{"id":77744,"date":"2024-05-17T15:37:44","date_gmt":"2024-05-17T06:37:44","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=77744"},"modified":"2024-08-21T11:14:24","modified_gmt":"2024-08-21T02:14:24","slug":"polygenicrisk-scorecardiorespiratory-fitness-and-cardiometabolicrisk-factors-wasedas-health-study%ef%bc%88published-in-political-behavior-may-2024%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/77744","title":{"rendered":"Polygenicrisk score,cardiorespiratory fitness, and cardiometabolicrisk factors: WASEDA’s Health Study\uff08Published in Medicine and Science in Sports and Exercise, May 2024\uff09"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n
Journal Title
\n\/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d<\/td>\n		Medicine and Science in Sports and Exercise<\/td>\n<\/tr>\n
Publication Year and Month
\n\/\u63b2\u8f09\u5e74\u6708<\/td>\n		May, 2024<\/td>\n<\/tr>\n
Paper Title
\n\/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/td>\n		Polygenicrisk score,cardiorespiratory fitness, and cardiometabolicrisk factors: WASEDA’s Health Study<\/td>\n<\/tr>\n
DOI
\n\/\u8ad6\u6587DOI<\/td>\n		10.1249\/MSS.0000000000003477<\/a><\/td>\n<\/tr>\n
\u00a0Author of Waseda University
\n\/\u672c\u5b66\u306e\u8457\u8005<\/td>\n		TANISAWA, Kumpei(Associate Professor, Faculty of Sport Sciences, School of Sport and Sciences):Lasr Author<\/td>\n<\/tr>\n
Related Websites
\n\/\u95a2\u9023Web<\/td>\n		–<\/td>\n<\/tr>\n
Abstract
\n\/\u6284\u9332<\/td>\n		\n

Purpose<\/h3>\n

This study estimated an individual’s genetic liability to cardiometabolic risk factors by polygenic risk score (PRS) construction and examined whether high cardiorespiratory fitness (CRF) modifies the association between PRS and cardiometabolic risk factors.<\/p>\n

Methods<\/h3>\n

This cross-sectional study enrolled 1,296 Japanese adults aged \u226540 years. The PRS for each cardiometabolic trait (blood lipids, glucose, hypertension, and obesity) was calculated using the LDpred2 and clumping and thresholding methods. Participants were divided into low-, intermediate-, and high-PRS groups according to PRS tertiles for each trait. CRF was quantified as peak oxygen uptake (VO2<\/sub>peak) per kg body weight. Participants were divided into low-, intermediate-, and high-CRF groups according to the tertile VO2<\/sub>peak value.<\/p>\n

Results<\/h3>\n

Linear regression analysis revealed a significant interaction between PRS for triglyceride (PRSTG<\/sub>) and CRF groups on serum TG levels regardless of the PRS calculation method, and attenuated the association between PRSTG<\/sub>\u00a0and TG levels in the high-CRF group. Logistic regression analysis revealed a significant sub-additive interaction between LDpred2 PRSTG<\/sub>\u00a0and CRF on the prevalence of high TG, indicating that high CRF attenuated the genetic predisposition to high TG. Furthermore, a significant sub-additive interaction between PRS for body mass index and CRF on obesity was detected regardless of the PRS calculation method. These significant interaction effects on high TG and obesity were diminished in the sensitivity analysis using VO2<\/sub>peak per kg fat-free mass as the CRF index. Effects of PRSs for other cardiometabolic traits were not significantly attenuated in the high-CRF group regardless of PRS calculation methods.<\/p>\n

Conclusions<\/h3>\n

The findings of the present study suggest that individuals with high CRF overcome the genetic predisposition to high TG levels and obesity.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Journal Title \/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d Medicine and Science in Sports and Exercise Publication Year and Month \/\u63b2\u8f09\u5e74\u6708 May, 2024 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[218,217],"class_list":["post-77744","post","type-post","status-publish","format-standard","hentry","tag-impact-en","tag-impact"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/77744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=77744"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/77744\/revisions"}],"predecessor-version":[{"id":78260,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/77744\/revisions\/78260"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=77744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=77744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=77744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}