{"id":80054,"date":"2025-03-12T11:00:05","date_gmt":"2025-03-12T02:00:05","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=80054"},"modified":"2025-03-12T10:16:21","modified_gmt":"2025-03-12T01:16:21","slug":"%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8e%e7%99%ba%e7%97%87%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0%e3%81%ae%e4%b8%80%e7%ab%af%e3%82%92%e7%99%ba%e8%a6%8b","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/80054","title":{"rendered":"\u8102\u80aa\u809d\u708e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u767a\u898b"},"content":{"rendered":"<h1 style=\"text-align: center;\"><strong>\u8102\u80aa\u809d\u708e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u767a\u898b<br \/>\n<\/strong><strong>\u809d\u81d3\u306b\u304a\u3051\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u6052\u5e38\u6027\u5236\u5fa1\u6a5f\u69cb<\/strong><\/h1>\n<h2><strong>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h2>\n<ul>\n<li>\u8102\u8cea\u4ee3\u8b1d\u3084\u89e3\u6bd2\u6a5f\u80fd\u306a\u3069\u3001\u591a\u69d8\u306a\u5f79\u5272\u3092\u62c5\u3046\u91cd\u8981\u306a\u81d3\u5668\u3067\u3042\u308b\u809d\u81d3\u306e\u8102\u8cea\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u3001\u300cNwd1\u907a\u4f1d\u5b50\u300d\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u62c5\u3046\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>Nwd1\u907a\u4f1d\u5b50\u3092\u6b20\u5931\u3057\u305f\u30de\u30a6\u30b9\u809d\u81d3\u3067\u306f\u3001\u8102\u80aa\u306e\u84c4\u7a4d\u3084\u7dda\u7dad\u5316\u3001\u708e\u75c7\u6027\u7d30\u80de\u6b7b\u306a\u3069\u306e\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u708e\uff08MASLD\/MASH\uff09\u69d8\u306e\u75c7\u72b6\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001Nwd1\u304c\u3001\u7d30\u80de\u8cea\u5074\u304b\u3089\u5c0f\u80de\u4f53\u5185\u3078\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u8f38\u9001\u3092\u5236\u5fa1\u3059\u308b\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bSERCA2\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u5c0f\u80de\u4f53\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/li>\n<li>\u3053\u306e\u7814\u7a76\u6210\u679c\u306f\u3001MASLD\/MASH\u306e\u75c5\u56e0\u89e3\u660e\u306b\u5bc4\u4e0e\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3084\u3001\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6cd5\u306e\u69cb\u7bc9\u306b\u3088\u308a\u3001\u65b0\u305f\u306a\u4e88\u9632\u30fb\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u53ef\u80fd\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<hr \/>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662\u306e<a href=\"https:\/\/researchmap.jp\/s.yamad\/research_experience\/46659336\" target=\"_blank\" rel=\"noopener\">\u5c71\u7530 \u6674\u4e5f\uff08\u3084\u307e\u3060 \u305b\u3044\u3084\uff09\u62db\u8058\u7814\u7a76\u54e1<\/a>\u3001\u540c<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001065_ja.html\" target=\"_blank\" rel=\"noopener\">\u698a\u539f \u4f38\u4e00\uff08\u3055\u304b\u304d\u3070\u3089 \u3057\u3093\u3044\u3061\uff09\u6559\u6388<\/a>\u3001\u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u85ac\u5b66\u90e8\u306e\u4e2d\u8218 \u548c\u5f66\uff08\u306a\u304b\u3060\u3066 \u304b\u305a\u3072\u3053\uff09\u6559\u6388\u304a\u3088\u3073\u7fa4\u99ac\u5927\u5b66\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u306e\u7551\u7530 \u51fa\u7a42\uff08\u306f\u305f\u3060 \u3044\u305a\u307b\uff09\u6559\u6388\u3089\u306b\u3088\u308b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u809d\u81d3\u306e\u8102\u8cea\u4ee3\u8b1d\u306e\u8abf\u7bc0\u306b\u304a\u3044\u3066\u3001Nwd1\u907a\u4f1d\u5b50\u304cCa\u00b2\u207a\u6052\u5e38\u6027\u3092\u7dad\u6301\u3057\u3001Nwd1\u306e\u6b20\u5931\u304c\u809d\u81d3\u5185\u306e\u8102\u80aa\u306e\u904e\u5270\u84c4\u7a4d\u3084\u7dda\u7dad\u5316\u3001\u708e\u75c7\u6027\u7d30\u80de\u6b7b\u306a\u3069\u5b9f\u969b\u306e\u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u8102\u80aa\u809d\u708e\uff08MASH\uff09<sup>\u203b\uff11<\/sup>\u60a3\u8005\u3068\u540c\u69d8\u306e\u8868\u73fe\u7cfb\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\u300eCommunications Biology\u300f\uff08\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s42003-025-07717-5\" target=\"_blank\" rel=\"noopener\">Induction of MASH-like pathogenesis in the <em>Nwd1<sup>\u2212\/\u2212<\/sup><\/em> mouse liver<\/a>\uff09\u306b\u3066\u30012025\u5e743\u670811\u65e5\uff08\u706b\uff09\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_80055\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-80055\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-scaled.jpg\" alt=\"\" width=\"583\" height=\"394\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-scaled.jpg 2560w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-610x412.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-940x635.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-768x519.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-1536x1037.jpg 1536w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-2048x1383.jpg 2048w\" sizes=\"auto, (max-width: 583px) 100vw, 583px\" \/><p class=\"wp-caption-text\">\u56f3\uff11\uff1aNwd1\u6b20\u5931\u306b\u3088\u308aCA2+\u6052\u5e38\u6027\u304c\u5931\u308f\u308c\u3001MASH\u69d8\u306e\u8102\u80aa\u809d\u708e\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b<\/p><\/div>\n<h4>\uff08\uff11\uff09\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/h4>\n<p>\u809d\u81d3\u306f\u8102\u8cea\u4ee3\u8b1d\u3084\u89e3\u6bd2\u6a5f\u80fd\u306a\u3069\u3001\u591a\u69d8\u306a\u5f79\u5272\u3092\u62c5\u3046\u91cd\u8981\u306a\u81d3\u5668\u3067\u3059\u3002\u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff09\uff08\u65e7\uff1a\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3(NAFLD)\uff09\u3084\u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u8102\u80aa\u809d\u708e\uff08MASH\uff09\uff08\u65e7\uff1a\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u708e\uff08NASH\uff09\u306f\u3001\u4e16\u754c\u7684\u306b\u4eba\u53e3\u306e30\uff05\u306e\u6709\u75c5\u7387\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u809d\u786c\u5909\u3084\u809d\u304c\u3093\u3078\u3068\u9032\u884c\u3059\u308b\u30ea\u30b9\u30af\u3092\u4f34\u3046\u201c\u91cd\u7be4\u306a\u75be\u60a3\u201d\u3068\u3057\u3066\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001MASLD\/MASH\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3057\u3066\u306f\u3001\u305d\u306e\u5168\u8c8c\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001MASH\u306e\u6cbb\u7642\u306b\u95a2\u3057\u3066\u306f\u30012024\u5e743\u6708\u306b\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u304c\u521d\u3081\u3066\u6cbb\u7642\u85ac\u300cRezdiffra\u300d\uff08\u4e00\u822c\u540d\uff1aResmetirom\uff09\u3092\u627f\u8a8d\u3057\u305f\u3070\u304b\u308a\u3067\u3042\u308a\u3001\u6cbb\u7642\u85ac\u306f\u4f9d\u7136\u3068\u3057\u3066\u3053\u306e\uff11\u3064\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306b\u3088\u308a\