{"id":82560,"date":"2025-09-20T14:37:52","date_gmt":"2025-09-20T05:37:52","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=82560"},"modified":"2025-10-20T14:38:02","modified_gmt":"2025-10-20T05:38:02","slug":"heteroaromatic-swapping-in-aromatic-ketones%ef%bc%88published-in-nature-communications-september-2025%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/82560","title":{"rendered":"Heteroaromatic swapping in aromatic ketones\uff08Published in Nature Communications, September, 2025\uff09"},"content":{"rendered":"<table class=\"table table-bordered table-colored-tbhd\" style=\"height: 636px; width: 100%; border-collapse: collapse; border-style: solid;\" border=\"1\">\n<tbody>\n<tr style=\"height: 78px;\">\n<td style=\"width: 19.0523%; height: 78px;\">Journal Title<br \/>\n\/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d<\/td>\n<td style=\"width: 80.849%; height: 78px;\">Nature Communications<\/td>\n<\/tr>\n<tr style=\"height: 65px;\">\n<td style=\"width: 19.0523%; height: 80px;\">Publication Year and Month<br \/>\n\/\u63b2\u8f09\u5e74\u6708<\/td>\n<td style=\"width: 80.849%; height: 80px;\">September, 2025<\/td>\n<\/tr>\n<tr style=\"height: 55px;\">\n<td style=\"width: 19.0523%; height: 79px;\">Paper Title<br \/>\n\/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/td>\n<td style=\"width: 80.849%; height: 79px;\">Heteroaromatic swapping in aromatic ketones<\/td>\n<\/tr>\n<tr style=\"height: 85px;\">\n<td style=\"width: 19.0523%; height: 85px;\">DOI<br \/>\n\/\u8ad6\u6587DOI<\/td>\n<td style=\"width: 80.849%; height: 85px;\"><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-64041-6\">10.1038\/s41467-025-64041-6<\/a><\/td>\n<\/tr>\n<tr style=\"height: 59px;\">\n<td style=\"width: 19.0523%; height: 80px;\">\u00a0Author of Waseda University<br \/>\n\/\u672c\u5b66\u306e\u8457\u8005<\/td>\n<td style=\"width: 80.849%; height: 80px;\"><span style=\"font-family: inherit; font-size: inherit;\">NAKAHARA, Hikaru(Student, Faculty of Science and Engineering, Graduate School of Advanced Science and Engineering):Lead Author<\/span><\/td>\n<\/tr>\n<tr style=\"height: 68px;\">\n<td style=\"width: 19.0523%; height: 86px;\">Related Websites<br \/>\n\/\u95a2\u9023Web<\/td>\n<td style=\"width: 80.849%; height: 86px;\">&#8211;<\/td>\n<\/tr>\n<tr style=\"height: 138px;\">\n<td style=\"width: 19.0523%; height: 148px;\">Abstract<br \/>\n\/\u6284\u9332<\/td>\n<td style=\"width: 80.849%; height: 148px;\">\n<div id=\"abstractBox\" class=\"article_abstract-content hlFld-Abstract\">\n<p class=\"articleBody_abstractText\">The modification of aromatic rings to heteroaromatic rings is a widely employed strategy in medicinal chemistry, often used to modulate lipophilicity and improve metabolic stability. However, achieving a one-step, generalizable transformation of aromatic rings into diverse heteroaromatic rings\u2014termed \u201cheteroaromatic swapping\u201d\u2014remains a persistent challenge. Existing methods, such as skeletal editing and transition-metal-catalyzed aromatic ring exchange, are limited in substrate scope and efficiency. Here, we present an efficient strategy for heteroaromatic swapping via a Claisen\/retro-Claisen mechanism, utilizing heteroaryl esters and aromatic ketones. This approach enables the selective exchange of aromatic rings with heteroaromatic rings across a broad substrate range, overcoming the limitations of existing techniques. Notably, it achieves high-yield conversions of bioactive aromatic ketones into their heteroaromatic counterparts. This method expands the molecular editing toolkit, offering a practical and versatile platform for synthesizing bioactive compounds with enhanced physicochemical properties.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Journal Title \/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d Nature Communications Publication Year and Month \/\u63b2\u8f09\u5e74\u6708 September, 2025 Paper Title \/\u8ad6\u6587 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[218,217],"class_list":["post-82560","post","type-post","status-publish","format-standard","hentry","tag-impact-en","tag-impact"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/82560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=82560"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/82560\/revisions"}],"predecessor-version":[{"id":82561,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/82560\/revisions\/82561"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=82560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=82560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=82560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}