{"id":82033,"date":"2025-10-10T14:00:42","date_gmt":"2025-10-10T05:00:42","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=82033"},"modified":"2025-10-10T10:27:16","modified_gmt":"2025-10-10T01:27:16","slug":"%e3%83%99%e3%83%b3%e3%82%bc%e3%83%b3%e7%92%b0%e3%81%ae%e4%b8%80%e7%99%ba%e5%a4%89%e6%8f%9b%e3%81%a7%e5%89%b5%e8%96%ac%e5%8a%a0%e9%80%9f","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/82033","title":{"rendered":"\u30d9\u30f3\u30bc\u30f3\u74b0\u306e\u4e00\u767a\u5909\u63db\u3067\u5275\u85ac\u52a0\u901f"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong><span class=\"TextRun SCXW36494652 BCX8\" lang=\"JA-JP\" xml:lang=\"JA-JP\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW36494652 BCX8\">\u30d9\u30f3\u30bc\u30f3\u74b0\u306e\u4e00\u767a\u5909\u63db\u3067\u5275\u85ac\u52a0\u901f<\/span><\/span><\/strong><br \/>\n<strong><small><span class=\"NormalTextRun SCXW193904764 BCX8\">\uff5e<\/span><span 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href=\"https:\/\/w-rdb.waseda.jp\/html\/100001406_ja.html\">\u5c71\u53e3\u6f64\u4e00\u90ce\uff08\u3084\u307e\u3050\u3061\u3058\u3085\u3093\u3044\u3061\u308d\u3046\uff09\u6559\u6388<\/a>\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u53e4\u5178\u7684\u306aClaisen<\/span><sup><span data-contrast=\"auto\">\u203b4<\/span><\/sup><span data-contrast=\"auto\">\/\u9006Claisen\u53cd\u5fdc<\/span><sup><span data-contrast=\"auto\">\u203b5<\/span><\/sup><span data-contrast=\"auto\">\u3092\u5fdc\u7528\u3057\u3001\u82b3\u9999\u65cf\u30b1\u30c8\u30f3<\/span><sup><span data-contrast=\"auto\">\u203b1<\/span><\/sup><span data-contrast=\"auto\">\u3068\u30d8\u30c6\u30ed\u82b3\u9999\u65cf<\/span><sup><span data-contrast=\"auto\">\u203b2<\/span><\/sup><span data-contrast=\"auto\">\u30a8\u30b9\u30c6\u30eb\u3092\u4e00\u5ea6\u306b\u53cd\u5fdc\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u30ef\u30f3\u30b9\u30c6\u30c3\u30d7\u3067\u591a\u69d8\u306a\u30d8\u30c6\u30ed\u82b3\u9999\u65cf\u30b1\u30c8\u30f3\u3092\u5408\u6210\u3059\u308b\u65b0\u624b\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u672c\u53cd\u5fdc\u306f\u9ad8\u52b9\u7387\u3067\u9032\u884c\u3057\u3001\u533b\u85ac\u54c1\u3084\u5929\u7136\u7269\u7531\u6765\u306e\u8907\u96d1\u5206\u5b50\u306b\u3082\u9069\u7528\u53ef\u80fd\u3067\u3059\u3002\u3053\u306e\u6210\u679c\u306f\u5275\u85ac\u7814\u7a76\u3084\u65b0\u6750\u6599\u958b\u767a\u306b\u5e83\u304f\u5fdc\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/span><span data-ccp-props=\"{&quot;134245417&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559731&quot;:210,&quot;335559740&quot;:209,&quot;335559797&quot;:100}\"><br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\u30012025\u5e7410\u67089\u65e5 (\u6728)\u306b\u300cNature Communications\u300d\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n<\/span>\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-025-64041-6\">Heteroaromatic Swapping in Aromatic Ketones<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-82034\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/29d3bc99193cb0b837fb8cc53f050ae5-2.png\" alt=\"\" width=\"850\" height=\"478\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/29d3bc99193cb0b837fb8cc53f050ae5-2.png 1190w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/29d3bc99193cb0b837fb8cc53f050ae5-2-610x343.