{"id":80078,"date":"2025-03-13T09:00:10","date_gmt":"2025-03-13T00:00:10","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=80078"},"modified":"2025-03-13T08:53:42","modified_gmt":"2025-03-12T23:53:42","slug":"%e6%a5%b5%e3%82%81%e3%81%a6%e5%ae%89%e5%ae%9a%e3%81%aa%e6%96%b0%e8%a6%8f%e3%82%ab%e3%83%b3%e3%83%8a%e3%83%93%e3%83%8e%e3%82%a4%e3%83%89%e7%94%9f%e7%89%a9%e5%ad%a6%e7%9a%84%e7%ad%89%e4%be%a1%e4%bd%93-2","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/80078","title":{"rendered":"\u300c\u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u3067\u30de\u30a6\u30b9\u4f53\u5185\u306e\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u53ef\u8996\u5316"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong>\u300c\u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u3067\u30de\u30a6\u30b9\u4f53\u5185\u306e\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u53ef\u8996\u5316<br \/>\n<small>\u304c\u3093\u6cbb\u7642\u85ac\u306e\u9577\u671f\u7684\u306a\u52d5\u614b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u5411\u3051\u3066<\/small><\/strong><\/h2>\n<h3>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul>\n<li>\u304c\u3093\u6cbb\u7642\u85ac\u3092\u816b\u760d\u3078\u904b\u3076\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853\u3092\u30de\u30a6\u30b9\u5b9f\u9a13\u3067\u5b9f\u8a3c<\/li>\n<li>\u3053\u308c\u307e\u3067\u56f0\u96e3\u3060\u3063\u305f\u6838\u533b\u5b66\u6cbb\u7642\u85ac\uff08\u30a2\u30eb\u30d5\u30a1\u7dda\u653e\u51fa\u6838\u7a2e\uff09\u306e\u9577\u671f\u52d5\u614b\u8ffd\u8de1\u3092\u5b9f\u73fe<\/li>\n<li>\u69d8\u3005\u306a\u6cbb\u7642\u85ac\u306e\u9577\u671f\u7684\u306a\u4f53\u5185\u52d5\u614b\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u624b\u6cd5\u3068\u3057\u3066\u306e\u5fdc\u7528\u306b\u671f\u5f85<\/li>\n<\/ul>\n<h3>\u6982\u8981<\/h3>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u5927\u5b66\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b1\u5e74\u306e\u8d8a\u5ddd \u4e03\u661f\uff08\u3053\u3057\u304b\u308f \u306a\u306a\u305b\uff09\u3068\u3001\u540c\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001002_ja.html\" target=\"_blank\" rel=\"noopener\">\u7247\u5ca1 \u6df3<\/a>\uff08\u304b\u305f\u304a\u304b \u3058\u3085\u3093\uff09\u6559\u6388\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u5927\u962a\u5927\u5b66\u653e\u5c04\u7dda\u79d1\u5b66\u57fa\u76e4\u6a5f\u69cb\u306e\u8c4a\u5d8b \u539a\u53f2\uff08\u3068\u3088\u3057\u307e \u3042\u3064\u3057\uff09\u6559\u6388\u3001\u89d2\u6c38 \u60a0\u4e00\u90ce\uff08\u304b\u3069\u306a\u304c \u3086\u3046\u3044\u3061\u308d\u3046\uff09\u7279\u4efb\u52a9\u6559\uff08\u5e38\u52e4\uff09\u3001\u52a0\u85e4 \u5f18\u6a39\uff08\u304b\u3068\u3046 \u3072\u308d\u304d\uff09\u7279\u4efb\u6559\u6388\uff08\u5e38\u52e4\uff09\u3001\u4eac\u90fd\u5927\u5b66\u8907\u5408\u539f\u5b50\u529b\u79d1\u5b66\u7814\u7a76\u6240\u306e\u9ad8\u5bae \u5e78\u4e00\uff08\u305f\u304b\u307f\u3084 \u3053\u3046\u3044\u3061\uff09\u6559\u6388\u3089\u3068\u5171\u540c\u3067\u3001\u85ac\u5264\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u308b\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u76f4\u63a5\u53ef\u8996\u5316\u3059\u308b\u300c\u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<sup>\u203b\uff11<\/sup>\u300d\u3092\u63d0\u6848\u3057\u3001\u5b9f\u969b\u306b\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u30de\u30a6\u30b9\u306b\u6295\u4e0e\u3057\u3066\u4f53\u5185\u5206\u5e03\u3092\u53ef\u8996\u5316\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001\u816b\u760d\u3092\u30d4\u30f3\u30dd\u30a4\u30f3\u30c8\u3067\u653b\u6483\u3059\u308b\u30a2\u30eb\u30d5\u30a1\u7dda<sup>\u203b\uff12<\/sup>\u6cbb\u7642\u85ac\u30a2\u30b9\u30bf\u30c1\u30f3At-211\u3092\u3001\u653e\u5c04\u5316\u91d1\u30ca\u30ce\u7c92\u5b50\u306b\u6a19\u8b58<sup>\u203b\uff13<\/sup>\u3059\u308b\u3053\u3068\u306b\u3082\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u56f0\u96e3\u3067\u3042\u3063\u305fAt-211\u306e\u9577\u671f\u7684\u306a\u52d5\u614b\u8ffd\u8de1\u3092\u5b9f\u73fe\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u69d8\u3005\u306a\u6cbb\u7642\u85ac\u3067\u3001\u52d5\u614b\u53ef\u8996\u5316\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u672c\u6210\u679c\u3092\u307e\u3068\u3081\u305f\u8ad6\u6587\u306f\u3001\u8ad6\u6587\u8a8c\u300eApplied Physics Letters\u300f\u306e\u201dFeatured article\u201d\u306b\u9078\u3070\u308c\u305f\u307b\u304b\u3001AIP\uff08\u7c73\u56fd\u7269\u7406\u5b66\u5354\u4f1a\uff09\u767a\u884c\u306e\u8ad6\u6587\u5168\u4f53\u304b\u3089\u9855\u8457\u306a\u6210\u679c\u3092\u7279\u96c6\u3059\u308bScilight (Science