{"id":81712,"date":"2025-08-06T11:00:40","date_gmt":"2025-08-06T02:00:40","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=81712"},"modified":"2025-08-04T18:04:19","modified_gmt":"2025-08-04T09:04:19","slug":"%e7%b7%a8%e9%9b%86%e4%b8%ad-19","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/81712","title":{"rendered":"\u6b63\u5e38\u306a\u795e\u7d4c\u7d30\u80de\u5206\u5316\u3001\u9375\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong>\u6b63\u5e38\u306a\u795e\u7d4c\u7d30\u80de\u5206\u5316\u3001\u9375\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6<\/strong><br 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Communications\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-81715\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/29d3bc99193cb0b837fb8cc53f050ae5.png\" alt=\"\" width=\"660\" height=\"409\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/29d3bc99193cb0b837fb8cc53f050ae5.png 660w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/29d3bc99193cb0b837fb8cc53f050ae5-610x378.png 610w\" sizes=\"auto, (max-width: 660px) 100vw, 660px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/h3>\n<p>ATRX\u3001\u6db2-\u6db2\u76f8\u5206\u96e2\uff08LLPS: Liquid-Liquid phase separation\uff09\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3001\u7d30\u80de\u904b\u547d\u6c7a\u5b9a<\/p>\n<h3><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/strong><\/h3>\n<p>ATRX\u306f\u3001\u6838\u5185\u3067DNA\u306e\u69cb\u9020\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u30af\u30ed\u30de\u30c1\u30f3\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u56e0\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30af\u30ed\u30de\u30c1\u30f3\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3068\u306f\u3001DNA\u3068\u30d2\u30b9\u30c8\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u306a\u308b\u30af\u30ed\u30de\u30c1\u30f3\u306e\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u4ed5\u7d44\u307f\u3067\u3059\u3002\u3053\u306eATRX\u306b\u5909\u7570\u304c\u751f\u3058\u308b\u3068\u3001\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u3084\u304c\u3093\u306e\u767a\u75c7\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u795e\u7d4c\u5206\u5316\u306b\u304a\u3044\u3066\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001ATRX\u304c\u4e3b\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u6291\u5236\u3055\u308c\u305f\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u9818\u57df\u306b\u96c6\u7a4d\u3059\u308b\u3053\u3068\u306b\u6ce8\u76ee\u304c\u96c6\u307e\u308a\u3001\u7279\u306b\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u3084\u30c6\u30ed\u30e1\u30a2\u3068\u3044\u3063\u305f\u9818\u57df\u3067\u306e\u6a5f\u80fd\u304c\u89e3\u6790\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u4e3b\u306b\u30e2\u30c7\u30eb\u52d5\u7269\u3067\u3082\u3042\u308b\u30de\u30a6\u30b9\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u304c\u4e2d\u5fc3\u3067\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001ATRX\u304c\u795e\u7d4c\u5206\u5316\u306e\u904e\u7a0b\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u306e\u8a73\u7d30\u306f\u307e\u3060\