{"id":79472,"date":"2024-12-25T14:00:26","date_gmt":"2024-12-25T05:00:26","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=79472"},"modified":"2024-12-25T12:36:19","modified_gmt":"2024-12-25T03:36:19","slug":"%e5%a4%9a%e6%a9%9f%e8%83%bd%e3%82%ad%e3%83%a1%e3%83%a9%e6%a0%b8%e9%85%b8%e3%81%ab%e3%82%88%e3%82%8b%e3%83%87%e3%83%b3%e3%82%b0%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e5%a2%97%e6%ae%96%e6%8a%91%e5%88%b6","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/79472","title":{"rendered":"\u591a\u6a5f\u80fd\u30ad\u30e1\u30e9\u6838\u9178\u306b\u3088\u308b\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u5897\u6b96\u6291\u5236"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong>\u591a\u6a5f\u80fd\u30ad\u30e1\u30e9\u6838\u9178\u306b\u3088\u308b\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u5897\u6b96\u6291\u5236<br \/>\n<\/strong><strong><small>\u5c06\u6765\u306e\u611f\u67d3\u75c7\u533b\u85ac\u958b\u767a\u3078\u5e45\u5e83\u3044\u5fdc\u7528\u306e\u53ef\u80fd\u6027<\/small><\/strong><\/h2>\n<h4><strong>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h4>\n<ul>\n<li>\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\uff08\u7565\u79f0DENV\uff09\u306f\u3001\u30c7\u30f3\u30b0\u71b1\u3092\u5f15\u304d\u8d77\u3053\u3059\u30a6\u30a4\u30eb\u30b9\u3067\u3059\u3002\u868a\u3092\u4ecb\u3057\u3066\u4eba\u304b\u3089\u4eba\u3078\u611f\u67d3\u3059\u308b\u868a\u5a92\u4ecb\u6027\u30a6\u30a4\u30eb\u30b9\u3068\u3057\u3066\u77e5\u3089\u308c\u3001\u6709\u52b9\u306a\u4e88\u9632\u85ac\u3001\u6cbb\u7642\u85ac\u306f\u672a\u3060\u3042\u308a\u307e\u305b\u3093\u3002\u91cd\u75c7\u5316\u3059\u308b\u3068\u30c7\u30f3\u30b0\u51fa\u8840\u71b1\u3084\u30c7\u30f3\u30b0\u30b7\u30e7\u30c3\u30af\u75c7\u5019\u7fa4\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u6b7b\u306b\u81f3\u308b\u5371\u967a\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<li>DENV\u306e\u4e88\u9632\u53ca\u3073\u6cbb\u7642\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u6838\u9178\u533b\u85ac\u3068\u3057\u3066\u77e5\u3089\u308c\u6a5f\u80fd\u304c\u7570\u306a\u308b2\u7a2e\u306e\u5206\u5b50\u3001small interfering RNA (siRNA)\u3068RNA\u30a2\u30d7\u30bf\u30de\u30fc\u3068\u30921\u3064\u306e\u8907\u5408\u4f53\u3068\u3059\u308b\u3053\u3068\u3067DENV\u306b\u7d50\u5408\u3059\u308b\u6a5f\u80fd\u3068DENV\u7531\u6765\u907a\u4f1d\u5b50\u3092\u5206\u89e3\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3064DENV\u5897\u6b96\u6291\u5236\u6838\u9178\u5206\u5b50\u300c\u30ad\u30e1\u30e9\u6838\u9178\u300d\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>\u30ad\u30e1\u30e9\u6838\u9178\u306f\u4eca\u5f8c\u3001\u69d8\u3005\u306a\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u5bfe\u3057\u5e45\u5e83\u304f\u5fdc\u7528\u3067\u304d\u308b\u5206\u5b50\u5f62\u614b\u3067\u3042\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<div id=\"attachment_79473\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-79473\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/12\/29d3bc99193cb0b837fb8cc53f050ae5-8.png\" alt=\"\" width=\"1226\" height=\"668\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/12\/29d3bc99193cb0b837fb8cc53f050ae5-8.png 1226w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/12\/29d3bc99193cb0b837fb8cc53f050ae5-8-610x332.