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Tg)\u3092\u4f5c\u6210\u3057\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u795e\u7d4c\u7d30\u80de\u306b\u904e\u5270\u306b\u767a\u73fe\u3055\u305b\u3066\u3001\u305d\u308c\u305e\u308c\u5358\u72ec\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3068\u306e\u75c5\u614b\u9032\u884c\u3092\uff18\u304b\u6708\u9f62\u3067\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u306e\u9032\u884c\u3001\u8133\u5185\u708e\u75c7\u306e\u9032\u884c\u3001\u795e\u7d4c\u7d30\u80de\u6b7b\u306e\u9032\u884c\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f2025\u5e747\u670825\u65e5\u306b\u300cMolecular Neurobiology\u300d\u306b\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306f\u3068\u3082\u306b\u8a8d\u77e5\u75c7\u306e\u539f\u56e0\u75be\u60a3\u3067\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306f\u65e5\u672c\u306b\u304a\u3044\u3066\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3064\u3044\u3067\uff12\u756a\u76ee\u306b\u60a3\u8005\u6570\u304c\u591a\u3044\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u795e\u7d4c\u7d30\u80de\u5185\u306b\u30ea\u30f3\u9178\u5316\u3055\u308c\u305f\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u3067\u306f\u30ea\u30f3\u9178\u5316\u3055\u308c\u305f\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3(\u4ee5\u4e0b\u30b7\u30cc\u30af\u30ec\u30a4\u30f3)\u304c\u51dd\u96c6\u3057\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u3001\u6a5f\u80fd\u969c\u5bb3\u3092\u8d77\u3053\u3057\u3001\u3084\u304c\u3066\u7d30\u80de\u6b7b\u306b\u81f3\u308a\u3001\u305d\u306e\u305f\u3081\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u969c\u5bb3\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u4e8c\u3064\u306e\u75c5\u614b\u306f\u5358\u72ec\u3067\u8d77\u3053\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u8907\u5408\u3057\u305f\u75c5\u614b\u304c\u8d77\u304d\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u84c4\u7a4d\u304c\u4e2d\u8133\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u7523\u751f\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3082\u306b\u8d77\u3053\u308a\u3001\u7d30\u80de\u6b7b\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u306e\u304c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u3059\u3002<\/p>\n<p>\u305d\u308c\u305e\u308c\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u304c\u884c\u306a\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u306e\u84c4\u7a4d\u3092\u518d\u73fe\u3057\u305f\u30e2\u30c7\u30eb\u3068\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u3092\u518d\u73fe\u3057\u305f\u30e2\u30c7\u30eb\u304c\u3042\u308a\u307e\u3059\u3002\u5f8c\u8005\u3067\u306f\u3001\u5bb6\u65cf\u4f8b\u3067\u307f\u3089\u308c\u308b\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u3067\u51dd\u96c6\u6027\u304c\u9ad8\u307e\u308b\u3053\u3068\u304b\u3089\u3001\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u3092\u5c0e\u5165\u3057\u305f\u30d2\u30c8\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u795e\u7d4c\u7d30\u80de\u5185\u306b\u767a\u73fe\u3055\u305b\u305f\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u304c\u958b\u767a\u3055\u308c\u3001\u7814\u7a76\u306b\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306e\u30e2\u30c7\u30eb\u3082\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u306b\u3088\u308a\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u51dd\u96c6\u6027\u304c\u9ad8\u307e\u308b\u305f\u3081\u3001\u5909\u7570\u578b\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u3092\u795e\u7d4c\u7d30\u80de\u306b\u904e\u5270\u306b\u767a\u73fe\u3055\u305b\u305f\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u304c\u7814\u7a76\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u304c\u795e\u7d4c\u7d30\u80de\u9593\u3067\u4f1d\u64ad\u3059\u308b\u73fe\u8c61\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u4e21\u75be\u60a3\u306e\u9593\u3067\u3082\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u4f53\u3092\u8133\u5185\u306b\u6ce8\u5165\u3057\u3066\u3001\u84c4\u7a4d\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u691c\u8a0e\u3059\u308b\u7814\u7a76\u304c\u884c\u306a\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5909\u7570\u578b\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u795e\u7d4c\u7d30\u80de\u306b\u904e\u5270\u767a\u73fe\u3055\u305b\u305f\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h3><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3068\u3057\u3066\