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u306e\u80cc\u666f\u306b\u306f\u3001\u30d2\u30c8\u3068\u30de\u30a6\u30b9\u306e\u9593\u306b\u5b58\u5728\u3059\u308b\u7a2e\u5dee\u3084\u3001ATRX\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6d3b\u767a\u306a\u9818\u57df\uff08\u30e6\u30fc\u30af\u30ed\u30de\u30c1\u30f3\uff09\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u306eiPS\u7d30\u80de\u7531\u6765\u795e\u7d4c\u7cfb\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u3053\u308c\u307e\u3067\u5341\u5206\u306b\u8a55\u4fa1\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305fATRX\u306e\u65b0\u305f\u306a\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002<\/p>\n<h3><strong>\u4eca\u56de\u306e\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u3001\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h3>\n<ul>\n<li><strong>ATRX<\/strong><strong>\u306e\u76f8\u5206\u96e2\u80fd\u306e\u8a55\u4fa1<\/strong><\/li>\n<\/ul>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306b\u304a\u3044\u3066\u3001ATRX\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6838\u5185\u306b\u6db2-\u6db2\u76f8\u5206\u96e2\uff08LLPS\uff09\u306b\u3088\u308b\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002ATRX\u306f\u5927\u304d\u306a\u5929\u7136\u5909\u6027\u9818\u57df<sup>\u203b5<\/sup>\uff08IDR\uff09\u3092\u6301\u3064\u3053\u3068\u304b\u3089\u3001\u7d30\u80de\u5185\u3067\u819c\u3092\u6301\u305f\u306a\u3044\u69cb\u9020\u4f53\uff08\u30b3\u30f3\u30c7\u30f3\u30bb\u30fc\u30c8\uff09\u3092\u5f62\u6210\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002<\/p>\n<p>ATRX\u306b\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8ceaEGFP\u3092\u878d\u5408\u3055\u305b\u305f\u7d30\u80de\u3067FRAP\u89e3\u6790<sup>\u203b6<\/sup>\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u5f62\u6210\u3055\u308c\u305f\u51dd\u96c6\u4f53\u306f\u5206\u5b50\u304c\u51fa\u5165\u308a\u53ef\u80fd\u306a\u6d41\u52d5\u6027\u3092\u6301\u3061\u3001LLPS\u306b\u3088\u308b\u69cb\u9020\u4f53\u3067\u3042\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\uff08\u56f32\u53c2\u7167\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-81716\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/cbf5b9f60da99bf791c0aa12a770f429.png\" alt=\"\" width=\"503\" height=\"410\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-81717\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/5e4896966c9944fcf00890f4502605bf.png\" alt=\"\" width=\"1489\" height=\"660\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/5e4896966c9944fcf00890f4502605bf.png 1489w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/5e4896966c9944fcf00890f4502605bf-610x270.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/5e4896966c9944fcf00890f4502605bf-940x417.