{"id":77567,"date":"2024-05-24T13:17:35","date_gmt":"2024-05-24T04:17:35","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=77567"},"modified":"2024-05-24T13:17:35","modified_gmt":"2024-05-24T04:17:35","slug":"%e9%ab%98%e4%b8%ad%e6%80%a7%e8%84%82%e8%82%aa%e8%a1%80%e7%97%87%e3%83%bb%e8%82%a5%e6%ba%80%e3%81%ae%e3%80%8e%e9%81%ba%e4%bc%9d%e7%9a%84%e3%81%aa%e3%83%aa%e3%82%b9%e3%82%af%e3%80%8f%e3%82%92%e6%8a%91","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/77567","title":{"rendered":"\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u30fb\u80a5\u6e80\u306e\u300e\u907a\u4f1d\u7684\u306a\u30ea\u30b9\u30af\u300f\u3092\u6291\u5236"},"content":{"rendered":"<h1>\u5168\u8eab\u6301\u4e45\u529b\u5411\u4e0a\u3078\u306e\u53d6\u308a\u7d44\u307f\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u52b9\u679c<\/h1>\n<h2>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/h2>\n<ul>\n<li>\u80a5\u6e80\u3001\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\uff08\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3001\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff09\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001\u6570\u5341\u4e07\u306e\u4e00\u5869\u57fa\u591a\u578b\u306e\u5f71\u97ff\u3092\u70b9\u6570\u5316\u3057\u305f\u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08polygenic risk score\uff1aPRS\uff09\u3092\u69cb\u7bc9<\/li>\n<li>\u69cb\u7bc9\u3057\u305fPRS\u3092\u7528\u3044\u3066\u3001\u80a5\u6e80\u3001\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u306b\u5bfe\u3059\u308b\u5168\u8eab\u6301\u4e45\u529b\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u691c\u8a0e<\/li>\n<li>\u9ad8\u3044\u5168\u8eab\u6301\u4e45\u529b\u3092\u6709\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u304a\u3088\u3073\u80a5\u6e80\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b<\/li>\n<\/ul>\n<h3><strong>\u6982\u8981<\/strong><\/h3>\n<p><a href=\"https:\/\/www.waseda.jp\/fsps\/\" target=\"_blank\" rel=\"noopener\">\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662<\/a>\u306e<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001823_ja.html\" target=\"_blank\" rel=\"noopener\">\u8c37\u6fa4\u85ab\u5e73<\/a>\u51c6\u6559\u6388\u3068<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000055_ja.html\" target=\"_blank\" rel=\"noopener\">\u5ca1\u6d69\u4e00\u6717<\/a>\u6559\u6388\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u9ad8\u3044\u5168\u8eab\u6301\u4e45\u529b<sup>\u203b1<\/sup>\u3092\u6709\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u304a\u3088\u3073\u80a5\u6e80\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\u300e<a href=\"https:\/\/www.acsm.org\/education-resources\/journals\/medicine-science-in-sports-exercise\" target=\"_blank\" rel=\"noopener\">Medicine &amp; Science in Sports &amp; Exercise<\/a>\u300f\uff08\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/journals.lww.com\/acsm-msse\/abstract\/9900\/polygenic_risk_score,_cardiorespiratory_fitness,.539.aspx\" target=\"_blank\" rel=\"noopener\">Polygenic risk score, cardiorespiratory fitness, and cardiometabolic risk factors: WASEDA\u2019S Health