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/12\/29d3bc99193cb0b837fb8cc53f050ae5-8-940x512.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/12\/29d3bc99193cb0b837fb8cc53f050ae5-8-768x418.png 768w\" sizes=\"auto, (max-width: 1226px) 100vw, 1226px\" \/><p class=\"wp-caption-text\">\u30ad\u30e1\u30e9\u6838\u9178\u304cDENV\u306b\u4f5c\u7528\u3059\u308b\u6982\u5ff5\u56f3<\/p><\/div>\n<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>\u6771\u4eac\u5927\u5b66\u533b\u79d1\u5b66\u7814\u7a76\u6240RNA\u533b\u79d1\u5b66\u793e\u4f1a\u9023\u643a\u7814\u7a76\u90e8\u9580\u306e\u9ad8\u6a4b\u7406\u8cb4\u7279\u4efb\u51c6\u6559\u6388\uff08\u958b\u767a\u5f53\u6642\uff09\u3001\u682a\u5f0f\u4f1a\u793e\u30ea\u30dc\u30df\u30c3\u30af\u306e\u4e2d\u6751\u7fa9\u4e00\u4ee3\u8868\u53d6\u7de0\u5f79\u793e\u9577\uff08\u6771\u4eac\u5927\u5b66\u540d\u8a89\u6559\u6388\uff09\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u56fd\u969b\u4fdd\u5065\u5b66\u5c02\u653b\u56fd\u969b\u751f\u7269\u533b\u79d1\u5b66\u8b1b\u5ea7\u306eMOI MENG LING\u6559\u6388\u3001\u6771\u4eac\u5927\u5b66\u533b\u79d1\u5b66\u7814\u7a76\u6240\u9644\u5c5e\u30a2\u30b8\u30a2\u611f\u67d3\u75c7\u7814\u7a76\u62e0\u70b9\u306e\u5c71\u672c\u745e\u751f\u7279\u4efb\u8b1b\u5e2b\u3001\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001261_ja.html\" target=\"_blank\" rel=\"noopener\">\u6d5c\u7530\u9053\u662d\u6559\u6388<\/a>\u3089\u306b\u3088\u308b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001DENV\u306e\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u65b0\u305f\u306a\u6838\u9178\u5206\u5b50\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>DENV\u306f\u5927\u304d\u304f\u5206\u3051\u30664\u3064\u306e\u7a2e\u985e\uff08DENV1\uff5e4\u306e\u8840\u6e05\u578b\u3001\u6ce8\uff11\uff09\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u305d\u308c\u306b\u5bfe\u5fdc\u3059\u308b\u30ef\u30af\u30c1\u30f3\u958b\u767a\u3082\u9032\u3093\u3067\u3044\u308b\u4e00\u65b9\u3067\u3001\u672a\u3060\u6709\u52b9\u306a\u4e88\u9632\u85ac\u3001\u6cbb\u7642\u85ac\u304c\u7121\u3044\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u8ab2\u984c\u514b\u670d\u306e\u305f\u3081\u3001\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u5168\u8840\u6e05\u578b\u306eDENV\u306b\u5bfe\u3057\u3066\u3001DENV\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u69cb\u9020\u76f8\u88dc\u6027\u3067\u7d50\u5408\u3059\u308bRNA\u30a2\u30d7\u30bf\u30de\u30fc\uff08\u6ce8\uff12\uff09\u3068\u3001DENV\u7531\u6765\u306eRNA\u306b\u5869\u57fa\u914d\u5217\u76f8\u88dc\u6027\u3067\u5206\u89e3\u306b\u5c0e\u304fsiRNA\uff08\u6ce8\uff13\uff09\u3068\u3092\u500b\u5225\u306b\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001\u305d\u308c\u3089\u6838\u9178\u5206\u5b50\u30921\u5206\u5b50\u3068\u3057\u3066\u7d50\u5408\u3055\u305b\u308b\u3053\u3068\u3067\u3001DENV\u306b\u7d50\u5408\u3057\u3001DENV\u611f\u67d3\u3068\u5171\u306b\u7d30\u80de\u5185\u306b\u4fb5\u5165\u3059\u308b\u3053\u3068\u3067\u30a6\u30a4\u30eb\u30b9\u7531\u6765\u306eRNA\u3092\u611f\u67d3\u3057\u305f\u7d30\u80de\u5185\u3067\u5206\u89e3\u3059\u308b\u591a\u6a5f\u80fd\u6838\u9178\u5206\u5b50\u300c\u30ad\u30e1\u30e9\u6838\u9178\uff08siRNA-aptamer\u8907\u5408\u4f53\uff09\u300d\u3092\u958b\u767a\u3057\u3001\u305d\u306e\u6709\u52b9\u6027\u3092\u7591\u4f3c\u7684\u306a\u611f\u67d3\u8a55\u4fa1\u7cfb\u304a\u3088\u3073\u5b9f\u969b\