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/5e4896966c9944fcf00890f4502605bf-768x340.png 768w\" sizes=\"auto, (max-width: 1489px) 100vw, 1489px\" \/><\/p>\n<ul>\n<li><strong>ATRX\u306e\u76f8\u5206\u96e2\u80fd\u306f\u795e\u7d4c\u5206\u5316\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b<\/strong><\/li>\n<\/ul>\n<p>\u6700\u5f8c\u306b\u3001ATRX\u306eIDR\u306e\u4e2d\u3067\u3082\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u304c\u9ad8\u5bc6\u5ea6\u306b\u5b58\u5728\u3059\u308b\u300cpoly-E\u9818\u57df\u300d\u304c\u3001\u51dd\u96c6\u4f53\u306e\u5f62\u6210\u306b\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u30b2\u30ce\u30e0\u7de8\u96c6<sup>\u203b10<\/sup>\u306b\u3088\u308a\u3001\u3053\u306epoly-E\u9818\u57df\u3092\u30b3\u30fc\u30c9\u3059\u308bExon15\u3092CRISPR\/Cas9\u3067\u6b20\u640d\u3055\u305b\u305f\u5909\u7570\u4f53\uff08\u0394Ex15\uff09\u3067\u306f\u3001ATRX\u306e\u6838\u5185\u51dd\u96c6\u4f53\u304c\u5f62\u6210\u3055\u308c\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3092\u7528\u3044\u305f\u514d\u75ab\u67d3\u8272\u306e\u7d50\u679c\u3001\u0394Ex15\u3067\u306f\u795e\u7d4c\u7ba1\u69d8\u69cb\u9020\u306e\u5f62\u6210\u304c\u963b\u5bb3\u3055\u308c\u3001\u795e\u7d4c\u5206\u5316\u304c\u6b63\u5e38\u306b\u9032\u884c\u3057\u306a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u56f34\u53c2\u7167\uff09\u3002\u3053\u3053\u3067\u306f\u3001ZO-1\u30b7\u30b0\u30ca\u30eb\uff08\u7dd1\u8272\uff09\u3092\u4e2d\u5fc3\u306bSOX1\u967d\u6027\u7d30\u80de\uff08\u7d2b\u8272\uff09\u304c\u74b0\u72b6\u306b\u96c6\u7a4d\u3059\u308b\u69cb\u9020\u3092\u795e\u7d4c\u7ba1\u69d8\u69cb\u9020\u3068\u3057\u3066\u8a55\u4fa1\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u30de\u30fc\u30ab\u30fc\u304c\u9670\u6027\u306e\u5834\u5408\u306fDAPI\u306b\u3088\u308b\u6838\u67d3\u8272\uff08\u9752\u8272\uff09\u306e\u307f\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-81718\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/08\/1efad1b5aa917a846fa5b3fc11367269.png\" alt=\"\" width=\"574\" height=\"318\" \/><\/p>\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001ATRX\u304cLLPS\u3092\u4ecb\u3057\u3066\u30e6\u30fc\u30af\u30ed\u30de\u30c1\u30f3\u4e0a\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u306b\u95a2\u308f\u308a\u3001\u795e\u7d4c\u5206\u5316\u3092\u652f\u3048\u3066\u3044\u308b\u3068\u3044\u3046\u65b0\u305f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h3><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001ATRX\u304c\u6db2-\u6db2\u76f8\u5206\u96e2\uff08LLPS\uff09\u3092\u4ecb\u3057\u3066\u30e6\u30fc\u30af\u30ed\u30de\u30c1\u30f3\u9818\u57df\u3067\u6a5f\u80fd\u3059\u308b\u3068\u3044\u3046\u65b0\u305f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067ATRX\u306f\u4e3b\u306b\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u306e\u5236\u5fa1\u3084\u30b2\u30ce\u30e0\u5b89\u5b9a\u6027\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3059\u308b\u56e0\u5b50\u3068\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u672c\u7814\u7a76\u306f\u3001\u3053\u308c\u307e\u3067\u60f3\u5b9a\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u8ee2\u5199\u6d3b\u6027\u5316\u9818\u57df\u3067\u306e\u6a5f\u80fd\u3092\u793a\u3057\u305f\u521d\u306e\u6210\u679c\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u77e5\u898b\u306f\u3001ATRX\u306e\u6a5f\u80fd\u7684\u591a\u69d8\u6027\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u5927\u304d\u306a\u524d\u9032\u3067\u3042\u308a\u3001\u3053\u308c\u307e\u3067\u5341\u5206\u306b\u8aac\u660e\u3067\u304d\u306a\u304b\u3063\u305f\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