highlight) \u3067\u7d39\u4ecb\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u30012025\u5e743\u670812\u65e5\uff08\u6c34\uff09\u5348\u524d10\u6642\uff08\u7c73\u56fd\u6771\u90e8\u6a19\u6e96\u6642\uff09\u306b\u300eApplied Physics Letters\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><strong style=\"font-size: 14px;\">\u3010\u8ad6\u6587\u60c5\u5831\u3011<br \/>\n<\/strong><span style=\"font-size: 14px;\">\u96d1\u8a8c\u540d\uff1aApplied Physics Letters<br \/>\n<\/span><span style=\"font-size: 14px;\">\u8ad6\u6587\u540d\uff1aActivation imaging of gold nanoparticles for versatile drug visualization: an in vivo demonstration<br \/>\n<\/span><span style=\"font-size: 14px;\">DOI\uff1a10.1063\/5.0251048<\/span><\/p>\n<div id=\"attachment_80079\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-80079\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/ff121ba43cf76dc1c6e4a4d654ad4ea6.png\" alt=\"\" width=\"369\" height=\"263\" \/><p class=\"wp-caption-text\">\u56f3\uff1a\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/p><\/div>\n<h3><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u304c\u3093\u306f\u3001\u9577\u304d\u306b\u308f\u305f\u3063\u3066\u65e5\u672c\u4eba\u306e\u6b7b\u56e0\u7b2c\u4e00\u4f4d\u3067\u3042\u308a\u3001\u52b9\u679c\u7684\u3067\u8ca0\u62c5\u306e\u5c11\u306a\u3044\u6cbb\u7642\u6cd5\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u304c\u3093\u306e\u6cbb\u7642\u6cd5\u306b\u306f\u69d8\u3005\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u653e\u5c04\u6027\u306e\u6cbb\u7642\u85ac\u3092\u6295\u4e0e\u3057\u3066\u816b\u760d\u3078\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u308b\u6838\u533b\u5b66\u6cbb\u7642\u306f\u3001\u624b\u8853\u304c\u8981\u3089\u305a\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u65b9\u6cd5\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u8fd1\u5e74\u3001\u6838\u533b\u5b66\u306e\u5206\u91ce\u3067\u306f\u3001\u30a2\u30eb\u30d5\u30a1\u7dda\u3092\u653e\u51fa\u3059\u308b\u6cbb\u7642\u85ac\u304c\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30eb\u30d5\u30a1\u7dda\u306f\u72ed\u3044\u7bc4\u56f2\u306b\u5927\u304d\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4e0e\u3048\u308b\u653e\u5c04\u7dda\u3067\u3001\u816b\u760d\u3060\u3051\u3092\u52b9\u679c\u7684\u306b\u653b\u6483\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u4e2d\u3067\u3082\u8cea\u91cf\u6570211\u306e\u30a2\u30b9\u30bf\u30c1\u30f3\uff08At-211\uff09\u306f\u3001\u56fd\u5185\u306e\u30b5\u30a4\u30af\u30ed\u30c8\u30ed\u30f3\u3067\u6bd4\u8f03\u7684\u7c21\u5358\u306b\u88fd\u9020\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u6709\u671b\u8996\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001At-211\u306f\u30a2\u30eb\u30d5\u30a1\u7dda\u3060\u3051\u3067\u306a\u304f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc79 keV\uff08\u30ad\u30ed\u96fb\u5b50\u30dc\u30eb\u30c8\uff09\u306eX\u7dda<sup>\u203b\uff12<\/sup>\u3092\u653e\u51fa\u3057\u307e\u3059\u3002\u30de\u30a6\u30b9\u306e\u4f53\u3092\u900f\u904e\u3057\u3066\u304d\u305fX\u7dda\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u3067\u3001At-211\u3092\u4f53\u306e\u5916\u304b\u3089\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u52b9\u679c\u7684\u304b\u3064\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u6cbb\u7642\u3092\u5b9f\u73fe\u3059\u308b\u306b\u306f\u3001At-211\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u6cbb\u7642\u85ac\u3092\u816b\u760d\u3078\u5c4a\u3051\u3001\u96c6\u7a4d\u3055\u305b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6cbb\u7642\u85ac\u3092\u816b\u760d\u3078\u904b\u3076\u300c\u85ac\u5264\u30ad\u30e3\u30ea\u30a2\u300d\u3068\u3057\u3066\u7279\u306b\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u308b\u306e\u304c\u3001\u30ca\u30ce\u30b5\u30a4\u30ba\uff08\u76f4\u5f84\u304c10<sup>-9<\/sup> m\u7a0b\u5ea6\uff09\u306e\u91d1\u306e\u7c92\u5b50\uff08\u91d1\u30ca\u30ce\u7c92\u5b50\uff09\u3067\u3059\u3002\u5b9f\u969b\u306b\u3001\u56f31 (a)\u306e\u3088\u3046\u306b\u91d1\u30ca\u30ce\u7c92\u5b50\u306bAt-211\u3092\u6a19\u8b58\u3057\u3066\u816b\u760d\u306b\u6295\u4e0e\u3059\u308b\u3068\u3001\u56f31 (b)\u306e\u3088\u3046\u306b\u91d1\u30ca\u30ce\u7c92\u5b50\u304c\u816b\u760d\u306b\u7559\u307e\u308a\u3001\u9ad8\u3044\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059<sup>[1]<\/sup>\u3002\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u3068\u3057\u3066\u3001\u30de\u30a6\u30b9\u5b9f\u9a13\u306b\u3088\u308a\u96c6\u7a4d\u304b\u3089\u6392\u51fa\u307e\u3067\u3001\u6570\u65e5\u9593\u306b\u308f\u305f\u308b\u9577\u671f\u306e\u52d5\u614b\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u3001At-211\u304b\u3089\u306eX\u7dda\u3092\u4f7f\u3063\u3066At-211\u6a19\u8b58\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u304c\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001At-211\u306e\u534a\u6e1b\u671f\u306f7.2\u6642\u9593\u3068\u77ed\u304f\u3001\u6295\u4e0e\u304b\u30892\u65e5\u5f8c\u306b\u306fX\u7dda\u306e\u5f37\u5ea6\u306f\u7d041\/100\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u305f\u3081\u3001\u6570\u65e5\u9593\u306b\u308f\u305f\u308b\u52d5\u614b\u3092\u8ffd\u3046\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u306e\u65b9\u6cd5\u3067\u306f\u4f53\u5185\u3067At-211\u3068\u91d1\u30ca\u30ce\u7c92\u5b50\u304c\u5206\u96e2\u3057\u3066\u3057\u307e\u3063\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u8abf\u3079\u3089\u308c\u306a\u3044\u3053\u3068\u3082\u554f\u984c\u3067\u3057\u305f\u3002<\/p>\n<div