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u7cfb\u7d71\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306f\u3001\u524d\u8ff0\u306e\u69d8\u306b\u30a2\u30df\u30ed\u30a4\u30c9\u75c5\u5909\u3092\u4e3b\u4f53\u3068\u3057\u305f\u3082\u306e\u3068\u30bf\u30a6\u75c5\u5909\u3092\u4e3b\u4f53\u3068\u3057\u305f\u3082\u306e\u306b\u5927\u5225\u3055\u308c\u307e\u3059\u304c\u3001\u4eca\u56de\u306f\u30bf\u30a6\u75c5\u5909\u3092\u4e3b\u4f53\u3068\u3057\u305f\u3082\u306e\u3067\u3001P301S\u5909\u7570(301\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c\u30d7\u30ed\u30ea\u30f3\u304c\u30bb\u30ea\u30f3\u3078\u5909\u7570)\u3092\u6709\u3059\u308bPS19\u30e9\u30a4\u30f3(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17270732\/\">Tau Tg, Yoshiyama et al., 2007<\/a>)\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3068\u3057\u3066\u306f\u3001\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306eA53T(53\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u306e\u30a2\u30e9\u30cb\u30f3\u304c\u30c8\u30ec\u30aa\u30cb\u30f3\u3078\u5909\u7570)\u5909\u7570\u3092\u6709\u3059\u308b\u3082\u306e\u3067(<a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.132197599\">\u03b1-syn Tg, Lee et al., 2002<\/a>)\u3001\u5909\u7570\u578b\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u304c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u5e83\u304f\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u6700\u521d\u306e\u5831\u544a\u3067\u306f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u30e2\u30c7\u30eb\u3068\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3068\u3057\u3066\u7528\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u639b\u3051\u3042\u308f\u305b\u3066\u3001\uff12\u91cd\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9(Double Tg)\u3092\u4f5c\u6210\u3057\u3001Tau Tg\u53ca\u3073-syn Tg\u3068\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u3001\uff18\u304b\u6708\u9f62\u306b\u304a\u3051\u308b\u30ea\u30f3\u9178\u5316\u30bf\u30a6\u3001\u30ea\u30f3\u9178\u5316a-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u3001\u795e\u7d4c\u708e\u75c7\u3001\u795e\u7d4c\u7d30\u80de\u6570\u3001\u306b\u3064\u3044\u3066\u3001\u6d77\u99ac\u3092\u7d44\u7e54\u5b66\u7684\u306b\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u884c\u52d5\u89e3\u6790\u3068\u3057\u3066\u3001\uff15\u6708\u9f62\u3068\uff18\u6708\u9f62\u3067\u6050\u6016\u6761\u4ef6\u4ed8\u3051\u6587\u8108\u8a18\u61b6\u306b\u304a\u3051\u308b\u3059\u304f\u307f\u6642\u9593(freezing time)\u203b1\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u6d77\u99ac\u306eCA1\u9818\u57df\u306b\u304a\u3044\u3066\u3001\u30ea\u30f3\u9178\u5316\u30bf\u30a6\u306e\u5897\u52a0\u3068\u3001\u795e\u7d4c\u708e\u75c7\u306e\u9032\u884c\u3001\u795e\u7d4c\u7d30\u80de\u6570\u6e1b\u5c11\u306e\u60aa\u5316\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f(\u56f3\uff11)\u3002\u307e\u305f\u3001\u6050\u6016\u6761\u4ef6\u4ed8\u3051\u6587\u8108\u8a18\u61b6\u306b\u304a\u3051\u308bfreezing time\u304cDouble Tg\u306b\u304a\u3044\u3066\u77ed\u7e2e\u3057\u3066\u304a\u308a\u3001\u6587\u8108\u8a18\u61b6\u306e\u4f4e\u4e0b\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f(\u56f3\uff12)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-81675\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/af4dbeefc4f87026f221546c6bf905ca.png\" alt=\"\" width=\"2133\" height=\"682\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/af4dbeefc4f87026f221546c6bf905ca.png 2133w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/af4dbeefc4f87026f221546c6bf905ca-610x195.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/af4dbeefc4f87026f221546c6bf905ca-940x301.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/af4dbeefc4f87026f221546c6bf905ca-768x246.png 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/af4dbeefc4f87026f221546c6bf905ca-1536x491.png 1536w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/af4dbeefc4f87026f221546c6bf905ca-2048x655.png 2048w\" sizes=\"auto, (max-width: 2133px) 100vw, 2133px\" \/><\/p>\n<p style=\"text-align: center;\">\u56f31 \u3000\u6d77\u99acCA1\u9818\u57df\u306e\u795e\u7d4c\u7d30\u80de\u6570\u306e\u6bd4\u8f03<\/p>\n<p>\u203b \u6d77\u99acCA1\u9818\u57df\u306e\u795e\u7d4c\u7d30\u80de\u3092\u30de\u30fc\u30ab\u30fc\u306eNeuN\u3067\u67d3\u8272\u3057\u305f\u8133\u7d44\u7e54\u306e\u753b\u50cf(a)\u3068\u3001\u967d\u6027\u7d30\u80de\u6570\u3092\u30ab\u30a6\u30f3\u30c8\u3057\u3001\u91ce\u751f\u3000\u578b(WT)\u3001\u30bf\u30a6Tg(TauTg)\u3001\u30b7\u30cc\u30af\u30ec\u30a4\u30f3Tg(\u03b1-syn Tg) \u3001Double Tg\u3067\u6bd4\u8f03\u3057\u305f(b)\u3002\u305d\u306e\u7d50\u679c\u3001Double Tg\u306f\u5358\u72ec\u306eTg\u3088\u308a\u795e\u7d4c\u7d30\u80de\u6570\u306e\u6e1b\u5c11\u304c\u7d71\u8a08\u7684\u6709\u610f\u306b\u8a8d\u3081\u3089\u308c\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-81676 size-medium\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/4e0de923a934a3ff4dd966797abf50af-610x383.png\" alt=\"\" width=\"610\" height=\"383\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/4e0de923a934a3ff4dd966797abf50af-610x383.