3001\u3053\u306e\u3046\u3061\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u5b58\u5728\u3059\u308b\u3082\u306e\u3092\u7279\u306b\u9577\u9396\u975e\u30b3\u30fc\u30c9RNA\uff08intronic long non-coding RNA\uff09\u3068\u547c\u3076\u3002\u4e00\u65b9\u3001\u9577\u3055\u304c20\uff5e30\u5869\u57fa\u7a0b\u5ea6\u306e\u77ed\u3044\u975e\u30b3\u30fc\u30c9RNA\u3092small RNA\u3068\u547c\u3076\u3002<\/p>\n<p>[4] \u30db\u30ed\u9175\u7d20<br \/>\n\u30bf\u30f3\u30d1\u30af\u8cea\u6210\u5206\u306e\u4ed6\u306b\u3001\u6d3b\u6027\u306b\u5fc5\u8981\u306a\u975e\u30bf\u30f3\u30d1\u30af\u8cea\u6210\u5206\u3092\u542b\u3080\u9175\u7d20\u3002\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u92f3\u578bRNA\u304b\u3089\u6210\u308b\u30db\u30ed\u9175\u7d20\u306b\u5206\u985e\u3055\u308c\u308b\u3002<\/p>\n<p>[5] \u9006\u8ee2\u5199\u53cd\u5fdc<br \/>\nRNA\u3092\u92f3\u578b\u306b\u3057\u3066\u76f8\u88dc\u7684\u306aDNA\u3092\u5408\u6210\u3059\u308b\u9175\u7d20\u53cd\u5fdc\u3002<\/p>\n<p>[6] eCLIP\u6cd5<br \/>\n\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u305d\u3053\u306b\u7d50\u5408\u3059\u308bRNA\u3092\u751f\u4f53\u5185\u306b\u304a\u3044\u3066\u67b6\u6a4b\u3057\u3001\u305d\u306e\u5f8c\u76ee\u7684\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7d50\u5408RNA\u3068\u5171\u306b\u7cbe\u88fd\u3059\u308b\u624b\u6cd5\u3002\u7cbe\u88fd\u3055\u308c\u305fRNA\u306f\u3001\u914d\u5217\u304c\u8aad\u307e\u308c\u305f\u5f8c\u3001\u30b2\u30ce\u30e0\u4e0a\u306b\u30de\u30c3\u30d4\u30f3\u30b0\u3055\u308c\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u76ee\u7684\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3059\u308bRNA\u306e\u5869\u57fa\u914d\u5217\u3068\u305d\u306eRNA\u3092\u30b3\u30fc\u30c9\u3059\u308bDNA\u9818\u57df\u304c\u7db2\u7f85\u7684\u306b\u6c7a\u5b9a\u3055\u308c\u308b\u3002<\/p>\n<p>[7] \u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3001nmy-2<br \/>\n\u30df\u30aa\u30b7\u30f3\u306e\u3088\u3046\u306b\u3001\u7d30\u80de\u5185\u3067\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff08ATP\uff09\u306e\u5206\u89e3\u3067\u751f\u3058\u308b\u5316\u5b66\u30a8\u30cd\u30eb\u30ae\u30fc\u306a\u3069\u3092\u7528\u3044\u3066\u3001\u529b\u5b66\u7684\u306a\u4ed5\u4e8b\u3092\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u547c\u3076\u3002nmy-2\u306f\u3001\u7dda\u866b\u306e\u751f\u6b96\u7d30\u80de\u306a\u3069\u3067\u767a\u73fe\u3059\u308b\u975e\u7b4b\u8089\u578b\u30df\u30aa\u30b7\u30f3\u907a\u4f1d\u5b50\u3002<\/p>\n<p>[8] \u92f3\u578b\u914d\u5217<br \/>\n\u30c6\u30ed\u30e1\u30ec\u30fc\u30b9\u304c\u30c6\u30ed\u30e1\u30a2\u3092\u5408\u6210\u3059\u308b\u969b\u306b\u92f3\u578b\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308bRNA\u914d\u5217\u3002\u30c6\u30ed\u30e1\u30a2DNA\u914d\u5217\u3068\u76f8\u88dc\u7684\u306a10\u5869\u57fa\u7a0b\u5ea6\u306eRNA\u914d\u5217\u304c\u3053\u306e\u92f3\u578b\u914d\u5217\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002<\/p>\n<p>[9] \u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0<br \/>\n\u907a\u4f1d\u5b50\u304c\u767a\u73fe\u3059\u308b\u904e\u7a0b\u3067\u3001DNA\u304b\u3089RNA\u304c\u8ee2\u5199\u3055\u308c\u305f\u306e\u3061\u3001\u30b8\u30e3\u30f3\u30af\u914d\u5217\u3067\u3042\u308b\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u5207\u308a\u96e2\u3055\u308c\u308b\u904e\u7a0b\u3092\u6307\u3059\u3002\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u3088\u308a\u3001RNA\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u3092\u30b3\u30fc\u30c9\u3059\u308b\u30a8\u30ad\u30bd\u30f3\u9818\u57df\u3060\u3051\u304c\u3064\u306a\u304e\u5408\u308f\u3055\u308c\u305f\u6210\u719fRNA\u306b\u306a\u308b\u3002\u4e00\u65b9\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3067\u5207\u308a\u96e2\u3055\u308c\u305f\u30a4\u30f3\u30c8\u30ed\u30f3\u306f\u3001\u901a\u5e38\u5206\u89e3\u3055\u308c\u3066\u6368\u3066\u3089\u308c\u308b\u3002<\/p>\n<p>[10] \u30d7\u30ed\u30e2\u30fc\u30bf\u30fc<br 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