{"id":82483,"date":"2025-10-09T14:00:23","date_gmt":"2025-10-09T05:00:23","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=82483"},"modified":"2025-10-09T10:33:58","modified_gmt":"2025-10-09T01:33:58","slug":"%e3%81%8c%e3%82%93%e3%81%ae%e3%82%b5%e3%83%9d%e3%83%bc%e3%83%88%e5%bd%b9%e3%82%92%e7%8b%99%e3%81%84%e6%92%83%e3%81%a1-3d%e3%83%9f%e3%82%af%e3%83%ad%e8%85%ab%e7%98%8d%e3%81%a7%e8%a6%8b%e3%81%88","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/82483","title":{"rendered":"\u304c\u3093\u306e\u30b5\u30dd\u30fc\u30c8\u5f79\u3092\u72d9\u3044\u6483\u3061-3D\u30df\u30af\u30ed\u816b\u760d\u3067\u898b\u3048\u305f\u65b0\u305f\u306a\u304c\u3093\u6cbb\u7642\u6a19\u7684-"},"content":{"rendered":"<h2 style=\"text-align: center;\">\u304c\u3093\u306e\u30b5\u30dd\u30fc\u30c8\u5f79\u3092\u72d9\u3044\u6483\u3061<br \/>\n3D\u30df\u30af\u30ed\u816b\u760d\u3067\u898b\u3048\u305f\u65b0\u305f\u306a\u304c\u3093\u6cbb\u7642\u6a19\u7684<\/h2>\n<h3>\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul>\n<li>\u00a0\u4f53\u5185\u306b\u8fd1\u3044\u7acb\u4f53\u7684\u306a\u304c\u3093\u7d44\u7e54\uff083D\u30df\u30af\u30ed\u816b\u760d\uff09\u3092\u4f7f\u3063\u305f\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308a\u3001\u5f93\u6765\u306e\u65b9\u6cd5\u3067\u306f\u898b\u9003\u3055\u308c\u3066\u3044\u305f\u3001\u304c\u3093\u7d30\u80de\u306e\u307e\u308f\u308a\u306b\u3042\u308b\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u306e\u50cd\u304d\u3092\u5f31\u3081\u308b\u85ac\u3092\u591a\u6570\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>\u00a0\u300c\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u300d\u3068\u3044\u3046\u85ac\u304c\u3001\u30b5\u30dd\u30fc\u30c8\u5f79\u306e\u7d30\u80de\u306e\u4e00\u3064\u3067\u3042\u308b\u816b\u760d\u968f\u4f34\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u50cd\u304d\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u304c\u3093\u5897\u6b96\u3092\u6291\u3048\u3001\u65e2\u5b58\u306e\u6297\u304c\u3093\u5264\u3084\u514d\u75ab\u6cbb\u7642\u85ac\u3068\u306e\u4f75\u7528\u52b9\u679c\u3092\u9ad8\u3081\u307e\u3057\u305f\u3002<\/li>\n<li>\u00a0\uff13D\u30df\u30af\u30ed\u816b\u760d\u3092\u7528\u3044\u305f\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u3092\u72d9\u3044\u6483\u3064\u3053\u3068\u3067\u6cbb\u7642\u52b9\u679c\u3092\u4e0a\u3052\u308b\u3001\u65b0\u3057\u3044\u30bf\u30a4\u30d7\u306e\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<h3>\u6982\u8981<\/h3>\n<p>\u304c\u3093\u6cbb\u7642\u3068\u3044\u3048\u3070\u3001\u73fe\u5728\u306f\u304c\u3093\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u72d9\u3046\u85ac\u304c\u4e2d\u5fc3\u3067\u3059\u304c\u3001\u5b9f\u306f\u304c\u3093\u306e\u5468\u56f2\u306b\u3044\u308b\u304c\u3093\u3092\u201c\u30b5\u30dd\u30fc\u30c8\u201d\u3059\u308b\u7d30\u80de\u3082\u3001\u304c\u3093\u306e\u9032\u884c\u3084\u8ee2\u79fb\u3001\u60aa\u6027\u5316\u3092\u52a9\u3051\u308b\u5927\u4e8b\u306a\u8981\u7d20\u3067\u3059\u3002<br \/>\n<a href=\"https:\/\/www.waseda.jp\/inst\/wias\/\" target=\"_blank\" rel=\"noopener\">\u65e9\u7a32\u7530\u5927\u5b66\u9ad8\u7b49\u7814\u7a76\u6240<\/a>\u306e<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100003283_ja.html\" target=\"_blank\" rel=\"noopener\">\u897f\u7530\u5948\u592e\uff08\u306b\u3057\u3060\u306a\u304a\uff09\u8b1b\u5e2b<\/a>\u306f\u3001\u7c73\u56fd\u30d5\u30ec\u30c3\u30c9\u30fb\u30cf\u30c3\u30c1\u30f3\u30bd\u30f3\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u3068\u3068\u3082\u306b\u3001\u5b9f\u969b\u306e\u60a3\u8005\u4f53\u5185\u306e\u816b\u760d\u306b\u8fd1\u3044\u300c3D\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb<sup>\u203b\uff11<\/sup>\u300d\u3092\u4f7f\u3063\u3066\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001\u5f93\u6765\u306e\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6cd5\u3067\u306f\u898b\u9003\u3055\u308c\u3066\u3044\u305f\u3001\u304c\u3093\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u306b\u52b9\u304f\u85ac\u3092\u591a\u6570\u767a\u898b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u305d\u306e\u4e2d\u3067\u300c\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\uff08doramapimod\uff09<sup>\u203b\uff12<\/sup>\u300d\u3068\u3044\u3046\u3001\u672c\u6765\u6297\u708e\u75c7\u85ac\u5019\u88dc\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u5316\u5408\u7269\u304c\u3001\u304c\u3093\u306e\u5468\u56f2\u306b\u3042\u308b\u30b5\u30dd\u30fc\u30c8\u5f79\u306e\u7d30\u80de\u306e\u4e00\u3064\u3067\u3042\u308b\u816b\u760d\u968f\u4f34\u7dda\u7dad\u82bd\u7d30\u80de\uff08cancer-associated