{"id":78076,"date":"2024-07-18T16:17:57","date_gmt":"2024-07-18T07:17:57","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=78076"},"modified":"2024-08-21T11:10:06","modified_gmt":"2024-08-21T02:10:06","slug":"versatile-deacylative-cross-coupling-of-aromatic-ketones%ef%bc%88published-in-political-behavior-september-2024%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/78076","title":{"rendered":"Versatile Deacylative Cross-coupling of Aromatic Ketones\uff08Published in Chem, September 2024\uff09"},"content":{"rendered":"<table class=\"table table-bordered table-colored-tbhd\" style=\"height: 550px; width: 100%; border-collapse: collapse; border-style: solid;\" border=\"1\">\n<tbody>\n<tr style=\"height: 78px;\">\n<td style=\"width: 19.0523%; height: 78px;\">Journal Title<br \/>\n\/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d<\/td>\n<td style=\"width: 80.849%; height: 78px;\">Chem<\/td>\n<\/tr>\n<tr style=\"height: 65px;\">\n<td style=\"width: 19.0523%; height: 80px;\">Publication Year and Month<br \/>\n\/\u63b2\u8f09\u5e74\u6708<\/td>\n<td style=\"width: 80.849%; height: 80px;\">September, 2024<\/td>\n<\/tr>\n<tr style=\"height: 55px;\">\n<td style=\"width: 19.0523%; height: 79px;\">Paper Title<br \/>\n\/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/td>\n<td style=\"width: 80.849%; height: 79px;\">Versatile Deacylative Cross-coupling of Aromatic Ketones<\/td>\n<\/tr>\n<tr style=\"height: 85px;\">\n<td style=\"width: 19.0523%; height: 85px;\">DOI<br \/>\n\/\u8ad6\u6587DOI<\/td>\n<td style=\"width: 80.849%; height: 85px;\"><a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2024-hd62q\">10.26434\/chemrxiv-2024-hd62q<\/a><\/td>\n<\/tr>\n<tr style=\"height: 59px;\">\n<td style=\"width: 19.0523%; height: 80px;\">\u00a0Author of Waseda University<br \/>\n\/\u672c\u5b66\u306e\u8457\u8005<\/td>\n<td style=\"width: 80.849%; height: 80px;\"><span style=\"font-family: inherit; font-size: inherit;\">Hikaru Nakahara(Student, Faculty of Science and Engineering, School of Advanced Science and Engineering):Lasr Author<\/span><\/td>\n<\/tr>\n<tr style=\"height: 68px;\">\n<td style=\"width: 19.0523%; height: 86px;\">Related Websites<br \/>\n\/\u95a2\u9023Web<\/td>\n<td style=\"width: 80.849%; height: 86px;\">&#8211;<\/td>\n<\/tr>\n<tr style=\"height: 138px;\">\n<td style=\"width: 19.0523%; height: 148px;\">Abstract<br \/>\n\/\u6284\u9332<\/td>\n<td style=\"width: 80.849%; height: 148px;\">Transition metal-catalyzed cross-couplings represent the most dependable techniques for linking aryl electrophiles with nucleophiles to synthesize a diverse array of valuable aromatic compounds. While aromatic ketones are crucial intermediates in the synthesis of aromatic compounds with numerous known methods for carbonyl transformations and aromatic ring modifications, few consider them as aryl electrophiles suitable for cross-coupling. This is primarily because forming new bonds with nucleophiles requires the cleavage of a strong C\u2013C bond. Herein, we introduce a cross-coupling method that effectively utilizes aromatic ketones as versatile aryl electrophiles. The cornerstone of our strategy is the transformation of aromatic ketones into aromatic esters via sequential Claisen and regioselective retro-Claisen condensations. The resulting esters are then capable of undergoing reactions with various nucleophiles in a one-pot process.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Journal Title \/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d Chem Publication Year and Month \/\u63b2\u8f09\u5e74\u6708 September, 2024 Paper Title \/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb Versatile De [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[218,217],"class_list":["post-78076","post","type-post","status-publish","format-standard","hentry","tag-impact-en","tag-impact"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/78076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=78076"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/78076\/revisions"}],"predecessor-version":[{"id":78253,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/78076\/revisions\/78253"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=78076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=78076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=78076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}