u3001MASLD\/MASH\u306e\u767a\u75c7\u306b\u306f\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u306e\u5c0f\u80de\u4f53\u304c\u5bc6\u63a5\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u5c0f\u80de\u4f53\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\uff08Ca\u00b2\u207a\uff09\u306e\u8caf\u8535\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u305f\u305f\u307f\u3001\u8102\u8cea\u4ee3\u8b1d\u306a\u3069\u3092\u62c5\u3046\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u3068\u3057\u3066\u77e5\u3089\u308c\u3001\u5c0f\u80de\u4f53\u5185Ca\u00b2\u207a\u306e\u30d0\u30e9\u30f3\u30b9\uff08Ca\u00b2\u207a\u6052\u5e38\u6027<sup>\u203b\uff12<\/sup>\uff09\u304c\u5d29\u308c\u308b\u3068\u3001\u809d\u81d3\u306e\u8102\u8cea\u84c4\u7a4d\u3084\u708e\u75c7\u3001\u7dda\u7dad\u5316\u304c\u9032\u884c\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001Sarco\/Endoplasmic Reticulum Ca\u00b2\u207a-ATPase 2(SERCA2)\u306f\u3001\u305d\u306e\u6a5f\u80fd\u4e0d\u5168\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9<sup>\u203b\uff13<\/sup>\u306e\u5897\u52a0\u3084\u8102\u8cea\u6ef4\u306e\u5f62\u6210\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001SERCA2\u306e\u6a5f\u80fd\u304c\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3082\u672a\u3060\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<h4>\uff08\uff12\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/h4>\n<p>\u7814\u7a76\u3067\u306f\u307e\u305a\u3001\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u7740\u76ee\u3057\u3066\u304d\u305f\u907a\u4f1d\u5b50Nwd1\u3092\u6b20\u5931\u3055\u305b\u305f\u30de\u30a6\u30b9\u3092\u65b0\u305f\u306b\u4f5c\u88fd\u3057\u3001Nwd1\u306e\u751f\u4f53\u6a5f\u80fd\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002Nwd1\u6b20\u5931\u578b\u30de\u30a6\u30b9\u306e\u809d\u81d3\u306f\u3001\u8089\u773c\u89e3\u5256\u304a\u3088\u3073\u91cd\u91cf\u6e2c\u5b9a\u306e\u7d50\u679c\u304b\u3089\u3001\u91ce\u751f\u578b\u3068\u6bd4\u8f03\u3057\u3066\u9855\u8457\u306b\u80a5\u5927\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u809d\u81d3\u306e\u80a5\u5927\u306e\u4e00\u65b9\u3067\u3001\u4f53\u91cd\u306b\u306f\u5927\u304d\u306a\u5909\u5316\u3092\u4f34\u308f\u306a\u304b\u3063\u305f\u305f\u3081\u3001Nwd1\u306e\u6b20\u5931\u304c\u809d\u81d3\u306b\u7279\u7570\u7684\u306a\u75c5\u614b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\uff08\u56f32\uff09\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-1 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 50%;\n\t\t\t}\n\t\t\t#gallery-1 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-1' class='gallery galleryid-80054 gallery-columns-2 gallery-size-medium'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon portrait'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"610\" height=\"618\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-2-610x618.jpg\" class=\"attachment-medium size-medium\" alt=\"\" aria-describedby=\"gallery-1-80056\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-2-610x618.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-2-940x952.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-2-768x778.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-2-1516x1536.jpg 1516w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-2.jpg 1544w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-80056'>\n\t\t\t\t\u56f3\uff12\uff1aNwd1\u6b20\u5931\u306b\u3088\u308a\u809d\u81d3\u306e\u80a5\u5927\u5316\u304c\u751f\u3058\u308b\u3002\n\t\t\t\t<\/dd><\/dl><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"610\" height=\"404\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-3-610x404.jpg\" class=\"attachment-medium size-medium\" alt=\"\" aria-describedby=\"gallery-1-80057\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-3-610x404.