fibroblast, CAF\uff09<sup>\u203b\uff13<\/sup>\u306e\u50cd\u304d\u3092\u5f31\u3081\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u5897\u6b96\u3092\u6291\u5236\u3057\u6297\u304c\u3093\u5264\u3084\u514d\u75ab\u6cbb\u7642\u85ac\u306e\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n\u672c\u7814\u7a76\u3067\u7528\u3044\u305f\u624b\u6cd5\u306f\u3001\u304c\u3093\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u6210\u679c\u3067\u3059\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\uff12\uff10\uff12\uff15\u5e74\uff19\u6708\uff11\uff19\u65e5\u306b\u56fd\u969b\u5b66\u8853\u8a8cCell Reports Medicine\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff09\u306b\u5148\u884c\u516c\u958b\u3055\u308c\u300110\u6708\u53f7\u306b\u51fa\u7248\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-82484\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/nishida_pict1.png\" alt=\"\" width=\"461\" height=\"461\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/nishida_pict1.png 1498w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/nishida_pict1-610x610.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/nishida_pict1-940x940.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/nishida_pict1-768x768.png 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/10\/nishida_pict1-290x290.png 290w\" sizes=\"auto, (max-width: 461px) 100vw, 461px\" \/><\/p>\n<h3>\u30ad\u30fc\u30ef\u30fc\u30c9<\/h3>\n<p>\u304c\u3093\u3001\u816b\u760d\u3001\u304c\u3093\u6cbb\u7642\u3001\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u3001\u816b\u760d\u968f\u4f34\u7dda\u7dad\u82bd\u7d30\u80de\uff08Cancer associated fibroblast, CAF\uff09\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9 (Extracellular matrix, ECM)\u3001\u6297\u304c\u3093\u5264\u3001\uff13D\u816b\u760d\u30e2\u30c7\u30eb\u3001\u30ad\u30ca\u30fc\u30bc\u3001\u500b\u5225\u5316\u533b\u7642 (precision medicine)\u3001\u975e\u53e4\u5178\u7684\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\u7d4c\u8def(non-canonical hedgehog pathway)<\/p>\n<h3><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u304c\u3093\u306f\u73fe\u5728\u3082\u65e5\u672c\u4eba\u306e\u6b7b\u56e0\u306e\u7b2c1\u4f4d\u3067\u3042\u308a\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u5f37\u304f\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306e\u304c\u3093\u6cbb\u7642\u306f\u3001\u304c\u3093\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u76f4\u63a5\u653b\u6483\u3059\u308b\u85ac\u306e\u958b\u767a\u304c\u4e2d\u5fc3\u3067\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u5275\u85ac\u958b\u767a\u6642\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u307f\u3092\u7d14\u7c8b\u306b\u57f9\u990a\u76bf\u3067\u80b2\u3066\u308b\u300c2\u6b21\u5143\u57f9\u990a\u300d\u3067\u5019\u88dc\u5316\u5408\u7269\u3092\u7d5e\u308a\u8fbc\u3093\u3067\u304d\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n\u3057\u304b\u3057\u8fd1\u5e74\u3001\u304c\u3093\u306e\u307e\u308f\u308a\u306b\u3044\u308b\u7d30\u80de\uff08\u8840\u7ba1\u7d30\u80de\u3001\u514d\u75ab\u7d30\u80de\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306a\u3069\uff09\u304c\u3001\u304c\u3093\u306e\u5897\u6b96\u3084\u8ee2\u79fb\u3001\u60aa\u6027\u5316\u3092\u300c\u30b5\u30dd\u30fc\u30c8\u300d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u5b9f\u969b\u306b\u3001\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u3084\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306a\u3069\u3001\u304c\u3093\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u85ac\u3082\u5b9f\u7528\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u305d\u306e\u305f\u3081\u3001\u304c\u3093\u7d30\u80de\u3068\u5468\u56f2\u306e\u7d30\u80de\u3092\u4e00\u4f53\u3068\u3057\u3066\u6349\u3048\u305f\u3001\u3088\u308a\u73fe\u5b9f\u306b\u8fd1\u3044\u65b0\u3057\u3044\u5275\u85ac\u30e2\u30c7\u30eb\u306e\u5fc5\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<h3><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u4eca\u56de\u3001\u65e9\u7a32\u7530\u5927\u5b66\u9ad8\u7b49\u7814\u7a76\u6240\u306e\u897f\u7530\u5948\u592e\u8b1b\u5e2b\u3068\u7c73\u56fdFred