u3084\u816b\u760d\u3078\u306e\u95a2\u4e0e\u3092\u89e3\u660e\u3059\u308b\u624b\u304c\u304b\u308a\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001ATRX\u3092\u4ecb\u3057\u305f\u907a\u4f1d\u5b50\u5236\u5fa1\u306e\u7834\u7dbb\u304c\u3001\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306e\u767a\u75c7\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304b\u3092\u63a2\u308b\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001ATRX\u51dd\u96c6\u4f53\u5f62\u6210\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u958b\u767a\u306e\u53ef\u80fd\u6027\u3082\u62d3\u3051\u307e\u3059\u3002<\/p>\n<h3><strong>\u4eca\u5f8c\u306e\u8ab2\u984c\u3001\u5c55\u671b<\/strong><\/h3>\n<p>\u4eca\u5f8c\u306f\u3001ATRX\u51dd\u96c6\u4f53\u5f62\u6210\u306e\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3088\u308a\u8a73\u7d30\u306b\u89e3\u6790\u3057\u3001\u4ed6\u306e\u8133\u75be\u60a3\u3078\u306e\u95a2\u4e0e\u3084\u5fdc\u7528\u53ef\u80fd\u6027\u3092\u63a2\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u51dd\u96c6\u4f53\u5f62\u6210\u3092\u5236\u5fa1\u3059\u308b\u85ac\u5264\u958b\u767a\u306a\u3069\u81e8\u5e8a\u5fdc\u7528\u3092\u8996\u91ce\u306b\u5165\u308c\u305f\u7814\u7a76\u3092\u9032\u3081\u308b\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n<h3><strong>\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n<p>\u3088\u304f\u77e5\u3089\u308c\u305f\u907a\u4f1d\u5b50\u3067\u3082\u3001\u7570\u306a\u308b\u8996\u70b9\u304b\u3089\u898b\u308b\u3053\u3068\u3067\u3001\u3053\u308c\u307e\u3067\u6c17\u3065\u304b\u308c\u306a\u304b\u3063\u305f\u6027\u8cea\u304c\u898b\u3048\u3066\u304d\u307e\u3059\u3002\u4eca\u56de\u306e\u767a\u898b\u306e\u3088\u3046\u306a\u6838\u5185\u306e\u5c0f\u3055\u306a\u5909\u5316\u304c\u3001\u75c5\u6c17\u3068\u3044\u3046\u5927\u304d\u306a\u9055\u3044\u306b\u3064\u306a\u304c\u308b\u4ed5\u7d44\u307f\u3092\u3001\u4eca\u5f8c\u3055\u3089\u306b\u89e3\u304d\u660e\u304b\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n<p>\u203b1\u3000\u30af\u30ed\u30de\u30c1\u30f3<\/p>\n<p>DNA\u3068\u30d2\u30b9\u30c8\u30f3\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7d50\u3073\u3064\u3044\u305f\u69cb\u9020\u3067\u3001\u7d30\u80de\u306e\u6838\u306e\u4e2d\u306b\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u304c\u4f7f\u308f\u308c\u3084\u3059\u3044\u300c\u30e6\u30fc\u30af\u30ed\u30de\u30c1\u30f3\uff08\u958b\u3044\u305f\u69cb\u9020\uff09\u300d\u3068\u3001\u4f7f\u308f\u308c\u306b\u304f\u3044\u300c\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\uff08\u9589\u3058\u305f\u69cb\u9020\uff09\u300d\u304c\u3042\u308a\u3001\u7d30\u80de\u306f\u3053\u308c\u3089\u3092\u4f7f\u3044\u5206\u3051\u3066\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u8abf\u6574\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u67d3\u8272\u4f53\u306e\u4e2d\u592e\u4ed8\u8fd1\u306b\u3042\u308b\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u3084\u672b\u7aef\u306b\u4f4d\u7f6e\u3059\u308b\u30c6\u30ed\u30e1\u30a2\u306f\u3001\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u306e\u4ee3\u8868\u7684\u306a\u69cb\u9020\u3067\u3042\u308a\u3001\u67d3\u8272\u4f53\u306e\u5b89\u5b9a\u6027\u7dad\u6301\u3084\u5206\u914d\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n<p>\u203b2\u3000 