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-3-940x622.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-3-768x508.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-3-1536x1016.jpg 1536w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-3-2048x1355.jpg 2048w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-80057'>\n\t\t\t\t\u56f3\uff13\uff1aNwd1\u6b20\u5931\u306b\u3088\u308a\u809d\u81d3\u5185\u306b\u4e2d\u6027\u8102\u80aa\u3068\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u84c4\u7a4d\u3059\u308b\u3002\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p>\u7d9a\u3044\u3066\u3001Nwd1\u6b20\u5931\u578b\u30de\u30a6\u30b9\u809d\u81d3\u306b\u304a\u3051\u308b\u8102\u8cea\u4ee3\u8b1d\u7570\u5e38\u306e\u53ef\u80fd\u6027\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u7d44\u7e54\u5185\u306e\u4e2d\u6027\u8102\u80aa\u304a\u3088\u3073\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u542b\u91cf\u306f\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u84c4\u7a4d\u304c\u4fc3\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u307e\u305f\u3001\u7d44\u7e54\u5b66\u7684\u89e3\u6790\u304b\u3089\u3001\u809d\u81d3\u306e\u809d\u7d30\u80de\u3078\u306e\u904e\u5270\u306a\u8102\u8cea\u306e\u84c4\u7a4d\u306b\u52a0\u3048\u3001\u5b9f\u969b\u306eMASH\u60a3\u8005\u306e\u8868\u73fe\u7cfb\u3068\u540c\u69d8\u306a\u7dda\u7dad\u5316\u306e\u9032\u884c\u3084\u708e\u75c7\u6027\u7d30\u80de\u6b7b\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306eNwd1\u6b20\u5931\u578b\u30de\u30a6\u30b9\u306e\u62b9\u6d88\u8840\u6db2\u4e2d\u306e\u4e2d\u6027\u8102\u80aa\u3084\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u306f\u5927\u304d\u306a\u5909\u5316\u304c\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u809d\u81d3\u304c\u8102\u8cea\u3092\u62b1\u3048\u8fbc\u307f\u3001\u6392\u51fa\u3067\u304d\u306a\u3044\u72b6\u614b\u306b\u9665\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u84c4\u7a4d\u72b6\u614b\u3092\u3055\u3089\u306b\u8a73\u7d30\u306b\u691c\u8a0e\u3059\u308b\u305f\u3081\u3001Nwd1\u6b20\u5931\u578b\u30de\u30a6\u30b9\u809d\u81d3\u306e\u7d44\u7e54\u50cf\u3092\u96fb\u5b50\u9855\u5fae\u93e1\u3084\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u67d3\u8272\u3067\u8a73\u7d30\u306b\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001\u91ce\u751f\u578b\u306b\u6bd4\u3079\u3066\u591a\u6570\u306e\u5de8\u5927\u306a\u8102\u80aa\u6ef4\u304c\u5f62\u6210\u3055\u308c\u3001\u5c0f\u80de\u4f53\u7531\u6765\u3068\u307f\u3089\u308c\u308b\u7570\u5e38\u306a\u7a7a\u80de\u69cb\u9020\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u56f34\uff09\u3002\u3055\u3089\u306b\u3001\u91ce\u751f\u578b\u3067\u306f\u8102\u80aa\u6ef4\u304c\u985e\u6d1e\u3078\u3068\u653e\u51fa\u3055\u308c\u308b\u69d8\u5b50\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u304c\u3001Nwd1\u6b20\u5931\u578b\u30de\u30a6\u30b9\u809d\u81d3\u3067\u306f\u985e\u6d1e\u3078\u306e\u653e\u51fa\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u809d\u81d3\u5185\u306e\u8102\u8cea\u306e\u84c4\u7a4d\u7570\u5e38\u306f\u8102\u8cea\u3092\u6392\u51fa\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306b\u3001\u3053\u308c\u3089\u306e\u7570\u5e38\u304c\u5c0f\u80de\u4f53\u306b