u306e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u8a55\u4fa1\u7cfb\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u6211\u3005\u304c\u958b\u767a\u3057\u305f\u30ad\u30e1\u30e9\u6838\u9178\u306fDENV\u306e\u5897\u6b96\u3092\u5f37\u304f\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u8907\u6570\u5b58\u5728\u3059\u308b\u8840\u6e05\u578b\u306b\u5bfe\u3057\u3066\u3082\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u7d50\u679c\u3082\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u5206\u5b50\u306e\u958b\u767a\u6226\u7565\u306f\u3001DENV\u4ee5\u5916\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u3082\u9069\u5fdc\u3067\u304d\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u5e45\u5e83\u3044\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u4e88\u9632\u53ca\u3073\u6cbb\u7642\u5206\u5b50\u306e\u8fc5\u901f\u306a\u958b\u767a\u306b\u65b0\u305f\u306a\u9078\u629e\u80a2\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u672c\u6210\u679c\u306f12\u670825\u65e5\u3001\u56fd\u969b\u5b66\u8853\u5c02\u9580\u8a8c\u300c<em>Nucleic Acids Research Molecular Medicine<\/em>\u300d\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>\u7814\u7a76\u5185\u5bb9<\/strong><\/h4>\n<p>RNA\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u3001\u4e00\u672c\u9396\u6838\u9178\u304c\u5f62\u6210\u3059\u308b\u69d8\u3005\u306a\u7acb\u4f53\u69cb\u9020\u3092\u57fa\u76e4\u3068\u3057\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u591a\u69d8\u306a\u6a19\u7684\u306b\u5bfe\u3057\u3066\u69cb\u9020\u76f8\u88dc\u6027\u3067\u7d50\u5408\u3059\u308b\u5206\u5b50\u3067\u3059\u3002\u6a19\u7684\u306b\u5bfe\u3059\u308b\u9ad8\u3044\u7279\u7570\u6027\u3068\u89aa\u548c\u6027\u3092\u6709\u3057\u3001\u5316\u5b66\u7684\u306b\u6539\u5909\u30fb\u52a0\u5de5\u304c\u5bb9\u6613\u3067\u3042\u308a\u3001\u514d\u75ab\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u306b\u304f\u3044\u306a\u3069\u306e\u7279\u5fb4\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u6297\u4f53\u533b\u85ac\u306b\u4ee3\u308f\u308b\u6b21\u4e16\u4ee3\u533b\u85ac\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u8840\u6db2\u4e2d\u306e\u6db2\u6027\u56e0\u5b50\u3092\u6a19\u7684\u3068\u3057\u3066\u6a5f\u80fd\u963b\u5bb3\u3059\u308b\u533b\u85ac\u54c1\u3068\u3057\u3066\u793e\u4f1a\u5b9f\u88c5\u3055\u308c\u3066\u304d\u305f\u3053\u3068\u306b\u52a0\u3048\u3001\u8fd1\u5e74\u3067\u306f\u7d30\u80de\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3059\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u4efb\u610f\u306e\u7d30\u80de\u306b\u7a2e\u3005\u306e\u85ac\u5264\u3092\u9001\u9054\u3059\u308b\u5206\u5b50\u3068\u3057\u3066\u306e\u6d3b\u7528\u6cd5\u3082\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u540c\u3058\u304f\u6838\u9178\u533b\u85ac\u3068\u3057\u3066\u77e5\u3089\u308c\u308bsiRNA\u306f\u3001\u5869\u57fa\u914d\u5217\u76f8\u88dc\u6027\u3067\u6a19\u7684\u3068\u3059\u308b\u7d30\u80de\u5185\u306e\u4efb\u610f\u306eRNA\u306b\u7d50\u5408\u3057\u5206\u89e3\u306b\u5c0e\u304f\u5206\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6a19\u7684RNA\u306b\u5bfe\u3059\u308b\u7279\u7570\u6027\u30fb\u9078\u629e\u6027\u304c\u9ad8\u304f\u3001\u5206\u5b50\u8a2d\u8a08\u304c\u6bd4\u8f03\u7684\u5bb9\u6613\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u6c4e\u7528\u7684\u7814\u7a76\u30c4\u30fc\u