Hutchinson Cancer Center\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u5b9f\u969b\u306e\u816b\u760d\u306b\u8fd1\u3044\u201c3D\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb\u201d\u3092\u7528\u3044\u3066\u3001\u6a5f\u68b0\u5b66\u7fd2\u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u65b0\u305f\u306a\u85ac\u5264\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u306e\u4e73\u304c\u3093\u3084\u81b5\u304c\u3093\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\uff14\uff10\uff10\u7a2e\u985e\u4ee5\u4e0a\u306e\u85ac\u5264\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u305f\u3068\u3053\u308d\u3001\u300c\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u300d\u3068\u3044\u3046\u3001\u304c\u3093\u7d30\u80de\u3092\u76f4\u63a5\u653b\u6483\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u304c\u3093\u7d30\u80de\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u816b\u760d\u968f\u4f34\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u306e\u4f5c\u7528\u6a5f\u69cb\u3092\u8abf\u3079\u308b\u904e\u7a0b\u3067\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3092\u751f\u7523\u3059\u308b\u7d4c\u8def\u3068\u3057\u3066\u3001\u65b0\u305f\u306b\u975e\u53e4\u5178\u7684\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\u7d4c\u8def\u300cDDR1\/2\u2013MAPK12\u2013GLI1\u300d\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<br \/>\n\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u30de\u30a6\u30b9\u7531\u6765\u306e\u4e73\u304c\u3093\u304a\u3088\u3073\u81b5\u304c\u3093\u7d44\u7e54\u304b\u3089\u4f5c\u88fd\u3057\u305f\uff13D\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u3001\uff13\uff11\u7a2e\u985e\u306e\u30ad\u30ca\u30fc\u30bc<sup>\u203b\uff14<\/sup>\u963b\u5bb3\u5264\u3068\u3044\u3046\u3001\u7d30\u80de\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u306e\u52b9\u679c\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u3053\u306e\u5b9f\u9a13\u7d50\u679c\u3068\u65e2\u77e5\u306e\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u306e\u52b9\u679c\u3092\u4f75\u305b\u3066\u6a5f\u68b0\u5b66\u7fd2\u3092\u7528\u3044\u3066\u3001\u5168\u3066\u5b9f\u9a13\u7684\u306b\u8a66\u9a13\u3059\u308b\u3053\u3068\u306a\u304f\u3001\uff14\uff10\uff10\u7a2e\u985e\u4ee5\u4e0a\u306e\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u306b\u5bfe\u3059\u308b\u5fdc\u7b54\u3092\u4e88\u6e2c\u3057\u307e\u3057\u305f\u3002\u540c\u69d8\u306e\u8a66\u9a13\u3092\u540c\u3058\u304c\u3093\u7d30\u80de\u3092\u5b9f\u9a13\u5ba4\u3067\u5e73\u9762\u57f9\u990a\u3057\u305f\u5834\u5408\u3067\u3082\u5b9f\u65bd\u3057\u3066\u3001\u963b\u5bb3\u5264\u306e\u52b9\u679c\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<br \/>\n\u85ac\u5264\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3044\u30663D\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u6709\u52b9\u3060\u3068\u3057\u3066\u898b\u51fa\u3055\u308c\u305f\u85ac\u5264\u306f\u3001\u4e00\u822c\u7684\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\uff12\u6b21\u5143\u304c\u3093\u57f9\u990a\u7d30\u80de\u306b\u6709\u52b9\u306a\u85ac\u5264\u306e\u6570\u3068\u6bd4\u8f03\u3057\u3066\u3001\uff13\u500d\u4ee5\u4e0a\u3067\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u624b\u6cd5\u3067\u306f\u898b\u9003\u3055\u308c\u3066\u3044\u305f\u85ac\u5264\u304c\u591a\u6570\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e3D\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb\u306f\u3001\u816b\u760d\u3092\u751f\u304d\u305f\u307e\u307e\u30df\u30af\u30ed\u30b5\u30a4\u30ba\u306b\u5207\u3063\u3066\u5b9f\u9a13\u5ba4\u3067\u7dad\u6301\u3057\u305f\u3082\u306e\u3067\u3001\u3082\u3068\u3082\u3068\u306e\u816b\u760d\u7d44\u7e54\u306e\u69cb\u9020\u3084\u5185\u90e8\u306e\u304c\u3093\u7d30\u80de\u3068\u5468\u8fba\u7d30\u80de\u306e\u