\u8d77\u56e0\u3059\u308b\u53ef\u80fd\u6027\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002Nwd1\u304c\u3069\u306e\u3088\u3046\u306b\u5c0f\u80de\u4f53\u6a5f\u80fd\u3084\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u3001Nwd1\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7db2\u7f85\u7684\u306b\u63a2\u7d22\u30fb\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001Nwd1\u306f\u5c0f\u80de\u4f53\u5185Ca\u00b2\u207a\u6fc3\u5ea6\u3092\u5236\u5fa1\u3059\u308bSERCA2\u3068\u7d50\u5408\u3057\u3001\u5171\u306b\u5c0f\u80de\u4f53\u4e0a\u3067\u5171\u5c40\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f35\uff09\u3002\u5b9f\u969b\u306bNwd1\u6b20\u5931\u578b\u30de\u30a6\u30b9\u306e\u809d\u81d3\u5185\u3067SERCA2\u306eCa<sup>2+<\/sup>\u6fc3\u5ea6\u3092\u5236\u5fa1\u3059\u308b\u6d3b\u6027\uff08ATPase\u6d3b\u6027<sup>\u203b\uff14<\/sup>\uff09\u3092\u6e2c\u5b9a\u3059\u308b\u3068\u3001\u91ce\u751f\u578b\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u5c0f\u80de\u4f53\u5185\u306b\u8caf\u8535\u3055\u308c\u308bCa\u00b2\u207a\u306b\u304a\u3044\u3066\u3082\u9855\u8457\u306b\u6e1b\u5c11\u3057\u3066\u304a\u308a\u3001Nwd1\u3068SERCA2\u306e\u76f8\u4e92\u4f5c\u7528\u304cCa\u00b2\u207a\u6052\u5e38\u6027\u306e\u7dad\u6301\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f35\uff09\u3002<\/p>\n<p>\u672c\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u304b\u3089\u3001Nwd1\u3068SERCA2\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u809d\u81d3\u5185\u306eCa\u00b2\u207a\u6052\u5e38\u6027\u7dad\u6301\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u305d\u306e\u7834\u7dbb\u304cMASH\u69d8\u306e\u75c5\u614b\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-2 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 50%;\n\t\t\t}\n\t\t\t#gallery-2 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-2' class='gallery galleryid-80054 gallery-columns-2 gallery-size-medium'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"610\" height=\"432\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-4-610x432.jpg\" class=\"attachment-medium size-medium\" alt=\"\" aria-describedby=\"gallery-2-80058\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-4-610x432.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-4-940x666.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-4-768x544.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-4-1536x1088.jpg 1536w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-4-2048x1451.jpg 2048w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-2-80058'>\n\t\t\t\t\u56f3\uff14\uff1aNwd1\u6b20\u5931\u306b\u3088\u308a\u809d\u7d30\u80de\u5185\u3067\u8102\u80aa\u6ef4\uff08\u8d64\u77e2\u5370\uff09\u3068\u7570\u5e38\u306a\u5c0f\u80de\u4f53\u7531\u6765\u306e\u7a7a\u80de\uff08\u9ed2\u77e2\u5c3b\uff09\u69cb\u9020\u304c\u5f62\u6210\u3055\u308c\u308b\u3002\n\t\t\t\t<\/dd><\/dl><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon portrait'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"610\" height=\"617\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-5-610x617.jpg\" class=\"attachment-medium size-medium\" alt=\"\" aria-describedby=\"gallery-2-80059\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-5-610x617.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-5-940x951.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-5-768x777.