ATRX (Alpha-thalassemia\/mental retardation syndrome X-linked)<\/p>\n<p>ATRX\u306f\u3001\u7cbe\u795e\u767a\u9054\u969c\u5bb3\u3092\u4e3b\u306a\u75c7\u72b6\u3068\u3059\u308bATRX\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305fX\u67d3\u8272\u4f53\u4e0a\u306e\u907a\u4f1d\u5b50\u3067\u3001\u6838\u5185\u3067DNA\u306e\u69cb\u9020\u3092\u8abf\u7bc0\u3059\u308b\u30af\u30ed\u30de\u30c1\u30f3\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u9818\u57df\u306b\u7d50\u5408\u3057\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5236\u5fa1\u3084\u67d3\u8272\u4f53\u306e\u5b89\u5b9a\u7dad\u6301\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306bATRX\u306f\u3001\u81a0\u82bd\u816b\u306a\u3069\u306e\u60aa\u6027\u8133\u816b\u760d\u306b\u304a\u3044\u3066\u3082\u3057\u3070\u3057\u3070\u5909\u7570\u304c\u8a8d\u3081\u3089\u308c\u3001\u304c\u3093\u306e\u9032\u5c55\u3068\u306e\u95a2\u4fc2\u3082\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b3\u3000\u6db2-\u6db2\u76f8\u5206\u96e2\uff08Liquid-Liquid Phase Separation\uff09<\/p>\n<p>\u7d30\u80de\u5185\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3084RNA\u304c\u96c6\u307e\u308a\u3001\u6cb9\u3068\u6c34\u306e\u3088\u3046\u306b\u81ea\u7136\u306b\u5206\u304b\u308c\u3066\u3001\u819c\u306e\u306a\u3044\u6db2\u6ef4\u72b6\u306e\u69cb\u9020\u3092\u3064\u304f\u308b\u73fe\u8c61\u3067\u3059\u3002\u5206\u5b50\u3092\u4e00\u6642\u7684\u306b\u96c6\u4e2d\u30fb\u5206\u96e2\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185\u306e\u53cd\u5fdc\u3084\u60c5\u5831\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3053\u306e\u3057\u304f\u307f\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u3084\u6838\u5c0f\u4f53\u306a\u3069\u591a\u304f\u306e\u7d30\u80de\u69cb\u9020\u306e\u5f62\u6210\u306b\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u6700\u8fd1\u3067\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306a\u3069\u3068\u306e\u95a2\u9023\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b4\u3000\u795e\u7d4c\u5206\u5316<\/p>\n<p>\u672a\u5206\u5316\u306a\u7d30\u80de\uff08\u795e\u7d4c\u5e79\u7d30\u80de\u306a\u3069\uff09\u304c\u3001\u795e\u7d4c\u7d30\u80de\u3084\u30b0\u30ea\u30a2\u7d30\u80de\u306a\u3069\u3001\u8133\u3084\u795e\u7d4c\u7cfb\u306e\u306f\u305f\u3089\u304d\u3092\u62c5\u3046\u5c02\u9580\u7684\u306a\u7d30\u80de\u306b\u5909\u308f\u3063\u3066\u3044\u304f\u904e\u7a0b\u3067\u3059\u3002\u767a\u9054\u3084\u518d\u751f\u533b\u7642\u3001\u795e\u7d4c\u75be\u60a3\u306e\u7814\u7a76\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u73fe\u8c61\u3067\u3059\u3002<\/p>\n<p>\u203b5\u3000\u5929\u7136\u5909\u6027\u9818\u57df\uff08IDR: Intrinsically Disordered