30eb\u3068\u3057\u3066\u3082\u6d3b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u533b\u85ac\u54c1\u3068\u3057\u3066\u306e\u6d3b\u7528\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u306f\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3059\u308b\u305f\u3081\u306e\u9001\u9054\u6280\u8853\u304c\u5fc5\u9808\u3067\u3042\u308a\u3001\u5b89\u5168\u3067\u52b9\u7387\u7684\u306a\u9001\u9054\u6280\u8853\u306e\u78ba\u7acb\u304c\u8ab2\u984c\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30d7\u30bf\u30de\u30fc\u53ca\u3073siRNA\u306e\u4e21\u8005\u306b\u304a\u3044\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u6cbb\u7642\u3084\u4e88\u9632\u3092\u76ee\u7684\u3068\u3057\u305f\u7814\u7a76\u958b\u767a\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u305e\u308c\u5358\u5264\u3068\u3057\u3066\u306f\u4e2d\u548c\u6d3b\u6027\u3084\u85ac\u5264\u9001\u9054\u304c\u8ab2\u984c\u3068\u306a\u308a\u793e\u4f1a\u5b9f\u88c5\u304c\u56f0\u96e3\u3067\u3042\u308b\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u3067\u306f\u30014\u3064\u306e\u7a2e\u985e\u30fb\u8840\u6e05\u578b\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3067\u672a\u3060\u6709\u52b9\u306a\u4e88\u9632\u85ac\u3084\u6cbb\u7642\u85ac\u304c\u5b58\u5728\u305b\u305a\u4e16\u754c\u7684\u306b\u611f\u67d3\u8005\u306e\u591a\u3044DENV\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u5168\u3066\u306e\u8840\u6e05\u578b\u306eDENV\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3059\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u3068\u3001\u5168\u8840\u6e05\u578b\u306eDENV\u7531\u6765RNA\u3092\u5206\u89e3\u3059\u308bsiRNA\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3067\u3001\u8840\u6e05\u578b\u3092\u554f\u308f\u305aDENV\u3092\u5897\u6b96\u6291\u5236\u3059\u308b\u30ad\u30e1\u30e9\u6838\u9178\u306e\u958b\u767a\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u30a2\u30d7\u30bf\u30de\u30fc\u5275\u88fd\u306b\u3064\u3044\u3066\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u69d8\u7c92\u5b50\uff08VLP\uff09\u3092\u7528\u3044\u305f\u72ec\u81ea\u306e\u30a2\u30d7\u30bf\u30de\u30fc\u5275\u88fd\u6cd5\uff08VLP-SELEX\u6cd5\uff09\uff08Takahashi M et al., <em>PNAS<\/em> 2020\uff09\u3068\u30a2\u30d7\u30bf\u30de\u30fc\u5275\u88fd\u306b\u7279\u5316\u3057\u305f\u9ad8\u5ea6\u306a\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9(Ishida R et al., <em>NAR<\/em> 2020)\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u958b\u767a\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u7279\u5fb4\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u611f\u67d3\u7d30\u80de\u306e\u819c\u878d\u5408\u904e\u7a0b\u3092\u8a55\u4fa1\u3059\u308b\u7279\u6b8a\u306a\u611f\u67d3\u89e3\u6790\u624b\u6cd5(Yamamoto M et al., <em>Viruses<\/em> 2020)\u3067\u8a55\u4fa1\u3057\u305f\u7d50\u679c\u3001\u958b\u767a\u3057\u305f\u30a2\u30d7\u30bf\u30de\u30fc\u306fDENV\u306b\u5bfe\u3057\u3066\u5f37\u3044\u7d50\u5408\u529b\u3092\u6301\u3064\u4e00\u65b9\u3067\u3001\u91cd\u8981\u306a\u611f\u67d3\u904e\u7a0b\u306e\u4e00\u3064\u3067\u3042\u308b\u819c\u878d\u5408\u306f\u963b\u5bb3\u3057\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u5168\u8840\u6e05\u578bDENV\u306b\u5171\u901a\u3059\u308bRNA\u914d\u5217\u3092\u6a19\u7684\u3068\u3057\u3066siRNA\u3092\u8a2d\u8a08\u3057\u6d3b\u6027\