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-5-1518x1536.jpg 1518w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2025\/03\/sakakibara2503-5-2025x2048.jpg 2025w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-2-80059'>\n\t\t\t\t\u56f3\uff15\uff1aNwd1\uff08\u7dd1\uff09\u306fSERCA2\uff08\u8d64\uff09\u3068\u5171\u306b\u5c40\u5728\u3059\u308bNwd1\u306e\u6b20\u5931\u306b\u3088\u308aSERCA2\u306e\u6d3b\u6027\u304c\u6e1b\u5c11\u3057\u3001\u5c0f\u80de\u4f53\u5185\u306eCa\uff12+\u6fc3\u5ea6\u304c\u6e1b\u5c11\u3059\u308b\u3002\u30b0\u30e9\u30d5\u306f\u91ce\u751f\u578b\u306b\u5bfe\u3059\u308b\u76f8\u5bfe\u5024\u3092\u793a\u3059\u3002\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p>&nbsp;<\/p>\n<h4>\uff08\uff13\uff09\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/h4>\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001Nwd1\u304c\u5c0f\u80de\u4f53\u819c\u4e0a\u306b\u304a\u3044\u3066Ca\u00b2\u207a\u6052\u5e38\u6027\u3092\u7dad\u6301\u3057\u3001\u809d\u7d30\u80de\u306e\u8102\u8cea\u4ee3\u8b1d\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u57fa\u76e4\u306e\u4e00\u7aef\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u5b9f\u969b\u306eMASH\u60a3\u8005\u691c\u4f53\u306e\u809d\u81d3\u3067\u306f\u3001Nwd1\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u4ed6\u306e\u7814\u7a76\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u6210\u679c\u306f\u3001\u4e16\u754c\u7684\u306b\u4eba\u53e3\u306e30%\u304c\u767a\u75c7\u3059\u308b\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u708e\uff08MASLD\/MASH\uff09\u306e\u75c5\u56e0\u89e3\u660e\u306b\u5bc4\u4e0e\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5c06\u6765\u7684\u306b\u306f\u3001Nwd1\u3042\u308b\u3044\u306fSERCA2\u3092\u5206\u5b50\u6a19\u7684\u3068\u3059\u308bMASLD\/MASH\u306e\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3084\u3001Nwd1\/SERCA2\u306e\u6a5f\u80fd\u8a55\u4fa1\u3092\u7d44\u307f\u8fbc\u3093\u3060\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u624b\u6cd5\u306e\u69cb\u7bc9\u306b\u3088\u308a\u3001MASLD\/MASH\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u306b\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3082\u305f\u3089\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff14\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u4eca\u56de\u3001Nwd1\u304cSERCA2\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u809d\u7d30\u80de\u306b\u304a\u3051\u308b\u8102\u8cea\u4ee3\u8b1d\u3084\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3092\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u304c\u3001Nwd1\u304c\u3069\u306e\u3088\u3046\u306bSERCA2\u306e\u69cb\u9020\u5909\u5316\u3084ATPase\u6d3b\u6027\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3063\u305f\u5206\u5b50\u6a5f\u69cb\u306b\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u660e\u306a\u90e8\u5206\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff15\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/h4>\n<p>\u672c\u7814\u7a76\u306f\u65e9\u7a32\u7530\u5927\u5b66\u3092\u306f\u3058\u3081\u3001\u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u3084\u7fa4\u99ac\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u5354\u529b\u306b\u3088\u308a\u8ad6\u6587\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u809d\u81d3\u306b\u304a\u3051\u308b\u8102\u8cea\u4ee3\u8b1d\u7570\u5e38\u306b\u95a2\u308f\u308b\u75be\u60a3\u306e\u591a\u304f\u306f\u75be\u60a3\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3084\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u304c\u5341\u5206\u306b\u9032\u3093\u3067\u3044\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