Region\uff09<\/p>\n<p>\u6c7a\u307e\u3063\u305f\u7acb\u4f53\u69cb\u9020\u3092\u3068\u3089\u305a\u3001\u67d4\u8edf\u3067\u52d5\u304d\u3084\u3059\u3044\u6027\u8cea\u3092\u3082\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u90e8\u3067\u3059\u3002IDR\u306f\u3001\u4ed6\u306e\u5206\u5b50\u3068\u306e\u3086\u308b\u3084\u304b\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u7e70\u308a\u8fd4\u3057\u884c\u3046\u80fd\u529b\u304c\u3042\u308a\u3001\u6db2-\u6db2\u76f8\u5206\u96e2\u306e\u3088\u3046\u306a\u52d5\u7684\u306a\u69cb\u9020\u5f62\u6210\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3057\u307e\u3059\u3002\u307e\u305f\u3001IDR\u306f\u7d30\u80de\u5185\u306e\u74b0\u5883\u3084\u4fee\u98fe\u306b\u3088\u3063\u3066\u305d\u306e\u6027\u8cea\u304c\u5909\u308f\u308b\u305f\u3081\u3001\u6a5f\u80fd\u306e\u8abf\u7bc0\u306b\u3082\u95a2\u308f\u308b\u91cd\u8981\u306a\u9818\u57df\u3067\u3059\u3002<\/p>\n<p>\u203b6\u3000FRAP (Fluorescence recovery after photobleaching) \u89e3\u6790<\/p>\n<p>FRAP\u89e3\u6790\u306f\u3001\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u5206\u5b50\u306e\u52d5\u304d\u3092\u8abf\u3079\u308b\u624b\u6cd5\u3067\u3059\u3002\u86cd\u5149\u3067\u6a19\u8b58\u3057\u305f\u5206\u5b50\u306b\u5f37\u3044\u30ec\u30fc\u30b6\u30fc\u3092\u7167\u5c04\u3057\u3066\u4e00\u90e8\u3092\u201c\u5149\u9000\u8272\u201d\uff08\u86cd\u5149\u3092\u6d88\u3059\uff09\u3055\u305b\u3001\u305d\u306e\u5f8c\u306b\u5468\u56f2\u304b\u3089\u3069\u308c\u304f\u3089\u3044\u65e9\u304f\u86cd\u5149\u304c\u56de\u5fa9\u3059\u308b\u304b\u3092\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3067\u3001\u5206\u5b50\u306e\u62e1\u6563\u6027\u3084\u53ef\u52d5\u6027\u3092\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7d30\u80de\u5185\u3067\u3001\u6db2-\u6db2\u76f8\u5206\u96e2\u306e\u6027\u8cea\u3092\u6301\u3064\u304b\u3069\u3046\u304b\uff08\u6db2\u4f53\u306e\u3088\u3046\u306b\u5206\u5b50\u306e\u51fa\u5165\u308a\u304c\u3042\u308b\u304b\u3069\u3046\u304b\uff09\u3092\u898b\u5206\u3051\u308b\u306e\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u203b7\u3000CUT&amp;RUN<\/p>\n<p>\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304cDNA\u306e\u3069\u306e\u9818\u57df\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u304b\u3092\u9ad8\u7cbe\u5ea6\u3067\u8abf\u3079\u308b\u5b9f\u9a13\u624b\u6cd5\u3067\u3059\u3002\u6297\u4f53\u3092\u4f7f\u3063\u3066\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8a8d\u8b58\u3057\u3001\u305d\u308c\u306b\u7d50\u5408\u3057\u305f\u9175\u7d20\uff08\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\uff09\u304c\u5468\u8fba\u306eDNA\u3092\u5207\u65ad\u3057\u307e\u3059\u3002\u305d\u306e\u5207\u65ad\u65ad\u7247\u3092\u56de\u53ce\u30fb\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u67d3\u8272\u4f53\u4e0a\u3067\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d50\u5408\u4f4d\u7f6e\u3092\u7279\u5b9a\u3067\u304d\u307e\u3059\u3002\u30af\u30ed\u30de\u30c1\u30f3\u69cb\u9020\u3084\u8ee2\u5199\u5236\u5fa1\u306e\u7814\u7a76\u3067\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b8\u30001,6-Hexanediol<\/p>\n<p>\u6db2-\u6db2\u76f8\u5206\u96e2\uff08LLPS\uff09\u306e\u5b9f\u9a13\u3067\u7528\u3044\u3089\u308c\u308b\u5316\u5408\u7269\u3067\u3001\u5206\u5b50\u9593\u306e\u3086\u308b\u3084\u304b\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u4e00\u6642\u7684\u306b\u963b\u5bb3\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001LLPS\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u305f\u6db2\u6ef4\u69cb\u9020\uff08\u51dd\u96c6\u4f53\uff09\u3092\u53ef\u9006\u7684\u306b\u5206\u89e3\u3067\u304d\u308b\u305f\u3081\u3001\u305