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/4e0de923a934a3ff4dd966797abf50af-940x590.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/4e0de923a934a3ff4dd966797abf50af-768x482.png 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/07\/4e0de923a934a3ff4dd966797abf50af.png 1504w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/p>\n<p style=\"text-align: center;\">\u56f32 \u6050\u6016\u6761\u4ef6\u4ed8\u3051\u6587\u8108\u8a18\u61b6\u306b\u304a\u3051\u308b\u3059\u304f\u307f\u6642\u9593\uff08freezing time\uff09\u306e\u6bd4\u8f03<\/p>\n<p>\u203b 8\u304b\u6708\u9f62\u306b\u304a\u3044\u3066\u3001Double Tg\u306b\u304a\u3044\u3066\u306f\u3001freezing time\u304cWT\u3068Tau Tg\u306b\u6bd4\u3079\u3066\u77ed\u7e2e\u3057\u3066\u3044\u305f(p&lt;0.01)\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h3>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306e\u8907\u5408\u75c5\u614b\u306f\u3001\u5358\u72ec\u306e\u5834\u5408\u3088\u308a\u901f\u304f\u75c5\u614b\u304c\u9032\u884c\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u4e21\u75be\u60a3\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u539f\u56e0\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u795e\u7d4c\u7d30\u80de\u5185\u306b\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u304c\u8d77\u304d\u3066\u3001\u6a5f\u80fd\u969c\u5bb3\u3055\u3089\u306b\u306f\u7d30\u80de\u6b7b\u3078\u3068\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u51dd\u96c6\u3084\u84c4\u7a4d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u4e0a\u3067\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u306e\u767a\u5c55\u306b\u5bc4\u4e0e\u3059\u308b\u77e5\u898b\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n<h3><strong>\u8ab2\u984c\u3001\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h3>\n<p>\u30bf\u30a6\u3068\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u304c\u3069\u306e\u69d8\u306b\u795e\u7d4c\u7d30\u80de\u5185\u3067\u51dd\u96c6\u3057\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u969c\u5bb3\u3055\u305b\u3001\u7d30\u80de\u6b7b\u306b\u81f3\u308b\u304b\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u75be\u60a3\u6cbb\u7642\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u304c\u795e\u7d4c\u7d30\u80de\u5185\u306e\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30ea\u30f3\u9178\u5316\u3057\u3001\u51dd\u96c6\u3055\u305b\u308b\uff11\u3064\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001CRMP2\uff08\u30b3\u30e9\u30d7\u30b7\u30f3\u53cd\u5fdc\u5a92\u4ecb\u30bf\u30f3\u30d1\u30af\u8cea2\uff09\u306e\u30ea\u30f3\u9178\u5316\u304c\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u5831\u544a\u3057\u307e\u3057\u305f(Noguchi et al., 2025)\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001CRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30f3\u9178\u5316\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8cCRMP2\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u306e\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u4e88\u5b9a\u3067\u3042\u308a\u3001\u4eca\u56de\u306e\u8907\u5408\u7684\u306a\u75c5\u614b\u306e\u9032\u884c\u3092\u6291\u5236\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u304b\u3082\u691c\u8a0e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u3067\u306f\u3001\u30d2\u30c8\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u3001\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u306b\u4f34\u3044\u3001\u5927\u304d\u306a\u793e\u4f1a\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u8a8d\u77e5\u75c7\u306e\u75c5\u614b\u89e3\u660e\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u65b0\u305f\u306a\u77e5\u898b\u3092\u5f97\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u5411\u3051\u305f\u4e00\u6b69\u76ee\u3067\u3042\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u7814\u7a76\u3092\u767a\u5c55\u3055\u305b\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/h3>\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u3001\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3001\u795e\u7d4c\u7d30\u80de\u6b7b\u3001\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3<\/p>\n<h3><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h3>\n<p>\u203b1\u3000\u6050\u6016\u6761\u4ef6\u4ed8\u3051\u6587\u8108\u8a18\u61b6\u306b\u304a\u3051\u308b\u3059\u304f\u307f\u6642\u9593(freezing