002\u672c\u7814\u7a76\u306b\u3088\u308aMASH\u306b\u95a2\u9023\u3059\u308b\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u305f\u3053\u3068\u306f\u3001\u4eca\u5f8c\u306e\u57fa\u790e\u7814\u7a76\u306e\u307f\u306a\u3089\u305a\u3001\u809d\u75be\u60a3\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u3084\u4e88\u9632\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u3066\u610f\u7fa9\u304c\u5927\u304d\u3044\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002\uff08\u698a\u539f\uff09<\/p>\n<h4>\uff08\uff16\uff09\u7528\u8a9e\u89e3\u8aac<\/h4>\n<p><strong>\u203b\uff11 MASLD, MASH<\/strong><br \/>\nMASLD\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08\uff08\u65e7:\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3(NAFLD)\uff09\u3068MASH\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u809d\u708e\uff09\uff08\u65e7:\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u708e(NASH)\uff09\u306f\u4ee3\u8b1d\u7570\u5e38\u306b\u95a2\u9023\u3057\u305f\u8102\u80aa\u809d\u75be\u60a3\u306e\u65b0\u3057\u3044\u540d\u79f0\u3002MASLD\u306f\u8102\u80aa\u809d\u3068\u4ee3\u8b1d\u7570\u5e38\u3092\u6301\u3064\u72b6\u614b\u3092\u6307\u3057\u3001MASH\u306fMASLD\u304c\u9032\u884c\u3057\u3001\u8102\u8cea\u84c4\u7a4d\u306b\u52a0\u3048\u3066\u708e\u75c7\uff08\u809d\u708e\uff09\u3084\u7dda\u7dad\u5316\u3001\u7d30\u80de\u6b7b\u3092\u4f34\u3046\u75c5\u614b\u3092\u6307\u3059\u3002\u9032\u884c\u3059\u308b\u3068\u809d\u786c\u5909\u3084\u809d\u304c\u3093\u3092\u767a\u75c7\u3059\u308b\u3002<\/p>\n<p><strong>\u203b\uff12 Ca\u00b2\u207a\u6052\u5e38\u6027<\/strong><br \/>\n\u7d30\u80de\u5185\u5916\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u3092\u9069\u5207\u306b\u7dad\u6301\u3059\u308b\u4ed5\u7d44\u307f\u3002\u5c0f\u80de\u4f53\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304cCa\u00b2\u207a\u30dd\u30f3\u30d7\u3084\u30c1\u30e3\u30cd\u30eb\u3092\u7528\u3044\u3066Ca\u00b2\u207a\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3057\u3001\u7570\u5e38\u304c\u751f\u3058\u308b\u3068\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3084\u7d30\u80de\u6b7b\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002<\/p>\n<p><strong>\u203b\uff13 \u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9<\/strong><br \/>\n\u5c0f\u80de\u4f53\u5185\u3067\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9069\u5207\u306a\u6298\u308a\u305f\u305f\u307f\u306e\u969c\u5bb3\u3084\u3001\u672a\u6210\u719f\u307e\u305f\u306f\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u306e\u3053\u3068\u3002\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u304c\u6301\u7d9a\u3059\u308b\u3068\u708e\u75c7\u3084\u7d30\u80de\u6b7b\u3092\u8a98\u767a\u3057\u3001MASLD\/MASH\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306a\u3069\u306e\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<p><strong>\u203b\uff14 ATPase\u6d3b\u6027<\/strong><br \/>\nATP\u306e\u52a0\u6c34\u5206\u89e3\u3092\u4ecb\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4f9b\u7d66\u3057\u3001\u30a4\u30aa\u30f3\u8f38\u9001\u3084\u5206\u5b50\u30e2\u30fc\u30bf\u30fc\u306e\u99c6\u52d5\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u9175\u7d20\uff08ATPase\uff09\u6d3b\u6027\u3002SERCA2\u306eATPase\u6d3b\u6027\u306f\u3001\u5c0f\u80de\u4f53\u5185\u306eCa\u00b2\u207a\u6fc3\u5ea6\u8abf\u7bc0\u3092\u62c5\u3046\u3002<\/p>\n<h4>\uff08\uff17\uff09\u8ad6\u6587\u60c5\u5831<\/h4>\n<p>\u96d1\u8a8c\u540d\uff1aCommunications Biology<br \/>\n\u8ad6\u6587\u540d\uff1aInduction