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\u4e00\u65b9\u30012\u578b\u7cd6\u5c3f\u75c5\u3092\u4f75\u767a\u3057\u305f\u60a3\u8005\u3067\u306f\u8840\u4e2d\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/p><\/div>\n<p>\u3053\u306e\u7d50\u679c\u306f\u3001\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u304c\u30d2\u30c8\u81b5\u03b2\u7d30\u80de\u306e\u91cf\u306e\u8abf\u7bc0\u306b\u304b\u304b\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3001\u307e\u305f\u8840\u4e2d\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u30bf\u30f3\u30d1\u30af\u8cea\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u306e\u88dc\u5145\u7642\u6cd5\u304c\u7cd6\u5c3f\u75c5\u306e\u6539\u5584\u3092\u3082\u305f\u3089\u3057\u3046\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff13\uff09\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/h4>\n<p>\u3053\u308c\u307e\u3067\u306b\u7cd6\u5c3f\u75c5\u3092\u6839\u6cbb\u3067\u304d\u308b\u6cbb\u7642\u85ac\u306f\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u7cd6\u5c3f\u75c5\u306e\u6839\u6cbb\u306b\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u3092\u6301\u3063\u305f\u81b5\u03b2\u7d30\u80de\u306e\u91cf\u3092\u56de\u5fa9\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u4eca\u56de\u767a\u898b\u3057\u305f\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u306f\u81b5\u03b2\u7d30\u80de\u306e\u91cf\u3092\u56de\u5fa9\u3059\u308b\u4f5c\u7528\u3092\u793a\u3059\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u6b27\u7c73\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30a2\u30b8\u30a2\u4eba\u3001\u7279\u306b\u65e5\u672c\u4eba\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u304c\u4f4e\u304f\u3001\u7cd6\u5c3f\u75c5\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u4eba\u7a2e\u3067\u3059\u30022\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u8840\u4e2d\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u6fc3\u5ea6\u304c\u4f4e\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u306e\u88dc\u5145\u7642\u6cd5\u304c\u81b5\u03b2\u7d30\u80de\u306e\u91cf\u3092\u56de\u5fa9\u3057\u3001\u7cd6\u5c3f\u75c5\u3092\u6839\u6cbb\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u6709\u671b\u306a\u65b9\u6cd5\u306b\u306a\u308a\u3046\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8840\u4e2d\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u6fc3\u5ea6\u304c\u7cd6\u5c3f\u75c5\u767a\u75c7\u3092\u4e88\u898b\u3067\u304d\u308b\u65b0\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u4f7f\u3048\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff14\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u304c\u30d2\u30c8\u306e\u81b5\u03b2\u7d30\u80de\u306e\u5897\u6b96\u3092\u6d3b\u6027\u5316\u3067\u304d\u308b\u306e\u304b\u3001\u307e\u305f2\u578b\u7cd6\u5c3f\u75c5\u3060\u3051\u3067\u306a\u304f1\u578b\u7cd6\u5c3f\u75c5\u306e\u81b5\u81d3\u306b\u5bfe\u3057\u3066\u3082\u305d\u306e\u4f5c\u7528\u304c\u8a8d\u3081\u3089\u308c\u308b\u306e\u304b\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306f\u305d\u306e\u5b89\u5168\u6027\u306e\u691c\u8a3c\u306e\u307f\u306a\u3089\u305a\u3001\u81b5\u03b2\u7d30\u80de\u3078\u306e\u6307\u5411\u6027\u3092\u3069\u306e\u3088\u3046\u306b\u62c5\u4fdd\u3059\u3079\u304d\u304b\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u6210\u679c\u304c\u30d2\u30c8\u3067\u3082\u540c\u3