d\u306e\u5f62\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u3084\u751f\u7406\u7684\u610f\u7fa9\u3092\u8abf\u3079\u308b\u969b\u306b\u6709\u52b9\u3067\u3059\u3002\u7d30\u80de\u6a5f\u80fd\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c40\u5728\u5909\u5316\u3092\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306e\u30c4\u30fc\u30eb\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u203b9\u3000\u8ee2\u5199\u6d3b\u6027\u5316\u56e0\u5b50\uff08BRD4, MED1, P300, CHD7\uff09<\/p>\n<p>\u3053\u308c\u3089\u306f\u3001\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\uff08mRNA\u5408\u6210\uff09\u3092\u4fc3\u9032\u3059\u308b\u56e0\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002BRD4\u3068MED1\u3001P300\u306f\u3001\u6db2-\u6db2\u76f8\u5206\u96e2\uff08LLPS\uff09\u306b\u3088\u3063\u3066\u819c\u306e\u306a\u3044\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u3001RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306a\u3069\u306e\u56e0\u5b50\u3092\u52b9\u7387\u7684\u306b\u96c6\u3081\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001CHD7\u306f\u3001ATRX\u3068\u540c\u69d8\u306b\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306e\u6027\u8cea\u3092\u7dad\u6301\u3059\u308b\u3046\u3048\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b10\u3000\u30b2\u30ce\u30e0\u7de8\u96c6 (Exon, CRISPR\/cas9)<\/p>\n<p>\u30b2\u30ce\u30e0\u7de8\u96c6\u306f\u3001DNA\u306e\u7279\u5b9a\u306e\u90e8\u5206\u3092\u72d9\u3063\u3066\u5207\u65ad\u30fb\u6539\u5909\u3059\u308b\u6280\u8853\u3067\u3001\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3092\u8abf\u3079\u305f\u308a\u5236\u5fa1\u3057\u305f\u308a\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u624b\u6cd5\u3067\u3042\u308bCRISPR\/Cas9\u306f\u3001\u7d30\u83cc\u306e\u514d\u75ab\u6a5f\u69cb\u3092\u5fdc\u7528\u3057\u305f\u3082\u306e\u3067\u3001\u7279\u5b9a\u306eDNA\u914d\u5217\u3092\u5207\u65ad\u30fb\u4fee\u5fa9\u3059\u308b\u3053\u3068\u3067\u3001\u72d9\u3063\u305f\u907a\u4f1d\u5b50\u9818\u57df\u3092\u524a\u9664\u30fb\u7f6e\u63db\u30fb\u633f\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u9ad8\u3044\u7cbe\u5ea6\u3068\u64cd\u4f5c\u306e\u5bb9\u6613\u3055\u304b\u3089\u3001\u73fe\u5728\u3067\u306f\u751f\u547d\u79d1\u5b66\u7814\u7a76\u306b\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u30a8\u30af\u30bd\u30f3\uff08Exon\uff09\u306f\u3001\u907a\u4f1d\u5b50\u306e\u4e2d\u3067\u5b9f\u969b\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a2d\u8a08\u56f3\u3068\u306a\u308b\u60c5\u5831\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u90e8\u5206\u3067\u3001\u8907\u6570\u306e\u30a8\u30af\u30bd\u30f3\u304c\u9023\u7d50\u3055\u308c\u30661\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5408\u6210\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u914d\u5217\u3084\u69cb\u9020\u306e\u5909\u5316\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u306b\u76f4\u63a5\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001CRISPR\/Cas9\u3092\u7528\u3044\u3066\u3001ATRX\u907a\u4f1d\u5b50\u306eExon15\uff0815\u756a\u76ee\u306e\u30a8\u30af\u30bd\u30f3\uff09\u3092\u7279\u7570\u7684\u306b\u6b20\u640d\u3055\u305b\u307e\u3057\u305f\u3002\u3053\u306e\u6539\u5909\u306b\u3088\u308a\u3001ATRX\u306e\u51dd\u96c6\u4f53\u5f62\u6210\u3084\u795e\u7d4c\u5206\u5316\u3078\u306e\u5f71\u97ff\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n<h3><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h3>\n<p>\u96d1\u8a8c\u540d\uff1aNature