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/29d3bc99193cb0b837fb8cc53f050ae5-2-940x528.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/29d3bc99193cb0b837fb8cc53f050ae5-2-768x432.png 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/p>\n<h3>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/h3>\n<p>\u88fd\u85ac\u4f01\u696d\u306e\u5275\u85ac\u7814\u7a76\u8005\u306f\u3001\u85ac\u306e\u6027\u80fd\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u751f\u7269\u6d3b\u6027\u3092\u3082\u3064\u5316\u5408\u7269\uff08\u30b7\u30fc\u30c9\u5316\u5408\u7269\uff09\u3092\u6709\u6a5f\u5408\u6210\u5316\u5b66\u306e\u624b\u6cd5\u3067\u6539\u5909\u3057\u3001\u3088\u308a\u9ad8\u6d3b\u6027\u3067\u4ee3\u8b1d\u5b89\u5b9a\u6027\u306e\u9ad8\u3044\u85ac\u3078\u3068\u4f5c\u308a\u76f4\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001\u82b3\u9999\u74b0\uff08\u30d9\u30f3\u30bc\u30f3\u74b0\uff09\u3092\u3001\u7a92\u7d20\u306a\u3069\u3092\u542b\u3080\u5927\u304d\u3055\u306e\u8fd1\u3044\u30d8\u30c6\u30ed\u82b3\u9999\u74b0\u306b\u7f6e\u304d\u63db\u3048\u308b\u3068\u3001\u6c34\u6eb6\u6027\u3084\u4ee3\u8b1d\u5b89\u5b9a\u6027\u304c\u6539\u5584\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001\u6297\u3066\u3093\u304b\u3093\u85ac\u30da\u30e9\u30f3\u30d1\u30cd\u30eb\u306f\u3001\u30b7\u30fc\u30c9\u5316\u5408\u7269\u306e\u30d9\u30f3\u30bc\u30f3\u74b0\u3092\u30d4\u30ea\u30b8\u30f3\u74b0\u306b\u5909\u3048\u308b\u3053\u3068\u3067\u3001\u751f\u7269\u6d3b\u6027\u304c\u7d043\u500d\u5411\u4e0a\u3057\u307e\u3057\u305f\u3002<br 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-82037\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/cbf5b9f60da99bf791c0aa12a770f429-2.png\" alt=\"\" width=\"850\" height=\"478\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/cbf5b9f60da99bf791c0aa12a770f429-2.png 1170w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/cbf5b9f60da99bf791c0aa12a770f429-2-610x343.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/cbf5b9f60da99bf791c0aa12a770f429-2-940x529.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/cbf5b9f60da99bf791c0aa12a770f429-2-768x432.png 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-82039\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/09\/5e4896966c9944fcf00890f4502605bf.png\" alt=\"\" width=\"850\" height=\"480\" \/><\/p>\n<h3>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/h3>\n<p>\u4eca\u56de\u958b\u767a\u3057\u305f\u300c\u30d8\u30c6\u30ed\u82b3\u9999\u74b0\u30b9\u30ef\u30c3\u30d4\u30f3\u30b0\u300d\u306f\u3001\u85ac\u306e\u958b\u767a\u306b\u304a\u3051\u308b\u5927\u5e45\u306a\u52b9\u7387\u5316\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002\u5f93\u6765\u306f\u8907\u6570\u306e\u5de5\u7a0b\u3092\u5fc5\u8981\u3068\u3057\u3066\u3044\u305f\u69cb\u9020\u6539\u5909\u3092\u30ef\u30f3\u30b9\u30c6\u30c3\u30d7\u3067\u5b9f\u73fe\u3067\u304d\u308b\u305f\u3081\u3001\u7814\u7a76\u8005\u306f\u77ed\u671f\u9593\u3067\u591a\u304f\u306e\u5019\u88dc\u5316\u5408\u7269\u3092\u5408\u6210\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u65b0\u3057\u3044\u85ac\u306e\u63a2\u7d22\u3084\u6700\u9069\u5316\u304c\u5927\u304d\u304f\u52a0\u901f\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br 