time)<br \/>\n\u30de\u30a6\u30b9\u3092\u6240\u5b9a\u306e\u7bb1\u306b\u5165\u308c\u3001\u96fb\u6c17\u30b7\u30e7\u30c3\u30af\u3092\u4e0e\u3048\u308b\u300224\u6642\u9593\u5f8c\u306b\u30de\u30a6\u30b9\u3092\u540c\u3058\u7bb1\u306b\u5165\u308c\u308b\u3068\u3001\u30de\u30a6\u30b9\u306f\u7bb1\u306b\u5165\u308c\u3089\u308c\u308b\u3053\u3068\u3068\u96fb\u6c17\u30b7\u30e7\u30c3\u30af\u3092\u4e0e\u3048\u3089\u308c\u308b\u3053\u3068\u3092\u95a2\u9023\u4ed8\u3051\u3066\u8a18\u61b6\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3092\u6587\u8108\u8a18\u61b6\u3068\u547c\u3076\u3002\u6587\u8108\u8a18\u61b6\u306b\u3088\u308a\u30de\u30a6\u30b9\u306f\u6050\u6016\u306e\u305f\u3081\u3059\u304f\u307f(freezing)\u884c\u52d5\u3092\u793a\u3059\u30025\u5206\u9593\u306e\u89b3\u5bdf\u306e\u3046\u3061\u3067\u3001freezing\u3092\u793a\u3057\u305f\u5272\u5408\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u3001\u6587\u8108\u8a18\u61b6\u3092\u8a55\u4fa1\u3059\u308b\u3002\u3053\u306e\u7a2e\u306e\u8a18\u61b6\u304c\u969c\u5bb3\u3055\u308c\u308b\u3068\u3001freezing time (%)\u306f\u4f4e\u4e0b\u3059\u308b\u3002<\/p>\n<p><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/p>\n<p>\u96d1\u8a8c\u540d\uff1aMolecular Neurobiology<br \/>\n\u8ad6\u6587\u540d\uff1aCo-expression of mutant tau and \u03b1-synuclein in neurons promotes tau phosphorylation, neuronal loss and neuroinflammation in mouse brain<br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1aYuki Yamamoto\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001Toshiki Kubota\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001Daisuke Noguchi\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09\u3001Takaomi C Saido\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\uff09\u3001Toshio Ohshima\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09*<br \/>\n\u63b2\u8f09\u65e5\u6642\uff1a2025\u5e747\u670825\u65e5<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40707862\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40707862\/<\/a><br \/>\nDOI\uff1a<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05248-y\">https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05248-y<\/a><br \/>\n*\uff1a\u8cac\u4efb\u8457\u8005<\/p>\n<h3><strong>\u7814\u7a76\u52a9\u6210<br \/>\n<\/strong><\/h3>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u79d1\u5b66\u7814\u7a76\u8cbb \u57fa\u76e4\u7814\u7a76\uff08C\uff09 \u8ab2\u984c\u756a\u53f7\uff1a22K06464<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1aCRMP2\u30ea\u30f3\u9178\u5316\u306e\u795e\u7d4c\u56de\u8def\u5f62\u6210\u304a\u3088\u3073\u795e\u7d4c\u518d\u751f\u3078\u306e\u5f79\u5272\u89e3\u660e\u3068\u305d\u306e\u5fdc\u7528<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u5927\u5cf6\u3000\u767b\u5fd7\u7537\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306e\u8907\u5408\u75c5\u614b\u3067\u795e\u7d4c\u7d30\u80de\u6b7b\u304c\u9032\u884c\u3059\u308b \uff5e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u89e3\u6790\u306b\u3088\u308b\u7814\u7a76\u6210\u679c\uff5e \u30dd\u30a4\u30f3\u30c8 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306e\u8907\u5408\u3057\u305f\u75c5\u614b\u3092\u3001\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u691c\u8a3c\u3057\u305f\u3002\u4e21\u75be\u60a3\u3067\u306f\u3001 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":81679,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[145,178],"class_list":["post-81674","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/81674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=81674"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/81674\/revisions"}],"predecessor-version":[{"id":81844,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/81674\/revisions\/81844"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/81679"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=81674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=81674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=81674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}