7d44\u6210\u3092\u7dad\u6301\u3057\u3066\u304a\u308a\u3001\u5e83\u304f\u5b9f\u9a13\u3084\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3001\u304c\u3093\u7d30\u80de\u306e\u307f\u3092\u7d14\u7c8b\u306b\u30d7\u30ec\u30fc\u30c8\u4e0a\u30672\u6b21\u5143\u57f9\u990a\u3057\u305f\u30e2\u30c7\u30eb\u3068\u6bd4\u3079\u3066\u3001\u4f53\u5185\u306b\u3088\u308a\u8fd1\u3044\u72b6\u614b\u3067\u85ac\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002\u7814\u7a76\u8005\u3089\u306f\u3001\u30de\u30a6\u30b9\u4e73\u304c\u3093\u304a\u3088\u3073\u81b5\u304c\u3093\u306e\uff13\uff24\u304a\u3088\u3073\uff12\uff24\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u3001\u65b0\u85ac\u5019\u88dc\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001\u6a5f\u68b0\u5b66\u7fd2\u3092\u6d3b\u7528\u3057\u3066\u5b9f\u9a13\u52b9\u7387\u3092\u9ad8\u3081\u307e\u3057\u305f\u3002<br \/>\n\uff13\uff24\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb\u306b\u52b9\u679c\u304c\u9ad8\u3044\u85ac\u5264\u306e\u4e2d\u3067\u3082\u3001\u7279\u306b\u300c\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u300d\u3068\u3044\u3046p38\u963b\u5bb3\u5264\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002\u3082\u3068\u3082\u3068\u30ea\u30a6\u30de\u30c1\u306a\u3069\u306e\u708e\u75c7\u6027\u75be\u60a3\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u751f\u5b58\u3084\u5897\u6b96\u306b\u306f\u76f4\u63a5\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u816b\u760d\u968f\u4f34\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u816b\u760d\u306e\u5897\u6b96\u6291\u5236\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u306f\u3001CAF\u5185\u306eDDR1\/2\u3068\u3044\u3046\u30b3\u30e9\u30fc\u30b2\u30f3\u53d7\u5bb9\u4f53\u3001\u304a\u3088\u3073\u4e0b\u6d41\u306eMAPK12\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u963b\u5bb3\u3057\u3001CAF\u306b\u3088\u308b\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08ECM\uff09<sup>\u203b\uff15<\/sup>\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u3001\u304c\u3093\u7d30\u80de\u306e\u307e\u308f\u308a\u306b\u5e83\u304c\u308b\u8db3\u5834\u69cb\u9020\uff09\u306e\u7523\u751f\u3084\u3001\u708e\u75c7\u3092\u4fc3\u3059\u56e0\u5b50\u306e\u7523\u751f\u3092\u6291\u5236\u3057\u307e\u3057\u305f\u3002\u7d50\u679c\u3068\u3057\u3066\u3001\u514d\u75ab\u7d30\u80de\uff08\u7279\u306bCD8\u967d\u6027T\u7d30\u80de\uff09\u306e\u304c\u3093\u7d44\u7e54\u3078\u306e\u6d78\u6f64\u304c\u4fc3\u9032\u3055\u308c\u3001\u73fe\u5728\u81e8\u5e8a\u3067\u7528\u3044\u3089\u308c\u308b\u6297\u304c\u3093\u5264gemcitabine\u3084\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u3068\u306e\u4f75\u7528\u3067\u9ad8\u3044\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u306e\u816b\u760d\u6291\u5236\u52b9\u679c\u306f\u3001\u5b9f\u969b\u306e\u60a3\u8005\u7531\u6765\u306e\u816b\u760d\u30b9\u30e9\u30a4\u30b9\u3084\u8907\u6570\u306e\u30de\u30a6\u30b9\u304c\u3093\u79fb\u690d\u30e2\u30c7\u30eb\u3067\u3082\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002<br \/>\n\u3055\u3089\u306b\u4eca\u56de\u3001DDR1\/2\u2013MAPK12\u7d4c\u8def\u304c\u3001CAF\u5185\u306e\u8ee2\u5199\u56e0\u5b50GLI1<sup>\u203b\uff16<\/sup>\u3092\u6d3b\u6027\u5316\u3057\u3001ECM\u7523\u751f\u3092\u8a98\u5c0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067GLI1\u306f\u3001\u4e3b\u306b\u300c\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\u7d4c\u8def\uff08SHH-SMO\uff09<sup>\u203b\uff17<\/sup>\u300d\u306b\u3088\u308a\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u4eca\u56de\u306e\u77e5\u898b\u306f\u3001DDR1\/2-MAPK12\u7d4c\u8def\u304cGLI1\u3092\u6d3b\u6027\u5316\u3059\u308b\u300c\u975e\u53e4\u5178\u7684\uff08non-canonical\uff09\u300d\u306a\u7d4c\u8def\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001GLI1\u963b\u5bb3\u5264\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u3082\u540c\u69d8\u306bCAF\u6a5f\u80fd\u306e\u6291\u5236\u304c\u8d77\u3053\u308a\u3001\u816b\u760d\u6291\u5236\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n<h3>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/h3>\n<p>\u672c\u7814\u7a76\u3067\u78ba\u7acb\u3057\u305f\uff13D\