id=\"attachment_80083\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-80083\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/bceba7b58fdd6aada06bca56fba83f19.png\" alt=\"\" width=\"1280\" height=\"446\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/bceba7b58fdd6aada06bca56fba83f19.png 1280w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/bceba7b58fdd6aada06bca56fba83f19-610x213.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/bceba7b58fdd6aada06bca56fba83f19-940x328.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/bceba7b58fdd6aada06bca56fba83f19-768x268.png 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><p class=\"wp-caption-text\">\u56f3\uff11\uff1a(a) At-211\u6a19\u8b58\u91d1\u30ca\u30ce\u7c92\u5b50\u3002At-211\u306f\u30a2\u30eb\u30d5\u30a1\u7dda\u3068X\u7dda\u3092\u653e\u51fa\u3059\u308b\u3002(b) At-211\u6a19\u8b58\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u6295\u4e0e\u3057\u305f\u30e9\u30c3\u30c8\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7d50\u679c\uff08\u6295\u4e0e4\u6642\u9593\u5f8c\u3002Kato et al. (2021)[1]\u3088\u308a\u8ee2\u8f09\uff09\u3002<\/p><\/div>\n<h3><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u300c\u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u306b\u3088\u308a\u3001At-211\u3068\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u500b\u5225\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3001\u305d\u3057\u3066At-211\u6a19\u8b58\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u9577\u671f\u7684\u306a\u52d5\u614b\u8ffd\u8de1\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002\u653e\u5c04\u5316\u3068\u306f\u3001\u5b89\u5b9a\u306a\u539f\u5b50\u3092\u653e\u5c04\u6027\u540c\u4f4d\u4f53\u306b\u5909\u3048\u308b\u3053\u3068\u3067\u3059\u3002\u81ea\u7136\u754c\u306b\u5b58\u5728\u3059\u308b\u91d1\u306f\u8cea\u91cf\u6570\u304c197\u306e\u5b89\u5b9a\u306a\u5143\u7d20\u3067\u3059\u3002\u3053\u308c\u306b\u71b1\u4e2d\u6027\u5b50\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u4f4e\u3044\u4e2d\u6027\u5b50\uff09\u3092\u3076\u3064\u3051\u308b\u3068\u3001\u91d1\u306e\u539f\u5b50\u6838\u306e\u4e00\u90e8\u304c\u4e2d\u6027\u5b50\u3092\u53d6\u308a\u8fbc\u3093\u3067\u8cea\u91cf\u6570\u304c198\u306e\u91d1\uff08Au-198\uff09\u306b\u5909\u308f\u308a\u307e\u3059\u3002Au-198\u306f\u534a\u6e1b\u671f\u304c2.7\u65e5\u306e\u653e\u5c04\u6027\u540c\u4f4d\u4f53\u3067\u3001\u30a8\u30cd\u30eb\u30ae\u30fc412 keV\u306e\u30ac\u30f3\u30de\u7dda<sup>\u203b\uff12<\/sup>\u3092\u653e\u51fa\u3057\u307e\u3059\u3002\u91d1\u30ca\u30ce\u7c92\u5b50\u306b\u542b\u307e\u308c\u308b\u91d1\u306e\u4e00\u90e8\u3092\u653e\u5c04\u6027\u306eAu-198\u306b\u5909\u3048\u3001\u30ac\u30f3\u30de\u7dda\u3092\u4f53\u5916\u304b\u3089\u691c\u51fa\u3059\u308b\u3053\u3068\u3067\u3001\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u4f53\u5185\u5206\u5e03\u3092\u4f53\u5916\u304b\u3089\u53ef\u8996\u5316\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u6280\u8853\u306b\u306f\u3001\u4ed6\u306b\u3082\u30c8\u30ec\u30fc\u30b5\u30fc\uff08\u653e\u5c04\u6027\u7269\u8cea\u3084\u9020\u5f71\u5264\uff09\u306b\u3088\u308b\u6a19\u8b58\u3084CT\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff08\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u65ad\u5c64\u64ae\u5f71\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30c8\u30ec\u30fc\u30b5\u30fc\u304c\u91d1\u30ca\u30ce\u7c92\u5b50\u304b\u3089\u5916\u308c\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3001CT\u3067\u306f\u91d1\u30ca\u30ce\u7c92\u5b50\u304c\u9ad8\u6fc3\u5ea6\uff08mg\/mL\u7a0b\u5ea6\uff09\u3067\u306a\u3044\u3068\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306f\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u76f4\u63a5\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u624b\u6cd5\u3067\u3042\u308a\u30013\u6841\u3082\u4f4e\u3044\u6fc3\u5ea6\uff08\u03bcg\/mL\u7a0b\u5ea6\uff09\u3067\u3042\u3063\u3066\u3082\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u304c\u3067\u304d\u308b\u3068\u3044\u3046\u70b9\u3067\u3001\u3053\u308c\u307e\u3067\u306e\u5236\u9650\u3092\u6253\u7834\u3059\u308b\u65b9\u6cd5\u3068\u306a\u308a\u5f97\u307e\u3059\u3002At-211\u6a19\u8b58\u3057\u305f\u653e\u5c04\u5316\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u56f32 (a)\u306b\u793a\u3057\u307e\u3059\u300279 keV\u306eX\u7dda\u3001412 keV\u306e\u30ac\u30f3\u30de\u7dda\u3092\u4f7f\u3063\u3066At-211\u3068\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u5206\u5e03\u3092\u500b\u5225\u306b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3057\u3001At-211\u304c\u91d1\u30ca\u30ce\u7c92\u5b50\u304b\u3089\u5916\u308c\u3066\u3044\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3067\u304d\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001At-211\u306f\u534a\u6e1b\u671f7.2\u6642\u9593\u3067\u6025\u6fc0\u306b\u6e1b\u8870\u3057\u307e\u3059\u304c\u3001\u534a\u6e1b\u671f2.7\u65e5\u306eAu-198\u306f\u6570\u65e5\u9593\u30ac\u30f3\u30de\u7dda\u3092\u51fa\u3057\u7d9a\u3051\u308b\u306e\u3067\u3001At-211\u6a19\u8b58\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u96c6\u7a4d\u3068\u4ee3\u8b1d\u3092\u6570\u65e5\u9593\u306b\u308f\u305f\u308a\u8ffd\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>At-211\u3068\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u72ec\u7acb\u306b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u306b\u306f\u3001\u6570\u5341 keV\u304b\u3089MeV\uff08\u30e1\u30ac\u96fb\u5b50\u30dc\u30eb\u30c8\uff09\u4ed8\u8fd1\u307e\u3067\u3001\u5e45\u5e83\u3044X\u7dda\u30fb\u30ac\u30f3\u30de\u7dda\u30921\u53f0\u304b\u3064\u540c\u6642\u306b\u8b58\u5225\u3067\u304d\u308b\u300c\u5e83\u5e2f\u57df\u306e\u30ab\u30e1\u30e9\u300d\u304c\u5fc5\u8981\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u5f93\u6765\u306eSPECT\uff08\u5358\u4e00\u5149\u5b50\u653e\u5c04\u65ad\u5c64\u64ae\u5f71\uff09<sup>\u203b\uff14<\/sup>\u3067\u306f\u7d04300 keV\u4ee5\u4e0b\u3001PET\uff08\u967d\u96fb\u5b50\u653e\u51fa\u65ad\u5c64\u64ae\u5f71\uff09<sup>\u203b\uff15<\/sup>\u3067\u306f511 keV\u306e\u307f\u3068\u3001\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u304d\u308bX\u7dda\u30fb\u30ac\u30f3\u30de\u7dda\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u304c\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u300c\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9<sup>\u203b\uff16<\/sup>\u300d\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u88c5\u7f6e\u3068\u3057\u3066\u7528\u3044\u307e\u3057\u305f\u3002\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u306f\u3001\u4f4e\u30a8\u30cd\u30eb\u30ae\u30fc\uff08200 keV\u4ee5\u4e0b\uff09\u7528\u306e\u30d4\u30f3\u30db\u30fc\u30eb\u30e2\u30fc\u30c9\u3068\u9ad8\u30a8\u30cd\u30eb\u30ae\u30fc\uff08200 keV\u4ee5\u4e0a\uff09\u7528\u306e\u30b3\u30f3\u30d7\u30c8\u30f3\u30e2\u30fc\u30c9\u306e2\u7a2e\u985e\u306e\u65b9\u6cd5\u3067\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u304c\u3067\u304d\u307e\u3059\u3002\u56f32 (b)\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u88c5\u7f6e\u306f2\u679a\u306e\u691c\u51fa\u5668\uff08\u6563\u4e71\u4f53\u3068\u5438\u53ce\u4f53\uff09\u3067\u69cb\u6210\u3055\u308c\u3001\u6563\u4e71\u4f53\u306b\u306f3\u00d73 mm<sup>2<\/sup>\u306e\u5b54\u304c\u7a7a\u3044\u3066\u3044\u307e\u3059\u3002\u4f4e\u30a8\u30cd\u30eb\u30ae\u30fc\u306eX\u7dda\u30fb\u30ac\u30f3\u30de\u7dda\u306f\u6563\u4e71\u4f53\u306b\u5f53\u305f\u308b\u3068\u5438\u53ce\u3055\u308c\u3001\u5b54\u3092\u901a\u3063\u305f\u3082\u306e\u3060\u3051\u304c\u5438\u53ce\u4f53\u306b\u5c4a\u304f\u306e\u3067\u3001\u30d4\u30f3\u30db\u30fc\u30eb\u30ab\u30e1\u30e9\u306e\u539f\u7406\u3067\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u304c\u3067\u304d\u307e\u3059\uff08\u56f3\u4e2d\u2460\uff09\u3002\u9ad8\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u30ac\u30f3\u30de\u7dda\u306f\u6563\u4e71\u4f53\u3067\u30b3\u30f3\u30d7\u30c8\u30f3\u6563\u4e71\u3055\u308c\u3001\u5438\u53ce\u4f53\u3067\u5438\u53ce\u3055\u308c\u307e\u3059\u3002\u6563\u4e71\u4f53\u30fb\u5438\u53ce\u4f53\u3067\u306e\u691c\u51fa\u30a8\u30cd\u30eb\u30ae\u30fc\u304b\u3089\u6563\u4e71\u89d2\u3092\u8a08\u7b97\u3059\u308b\u3053\u3068\u3067\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u304c\u53ef\u80fd\u3067\u3059\uff08\u56f3\u4e2d\u2461\uff09\u3002<\/p>\n<div id=\"attachment_80086\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-80086 size-full\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/c26494c722cd81b950f66d446897ebd9.png\" alt=\"\" width=\"1242\" height=\"522\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/c26494c722cd81b950f66d446897ebd9.png 1242w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/c26494c722cd81b950f66d446897ebd9-610x256.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/c26494c722cd81b950f66d446897ebd9-940x395.