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\/>\n\u4eca\u5f8c\u306f\u3001\u3053\u306e\u5236\u9650\u3092\u514b\u670d\u3057\u3001\u3088\u308a\u591a\u69d8\u306a\u30d9\u30f3\u30bc\u30f3\u74b0\u3092\u3082\u3064\u5316\u5408\u7269\u306b\u9069\u7528\u3067\u304d\u308b\u3088\u3046\u306a\u65b0\u3057\u3044\u6539\u826f\u6cd5\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u3088\u308a\u5e45\u5e83\u3044\u533b\u85ac\u54c1\u5019\u88dc\u5316\u5408\u7269\u3084\u6a5f\u80fd\u6027\u5316\u5408\u7269\u306b\u672c\u624b\u6cd5\u3092\u5fdc\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u5275\u85ac\u3084\u6750\u6599\u958b\u767a\u306b\u304a\u3051\u308b\u53ef\u80fd\u6027\u304c\u3055\u3089\u306b\u5e83\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3><strong>\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n<p>\u6559\u79d1\u66f8\u306b\u660e\u8a18\u3055\u308c\u3066\u304d\u305f\u901a\u8aac\u306b\u4f8b\u5916\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u305b\u305f\u306e\u306f\u3001\u79c1\u305f\u3061\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u9a5a\u304d\u3067\u3042\u308a\u3001\u5927\u304d\u306a\u9054\u6210\u611f\u3092\u5f97\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30b7\u30f3\u30d7\u30eb\u3067\u5b9f\u7528\u7684\u306a\u624b\u6cd5\u306f\u3001\u5275\u85ac\u7814\u7a76\u306b\u643a\u308f\u308b\u591a\u304f\u306e\u7814\u7a76\u8005\u306e\u52a9\u3051\u306b\u306a\u308b\u3068\u78ba\u4fe1\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3082\u6709\u6a5f\u5316\u5b66\u306e\u57fa\u790e\u53cd\u5fdc\u3092\u65b0\u3057\u3044\u8996\u70b9\u304b\u3089\u898b\u76f4\u3057\u3001\u793e\u4f1a\u306b\u8ca2\u732e\u3067\u304d\u308b\u5206\u5b50\u5909\u63db\u6280\u8853\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n<p>\u203b1 \u82b3\u9999\u65cf\u30b1\u30c8\u30f3<br \/>\n\u30d9\u30f3\u30bc\u30f3\u74b0\u306a\u3069\u306e\u82b3\u9999\u74b0\u306b\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\uff08C=O\uff09\u304c\u7d50\u5408\u3057\u305f\u5316\u5408\u7269\u3002\u533b\u85ac\u54c1\u3084\u6a5f\u80fd\u6027\u5206\u5b50\u306e\u5408\u6210\u4e2d\u9593\u4f53\u3068\u3057\u3066\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b2 \u30d8\u30c6\u30ed\u82b3\u9999\u74b0<br \/>\n\u30d9\u30f3\u30bc\u30f3\u74b0\u306e\u3088\u3046\u306a\u82b3\u9999\u74b0\u306e\u4e00\u90e8\u304c\u7a92\u7d20\u3084\u9178\u7d20\u3001\u786b\u9ec4\u306a\u3069\u306e\u539f\u5b50\u306b\u7f6e\u304d\u63db\u308f\u3063\u305f\u74b0\u69cb\u9020\u3002\u85ac\u306e\u6eb6\u89e3\u6027\u3084\u5b89\u5b9a\u6027\u3092\u6539\u5584\u3059\u308b\u52b9\u679c\u304c\u3042\u308a\u3001\u591a\u304f\u306e\u533b\u85ac\u54c1\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b3 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\/>\n\u30a8\u30b9\u30c6\u30eb\u3084\u30b1\u30c8\u30f3\u306e\u30a8\u30ce\u30e9\u30fc\u30c8\u304c\u7e2e\u5408\u3057\u30661,3-\u30b8\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u3092\u3064\u304f\u308b\u6709\u6a5f\u5316\u5b66\u306e\u57fa\u672c\u53cd\u5fdc\u300219\u4e16\u7d00\u672b\u306b\u30c9\u30a4\u30c4\u306e\u5316\u5b66\u8005\u30eb\u30fc\u30c8\u30f4\u30a3\u30d2\u30fb\u30af\u30e9\u30a4\u30bc\u30f3\u304c\u767a\u898b\u3002<\/p>\n<p>\u203b5 \u9006Claisen\u53cd\u5fdc<br \/>\n1,3-\u30b8\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u304c\u9006\u65b9\u5411\u306b\u5206\u89e3\u3057\u30012\u3064\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\uff08\u4eca\u56de\u306f\u30b1\u30c8\u30f3\u3068\u30a8\u30b9\u30c6\u30eb\uff09\u306b\u623b\u308b\u53cd\u5fdc\u3002<\/p>\n<p>\u203b6 \u5b98\u80fd\u57fa\u8010\u6027<br 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