{"id":78062,"date":"2024-07-22T13:00:40","date_gmt":"2024-07-22T04:00:40","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=78062"},"modified":"2024-07-23T10:42:14","modified_gmt":"2024-07-23T01:42:14","slug":"%e5%85%89%e3%81%a7%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%ae%e5%87%9d%e9%9b%86%e3%82%92%e8%aa%98%e5%b0%8e%e3%81%99%e3%82%8b%e3%83%84%e3%83%bc%e3%83%ab%e3%81%8c%e3%82%a2%e3%83%ab%e3%83%84","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/78062","title":{"rendered":"\u5149\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u3092\u8a98\u5c0e\u3059\u308b\u30c4\u30fc\u30eb\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u7b49\u306e\u8133\u306b\u751f\u3058\u308b\u30bf\u30a6\u51dd\u96c6\u751f\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u65b0\u305f\u306a\u7406\u89e3\u3092\u5c0e\u304f"},"content":{"rendered":"<h2>\u5149\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u3092\u8a98\u5c0e\u3059\u308b\u30c4\u30fc\u30eb\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u7b49\u306e\u8133\u306b\u751f\u3058\u308b\u30bf\u30a6\u51dd\u96c6\u751f\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u65b0\u305f\u306a\u7406\u89e3\u3092\u5c0e\u304f<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78063\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/07\/29d3bc99193cb0b837fb8cc53f050ae5-3.jpg\" alt=\"\" width=\"1190\" height=\"1190\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/07\/29d3bc99193cb0b837fb8cc53f050ae5-3.jpg 1190w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/07\/29d3bc99193cb0b837fb8cc53f050ae5-3-610x610.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/07\/29d3bc99193cb0b837fb8cc53f050ae5-3-940x940.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/07\/29d3bc99193cb0b837fb8cc53f050ae5-3-768x768.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/07\/29d3bc99193cb0b837fb8cc53f050ae5-3-290x290.jpg 290w\" sizes=\"auto, (max-width: 1190px) 100vw, 1190px\" \/><\/p>\n<h3>\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul>\n<li>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u542b\u3080\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u3068\u7dcf\u79f0\u3055\u308c\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u60a3\u8005\u8133\u3067\u306f\u3001\u30bf\u30a6\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7570\u5e38\u306b\u96c6\u307e\u308a\u3001\u5927\u304d\u306a\u584a\uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316<sup>\u203b\uff11<\/sup>\uff09\u3068\u306a\u3063\u3066\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u524d\u6bb5\u968e\u306b\u306f\u5c0f\u3055\u306a\u584a\uff08\u30aa\u30ea\u30b4\u30de\u30fc\uff09\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3069\u306e\u3088\u3046\u306b\u305d\u308c\u3089\u304c\u5f62\u6210\u3059\u308b\u304b\u306f\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/li>\n<li>\u5149\u611f\u53d7\u6027\u30bf\u30f3\u30d1\u30af\u8ceaCRY2olig\u3092\u7528\u3044\u3066\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c0f\u3055\u306a\u584a\u304b\u3089\u5927\u304d\u306a\u584a\u307e\u3067\u306e\u51dd\u96c6\u904e\u7a0b\u3092\u5236\u5fa1\u3059\u308b\u5b9f\u9a13\u7cfb\u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>\u3053\u306e\u7814\u7a76\u306f\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304a\u308a\u3001\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u75c5\u614b\u7406\u89e3\u306e\u305f\u3081\u306e\u57fa\u790e\u7684\u77e5\u898b\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n<h4>\u6982\u8981<\/h4>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001951_ja.html\" target=\"_blank\" rel=\"noopener\">\u5742\u5185\u535a\u5b50<\/a>\u6559\u6388\u3001\u5b66\u7fd2\u9662\u5927\u5b66\u7406\u5b66\u90e8\u751f\u547d\u79d1\u5b66\u79d1\u306e\u6dfb\u7530\u7fa9\u884c\u52a9\u6559\u