Communications<br \/>\n\u8ad6\u6587\u540d\uff1aPhase Separated Condensates of ATRX Regulate Neural Progenitor Identity<br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u53cb\u5ca1\u9818\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001\u4f50\u91ce\u5742\u53f8\uff08\u6176\u61c9\u7fa9\u587e\u5927\u5b66\uff09\u3001\u5bae\u57ce\u78a7\u6c34\uff08\u6771\u4eac\u533b\u79d1\u5927\u5b66\uff09\u3001\u5b89\u85e4(\u91ce\u7530)\u53cb\u5b50\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001\u5742\u91ce\u8061\u91cd\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001\u6e9d\u7530\u7d00\u5b50\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001\u91d1\u8535\u5b5d\u4ecb\uff08\u6771\u4eac\u533b\u79d1\u5927\u5b66\uff09\u3001\u5ca1\u91ce\u6804\u4e4b\uff08\u6176\u61c9\u7fa9\u587e\u5927\u5b66\uff09\u3001\u795e\u5c71\u6df3\uff0a\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<br \/>\n\u63b2\u8f09\u65e5\u6642\uff1a2025\u5e747\u670814\u65e5\uff08\u6708\uff09<br \/>\nDOI\uff1a<a href=\"https:\/\/doi.org\/10.1038\/s41467-025-61881-0\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41467-025-61881-0<\/a><br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-025-61881-0\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41467-025-61881-0<\/a><\/p>\n<h3><strong>\u7814\u7a76\u52a9\u6210<br \/>\n<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u306f\u3001JSPS\u79d1\u7814\u8cbbJP19H03623, JP24K02571\u3001\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\uff08AMED\uff09\u518d\u751f\u533b\u7642\u5b9f\u73fe\u62e0\u70b9\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30d7\u30ed\u30b0\u30e9\u30e0(\u6280\u8853\u958b\u767a\u500b\u5225\u8ab2\u984c)\u3001\u300ciPS\u7d30\u80de\u7531\u6765\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u3092\u300e\u9ad8\u54c1\u8cea\u5316\u300f\u3059\u308b\u624b\u6cd5\u306e\u958b\u767a\u300d\u3001\u518d\u751f\u533b\u7642\u7b49\u5b9f\u7528\u5316\u7814\u7a76\u4e8b\u696d\u300c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u5bfe\u3059\u308b\u518d\u751f\u533b\u7642\u306e\u666e\u53ca\u306b\u8cc7\u3059\u308b\u7d30\u80de\u88fd\u5264\u4f5c\u88fd\u6280\u8853\u306e\u78ba\u7acb\u300d\u306e\u652f\u63f4\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6b63\u5e38\u306a\u795e\u7d4c\u7d30\u80de\u5206\u5316\u3001\u9375\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6 \uff5eATRX\u306e\u76f8\u5206\u96e2\u304c\u62c5\u3046\u8133\u306e\u767a\u9054\u3068\u75c5\u614b\u5f62\u6210\uff5e \u30dd\u30a4\u30f3\u30c8 \u77e5\u7684\u969c\u5bb3\u3084\u8133\u767a\u9054\u7570\u5e38\u306e\u539f\u56e0\u907a\u4f1d\u5b50ATRX\u304c\u3001\u8133\u7d30\u80de\u306e\u904b\u547d\u3092\u6c7a\u3081\u308b\u65b0\u305f\u306a\u4ed5\u7d44\u307f\u3092\u767a\u898b\u3002 ATRX\u304c\u6838\u5185\u306b\u300c\u51dd\u96c6\u4f53\uff08\u6db2\u6ef4\uff09\u300d\u3092\u4f5c 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