{"id":78755,"date":"2024-10-17T14:00:46","date_gmt":"2024-10-17T05:00:46","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=78755"},"modified":"2024-10-17T15:45:06","modified_gmt":"2024-10-17T06:45:06","slug":"%e7%95%b0%e5%b8%b8%e3%81%aa%e7%97%85%e7%9a%84%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%92%e4%bd%9c%e3%82%89%e3%81%aa%e3%81%84%e3%81%9f%e3%82%81%e3%81%ab%e2%80%95mrna%e3%81%ae%e5%93%81","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/78755","title":{"rendered":"\u7570\u5e38\u306a\u75c5\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u3089\u306a\u3044\u305f\u3081\u306b\u2015mRNA\u306e\u54c1\u8cea\u3092\u7ba1\u7406\u3059\u308b\u4ed5\u7d44\u307f\u306e\u767a\u898b\u2015"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong>\u7570\u5e38\u306a\u75c5\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u3089\u306a\u3044\u305f\u3081\u306b<br 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id=\"attachment_78757\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-78757\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/29d3bc99193cb0b837fb8cc53f050ae5-4.png\" alt=\"\" width=\"884\" height=\"464\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/29d3bc99193cb0b837fb8cc53f050ae5-4.png 884w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/29d3bc99193cb0b837fb8cc53f050ae5-4-610x320.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/29d3bc99193cb0b837fb8cc53f050ae5-4-768x403.png 768w\" sizes=\"auto, (max-width: 884px) 100vw, 884px\" \/><p 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3XT\u306e\u7ffb\u8a33\u7523\u7269\u304c\u3001\u76f8\u5206\u96e2\uff08\u6ce85\uff09\u5236\u5fa1\u3092\u4ecb\u3057\u3066\u7570\u5e38\u306a\u69cb\u9020\u4f53KeXT body\uff08\u6ce86\uff09\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f(\u56f31)\u3002<\/p>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30ca\u30ce\u30dd\u30a2\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\uff08\u6ce87\uff09\u3092\u7528\u3044\u305fdirect RNA 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height=\"382\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/cbf5b9f60da99bf791c0aa12a770f429-2.png 739w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/cbf5b9f60da99bf791c0aa12a770f429-2-610x315.png 610w\" sizes=\"auto, (max-width: 739px) 100vw, 739px\" \/><p class=\"wp-caption-text\">\u56f31\uff1aKCTD13 3XT\u7ffb\u8a33\u7523\u7269\u306f\u3001MTR4\u975e\u5b58\u5728\u4e0b\u306b\u304a\u3044\u3066KeXT 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3XT\u306b3XT\u3092\u5206\u985e(\u56f32)\u3057\u3001\u5206\u89e3\u6a5f\u69cb\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044multi-exon 3XT\u306b\u7740\u76ee\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u307e\u3057\u305f\u3002multi-exon 3XT\u306e\u4f38\u9577\u9818\u57df(3XR: 3\u2019 eXtended Region, \u56f32)\u306b\u5bfe\u3057\u3066\u30e2\u30c1\u30fc\u30d5\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001hnRNPK\u304c\u5f53\u8a723XRs\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u305d\u3053\u3067hnRNPK\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3068\u3001multi-exon 3XTs\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3055\u3089\u306b\u7814\u7a76\u3092\u9032\u3081\u3001hnRNPK\u306fmulti-exon 3XT\u306e3XR\u306b\u7d50\u5408\u3057\u3001RNA\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0-MTR4\u8907\u5408\u4f53\u3092\u5f53\u8a723XT\u306b\u30ea\u30af\u30eb\u30fc\u30c8\u3059\u308b\u3053\u3068\u3067\u3001multi-exon 