3001\u5927\u5b66\u9662\u751f\u306e\u5c0f\u6c60\u529b\u3055\u3093\u3001\u9ad8\u5cf6\u660e\u5f66\u6559\u6388\u3001\u690e\u8449\u4e00\u5fc3\u52a9\u6559\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7cfb\u7814\u7a76\u79d1\u306e\u5409\u6751\u82f1\u54f2\u52a9\u6559\u3089\u304b\u3089\u306a\u308b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u542b\u3080\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u3068\u7dcf\u79f0\u3055\u308c\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u60a3\u8005\u8133\u306b\u89b3\u5bdf\u3055\u308c\u308b\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u7570\u5e38\u306a\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u306e\u304b\u3001\u305d\u306e\u904e\u7a0b\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u5149\u53cd\u5fdc\u30bf\u30f3\u30d1\u30af\u8ceaCRY2olig\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u52d5\u304d\u3092\u5236\u5fa1\u3057\u3001\u75c5\u6c17\u306e\u9032\u884c\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u624b\u304c\u304b\u308a\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u3092\u4fc3\u9032\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u7b49\u306e\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u75c5\u614b\u7406\u89e3\u306e\u305f\u3081\u306e\u57fa\u790e\u7684\u77e5\u898b\u306e\u84c4\u7a4d\u306b\u8ca2\u732e\u3057\u307e\u3059\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u30012024\u5e747\u670820\u65e5\u5348\u524d1\u6642(\u65e5\u672c\u6642\u9593)\u306bCell Press\uff08\u7c73\u56fd\uff09\u306e\u79d1\u5b66\u96d1\u8a8c<em>Structure<\/em>\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>\u7814\u7a76\u306e\u80cc\u666f<\/h4>\n<p>\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7d30\u80de\u306e\u4e2d\u306b\u5b58\u5728\u3057\u3001\u5fae\u5c0f\u7ba1\u3068\u3044\u3046\u7d30\u80de\u306e\u69cb\u9020\u3092\u5b89\u5b9a\u3055\u305b\u308b\u7d30\u80de\u9aa8\u683c\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u306f\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7570\u5e38\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u7b49\u306b\u3088\u308a\u3001\u5fae\u5c0f\u7ba1\u304b\u3089\u96e2\u308c\u308b\u3053\u3068\u3001\u307e\u305f\u6c34\u6eb6\u6027\u306e\u72b6\u614b\u304b\u3089\u4e0d\u6eb6\u6027\u306e\u584a\u3092\u4f5c\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7570\u5e38\u306a\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5bc6\u306a\u584a\uff08\u51dd\u96c6\u4f53\uff09\u304c\u3001\u75c5\u6c17\u306e\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6db2\u4f53\u306e\u3088\u3046\u306a\u72b6\u614b\u304b\u3089\u56fa\u4f53\u306e\u584a\u306b\u5909\u308f\u308b\u904e\u7a0b\u304c\u75c5\u6c17\u306e\u7406\u89e3\u306b\u91cd\u8981\u3067\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u7814\u7a76\u306f\u5341\u5206\u306b\u884c\u308f\u308c\u3066\u304a\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u904e\u7a0b\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001\u9752\u8272\u306e\u5149\u3067\u53cd\u5fdc\u3059\u308b\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u3068\u3044\u3046\u690d\u7269\u7531\u6765\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5909\u7570\u4f53CRY2olig\u4f7f\u3063\u3066\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u3092\u5236\u5fa1\u3057\u3001\u305d\u306e\u904e\u7a0b\u3092\u8a73\u7d30\u306b\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>\u7814\u7a76\u306e\u5185\u5bb9<\/strong><\/h4>\n<p><strong>\u5149\u7167\u5c04\u306b\u3088\u308b\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5909\u5316<\/strong><\/p>\n<p>\u51dd\u96c6\u3057\u3084\u3059\u3044P301L\u5909\u7570\u3092\u6301\u3064\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5149\u611f\u53d7\u6027\u30bf\u30f3\u30d1\u30af\u8ceaCRY2olig\u3092\u878d\u5408\u3055\u305b\u305f\