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306f\u3001\u304c\u3093\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u3092\u72d9\u3044\u6483\u3064\u65b0\u305f\u306a\u304c\u3093\u6cbb\u7642\u85ac\u958b\u767a\u3092\u52a0\u901f\u3055\u305b\u308b\u57fa\u76e4\u6280\u8853\u3060\u3068\u8a00\u3048\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\uff13D\u30df\u30af\u30ed\u816b\u760d\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u816b\u760d\u968f\u4f34\u7dda\u7dad\u82bd\u7d30\u80de\uff08CAF\uff09\u3092\u72d9\u3044\u6483\u3064\u85ac\u5264\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u3092\u898b\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u85ac\u5264\u306f\u3001\u5f93\u6765\u306e\u304c\u3093\u7d30\u80de\u306e\u307f\u3092\uff12\u6b21\u5143\u57f9\u990a\u3057\u305f\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u306f\u3053\u308c\u307e\u3067\u898b\u9003\u3055\u308c\u3066\u304d\u305f\u3082\u306e\u3067\u3059\u3002\u5b9f\u969b\u306b\u3001\u4eca\u56de\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u306f\u30013D\u816b\u760d\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u306f\u5f93\u6765\u306e\uff12\uff24\u30e2\u30c7\u30eb\u306b\u6bd4\u8f03\u3057\u3066\uff13\u500d\u3082\u306e\u6cbb\u7642\u85ac\u5019\u88dc\u304c\u898b\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u304c\u3093\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u306e\u91cd\u8981\u6027\u304c\u5f37\u307e\u3063\u3066\u3044\u308b\u4e2d\u3001\u672c\u30b7\u30b9\u30c6\u30e0\u306f\u65b0\u305f\u306a\u5275\u85ac\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u3057\u3066\u671f\u5f85\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<br \/>\n\u3055\u3089\u306b\u3001\u3053\u306e\u85ac\u5264\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6cd5\u306f\u3001\u60a3\u8005\u3055\u3093\u304b\u3089\u624b\u8853\u3067\u6458\u51fa\u3057\u305f\u816b\u760d\u3092\u7528\u3044\u3066\u3082\u540c\u69d8\u306b\u5b9f\u65bd\u53ef\u80fd\u3067\u3042\u308a\u3001\u500b\u5225\u5316\u533b\u7642\uff08precision medicine\uff09<sup>\u203b\uff18<\/sup>\u3078\u5fdc\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u304c\u3093\u6cbb\u7642\u306b\u7528\u3044\u308b\u3053\u3068\u306e\u3067\u304d\u308b\u8907\u6570\u306e\u6cbb\u7642\u85ac\u306e\u4e2d\u304b\u3089\u3001\u307e\u305a\u3001\u624b\u8853\u691c\u4f53\u304b\u3089\u4f5c\u88fd\u3057\u305f\uff13\uff24\u816b\u760d\u30e2\u30c7\u30eb\u3067\u6cbb\u7642\u52b9\u679c\u3092\u691c\u8a3c\u3057\u3001\u60a3\u8005\u3055\u3093\u3054\u3068\u306b\u6700\u3082\u6709\u52b9\u306a\u85ac\u5264\u3092\u9078\u3093\u3067\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u4eca\u56de\u7279\u5b9a\u3057\u305f\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u306f\u3001\u7279\u306b\u3001\u81b5\u81d3\u304c\u3093\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08ECM\uff09\u304c\u591a\u304f\u7dda\u7dad\u5316\u304c\u5f37\u3044\u816b\u760d\uff08desmoplastic tumors\uff09<sup>\u203b\uff19<\/sup>\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u304c\u898b\u8fbc\u307e\u308c\u307e\u3059\u3002\u7dda\u7dad\u5316\u3057\u305f\u816b\u760d\u3067\u306f\u85ac\u5264\u304c\u816b\u760d\u5185\u90e8\u307e\u3067\u5230\u9054\u3057\u306b\u304f\u304f\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u306b\u304f\u3044\u3067\u3059\u304c\u3001\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u3067\u7dda\u7dad\u5316\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u85ac\u5264\u306e\u5230\u9054\u6027\u3092\u9ad8\u3081\u3001\u3055\u3089\u306b\u514d\u75ab\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u6cbb\u7642\u52b9\u679c\u3092\u5411\u4e0a\u3067\u304d\u308b\u3068\u898b\u8fbc\u3093\u3067\u3044\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001\u4eca\u56de\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u306e\u4f5c\u7528\u6a5f\u5e8f\u3092\u7814\u7a76\u3059\u308b\u904e\u7a0b\u3067\u3001CAF\u5185\u306b\u304a\u3044\u3066\u975e\u53e4\u5178\u7684\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\u7d4c\u8def\uff08DDR1\/2\u2013MAPK12\u2013GLI1\uff09\u306b\u3088\u308bECM\u7523\u751f\u5236\u5fa1\u304c\u65b0\u305f\u306b\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