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/c26494c722cd81b950f66d446897ebd9-768x323.png 768w\" sizes=\"auto, (max-width: 1242px) 100vw, 1242px\" \/><p class=\"wp-caption-text\">\u56f32\uff1a(a) At-211\u6a19\u8b58\u3057\u305f\u653e\u5c04\u5316\u91d1\u30ca\u30ce\u7c92\u5b50\u3002(b) \u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u3002 \u4f4e\u30a8\u30cd\u30eb\u30ae\u30fc\u306eX\u7dda\u30fb\u30ac\u30f3\u30de\u7dda\u306f\u2460\u306e\u3088\u3046\u306b\u3001\u9ad8\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u30ac\u30f3\u30de\u7dda\u306f\u2461\u306e\u3088\u3046\u306b\u691c\u51fa\u3055\u308c\u308b\u3002<\/p><\/div>\n<h3><strong>\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5\u3068\u3001\u305d\u308c\u306b\u3088\u308b\u5b9f\u8a3c\u7d50\u679c<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u307e\u305a\u30de\u30a6\u30b9\u306b\u6295\u4e0e\u3067\u304d\u308b\u3001\u6975\u5c0f\u30b5\u30a4\u30ba\u306e\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u5408\u6210\u3059\u308b\u624b\u6cd5\u3092\u6a21\u7d22\u3057\u307e\u3057\u305f\u3002\u8a66\u884c\u3092\u91cd\u306d\u3001\u56db\u5869\u5316\u91d1\u9178\uff08HAuCl<sub>4<\/sub>\uff09\u3092\u6750\u6599\u3068\u3057\u3066\u7c92\u5f845 nm\uff08\u30ca\u30ce\u30e1\u30fc\u30c8\u30eb\uff09\u307b\u3069\u306e\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u5b89\u5b9a\u7684\u306b\u5408\u6210\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u4eac\u90fd\u5927\u5b66\u7814\u7a76\u7528\u539f\u5b50\u7089\uff08KUR\uff09<sup>[4]<\/sup>\u3092\u7528\u3044\u3066\u56db\u5869\u5316\u91d1\u9178\u3092\u653e\u5c04\u5316\u3057\u3001\u540c\u3058\u624b\u9806\u306b\u6cbf\u3063\u3066\u653e\u5c04\u5316\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u5408\u6210\u3057\u307e\u3057\u305f\u3002\u7d9a\u3044\u3066\u3001At-211\u306e\u6a19\u8b58\u3067\u4e0d\u53ef\u6b20\u3068\u306a\u308b\u3001\u30e1\u30c8\u30ad\u30b7\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\uff08mPEG\uff09\u3067\u653e\u5c04\u5316\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u8868\u9762\u4fee\u98fe\u3057\u3001\u30de\u30a6\u30b9\u306e\u816b\u760d\u306b\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u3067\u5f97\u3089\u308c\u305f\u30ac\u30f3\u30de\u7dda\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30b9\u30da\u30af\u30c8\u30eb\u3092\u56f33 (a)\u306b\u793a\u3057\u307e\u3059\u3002412 keV\u306b\u30d4\u30fc\u30af\u304c\u898b\u3089\u308c\u3001\u653e\u5c04\u5316\u306b\u3088\u308bAu-198\u306e\u751f\u6210\u304c\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002\u6295\u4e0e9\u5206\u5f8c\u30014\u65e5\u5f8c\u306b\u3001\u30b3\u30f3\u30d7\u30c8\u30f3\u30e2\u30fc\u30c9\u3067\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3057\u305f\u7d50\u679c\u3092\u56f33 (b)\u306b\u793a\u3057\u307e\u3059\u30024\u65e5\u5f8c\u3082\u91d1\u30ca\u30ce\u7c92\u5b50\u304c\u816b\u760d\u4ed8\u8fd1\u306b\u7559\u307e\u3063\u3066\u3044\u308b\u69d8\u5b50\u3092\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u304d\u3001\u3053\u308c\u307e\u3067\u4e0d\u53ef\u80fd\u3067\u3042\u3063\u305f\u9577\u6642\u9593\u306e\u52d5\u614b\u8ffd\u8de1\u306b\u6709\u52b9\u306a\u65b9\u6cd5\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306b\u3001\u653e\u5c04\u5316\u91d1\u30ca\u30ce\u7c92\u5b50\u306bAt-211\u3092\u6a19\u8b58\u3057\u3001\u30de\u30a6\u30b9\u306e\u5c3e\u9759\u8108\u304b\u3089\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002\u6295\u4e0e9\u5206\u5f8c\u30012\u65e5\u5f8c\u306e\u30ac\u30f3\u30de\u7dda\u30a8\u30cd\u30eb\u30ae\u30fc\u30b9\u30da\u30af\u30c8\u30eb\u3068\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7d50\u679c\u3092\u56f34\u306b\u793a\u3057\u307e\u3059\u3002\u6295\u4e0e9\u5206\u5f8c\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30b9\u30da\u30af\u30c8\u30eb\u306b\u306f\u300179 keV\uff08At-211\uff09\u3068412 keV\uff08Au-198\uff09\u306b\u30d4\u30fc\u30af\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001At-211\u3068\u91d1\u30ca\u30ce\u7c92\u5b50\uff08Au-198\uff09\u305d\u308c\u305e\u308c\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u300279 keV\u306eX\u7dda\u306f\u30d4\u30f3\u30db\u30fc\u30eb\u30e2\u30fc\u30c9\u3001412 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keV\u306f\u30d4\u30fc\u30af\u306e\u9ad8\u3055\u304c\u3042\u307e\u308a\u5909\u308f\u308a\u307e\u305b\u3093\u3002\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7d50\u679c\u3067\u306f\u3001At-211\u306f\u6e1b\u8870\u306b\u3088\u308a\u5206\u5e03\u3092\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u306e\u306b\u5bfe\u3057\u3001\u91d1\u30ca\u30ce\u7c92\u5b50\u306f\u306f\u3063\u304d\u308a\u3068\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u304d\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u653e\u5c04\u5316\u3059\u308b\u3053\u3068\u3067\u3001At-211\u6a19\u8b58\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u9577\u671f\u7684\u306a\u52d5\u614b\u8ffd\u8de1\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_80089\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-80089\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/adb989ddc1dfb0965fd80ccfd71b04de.png\" alt=\"\" width=\"1280\" height=\"380\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/adb989ddc1dfb0965fd80ccfd71b04de.png 1280w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/adb989ddc1dfb0965fd80ccfd71b04de-610x181.