058\u3088\u3046\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u3001\u7cd6\u5c3f\u75c5\u306e\u6839\u6cbb\u7642\u6cd5\u306b\u306a\u308a\u5f97\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff15\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u7740\u76ee\u3057\u305f\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u306f\u3001\u81b5\u03b2\u7d30\u80de\u306b\u76f4\u63a5\u50cd\u304d\u304b\u3051\u3001\u305d\u306e\u7d30\u80de\u91cf\u3092\u5897\u3084\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u5206\u5b50\u3067\u3042\u308a\u3001\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u304c\u7cd6\u5c3f\u75c5\u306e\u6839\u6cbb\u6cbb\u7642\u6a19\u7684\u306b\u306a\u308a\u3048\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u671f\u5f85\u3057\u305f\u901a\u308a\u306e\u52b9\u679c\u304c\u30d2\u30c8\u3067\u3082\u8a8d\u3081\u3089\u308c\u308c\u3070\u3001\u7cd6\u5c3f\u75c5\u6839\u6cbb\u3078\u306e\u9053\u3092\u62d3\u304f\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u4fe1\u3058\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff16\uff09\u7528\u8a9e\u89e3\u8aac<\/h4>\n<p>\u203b1\u3000\u30d8\u30d1\u30c8\u30ab\u30a4\u30f3<br \/>\n\u809d\u81d3\u304b\u3089\u5206\u6ccc\u3055\u308c\u3001\u4f53\u5185\u306e\u4ed6\u306e\u81d3\u5668\u306b\u50cd\u304d\u304b\u3051\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u56e0\u5b50\u306e\u7dcf\u79f0<br \/>\n\u203b\uff12 ERBB<br \/>\n\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\u30014\u7a2e\u306e\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u3002<br \/>\n\u203b\uff13 MEK\/ERK\u30b7\u30b0\u30ca\u30eb\u7cfb<br \/>\nERK\u306f\u5897\u6b96\u56e0\u5b50\u306a\u3069\u306e\u7d30\u80de\u5206\u88c2\u4fc3\u9032\u56e0\u5b50\u306b\u3088\u3063\u3066\u6d3b\u6027\u304c\u5f37\u304f\u8a98\u5c0e\u3055\u308c\u308b\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u306e1\u3064\u3002MEK\u306fERK\u306e\u30b9\u30ec\u30aa\u30cb\u30f3\u3068\u30c1\u30ed\u30b7\u30f3\u3092\u30ea\u30f3\u9178\u5316\u3057\u6d3b\u6027\u5316\u3059\u308b\u4e0a\u4f4d\u306e\u30ad\u30ca\u30fc\u30bc\u3002<br \/>\n\u203b4 \u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff09<br \/>\n\u8102\u80aa\u809d\u306b\u52a0\u3048\u3001\u80a5\u6e80\u3001\u8010\u7cd6\u80fd\u7570\u5e38\u3001\u9ad8\u8840\u5727\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3001\u4f4eHDL\u8840\u75c7\u306e\u3044\u305a\u308c\u304b\u306e\u4ee3\u8b1d\u7570\u5e38\u3092\u4f75\u767a\u3057\u3066\u3044\u308b\u75be\u60a3\u3002\u4ee5\u524d\u306f\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u3068\u547c\u3070\u308c\u3066\u3044\u305f\u3002<\/p>\n<h4>\uff08\uff17\uff09\u8ad6\u6587\u60c5\u5831<\/h4>\n<p>\u96d1\u8a8c\u540d\uff1aNature Communications<br \/>\n\u8ad6\u6587\u540d\uff1aLiver-derived Neuregulin1\u03b1 stimulates compensatory pancreatic \u03b2 cell hyperplasia in insulin resistance<br \/>\n\u57f7\u7b46\u8005\u540d\uff1aTakatomo Arai\u00b9, Eriko Hayashi\u00b9, Sumie Maeda\u00b9, Tsutomu Matsubara\u00b3, Hideki Fujii\u00b3, Koya Shinohara\u00b2, Arisu Sogabe\u00b9, Sadatomo Wainai\u00b9, Daishi Tanaka\u00b9, Yutaro Ono\u00b9, Yumika Ono\u00b9, Minami Yoshikai\u00b9, Yuriko Sorimachi\u00b2, Cindy Yuet-Yin Kok\u2074\u2075, Masayuki Shimoda\u00b2, Minoru Tanaka\u00b2, Norifumi Kawada\u00b3, Nobuhito Goda\u00b9*\u3000*\u8cac\u4efb\u7b46\u8005<br \/>\n1\uff0e\u65e9\u7a32\u7530\u5927\u5b66\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1<br \/>\n2\uff0e\u56fd\u7acb\u56fd\u969b\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u6240<br \/>\n3\uff0e\u5927\u962a\u516c\u7acb\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1<br \/>\n4. Neuroscience Research Australia, NSW, 2031, Australia<br \/>\n5. Discipline of Medicine, Randwick Clinical Campus, University of New South Wales, Sydney, NSW 2031, Australia<br \/>\n\u63b2\u8f09\u65e5\u6642\uff1a2025\u5e743\u670813\u65e5\uff08\u6728\uff09<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57167-0\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41467-025-57167-0<\/a><br \/>\nDOI\uff1a<a href=\"https:\/\/doi.org\/10.1038\/s41467-025-57167-0\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41467-025-57167-0<\/a><\/p>\n<h4>\uff088\uff09\u7814\u7a76\u52a9\u6210<\/h4>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5236\u5fa1\u306b\u57fa\u3065\u304f\u6b21\u4e16\u4ee3\u578b\u5065\u5eb7\u5bff\u547d\u79d1\u5b66\u306e\u7814\u7a76\u62e0\u70b9\u5f62\u6210<br \/>\n\u7814\u7a76\u8cbb\u540d\uff1a\u79c1\u7acb\u5927\u5b66\u6226\u7565\u7684\u7814\u7a76\u57fa\u76e4\u5f62\u6210\u652f\u63f4\u4e8b\u696d 2012\u5e74 &#8211; 2016\u5e74<\/p>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u65b0\u898f\u30d8\u30d1\u30c8\u30ab\u30a4\u30f3\u306e\u30cb\u30e5\u30fc\u30ec\u30b0\u30ea\u30f31\u3092\u4ecb\u3057\u305f\u7cd6\u5c3f\u75c5\u306e\u75c5\u614b\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e<br \/>\n\u7814\u7a76\u8cbb\u540d\uff1a\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a \u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d \u57fa\u76e4\u7814\u7a76(C) JP17K08674<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u5408\u7530 \u4e98\u4eba<\/p>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u809d\u81d3\u7531\u6765\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u305f\u81d3\u5668\u9593\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306b\u57fa\u3065\u304f\u65b0\u3057\u3044\u8840\u7cd6\u8abf\u7bc0\u6a5f\u69cb\u306e\u89e3\u660e<br \/>\n\u7814\u7a76\u8cbb\u540d\uff1a\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a \u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d \u57fa\u76e4\u7814\u7a76(C) JP20K07345<br 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\/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u5408\u7530\u3000\u4e98\u4eba<\/p>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u4f4e\u9178\u7d20\u5fdc\u7b54\u30b7\u30b9\u30c6\u30e0\u3092\u4ecb\u3057\u305f\u65b0\u3057\u3044\u8102\u8cea\u4ee3\u8b1d\u5236\u5fa1\u6a5f\u69cb\u306e\u63a2\u7d22\u3068\u305d\u306e\u6a5f\u80fd\u306e\u89e3\u660e<br \/>\n\u7814\u7a76\u8cbb\u540d\uff1a\u65e9\u7a32\u7530\u5927\u5b66\u3000\u7279\u5b9a\u8ab2\u984c\uff08\u7814\u7a76\u57fa\u76e4\u5f62\u6210\uff092013B-174<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u5408\u7530\u3000\u4e98\u4eba<\/p>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u8102\u80aa\u84c4\u7a4d\u3092\u5236\u5fa1\u3059\u308b\u65b0\u3057\u3044\u4f4e\u9178\u7d20\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u89e3\u660e<br \/>\n\u7814\u7a76\u8cbb\u540d\uff1a\u65e9\u7a32\u7530\u5927\u5b66\u3000\u7279\u5b9a\u8ab2\u984c\uff08\u7814\u7a76\u57fa\u76e4\u5f62\u6210\uff092014B-313<br 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