002GLI1\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b0\u305f\u306a\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u898b\u3064\u304b\u3063\u305f\u3053\u3068\u3067\u3001\u904e\u53bb\u306b\u81b5\u81d3\u304c\u3093\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u81e8\u5e8a\u958b\u767a\u304c\u884c\u308f\u308c\u305f\u53e4\u5178\u7684\u306a\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\u7d4c\u8def\u306e\u963b\u5bb3\u85ac\u306e\u816b\u760d\u6291\u5236\u52b9\u679c\u304c\u4e0d\u5341\u5206\u3060\u3063\u305f\u7406\u7531\u304c\u8aac\u660e\u3067\u304d\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3001DDR1\/2\u3084GLI1\u306a\u3069\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u3068\u306e\u4f75\u7528\u306b\u3088\u308a\u3001CAF\u306b\u3088\u308bECM\u7523\u751f\u6a5f\u80fd\u3092\u6291\u5236\u3057\u3001\u816b\u760d\u6291\u5236\u52b9\u679c\u3092\u6539\u5584\u3059\u308b\u6cbb\u7642\u6226\u7565\u306b\u4f7f\u3046\u3053\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h3>\u8ab2\u984c\u3001\u4eca\u5f8c\u306e\u5c55\u671b<\/h3>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u3084GLI1\u963b\u5bb3\u5264\u306a\u3069\u3001\u304c\u3093\u7d30\u80de\u306e\u5468\u56f2\u306b\u3044\u308b\u201c\u30b5\u30dd\u30fc\u30c8\u7d30\u80de\u201d\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u304c\u3001\u4eca\u56de\u5f97\u3089\u308c\u305f\u6210\u679c\u3092\u3059\u3050\u306b\u81e8\u5e8a\u3078\u5fdc\u7528\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u306f\u3001\u3082\u3068\u3082\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u5bfe\u8c61\u306b\u81e8\u5e8a\u958b\u767a\u3055\u308c\u305f\u5316\u5408\u7269\u3067\u3059\u304c\u3001\u81e8\u5e8a\u958b\u767a\u306e\u904e\u7a0b\u3067\u809d\u6bd2\u6027\u306b\u3088\u308a\u4e2d\u6b62\u3055\u308c\u305f\u7d4c\u7def\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u3084GLI1\u963b\u5bb3\u5264\u306f\u3001\u672c\u6765\u6a19\u7684\u3068\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u4ee5\u5916\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3082\u4e00\u90e8\u963b\u5bb3\u52b9\u679c\u304c\u3042\u308b\u305f\u3081\u3001\u4e88\u671f\u3057\u306a\u3044\u526f\u4f5c\u7528\u304c\u751f\u3058\u308b\u61f8\u5ff5\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u809d\u6bd2\u6027\u306e\u8efd\u6e1b\u3068\u3001DDR1\/2\u2013MAPK12\u2013GLI1\u7d4c\u8def\u3092\u3088\u308a\u9078\u629e\u7684\u304b\u3064\u5b89\u5168\u306b\u6291\u3048\u308b\u65b0\u305f\u306a\u85ac\u5264\uff08\u985e\u7e01\u4f53\uff09\u306e\u958b\u767a\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u307e\u305f\u3001\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\u304c\u6a19\u7684\u3068\u3059\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u306eECM\u306f\u3001\u6b63\u5e38\u306a\u7e4a\u7dad\u82bd\u7d30\u80de\u306b\u3088\u308a\u7523\u751f\u3055\u308c\u3066\u3001\u3059\u3079\u3066\u306e\u6b63\u5e38\u7d44\u7e54\u306b\u3082\u5b58\u5728\u3057\u3001\u7d44\u7e54\u306e\u7dad\u6301\u3084\u4fee\u5fa9\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u963b\u5bb3\u52b9\u679c\u3092\u816b\u760d\u7d44\u7e54\u3084CAF\u3060\u3051\u306b\u9650\u5b9a\u3059\u308b\u3053\u3068\u304c\u4eca\u5f8c\u306e\u5927\u304d\u306a\u8ab2\u984c\u3067\u3059\u3002<\/p>\n<h3><strong>\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n<p>\u304c\u3093\u7d30\u80de\u306f\u3001\u4ed6\u306e\u7d30\u80de\u306e\u69d8\u3005\u306a\u7d30\u80de\u3068\u306e\u95a2\u4fc2\u6027\u306e\u4e2d\u3067\u751f\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u304c\u3093\u3092\u76f4\u63a5\u653b\u6483\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u3092\u72d9\u3046\u6cbb\u7642\u85ac\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u65b9\u6cd5\u8ad6\u3092\u63d0\u793a\u3057\u307e\u3057\u305f\u3002\u304c\u3093\u7d30\u80de\u3060\u3051\u3067\u306f\u306a\u304f\u3066\u3001\u305d\u306e\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u85ac\u3082\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u6cbb\u7642\u52b9\u679c\u3092\u4e0a\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u4e73\u304c\u3093\u3068\u81b5\u304c\u3093\u3092\u5bfe\u8c61\u306b\u5b9f\u9a13\u3092\u3057\u307e\u3057\u305f\u304c\u3001\u5225\u306e\u304c\u3093\u306b\u5fdc\u7528\u3059\u308b\u3068\u307e\u305f\u65b0\u3057\u3044\u85ac\u5264\u304c\u898b\u51fa\u3055\u308c\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n<p>\u203b\uff11\u30003D\u30df\u30af\u30ed\u816b\u760d\u30e2\u30c7\u30eb<br \/>\n\u751f\u4f53\u304b\u3089\u53d6\u308a\u51fa\u3057\u305f\u816b\u760d\u3092\u30df\u30af\u30ed\u30b5\u30a4\u30ba\u306b\u5207\u308a\u5206\u3051\u3001\u816b\u760d\u5185\u306e\u7d30\u80de\u69cb\u9020\u3084\u5fae\u5c0f\u74b0\u5883\u3092\u4fdd\u6301\u3057\u305f\u307e\u307e\u5b9f\u9a13\u5ba4\u3067\u57f9\u990a\u3067\u304d\u308b\u30e2\u30c7\u30eb\u3002\u4f53\u5185\u306e\u816b\u760d\u306b\u8fd1\u3044\u72b6\u614b\u3067\u85ac\u5264\u52b9\u679c\u3092\u8a55\u4fa1\u3067\u304d\u308b\u3002<\/p>\n<p>\u203b\uff12\u3000\u30c9\u30e9\u30de\u30d4\u30e2\u30c9\uff08Doramapimod\uff09<br \/>\n\u3082\u3068\u3082\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u708e\u75c7\u6027\u75be\u60a3\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305fMAPK\u963b\u5bb3\u85ac\u3002\u4eca\u56de\u3001CAF\u3092\u6a19\u7684\u3068\u3057\u3066\u6297\u304c\u3093\u4f5c\u7528\u3092\u793a\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002<\/p>\n<p>\u203b\uff13\u3000\u816b\u760d\u968f\u4f34\u7dda\u7dad\u82bd\u7d30\u80de\uff08CAF: Cancer-Associated Fibroblasts\uff09<br \/>\n\u304c\u3093\u7d30\u80de\u306e\u5468\u56f2\u306b\u5b58\u5728\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u3092\u7523\u751f\u3057\u3066\u816b\u760d\u3092\u652f\u3048\u308b\u300c\u30b5\u30dd\u30fc\u30c8\u5f79\u300d\u306e\u7d30\u80de\u3002\u304c\u3093\u306e\u6210\u9577\u3084\u8ee2\u79fb\u3092\u52a9\u3051\u308b\u3068\u540c\u6642\u306b\u3001\u85ac\u5264\u304c\u5c4a\u304d\u306b\u304f\u304f\u306a\u308b\u539f\u56e0\u3068\u3082\u306a\u308b\u3002<\/p>\n<p>\u203b\uff14\u3000\u30ad\u30ca\u30fc\u30bc<br \/>\n\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u30ea\u30f3\u9178\u3092\u4ed8\u3051\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u62c5\u3046\u9175\u7d20\u3002\u7d30\u80de\u306e\u5897\u6b96\u3084\u5206\u5316\u306a\u3069\u3001\u751f\u547d\u6d3b\u52d5\u3092\u5236\u5fa1\u3059\u308b\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3046\u3002<\/p>\n<p>\u203b\uff15\u3000\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08ECM: Extracellular Matrix\uff09<br \/>\n\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u3001\u7d30\u80de\u306e\u5916\u5074\u3092\u53d6\u308a\u56f2\u3080\u69cb\u9020\u4f53\u3002\u816b\u760d\u3067\u5897\u52a0\u3059\u308b\u3068\u201c\u7dda\u7dad\u5316\u201d\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u85ac\u5264\u306e\u6d78\u900f\u3092\u59a8\u3052\u308b\u3002<\/p>\n<p>\u203b\uff16\u3000GLI1<br \/>\n\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\u7d4c\u8def\u306e\u4e0b\u6d41\u306b\u3042\u308b\u8ee2\u5199\u56e0\u5b50\u3002CAF\u3067\u6d3b\u6027\u5316\u3059\u308b\u3068ECM\u7523\u751f\u3092\u4fc3\u9032\u3057\u3001\u816b\u760d\u9032\u5c55\u306b\u5bc4\u4e0e\u3059\u308b\u3002<\/p>\n<p>\u203b\uff17\u3000\u30d8\u30c3\u30b8\u30db\u30c3\u30b0\u7d4c\u8def\uff08Hedgehog signaling pathway\uff09<br \/>\n\u7d30\u80de\u306e\u5206\u5316\u3084\u767a\u751f\u3092\u5236\u5fa1\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3002\u304c\u3093\u3067\u7570\u5e38\u6d3b\u6027\u5316\u3059\u308b\u3068\u816b\u760d\u9032\u5c55\u306b\u95a2\u4e0e\u3059\u308b\u3002<br \/>\n\u53e4\u5178\u7684\u7d4c\u8def\uff1aSHH\u2013SMO\u3092\u4ecb\u3057\u3066GLI1\u3092\u6d3b\u6027\u5316\u3059\u308b\u30eb\u30fc\u30c8\u3002<br \/>\n\u975e\u53e4\u5178\u7684\u7d4c\u8def\uff1a\u53e4\u5178\u7684\u7d4c\u8def\u4ee5\u5916\u306e\u6d3b\u6027\u5316\u7d4c\u8def\u3002<\/p>\n<p>\u203b\uff18\u3000\u500b\u5225\u5316\u533b\u7642\uff08Precision Medicine\uff09<br \/>\n\u60a3\u8005\u3054\u3068\u306e\u816b\u760d\u3092\u4f7f\u3063\u3066\u85ac\u5264\u52b9\u679c\u3092\u4e8b\u524d\u306b\u8a55\u4fa1\u3057\u3001\u305d\u306e\u60a3\u8005\u306b\u6700\u3082\u6709\u52b9\u306a\u85ac\u3092\u9078\u3093\u3067\u6295\u4e0e\u3059\u308b\u533b\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u3002<\/p>\n<p>\u203b\uff19\u3000\u7dda\u7dad\u5316\u816b\u760d\uff08desmoplastic