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/adb989ddc1dfb0965fd80ccfd71b04de-940x279.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/adb989ddc1dfb0965fd80ccfd71b04de-768x228.png 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><p class=\"wp-caption-text\">\u56f33\uff1a(a) \u653e\u5c04\u5316\u91d1\u30ca\u30ce\u7c92\u5b50\u306eX\u7dda\u30fb\u30ac\u30f3\u30de\u7dda\u30a8\u30cd\u30eb\u30ae\u30fc\u30b9\u30da\u30af\u30c8\u30eb\u3002(b) 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\/>\n\u653e\u5c04\u7dda\u306b\u306f\u69d8\u3005\u306a\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u30a2\u30eb\u30d5\u30a1\u7dda\u306f\u30d8\u30ea\u30a6\u30e0\u306e\u539f\u5b50\u6838\u3067\u3001\u30d7\u30e9\u30b9\u306e\u96fb\u8377\u30922\u3064\u6301\u3061\u307e\u3059\u3002\u8cea\u91cf\u304c\u3068\u3066\u3082\u91cd\u304f\u3001\u4f53\u5185\u3067\u98db\u3076\u8ddd\u96e2\u304c\u6570\u5341\u30de\u30a4\u30af\u30ed\u30e1\u30fc\u30c8\u30eb\u3068\u77ed\u3044\uff08\u7d30\u80de\u306e\u30b5\u30a4\u30ba\u3068\u540c\u7a0b\u5ea6\uff09\u3053\u3068\u304c\u7279\u9577\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u3046\u307e\u304f\u816b\u760d\u306b\u96c6\u7a4d\u3055\u305b\u308b\u3068\u3001\u816b\u760d\u7d30\u80de\u306e\u307f\u3092\u9078\u629e\u7684\u306b\u6bba\u50b7\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\uff38\u7dda\u3084\u30ac\u30f3\u30de\u7dda\u306f\u96fb\u78c1\u6ce2\u306e\u4e00\u7a2e\u3067\u3001\u96fb\u8377\u3092\u6301\u3061\u307e\u305b\u3093\u3002\u3069\u3061\u3089\u3082\u4e0d\u5b89\u5b9a\u306a\u540c\u4f4d\u4f53\u304b\u3089\u51fa\u307e\u3059\u304c\u3001\u539f\u5b50\u6838\u304b\u3089\u51fa\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u9ad8\u3044\u96fb\u78c1\u6ce2\u3092\u30ac\u30f3\u30de\u7dda\u3001\u307e\u305f\u96fb\u5b50\u8ecc\u9053\u304b\u3089\u51fa\u308b\u6bd4\u8f03\u7684\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u4f4e\u3044\u96fb\u78c1\u6ce2\u3092X\u7dda\u3068\u3057\u3066\u533a\u5225\u3057\u307e\u3059\u3002<\/p>\n<p>\u203b\uff13 \u6a19\u8b58<br \/>\n\u5316\u5408\u7269\u4e2d\u3067\u3001\u7279\u5b9a\u306e\u539f\u5b50\u306b\u653e\u5c04\u6027\u6838\u7a2e\u3092\u7d50\u5408\u3059\u308b\u3053\u3068\u3092\u3044\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u91d1\u30ca\u30ce\u7c92\u5b50\u304c\u6cbb\u7642\u85ac\u3092\u904b\u3076\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u308a\u3001\u3053\u3053\u306b\u6cbb\u7642\u85ac\u672c\u4f53\u3067\u3042\u308b\u30a2\u30b9\u30bf\u30c1\u30f3\uff08At-211\uff09\u3092\u6a19\u8b58\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b\uff14 SPECT\uff08\u5358\u4e00\u5149\u5b50\u653e\u5c04\u65ad\u5c64\u64ae\u5f71\uff09<br \/>\n\u6838\u533b\u5b66\u8a3a\u65ad\u6cd5\u306e1\u3064\u3067\u3001\u653e\u5c04\u6027\u533b\u85ac\u54c1\u3092\u4f53\u5185\u306b\u6295\u4e0e\u3057\u3066\u3001\u305d\u306e\u5206\u5e03\u3092\u65ad\u5c64\u753b\u50cf\u3068\u3057\u3066\u63cf\u51fa\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070Tc-99m\uff08\u30c6\u30af\u30ce\u30c1\u30a6\u30e0\uff09\u3092\u9aa8\u306e\u4ee3\u8b1d\u3084\u53cd\u5fdc\u304c\u76db\u3093\u306a\u3068\u3053\u308d\u306b\u96c6\u307e\u308b\u6027\u8cea\u3092\u6301\u3064\u7269\u8cea\u3068\u5316\u5408\u3055\u305b\u3001\u304c\u3093\u304c\u9aa8\u306e\u3069\u306e\u90e8\u4f4d\u306b\u3069\u306e\u7a0b\u5ea6\u8ee2\u79fb\u3057\u3066\u3044\u308b\u304b\u3092\u8a3a\u65ad\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002Tc-99m\u306e\u53ef\u8996\u5316\u306b\u306f 140 keV\u306e\u30ac\u30f3\u30de\u7dda\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u4ed6\u306e\u85ac\u5264\u3067\u3082\u3001SPECT \u3067\u53ef\u8996\u5316\u3067\u304d\u308b\u30ac\u30f3\u30de\u7dda\u306f\u304a\u304a\u3080\u306d 300 keV \u4ee5\u4e0b\u306b\u9650\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u203b\uff15 PET (\u967d\u96fb\u5b50\u653e\u51fa\u65ad\u5c64\u64ae\u5f71)<br \/>\n\u3053\u3061\u3089\u3082\u5e83\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u6838\u533b\u5b66\u8a3a\u65ad\u6cd5\u3067\u3001\u967d\u96fb\u5b50\u3092\u653e\u51fa\u3059\u308b\u653e\u5c04\u6027\u6838\u7a2e\u3067\u6a19\u8b58\u3055\u308c\u305f\u533b\u85ac\u54c1\u3092\u4f53\u5185\u306b\u6295\u4e0e\u3057\u3001\u305d\u306e\u653e\u5c04\u7dda\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u3067\u3001\u816b\u760d\u306e\u4f4d\u7f6e\u3084\u6d3b\u6027\u5ea6\u3092\u753b\u50cf\u5316\u3059\u308b\u6838\u533b\u5b66\u691c\u67fb\u3067\u3059\u3002\u5bfe\u6d88\u6ec5\u3059\u308b\u30ac\u30f3\u30de\u7dda\u3092\u5bfe\u5411\u3059\u308b\u691c\u51fa\u5668\u3067\u6349\u3048\u308b\u305f\u3081\u3001\u539f\u7406\u4e0a 511 keV \u306e\u30ac\u30f3\u30de\u7dda\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6cd5\u3067\u3059\u3002<\/p>\n<p>\u203b\uff16 \u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9<br \/>\n\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u306f\u3001\u7570\u306a\u308b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853\u3067\u3042\u308b\u300c\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u300d\u3068\u300c\u30d4\u30f3\u30db\u30fc\u30eb\u30ab\u30e1\u30e9\u300d\u30921\u53f0\u3067\u5b9f\u73fe\u3059\u308b\u65b0\u3057\u3044\u6280\u8853\u3067\u3059\u3002\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u306f\u6563\u4e71\u4f53\u3068\u5438\u53ce\u4f53\u306e2\u679a\u306e\u691c\u51fa\u5668\u304b\u3089\u306a\u308a\u3001\u305d\u308c\u305e\u308c\u306e\u691c\u51fa\u5668\u306f\u30b7\u30f3\u30c1\u30ec\u30fc\u30bf\uff08\u653e\u5c04\u7dda\u304c\u5f53\u305f\u308b\u3068\u86cd\u5149\u3092\u793a\u3059\u7269\u8cea\uff09\u3068\u86cd\u5149\u3092\u8aad\u307f\u51fa\u3059\u30bb\u30f3\u30b5\u30fc\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u4f4e\u3044\u30a8\u30cd\u30eb\u30ae\u30fc\u306eX\u7dda\u306f\u3001\u6563\u4e71\u4f53\u3092\u900f\u904e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305a\u3001\u30d4\u30f3\u30db\u30fc\u30eb\u3092\u901a\u3063\u3066\u304d\u305f\u3082\u306e\u3060\u3051\u304c\u5438\u53ce\u4f53\u306b\u5c4a\u304d\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u300c\u6563\u4e71\u4f53\u304c\u30d2\u30c3\u30c8\u305b\u305a\u3001\u5438\u53ce\u4f53\u306e\u307f\u30d2\u30c3\u30c8\u3059\u308b\u300d\u300c\u5438\u53ce\u4f53\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u304c \uff08\u305f\u3068\u3048\u3070\uff09200keV\u4ee5\u4e0b\u300d\u306e\u6761\u4ef6\u3092\u8ab2\u305b\u3070\u3001\u30d4\u30f3\u30db\u30fc\u30eb\u30ab\u30e1\u30e9\u3068\u3057\u3066\u53ef\u8996\u5316\u3067\u304d\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u9ad8\u3044\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u30ac\u30f3\u30de\u7dda\u306f\u3001\u6563\u4e71\u4f53\u3092\u900f\u904e\u3057\u3066\u5438\u53ce\u4f53\u306b\u5c4a\u304f\u3082\u306e\u3001\u6563\u4e71\u4f53\u3067\u30b3\u30f3\u30d7\u30c8\u30f3\u6563\u4e71\u3057\u3066\u5438\u53ce\u4f53\u306b\u5c4a\u304f\u3082\u306e\u3001\u69d8\u3005\u306a\u6210\u5206\u304c\u6df7\u3056\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u300c\u6563\u4e71\u4f53\u3068\u5438\u53ce\u4f53\u304c\u540c\u6642\u306b\u30d2\u30c3\u30c8\u3059\u308b\u300d\u6761\u4ef6\u3092\u8ab2\u305b\u3070\u3001\u901a\u5e38\u306e\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u3068\u540c\u69d8\u306b\u53ef\u8996\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><strong>\u53c2\u8003\u60c5\u5831<\/strong><\/p>\n<p>[1] Kato et al. 2021, \u201cIntratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy\u201d, Journal of Nanobiotechnology, 19, 223,<br \/>\nDOI: 10.1186\/s12951-021-00963-9<\/p>\n<p>[2] \u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3064\u3044\u3066\u306f\u4ee5\u4e0b\u3092\u53c2\u7167<\/p>\n<ul>\n<li>Koshikawa et al. 2022, \u201cProof of concept of activation imaging with hybrid Compton camera\u201d, Applied Physics Letters, 121, 193701, DOI: 10.1063\/5.0116570<\/li>\n<li>Koshikawa et al. 2023, \u201cActivation imaging: New concept of visualizing drug distribution with wide-band X-ray and gamma-ray imager\u201d, Nuclear Instruments and Methods in Physics Research \u2013 section A, 1045, 167599, DOI: 10.1016\/j.nima.2022.167599<\/li>\n<li>\u300c\u69d8\u3005\u306a\u5143\u7d20\u306e\u5206\u5e03\u3092\u53ef\u8996\u5316\u3059\u308b\u300c\u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u306b\u6210\u529f\u300d<a href=\"https:\/\/www.waseda.jp\/top\/news\/85249\">https:\/\/www.waseda.jp\/top\/news\/85249<\/a><\/li>\n<\/ul>\n<p>[3] \u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u30b3\u30f3\u30d7\u30c8\u30f3\u30ab\u30e1\u30e9\u306b\u3064\u3044\u3066\u306f\u4ee5\u4e0b\u3092\u53c2\u7167<\/p>\n<ul>\n<li>Omata et al. 2020, \u201cPerformance demonstration of a hybrid Compton camera with an active pinhole for wide-band X-ray and gamma-ray imaging\u201d, Scientific Reports, 10, 14064<br \/>\nDOI: 