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u5168\u8840\u6e05\u578b\u306b\u5bfe\u5fdc\u3059\u308bsiRNA\u306e\u540c\u5b9a\u306b\u3082\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u4e21\u8005\u3092\u7d50\u5408\u3055\u305b\u305f\u8907\u5408\u4f53\u300c\u30ad\u30e1\u30e9\u6838\u9178\u300d\u306b\u3088\u308b\u5b9f\u969b\u306eDENV\u306b\u5bfe\u3059\u308b\u6291\u5236\u52b9\u679c\u3092\u78ba\u8a8d\u3057\u305f\u7d50\u679c\u3001\u8907\u6570\u306e\u8840\u6e05\u578b\u306b\u5bfe\u3057\u30a6\u30a4\u30eb\u30b9\u5897\u6b96\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3092\u3001\u53e4\u5178\u7684\u306aPCR\u6cd5\u306b\u52a0\u3048\u72ec\u81ea\u306e\u30a6\u30a4\u30eb\u30b9\u4e2d\u548c\u6d3b\u6027\u89e3\u6790\u624b\u6cd5 (Haga K et al., <em>Pathogens<\/em> 2023\uff09\u306b\u3088\u3063\u3066\u5b9f\u8a3c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\uff08\u56f3\uff09\u3002<\/p>\n<div id=\"attachment_79474\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-79474\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/12\/cbf5b9f60da99bf791c0aa12a770f429-2.png\" alt=\"\" width=\"428\" height=\"338\" \/><p class=\"wp-caption-text\">\u56f3\uff0e\u30ad\u30e1\u30e9\u6838\u9178\u306eDENV\u306b\u5bfe\u3059\u308b\u611f\u67d3\u9632\u5fa1\u52b9\u679c<br 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RNA\u533b\u79d1\u5b66\u793e\u4f1a\u9023\u643a\u7814\u7a76\u90e8\u9580<br \/>\n\u9ad8\u6a4b\u3000\u7406\u8cb4\u3000\u7814\u7a76\u5f53\u6642\uff1a\u7279\u4efb\u51c6\u6559\u6388<\/p>\n<p>\u682a\u5f0f\u4f1a\u793e\u30ea\u30dc\u30df\u30c3\u30af<br \/>\n\u4e2d\u6751\u3000\u7fa9\u4e00\u3000\u4ee3\u8868\u53d6\u7de0\u5f79\u793e\u9577\u3000\u517c\uff1a\u6771\u4eac\u5927\u5b66\u540d\u8a89\u6559\u6388<\/p>\n<p>\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1 \u56fd\u969b\u4fdd\u5065\u5b66\u5c02\u653b \u56fd\u969b\u751f\u7269\u533b\u79d1\u5b66\u8b1b\u5ea7 \u767a\u9054\u533b\u79d1\u5b66<br \/>\nMOI MENG LING\uff08\u30e2\u30a4 \u30e1\u30f3 \u30ea\u30f3\uff09\u3000\u6559\u6388<\/p>\n<p>\u6771\u4eac\u5927\u5b66\u533b\u79d1\u5b66\u7814\u7a76\u6240\u9644\u5c5e\u30a2\u30b8\u30a2\u611f\u67d3\u75c7\u7814\u7a76\u62e0\u70b9<br \/>\n\u5c71\u672c\u3000\u745e\u751f\u3000\u7279\u4efb\u8b1b\u5e2b<\/p>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662<br \/>\n\u6d5c\u7530\u3000\u9053\u662d\u3000\u6559\u6388<\/p>\n<h4>\u8ad6\u6587\u60c5\u5831<\/h4>\n<p><strong>\u96d1\u8a8c\u540d\uff1a<\/strong>Nucleic Acids Research Molecular Medicine<br \/>\n<strong>\u984c\u3000\u540d\uff1a<\/strong>A chimeric RNA consisting of siRNA and aptamer for inhibiting dengue virus replication<br \/>\n<strong>\u8457\u8005\u540d\uff1a<\/strong>Ryo Amano, Masaki Takahashi*, Kazumi Haga, Mizuki Yamamoto, Kaku Goto, Akiko Ichinose, Michiaki Hamada, Jin Gohda, Jun-ichiro Inoue, Yasushi Kawaguchi, Meng Ling Moi, Yoshikazu Nakamura(<sup>*<\/sup>\u8cac\u4efb\u8457\u8005)<br \/>\n<strong>DOI:<\/strong> 10.1093\/narmme\/ugae025<br \/>\n<strong>URL: <\/strong><a href=\"https:\/\/academic.oup.com\/narmolmed\/advance-article\/doi\/10.1093\/narmme\/ugae025\/7918429\">https:\/\/academic.oup.com\/narmolmed\/advance-article\/doi\/10.1093\/narmme\/ugae025\/7918429<\/a><\/p>\n<h4>\u7814\u7a76\u52a9\u6210<\/h4>\n<p>\u672c\u7814\u7a76\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09 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