tumors\uff09<br \/>\n\u816b\u760d\u7d44\u7e54\u3067\u7dda\u7dad\u6210\u5206\u304c\u7570\u5e38\u306b\u5897\u3048\u3001\u786c\u304f\u306a\u308b\u72b6\u614b\u3002\u81b5\u81d3\u304c\u3093\u306b\u5178\u578b\u7684\u3067\u3001\u6cbb\u7642\u85ac\u306e\u5230\u9054\u3092\u963b\u5bb3\u3057\u6cbb\u7642\u3092\u96e3\u3057\u304f\u3059\u308b\u3002<\/p>\n<h3><strong>\u63b2\u8f09\u8a8c\u60c5\u5831<\/strong><\/h3>\n<p>\u96d1\u8a8c\u540d\uff1aCell Reports Medicine<br \/>\n\u8ad6\u6587\u540d\uff1aDrug Screening in 3D Microtumors\u00a0Reveals DDR1\/2-MAPK12-GLI1 as a Vulnerability in Cancer-Associated Fibroblasts<br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u897f\u7530\u5948\u592e\uff08\u306b\u3057\u3060\u306a\u304a\uff09\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001Songli Zhu\uff08Fred Hutchinson Cancer Center\uff09\u3001Marina Chan\uff08Fred Hutchinson Cancer Center\uff09\u3001Yuqi Kang\uff08Fred Hutchinson Cancer Center\uff09\u3001Maihi Fujita (University of Utah)\u3001Xiuyun Jiang\uff08Univeristy of Washington\uff09\u3001Maxwell McCabe\uff08University of Colorado\uff09\u3001Joel M. Vaz\uff08Fred Hutchinson Cancer Center\uff09\u3001Nancy E. Davidson\uff08Fred Hutchinson Cancer Center\uff09\u3001Cyrus M. Ghajar\uff08Fred Hutchinson Cancer Center\uff09\u3001Kirk Hansen\uff08University of Colorado\uff09\u3001Alana L. Welm\uff08University of Utah\uff09\u3001Vanu G. Pillarisetty \uff08University of Washington\uff09\u3001Taranjit S. Gujral \uff08Fred Hutchinson Cancer Center\uff09<br \/>\n\u63b2\u8f09\u2f47\u6642\uff08\u2f47\u672c\u6642\u9593\uff09\uff1a 2025\u5e749\u670819\u65e5\uff08online first\uff09<br \/>\nDOI\uff1a <a href=\"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102357\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.xcrm.2025.102357<\/a><\/p>\n<h3>\u7814\u7a76\u52a9\u6210<\/h3>\n<p>\u672c\u7814\u7a76\u306f\u4ee5\u4e0b\u7814\u7a76\u52a9\u6210\u306e\u652f\u63f4\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>National Cancer Institute (R01CA273081 and R01-CA272677)\u3001<br \/>\nCancer Center Support Grant (NCI 5 P30 CA015704-49)\u3001<br \/>\nBreast Cancer Research Foundation (BCRF 17-035)\u3001<br \/>\nWashington Research Foundation\u3001<br \/>\nthe Fred Hutch Interdisciplinary Training Grant Dual Mentor Fellowship in Cancer Research\u3001<br \/>\nJSPS overseas research fellowship\uff08\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u3000\u6d77\u5916\u7279\u5225\u7814\u7a76\u54e1\u5236\u5ea6\uff09\u3001<br \/>\nthe Comparative Medicine, Cellular Imaging, and Experimental Histopathology Shared Resources of the Fred Hutch\/University of Washington Cancer\/Seattle Children\u2019s Cancer Consortium (P30 CA015704)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u304c\u3093\u306e\u30b5\u30dd\u30fc\u30c8\u5f79\u3092\u72d9\u3044\u6483\u3061 3D\u30df\u30af\u30ed\u816b\u760d\u3067\u898b\u3048\u305f\u65b0\u305f\u306a\u304c\u3093\u6cbb\u7642\u6a19\u7684 \u30dd\u30a4\u30f3\u30c8 \u00a0\u4f53\u5185\u306b\u8fd1\u3044\u7acb\u4f53\u7684\u306a\u304c\u3093\u7d44\u7e54\uff083D\u30df\u30af\u30ed\u816b\u760d\uff09\u3092\u4f7f\u3063\u305f\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308a\u3001\u5f93\u6765\u306e\u65b9\u6cd5\u3067\u306f\u898b\u9003\u3055\u308c\u3066\u3044\u305f\u3001\u304c\u3093\u7d30\u80de\u306e\u307e\u308f\u308a\u306b\u3042\u308b\u300c\u30b5\u30dd\u30fc [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82489,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[145,178],"class_list":["post-82483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/82483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=82483"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/82483\/revisions"}],"predecessor-version":[{"id":82488,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/82483\/revisions\/82488"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/82489"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=82483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=82483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=82483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}