of MASH-like pathogenesis in the Nwd1\u2212\/\u2212 mouse liver<br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u5c71\u7530 \u6674\u4e5f<sup>1,2<\/sup>*\u3001\u5c0f\u5ddd \u98af<sup>1<\/sup>\u3001\u8239\u6238 \u5fc3\u685c\u681e<sup>1<\/sup>\u3001\u52a0\u85e4 \u5b9f\u54b2<sup>1<\/sup>\u3001\u4e2d\u8218 \u548c\u5f66<sup>3<\/sup>\u3001<br \/>\n\u6c34\u8d8a \u667a\u4e5f<sup>1<\/sup>\uff64\u5ddd\u4e0a \u6e05\u660e<sup>3<\/sup>\uff64\u5c0f\u6797 \u826f\u7950<sup>4<\/sup>\uff64\u5800\u5c45 \u62d3\u90ce<sup>4<\/sup>\uff64\u7551\u7530 \u51fa\u7a42<sup>4,5<\/sup>\uff64\u698a\u539f \u4f38\u4e00<sup>1<\/sup>*<br \/>\n1. \u65e9\u7a32\u7530\u7a32\u7530\u5927\u5b66 \u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662 \u5206\u5b50\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u5ba4<br \/>\n2. \u30d8\u30eb\u30b7\u30f3\u30ad\u5927\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\uff08HiLIFE\uff09\u30cb\u30e5\u30fc\u30ed\u30b5\u30a4\u30a8\u30f3\u30b9\u30bb\u30f3\u30bf\u30fc<br \/>\n3. \u660e\u6cbb\u85ac\u79d1\u5927\u5b66 \u6a5f\u80fd\u5f62\u614b\u5b66\u7814\u7a76\u5ba4<br \/>\n4. \u7fa4\u99ac\u5927\u5b66 \u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240 \u751f\u4f53\u60c5\u5831\u30b2\u30ce\u30e0\u30ea\u30bd\u30fc\u30b9\u30bb\u30f3\u30bf\u30fc \u30b2\u30ce\u30e0\u79d1\u5b66\u30ea\u30bd\u30fc\u30b9\u5206\u91ce<br \/>\n5. \u7fa4\u99ac\u5927\u5b66 \u672a\u6765\u5148\u7aef\u7814\u7a76\u6a5f\u69cb(GIAR)\u3001 *\u8cac\u4efb\u8457\u8005<br \/>\n\u63b2\u8f09\u65e5\u6642\uff1a2025\u5e743\u670811\u65e5\uff08\u706b\uff0910:00\uff08GMT\uff09\u300119:00\uff08JST\uff09<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s42003-025-07717-5\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s42003-025-07717-5<\/a><br \/>\nDOI\uff1a<a href=\"https:\/\/doi.org\/10.1038\/s42003-025-07717-5\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s42003-025-07717-5<\/a><\/p>\n<h4>\uff08\uff18\uff09\u7814\u7a76\u52a9\u6210<\/h4>\n<ul>\n<li>\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\uff0821K20701, \u5c71\u7530 \u6674\u4e5f\uff09\uff0823K05996, \u698a\u539f \u4f38\u4e00\uff09<\/li>\n<li>\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u75db\u98a8\u30fb\u5c3f\u9178\u8ca1\u56e3 \u7814\u7a76\u52a9\u6210\uff082020, \u698a\u539f \u4f38\u4e00\uff09\uff082022, \u5c71\u7530 \u6674\u4e5f\uff09<\/li>\n<li>\u65e9\u7a32\u7530\u5927\u5b66\u7279\u5b9a\u8ab2\u984c\uff082021C-611, 2022C-611, \u5c71\u7530 \u6674\u4e5f\uff09\uff082022C-214, 2023C-207, \u698a\u539f \u4f38\u4e00\uff09<\/li>\n<li>\u5275\u85ac\u7b49\u5148\u7aef\u6280\u8853\u652f\u63f4\u57fa\u76e4\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u2015BINDS (AMED) \uff08JP21am0101120, \u7551\u7530 \u51fa\u7a42\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u8102\u80aa\u809d\u708e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u767a\u898b \u809d\u81d3\u306b\u304a\u3051\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u6052\u5e38\u6027\u5236\u5fa1\u6a5f\u69cb \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u8102\u8cea\u4ee3\u8b1d\u3084\u89e3\u6bd2\u6a5f\u80fd\u306a\u3069\u3001\u591a\u69d8\u306a\u5f79\u5272\u3092\u62c5\u3046\u91cd\u8981\u306a\u81d3\u5668\u3067\u3042\u308b\u809d\u81d3\u306e\u8102\u8cea\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u3001\u300cNwd1\u907a\u4f1d\u5b50\u300d\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u62c5\u3046\u3053\u3068\u3092\u660e\u3089\u304b\u306b 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