10.1038\/s41598-020-71019-5<\/li>\n<li>\u300cX\u7dda\u30ac\u30f3\u30de\u7dda\u306e\u540c\u6642\u53ef\u8996\u5316\u3092\u53ef\u80fd\u306b\u300d<a href=\"https:\/\/www.waseda.jp\/top\/news\/69935\">https:\/\/www.waseda.jp\/top\/news\/69935<\/a><\/li>\n<\/ul>\n<p>[4] \u4eac\u90fd\u5927\u5b66\u8907\u5408\u539f\u5b50\u529b\u79d1\u5b66\u7814\u7a76\u6240\u306e\u7814\u7a76\u7528\u539f\u5b50\u7089KUR \u306b\u3064\u3044\u3066\u306f\u4ee5\u4e0b\u3092\u53c2\u7167<br \/>\n<a href=\"https:\/\/www.rri.kyoto-u.ac.jp\/facilities\/kur\">https:\/\/www.rri.kyoto-u.ac.jp\/facilities\/kur<\/a><\/p>\n<p><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/p>\n<p>\u96d1\u8a8c\u540d\uff1aApplied Physics Letters<br \/>\n\u8ad6\u6587\u540d\uff1aActivation imaging of gold nanoparticles for versatile drug visualization: an in vivo demonstration<br \/>\n\u57f7\u7b46\u8005\u540d\uff1aNanase Koshikawa<sup>1<\/sup>\u3001Yuka Kikuchi<sup>1<\/sup>\u3001Kazuo S. Tanaka<sup>1<\/sup>\u3001Katsuyuki Tokoi<sup>2<\/sup>\u3001Akina Mitsukai<sup>2<\/sup>, Hiroki Aoto<sup>2<\/sup>, Yuichiro Kadonaga<sup>3<\/sup>, Atsushi Toyoshima<sup>3<\/sup>, Hiroki Kato<sup>3<\/sup>, Kazuhiro Ooe<sup>3<\/sup>, Koichi Takamiya<sup>4<\/sup>, Jun Kataoka<sup>1<\/sup><\/p>\n<p>1.\u3000\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u3000\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u3000\u7269\u7406\u5b66\u53ca\u5fdc\u7528\u7269\u7406\u5b66\u5c02\u653b<br \/>\n\u8d8a\u5ddd \u4e03\u661f\uff08\u8ad6\u6587\u7b46\u982d\u8457\u8005\uff09\u3001\u83ca\u6c60 \u512a\u82b1\u3001\u7530\u4e2d \u9999\u6d25\u751f\u3001\u7247\u5ca1 \u6df3<\/p>\n<p>2.\u3000\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u3000\u7406\u5b66\u7814\u7a76\u79d1\u3000\u5316\u5b66\u5c02\u653b<br \/>\n\u5e8a\u4e95 \u5065\u904b\u3001\u6c34\u98fc \u79cb\u83dc\u3001\u9752\u6238 \u5b8f\u6a39<\/p>\n<p>3.\u3000\u5927\u962a\u5927\u5b66\u3000\u653e\u5c04\u7dda\u79d1\u5b66\u57fa\u76e4\u6a5f\u69cb<br \/>\n\u89d2\u6c38 \u60a0\u4e00\u90ce\u3001\u8c4a\u5d8b \u539a\u53f2\u3001\u52a0\u85e4 \u5f18\u6a39\u3001\u5927\u6c5f \u4e00\u5f18<\/p>\n<p>4.\u3000\u4eac\u90fd\u5927\u5b66\u3000\u8907\u5408\u539f\u5b50\u529b\u79d1\u5b66\u7814\u7a76\u6240<br \/>\n\u9ad8\u5bae \u5e78\u4e00<br \/>\n\u63b2\u8f09\u4e88\u5b9a\u65e5\u6642\uff08\u7c73\u56fd\u6771\u90e8\u6a19\u6e96\u6642\uff09\uff1a2025\u5e743\u670812\u65e5\uff08\u6c34\uff09\u5348\u524d10\u6642<br \/>\n\u63b2\u8f09\u4e88\u5b9a\u65e5\u6642\uff08\u65e5\u672c\u6642\u9593\uff09\uff1a2025\u5e743\u670813\u65e5\uff08\u6728\uff09\u5348\u524d0\u6642<br \/>\nDOI\uff1a10.1063\/5.0251048<br \/>\n\u63b2\u8f09\u4e88\u5b9aURL\uff1a<a href=\"https:\/\/doi.org\/10.1063\/5.0251048\">https:\/\/doi.org\/10.1063\/5.0251048<\/a><\/p>\n<h3><strong>\u7814\u7a76\u52a9\u6210<\/strong><\/h3>\n<p>\u672c\u7814\u7a76\u306f\u3001\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09\u6226\u7565\u7684\u5275\u9020\u7814\u7a76\u63a8\u9032\u4e8b\u696d ERATO\u300c\u7247\u5ca1\u30e9\u30a4\u30f3X\u7dda\u30ac\u30f3\u30de\u7dda\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u300d\uff082021~2026\u5e74\u5ea6\uff1b\u30b0\u30e9\u30f3\u30c8\u756a\u53f7 JPMJER2102\uff09\u306e\u652f\u63f4\u3092\u5f97\u3066\u5b9f\u65bd\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u3053\u3053\u306b\u6df1\u304f\u611f\u8b1d\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u300c\u653e\u5c04\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u3067\u30de\u30a6\u30b9\u4f53\u5185\u306e\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u53ef\u8996\u5316 \u304c\u3093\u6cbb\u7642\u85ac\u306e\u9577\u671f\u7684\u306a\u52d5\u614b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u5411\u3051\u3066 \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u304c\u3093\u6cbb\u7642\u85ac\u3092\u816b\u760d\u3078\u904b\u3076\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853\u3092\u30de\u30a6\u30b9\u5b9f\u9a13\u3067\u5b9f\u8a3c \u3053\u308c\u307e\u3067\u56f0\u96e3\u3060\u3063\u305f\u6838\u533b\u5b66\u6cbb\u7642\u85ac\uff08 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":80093,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[145,178],"class_list":["post-80078","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/80078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=80078"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/80078\/revisions"}],"predecessor-version":[{"id":80097,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/80078\/revisions\/80097"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/80093"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=80078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=80078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=80078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}