3XT\u3092\u5206\u89e3\u3059\u308b\u4ed5\u7d44\u307f\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u6700\u5f8c\u306b\u3001MTR4\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b3XTs\u304b\u3089\u751f\u6210\u3055\u308c\u308b\u7570\u5e38\u306a\u7ffb\u8a33\u7523\u7269\u304c\u7570\u5e38\u69cb\u9020\u4f53\u3092\u5f62\u6210\u3059\u308b\u306e\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u307e\u305a\u69cb\u9020\u4f53\u5f62\u6210\u4e88\u6e2c\u3092\u884c\u3044\u3001KCTD13\u907a\u4f1d\u5b50\u5ea7\u304b\u3089\u767a\u73fe\u3059\u308bKCTD13 3XT\u7531\u6765\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u76f8\u5206\u96e2\u3092\u8d77\u3053\u3059\u53ef\u80fd\u6027\u3092\u6709\u3059\u308b\u30da\u30d7\u30c1\u30c9\u914d\u5217\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u69cb\u9020\u4f53\u3092\u5f62\u6210\u3059\u308b\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001KCTD13 3XT\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u4f5c\u6210\u3057\u3001MTR4\u3092\u767a\u73fe\u6291\u5236\u3057\u305f\u30d2\u30c8\u5b50\u5bae\u9838\u304c\u3093\u7d30\u80de\u682aHeLa\u7d30\u80de\u306b\u304a\u3051\u308b\u5c40\u5728\u3092\u78ba\u8a8d\u3057\u305f\u3068\u3053\u308d\u3001KCTD13 3XT\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u76f8\u5206\u96e2\u5236\u5fa1\u3092\u4ecb\u3057\u3066\u7570\u5e38\u306a\u75c5\u7684\u69cb\u9020\u4f53KeXT body\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001RNA\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u7570\u5e38\u3092\u6709\u3059\u308b\u7570\u5e38RNA\u3092\u5206\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u7570\u5e38RNA\u304b\u3089\u7ffb\u8a33\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u75c5\u7684\u69cb\u9020\u4f53\u306e\u5f62\u6210\u3092\u963b\u5bb3\u3059\u308bRNA\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306fRNA\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306e\u7834\u7dbb\u306b\u3088\u308b\u75c5\u7684\u69cb\u9020\u4f53\u5f62\u6210\u304c\u69d8\u3005\u306a\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u69d8\u3005\u306a\u75be\u60a3\u306b\u5bfe\u3059\u308bRNA\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u3092\u6a19\u7684\u306b\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u767a\u5c55\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<div id=\"attachment_78760\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-78760\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/5e4896966c9944fcf00890f4502605bf-1.png\" alt=\"\" width=\"801\" height=\"238\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/5e4896966c9944fcf00890f4502605bf-1.png 801w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/5e4896966c9944fcf00890f4502605bf-1-610x181.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/10\/5e4896966c9944fcf00890f4502605bf-1-768x228.png 768w\" sizes=\"auto, (max-width: 801px) 100vw, 801px\" \/><p class=\"wp-caption-text\">\u56f32\uff1a3XT\u53ca\u30733XR\u306e\u5b9a\u7fa9<\/p><\/div>\n<h4>\u767a\u8868\u8005\u30fb\u7814\u7a76\u8005\u7b49\u60c5\u5831<\/h4>\n<p>\u6771\u4eac\u5927\u5b66<br \/>\n\u30a2\u30a4\u30bd\u30c8\u30fc\u30d7\u7dcf\u5408\u30bb\u30f3\u30bf\u30fc<br \/>\n\u79cb\u5149\u3000\u4fe1\u4f73\u3000\u6559\u6388<br \/>\n\u8c37\u4e0a\u3000\u8ce2\u745e\u3000\u7279\u4efb\u51c6\u6559\u6388<br \/>\nHan\u3000 Han \u3000\u7814\u7a76\u5f53\u6642\uff1a\u535a\u58eb\u8ab2\u7a0b<\/p>\n<p>\u5927\u5b66\u9662\u65b0\u9818\u57df\u5275\u6210\u79d1\u5b66\u7814\u7a76\u79d1<br \/>\n\u9234\u6728\u3000\u7a63\u3000\u3000\u6559\u6388<br \/>\n\u95a2\u3000\u3000\u771f\u79c0\u3000\u7279\u4efb\u51c6\u6559\u6388<\/p>\n<p>\u65e9\u7a32\u7530\u5927\u5b66<br \/>\n\u7406\u5de5\u5b66\u8853\u9662<br \/>\n\u6d5c\u7530\u3000\u9053\u662d\u3000\u6559\u6388<br \/>\n\u66fd \u3000 \u8d85\u3000\u3000\u6b21\u5e2d\u7814\u7a76\u54e1 (\u7814\u7a76\u9662\u8b1b\u5e2b)<\/p>\n<h4>\u8ad6\u6587\u60c5\u5831<\/h4>\n<p><strong>\u96d1\u8a8c\u540d\uff1a<\/strong>Nature Communications<br \/>\n<strong>\u984c\u3000\u540d\uff1a<\/strong>The MTR4\/hnRNPK complex surveils aberrant polyadenylated RNAs with multiple exons<br \/>\n<strong>\u8457\u8005\u540d\uff1a<\/strong>Kenzui Taniue*, Anzu Sugawara, Chao Zeng, Han Han, Xinyue Gao, Yuki Shimoura, Atsuko Nakanishi Ozeki, Rena Onoguchi-Mizutani, Masahide Seki, Yutaka Suzuki, Michiaki Hamada, Nobuyoshi Akimitsu*<br \/>\n<strong>DOI:<\/strong> 10.1038\/s41467-024-51981-8<br \/>\n<strong>URL:<\/strong> <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-51981-8\">https:\/\/www.nature.com\/articles\/s41467-024-51981-8<\/a><\/p>\n<h4>\u7528\u8a9e\u89e3\u8aac<\/h4>\n<p>(\u6ce81) MTR4<br \/>\nRNA\u30d8\u30ea\u30ab\u30fc\u30bcMTR4\uff08MTREX\uff09\u306f\u3001\u6838\u5185\u306b\u5c40\u5728\u3057\u3001RNA\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u306e\u30a2\u30af\u30bb\u30b5\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3066\u69d8\u3005\u306a\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3001\u305d\u308c\u305e\u308c\u7279\u5b9a\u306e\u6a19\u7684RNA\u7fa4\u3092\u8b58\u5225\u3059\u308b\u3002\u307e\u305f\u3001MTR4\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u6a5f\u69cb\u306b\u3082\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u591a\u6a5f\u80fd\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u69d8\u3005\u306a\u5c40\u9762\u3067\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>(\u6ce82) hnRNPK<br \/>\nhnRNPK\u306f\u3001\u6838\u306b\u5c40\u5728\u3059\u308bDNA\/RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u69d8\u3005\u306a\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3059\u308b\u3002hRNPK\u306e\u767a\u73fe\u7570\u5e38\u306f\u3001\u764c\u306a\u3069\u306e\u75be\u60a3\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u3002hnRNPK\u306f\u3001RNA\u3084\u4e00\u672c\u9396DNA\u3092\u8a8d\u8b58\u3059\u308b3\u3064\u306eKH\u30c9\u30e1\u30a4\u30f3\u3001\u6838\u5c40\u5728\u5316\u30b7\u30b0\u30ca\u30eb\u3001\u6838\u30b7\u30e3\u30c8\u30ea\u30f3\u30b0\u30c9\u30e1\u30a4\u30f3\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u8ee2\u5199\u3001mRNA\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3001RNA\u306e\u8f38\u9001\u3001\u7ffb\u8a33\u306a\u3069\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001hnRNPK\u304c\u6838\u5185RNA\u5206\u89e3\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n<p>(\u6ce83) RNA\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0<br \/>\nRNA\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3068\u306f\u3001\u7d30\u80de\u5185\u3067\u5408\u6210\u3055\u308c\u305fRNA\u5206\u5b50\u304c\u6a5f\u80fd\u7684\u306a\u6210\u719fRNA\u306b\u5909\u63db\u3055\u308c\u308b\u904e\u7a0b\u306e\u3053\u3068\u3002RNA \u30dd\u30ea\u30e1\u30e9\u30fc\u30bc \u2161\u306b\u3088\u308b\u8ee2\u5199\u53cd\u5fdc\u3067\u524d\u99c6\u4f53 mRNA\uff08pre-mRNA\uff09\u304c\u5408\u6210\u3055\u308c\u308b\u3068\u30015\u2019\u672b\u7aef\u30ad\u30e3\u30c3\u30d4\u30f3\u30b0\uff0c\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\uff0c3\u2019\u672b\u7aef\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u306a\u3069\u69d8\u3005\u306a\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u53cd\u5fdc\u306b\u3088\u308a\u6210\u719f mRNA \u3068\u306a\u308b\u3002\u307e\u305f\u3001\u9078\u629e\u7684RNA\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3084\u9078\u629e\u7684\u30dd\u30eaA\u4ed8\u52a0\u306b\u3088\u3063\u3066\u3001\u907a\u4f1d\u5b50\u7279\u7570\u7684\u304b\u3064\u7d30\u80de\u578b\u7279\u7570\u7684\u306bRNA\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3092\u751f\u6210\u3055\u308c\u308b\u3002\u9078\u629e\u7684RNA\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3084\u9078\u629e\u7684\u30dd\u30eaA\u4ed8\u52a0\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u591a\u69d8\u6027\u306e\u7372\u5f97\u306b\u5bc4\u4e0e\u3057\u3001\u591a\u69d8\u306a\u751f\u7406\u7684\u6761\u4ef6\u4e0b\u3067\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>(\u6ce84) 3XT (3\u2019 e<u>X<\/u>tended <u>T<\/u>ranscript)<br \/>\n\u30dd\u30ea\u30a2\u30c7\u30cb\u30eb\u5316\u306e\u8131\u5236\u5fa1\u306b\u3088\u308a\u8ee2\u5199\u304c\u9014\u4e2d\u3067\u7d42\u7d50\u3057\u3001\u6700\u7d42\u30a8\u30ad\u30bd\u30f3\u304c3\u2019\u5074\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u307e\u3067\u4f38\u9577\u3057\u305f\u7570\u5e38RNA\u306e\u3053\u3068\u30023XT\u306f\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u767a\u898b\u3057\u3001\u7b2c1\u30a8\u30ad\u30bd\u30f3\u304c\u4f38\u9577\u3057\u305f3XT\u3092mono-exon 3XT\u30012\u3064\u76ee\u4ee5\u964d\u306e\u30a8\u30ad\u30bd\u30f3\u304c\u4f38\u9577\u3057\u305f3XT\u3092multi-exon 3XT\u3068\u547d\u540d\u3057\u305f\u3002\u5f93\u6765\u306e\u30a8\u30ad\u30bd\u30f3\u304b\u3089\u30a4\u30f3\u30c8\u30ed\u30f3\u307e\u3067\u4f38\u9577\u3057\u305f\u9818\u57df\u30923XR (3\u2019 eXtended Region)\u3068\u547d\u540d\u3057\u305f\u3002\u56f32\u53c2\u7167\u3002<\/p>\n<p>(\u6ce85) \u76f8\u5206\u96e2<br \/>\n\u76f8\u5206\u96e2\u306f\u3001\u751f\u7269\u5b66\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308a\u3001\u7279\u5b9a\u306e\u6761\u4ef6\u4e0b\u3067\u7d30\u80de\u5185\u306e\u5206\u5b50\u304c\u81ea\u767a\u7684\u306b\u5206\u96e2\u3057\u3001\u7570\u306a\u308b\u76f8\uff08phase\uff09\u3092\u5f62\u6210\u3059\u308b\u73fe\u8c61\u3092\u6307\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u306e\u7279\u5b9a\u306e\u533a\u57df\u306b\u5206\u5b50\u304c\u96c6\u4e2d\u3057\u3001\u9ad8\u6b21\u69cb\u9020\u4f53\u3084\u30b2\u30eb\u306e\u3088\u3046\u306a\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u3001\u52b9\u7387\u7684\u306a\u751f\u5316\u5b66\u53cd\u5fdc\u3084\u8ee2\u5199\u3084\u7ffb\u8a33\u306a\u3069\u306e\u8abf\u7bc0\u6a5f\u69cb\u3092\u52b9\u679c\u7684\u306b\u5b9f\u884c\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308b\u3002\u8fd1\u5e74\u3001\u76f8\u5206\u96e2\u304c\u591a\u304f\u306e\u751f\u7269\u5b66\u7684\u904e\u7a0b\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u76f8\u5206\u96e2\u306e\u7570\u5e38\u306b\u3088\u3063\u3066\u304c\u3093\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u306b\u7e4b\u304c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>(\u6ce86) KeXT body (<u>K<\/u>CTD13 3<u>eX<\/u>tended <u>T<\/u>ranscript-derived protein <u>body)<br \/>\n<\/u><em>KCTD13<\/em>\u907a\u4f1d\u5b50\u5ea7\u304b\u3089\u767a\u73fe\u3059\u308bKCTD13 3XT\u306e\u7ffb\u8a33\u7523\u7269\u304c\u5f62\u6210\u3059\u308b\u7570\u5e38\u69cb\u9020\u4f53\u306e\u3053\u3068\u3002KeXT body\u306f\u4e3b\u306b\u7d30\u80de\u8cea\u3067\u69cb\u6210\u3055\u308c\u308b\u304c\u3001\u305d\u306e\u69cb\u6210\u56e0\u5b50\u3084\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u4e0d\u660e\u3067\u3042\u308b\u3002<\/p>\n<p>(\u6ce87) \u30ca\u30ce\u30dd\u30a2\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc<br \/>\n\u7d30\u80de\u819c\u306b\u5b58\u5728\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305f\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u306e\u5b54\uff08\u30ca\u30ce\u30dd\u30a2\uff09\u3092\u4f7f\u3063\u3066\u3001DNA\u3084RNA\u306e\u5869\u57fa\u914d\u5217\u3092\u76f4\u63a5\u8aad\u307f\u53d6\u308b\u6280\u8853\u3092\u7528\u3044\u305f\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u306e\u3053\u3068\u3002\u30ca\u30ce\u30dd\u30a2\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u306f\u3001\u4ed6\u306e\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u3068\u6bd4\u3079\u3066\u975e\u5e38\u306b\u9577\u3044\u30ea\u30fc\u30c9\uff08\u6570\u4e07\u5869\u57fa\u306b\u53ca\u3076\u3053\u3068\u3082\u53ef\u80fd\uff09\u3092\u8aad\u307f\u53d6\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u8907\u96d1\u306a\u30b2\u30ce\u30e0\u9818\u57df\u3084\u69cb\u9020\u5909\u7570\u3001RNA\u306e\u5168\u9577\u69cb\u9020\u306e\u89e3\u6790\u306a\u3069\u306e\u89e3\u6790\u304c\u53ef\u80fd\u306b\u306a\u308b\u3002\u307e\u305f\u3001DNA\u3060\u3051\u3067\u306a\u304f\u3001RNA\u3082\u76f4\u63a5\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3067\u304d\u308b\u305f\u3081\u3001\u8ee2\u5199\u5f8c\u4fee\u98fe\u306e\u7814\u7a76\u306b\u3082\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>(\u6ce88) direct RNA sequencing\u6280\u8853<br \/>\n\u30ca\u30ce\u30dd\u30a2\u30b7\u30fc\u30af\u30a8\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u306b\u3088\u308bRNA\u5206\u5b50\u3092\u76f4\u63a5\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3059\u308b\u6280\u8853\u306e\u3053\u3068\u3002RNA\u5206\u5b50\u304c\u30ca\u30ce\u30dd\u30a2\u3092\u901a\u904e\u3059\u308b\u969b\u306b\u3001\u5404\u5869\u57fa\uff08A\u3001U\u3001C\u3001G\uff09\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u96fb\u6d41\u306e\u5909\u5316\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u691c\u51fa\u3057\u3001\u96fb\u6d41\u306e\u5909\u5316\u30d1\u30bf\u30fc\u30f3\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001RNA\u306e\u5869\u57fa\u914d\u5217\u304c\u6c7a\u5b9a\u3059\u308b\u3002cDNA\u5408\u6210\u3084PCR\u5897\u5e45\u306a\u3069\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u7d4c\u305a\u306b\u3001RNA\u3092\u76f4\u63a5\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3059\u308b\u3053\u3068\u3067\u3001PCR\u30d0\u30a4\u30a2\u30b9\u3084\u9006\u8ee2\u5199\u30a8\u30e9\u30fc\u3092\u56de\u907f\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u308b\u3002<\/p>\n<p>(\u6ce89) RNA\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u8907\u5408\u4f53<br \/>\nRNA\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u8907\u5408\u4f53\u306f\u3001\u771f\u6838\u7d30\u80de\u306e\u6838\u5185\u3067RNA\u306e\u5206\u89e3\u3084\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u3053\u3068\u3002RNA\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u306f\u30019\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea(EXOSC1 \u2013 EXOSC9)\u304b\u3089\u69cb\u6210\u3055\u308c\u308bRNA\u5206\u89e3\u6d3b\u6027\u3092\u6301\u305f\u306a\u3044\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u30d0\u30ec\u30eb\u3068RNA\u5206\u89e3\u6d3b\u6027\u3092\u6709\u3059\u308bDIS3\u3084EXOSC10\u304b\u3089\u6210\u308b\u3002\u591a\u304f\u306eRNA\u5206\u5b50\u3092\u5bfe\u8c61\u3068\u3057\u3001\u4e3b\u306b\u4e0d\u5fc5\u8981\u306aRNA\u3084\u7570\u5e38\u306aRNA\u306e\u5206\u89e3\u3092\u884c\u3046\u3002RNA\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u8907\u5408\u4f53\u306e\u5236\u5fa1\u7570\u5e38\u306f\u3001\u304c\u3093\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u69d8\u3005\u306a\u75be\u60a3\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>(\u6ce810) 3\u2019\u672b\u7aef\u30b7\u30fc\u30af\u30a8\u30f3\u30b9<br 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