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8ceaOptoTau\u3092\u4f7f\u7528\u3057\u3001\u5149\u7167\u5c04\u306b\u5fdc\u7b54\u3057\u3066\u5909\u5316\u3059\u308b\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6319\u52d5\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u64cd\u4f5c\u3057\u307e\u3057\u305f\u3002\u9752\u8272\u5149\u306e\u7167\u5c04\u3067\u3001OptoTau\u306f\u75c5\u6c17\u3067\u89b3\u5bdf\u3055\u308c\u308b\u3088\u3046\u306a\u30ea\u30f3\u9178\u5316\u72b6\u614b\u306b\u5909\u308f\u308a\u3001\u307e\u305f\u3001\u7d30\u80de\u5185\u3067\u30bf\u30a6\u540c\u58eb\u304c\u96c6\u307e\u308b\u30af\u30e9\u30b9\u30bf\u30fc\u5f62\u6210\u304c\u4fc3\u9032\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u30af\u30e9\u30b9\u30bf\u30fc\u306f\u7d30\u80de\u6838\u306e\u5468\u308a\u306b\u96c6\u4e2d\u3057\u3066\u304a\u308a\u3001\u30a2\u30b0\u30ea\u30bd\u30fc\u30e0\u3068\u3044\u3046\u51dd\u96c6\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u51e6\u7406\u3059\u308b\u305f\u3081\u306e\u30b7\u30b9\u30c6\u30e0\u306b\u9694\u96e2\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><strong>\u30a2\u30b0\u30ea\u30bd\u30fc\u30e0\u306e\u7834\u58ca\u5b9f\u9a13<\/strong><\/p>\n<p>\u5fae\u5c0f\u7ba1\u306e\u5f62\u6210\u3092\u963b\u5bb3\u3059\u308b\u85ac\uff08\u30ce\u30b3\u30c0\u30be\u30fc\u30eb\uff09\u3092\u4f7f\u7528\u3057\u3001\u30a2\u30b0\u30ea\u30bd\u30fc\u30e0\u3092\u7834\u58ca\u3057\u307e\u3057\u305f\u3002\u5b9f\u9a13\u3067\u306f\u3001\u9752\u8272\u5149\u306e\u7167\u5c04\u306b\u3088\u3063\u3066OptoTau\u304c\u7d30\u80de\u5168\u4f53\u306b\u6563\u5728\u3057\u3001\u30a2\u30b0\u30ea\u30bd\u30fc\u30e0\u3067\u306f\u306a\u304f\u819c\u306e\u306a\u3044\u69cb\u9020\u4f53\u304c\u5f62\u6210\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u751f\u547d\u79d1\u5b66\u5206\u91ce\u3067\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30c8\u30d4\u30c3\u30af\u306e\uff11\u3064\u3067\u3042\u308b\u6db2-\u6db2\u76f8\u5206\u96e2<sup>\u203b2<\/sup>\u3067\u5f62\u6210\u3055\u308c\u308b\u30c9\u30ed\u30c3\u30d7\u30ec\u30c3\u30c8\u3067\u3042\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u7d50\u679c\u306f\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u6db2\u6ef4\u306e\u3088\u3046\u306a\u69cb\u9020\u304b\u3089\u56fa\u4f53\u306e\u584a\u306b\u5909\u308f\u308b\u904e\u7a0b\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>N<\/strong><strong>\u672b\u7aef\u6b20\u5931OptoTau\u306e\u52b9\u679c<\/strong><\/p>\n<p>\u3053\u306eOptoTau\u3092\u771f\u3093\u4e2d\u4ed8\u8fd1\u3067\u5207\u65ad\u3057\u305fN\u672b\u7aef<sup>\u203b3<\/sup>\u304c\u6b20\u5931\u3057\u3066\u3044\u308bOptoTau-\u0394N\u306f\u3001\u9752\u8272\u5149\u306e\u7167\u5c04\u306b\u3088\u3063\u3066OptoTau\u3088\u308a\u5f37\u529b\u306a\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u308c\u304c\u6b63\u5e38\u306a\u30bf\u30a6\u3092\u30bf\u30a6\u7dda\u7dad<sup>\u203b4<\/sup>\u306b\u5909\u63db\u3055\u305b\u308b\u7a2e\uff08\u30b7\u30fc\u30c9\uff09\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u3001N\u672b\u7aef\u306e\u6b20\u5931\u304c\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5f37\u5316\u3057\u3001\u6db2\u6ef4\u304b\u3089\u5b89\u5b9a\u3057\u305f\u51dd\u96c6\u4f53\u3078\u306e\u5909\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u305d\u306e\u30bf\u30a6\u306f\u3001\u6b63\u5e38\u306a\u30bf\u30a6\u3092\u7570\u5e38\u51dd\u96c6\u30bf\u30a6\u306b\u5909\u63db\u3055\u305b\u308b\u80fd\u529b\u3092\u6301\u3064\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>\u672c\u7814\u7a76\u6210\u679c\u304c\u793e\u4f1a\u306b\u4e0e\u3048\u308b\u5f71\u97ff\uff08\u672c\u7814\u7a76\u6210\u679c\u306e\u610f\u7fa9<\/strong>\uff09<\/h4>\n<p>\u672c\u7814\u7a76\u306f\u3001\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u7570\u5e38\u306a\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u306e\u304b\u3001\u305d\u306e\u904e\u7a0b\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u5149\u53cd\u5fdc\u30bf\u30f3\u30d1\u30af\u8ceaCRY2olig\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u52d5\u304d\u3092\u5236\u5fa1\u3057\u3001\u75c5\u6c17\u306e\u9032\u884c\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u624b\u304c\u304b\u308a\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u306e\u57fa\u790e\u7684\u77e5\u898b\u306e\u84c4\u7a4d\u306b\u8ca2\u732e\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4>\u767a\u8868\u8005<\/h4>\n<p>\u6dfb\u7530 \u7fa9\u884c \u5b66\u7fd2\u9662\u5927\u5b66\u7406\u5b66\u90e8\u751f\u547d\u79d1\u5b66\u79d1 \u52a9\u6559<br \/>\n\u5409\u6751 \u82f1\u54f2 \u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7cfb\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b \u52a9\u6559<br \/>\n\u5742\u5185 \u535a\u5b50 \u65e9\u7a32\u7530\u5927\u5b66\u5148\u9032\u7406\u5de5\u5b66\u90e8\u96fb\u6c17\u30fb\u60c5\u5831\u751f\u547d\u5de5\u5b66\u79d1 \u6559\u6388<br \/>\n\u5c0f\u6c60 \u529b \u5b66\u7fd2\u9662\u5927\u5b66\u2f24\u5b66\u9662\u2f83\u7136\u79d1\u5b66\u7814\u7a76\u79d1 \u535a\u58eb\u8ab2\u7a0b\uff13\u5e74\u751f<br \/>\n\u690e\u8449 \u4e00\u5fc3 \u5b66\u7fd2\u9662\u5927\u5b66\u7406\u5b66\u90e8\u751f\u547d\u79d1\u5b66\u79d1 \u52a9\u6559<br \/>\n\u9ad8\u5cf6 \u660e\u5f66 \u5b66\u7fd2\u9662\u5927\u5b66\u7406\u5b66\u90e8\u751f\u547d\u79d1\u5b66\u79d1 \u6559\u6388<\/p>\n<h4><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h4>\n<p>\u8ad6\u6587\u540d\uff1aIntracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils<br \/>\n\u96d1\u8a8c\uff1a<em>Structure<br \/>\n<\/em>\u8457\u8005\u540d\uff1aYoshiyuki Soeda, Hideaki Yoshimura, Hiroko Bannai, Riki Koike, Isshin Shiiba, Akihiko Takashima<br \/>\nDOI\uff1a<a href=\"https:\/\/doi.org\/10.1016\/j.str.2024.06.018\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.str.2024.06.018<\/a><\/p>\n<h4><strong>\u7814\u7a76\u52a9\u6210<\/strong><\/h4>\n<p>\u672c\u7814\u7a76\u306f\u3001\u6587\u90e8\u79d1\u5b66\u7701\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\u65b0\u5b66\u8853\u9818\u57df\u7814\u7a76\u300c\u30b7\u30f3\u30ae\u30e5\u30e9\u30ea\u30c6\u30a3\u751f\u7269\u5b66\u300d(\u9818\u57df\u756a\u53f78007) \uff08\u8ab2\u984c\u756a\u53f718H05414\u304a\u3088\u307318H05410\uff09\u3001\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\uff08Grant Number 20K06896\u300123K05993\u300123H02102\u00a0\u300123K18116\u300122K15399\u300122H05574\u304a\u3088\u307324H01327\uff09\u3001\u6b66\u7530\u79d1\u5b66\u632f\u8208\u8ca1\u56e3\u3001\u5b89\u500d\u80fd\u6210\u8a18\u5ff5\u6559\u80b2\u57fa\u91d1\u5b66\u8853\u7814\u7a76\u52a9\u6210\u91d1\u304a\u3088\u3073\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb(AMED)\u306e\u8ab2\u984c\u756a\u53f7JP15km0908001\u306e\u652f\u63f4\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u672c\u767a\u8868\u306f\u5b66\u7fd2\u9662\u5927\u5b66\u30b0\u30e9\u30f3\u30c9\u30c7\u30b6\u30a4\u30f3 2039\u300c\u56fd\u969b\u5b66\u8853\u8a8c\u8ad6\u6587\u63b2\u8f09\u88dc\u52a9\u4e8b\u696d\u300d\u3088\u308a\u63b2\u8f09\u8cbb\u306e\u52a9\u6210\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/h4>\n<p>\u203b1 \u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316<br \/>\n\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316\u306f\u3001\u8133\u306e\u795e\u7d4c\u7d30\u80de\u5185\u3067\u30bf\u30a6\u3068\u547c\u3070\u308c\u308b\u5fae\u5c0f\u7ba1\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7570\u5e38\u306b\u51dd\u96c6\u3057\u3001\u84c4\u7a4d\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u3053\u308c\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\uff11\u3064\u3067\u3042\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u7406\u5b66\u7684\u7279\u5fb4\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u30bf\u30a6\u304c\u7570\u5e38\u84c4\u7a4d\u3059\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u4ee5\u5916\u306b\u3082\u30d4\u30c3\u30af\u75c5\u3084\u6162\u6027\u5916\u50b7\u6027\u8133\u75c7\u306a\u3069\u304c\u3042\u308a\u3001\u305d\u308c\u3089\u306e\u75be\u60a3\u306f\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u3068\u7dcf\u79f0\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b2 \u6db2-\u6db2\u76f8\u5206\u96e2<br \/>\n\u6db2-\u6db2\u76f8\u5206\u96e2\uff08\u3048\u304d-\u3048\u304d\u305d\u3046\u3076\u3093\u308a\uff09\u3068\u306f\u30012\u3064\u4ee5\u4e0a\u306e\u6db2\u4f53\u304c\u6df7\u3056\u308a\u5408\u308f\u305a\u306b\u5225\u3005\u306e\u5c64\u3092\u5f62\u6210\u3059\u308b\u73fe\u8c61\u306e\u3053\u3068\u3067\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3082\u8d77\u3053\u308a\u3001\u5f62\u72b6\u306f\u7403\u72b6\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u5c40\u6240\u6fc3\u5ea6\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6db2-\u6db2\u76f8\u5206\u96e2\u3057\u3066\u8d77\u3053\u308b\u7403\u72b6\u306e\u69cb\u9020\u4f53\u306f\u30c9\u30ed\u30c3\u30d7\u30ec\u30c3\u30c8\u3001\u30b3\u30f3\u30c7\u30f3\u30bb\u30fc\u30c8\u3001\u30b3\u30a2\u30bd\u30eb\u30d9\u30fc\u30c8\u7b49\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b3 \u00a0N\u672b\u7aef<br \/>\n\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5148\u982d\u306f\u3001\u30a2\u30df\u30ce\u57fa\u306e\u3082\u3064N(\u7a92\u7d20\u539f\u5b50)\u306b\u7531\u6765\u3057\u3066N\u672b\u7aef\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u30bf\u30a6\u306b\u304a\u3044\u3066\u306f\u3001\u56f3\u306eN-terminal\u3068\u3044\u3046\u90e8\u5206\u304c\u8a72\u5f53\u3057\u307e\u3059\u3002<\/p>\n<p><strong>\u00a0<\/strong>\u203b4 \u30bf\u30a6\u7dda\u7dad<br \/>\n\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u7b49\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3044\u3066\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u591a\u6570\u96c6\u307e\u308b\u3053\u3068\u3067\u51dd\u96c6\u72b6\u614b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u51dd\u96c6\u72b6\u614b\u306f\u5c0f\u3055\u306a\u584a\u304b\u3089\u5927\u304d\u3044\u584a\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3067\u751f\u3058\u307e\u3059\u3002\u5927\u304d\u306a\u584a\u306b\u306f\u3001\u30bf\u30a6\u304c\u7dda\u7dad\u5316\u3057\u305f\u3082\u306e\u304c\u591a\u6570\u542b\u307e\u308c\u307e\u3059<strong>\u3002<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5149\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u3092\u8a98\u5c0e\u3059\u308b\u30c4\u30fc\u30eb\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u7b49\u306e\u8133\u306b\u751f\u3058\u308b\u30bf\u30a6\u51dd\u96c6\u751f\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u65b0\u305f\u306a\u7406\u89e3\u3092\u5c0e\u304f \u30dd\u30a4\u30f3\u30c8 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u542b\u3080\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u3068\u7dcf\u79f0\u3055\u308c\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u60a3\u8005\u8133\u3067\u306f\u3001\u30bf\u30a6\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":78067,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[145,178],"class_list":["post-78062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/78062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=78062"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/78062\/revisions"}],"predecessor-version":[{"id":78113,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/78062\/revisions\/78113"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/78067"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=78062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=78062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=78062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}