Study<\/a>\uff09\u306b\u3066\u30012024\u5e745\u670821\u65e5\uff08\u6c34\u66dc\u65e5\uff09\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>\uff081\uff09\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/h4>\n<p>\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u306f\u3001\u5168\u4e16\u754c\u306e\u6b7b\u56e0\u306e\u7d0432%\u3092\u5360\u3081\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u305d\u306e\u4e88\u9632\u306f\u4e16\u754c\u7684\u306b\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3059\u3002\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u7387\u306f\u3001\u80a5\u6e80\u3001\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u306a\u3069\u306e\u30ea\u30b9\u30af\u56e0\u5b50\uff08\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\uff09\u306e\u4fdd\u6709\u306b\u3088\u308a\u9ad8\u307e\u308a\u307e\u3059\u3002\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u306f\u826f\u3044\u751f\u6d3b\u7fd2\u6163\u306b\u3088\u308a\u6539\u5584\u3059\u308b\u4e00\u65b9\u3067\u3001\u907a\u4f1d\u306e\u5f71\u97ff\u3082\u5c11\u306a\u304b\u3089\u305a\u53d7\u3051\u308b\u305f\u3081\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8003\u616e\u3057\u3066\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u53d6\u308a\u7d44\u3080\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u751f\u6d3b\u7fd2\u6163\u306e\u4e2d\u3067\u3082\u3068\u308a\u308f\u3051\u8eab\u4f53\u6d3b\u52d5\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306f\u591a\u304f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5b58\u5728\u3057\u3001\u8eab\u4f53\u6d3b\u52d5\u91cf\u304c\u591a\u3044\u4eba\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u7387\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u304c\u4f4e\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u7fd2\u6163\u7684\u306a\u8eab\u4f53\u6d3b\u52d5\u30fb\u904b\u52d5\u306b\u3088\u308a\u5411\u4e0a\u3059\u308b\u5168\u8eab\u6301\u4e45\u529b\u304c\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u7387\u4f4e\u4e0b\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u591a\u6570\u5b58\u5728\u3057\u307e\u3059\u3002\u5168\u8eab\u6301\u4e45\u529b\u306f\u65e5\u5e38\u306e\u8eab\u4f53\u6d3b\u52d5\u91cf\u3092\u53cd\u6620\u3059\u308b\u6307\u6a19\u3067\u3042\u308b\u3053\u3068\u306b\u52a0\u3048\u3001\u5fc3\u81d3\u3084\u80ba\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u3001\u8eab\u4f53\u306e\u69d8\u3005\u306a\u5668\u5b98\u306e\u6a5f\u80fd\u3092\u53cd\u6620\u3059\u308b\u6307\u6a19\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5168\u8eab\u6301\u4e45\u529b\u306f\u8eab\u4f53\u6d3b\u52d5\u305d\u306e\u3082\u306e\u3088\u308a\u3082\u6b7b\u4ea1\u3084\u75be\u60a3\u767a\u75c7\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u304a\u308a\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u6307\u6a19\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u300c\u907a\u4f1d\u7684\u306b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306b\u304a\u3044\u3066\u3082\u3001\u5168\u8eab\u6301\u4e45\u529b\u5411\u4e0a\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u6539\u5584\u52b9\u679c\u306f\u5f97\u3089\u308c\u308b\u304b\uff1f\u300d\u3042\u308b\u3044\u306f\u300c\u5168\u8eab\u6301\u4e45\u529b\u3092\u9ad8\u304f\u4fdd\u3064\u3053\u3068\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u306a\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u5897\u52a0\u304c\u6291\u5236\u3055\u308c\u308b\u304b\uff1f\u300d\u3068\u3044\u3063\u305f\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u5bfe\u3059\u308b\u5168\u8eab\u6301\u4e45\u529b\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528<sup>\u203b2<\/sup>\u306f\u5341\u5206\u306b\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u5bfe\u3059\u308b\u5168\u8eab\u6301\u4e45\u529b\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u8abf\u3079\u305f\u7814\u7a76\u3067\u306f\u3001\u3042\u308b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphism\uff1aSNP\uff09<sup>\u203b3<\/sup>\u3092\u8907\u6570\u5206\u6790\u3057\u3001\u305d\u308c\u3089\u306e\u5f71\u97ff\u3092\u70b9\u6570\u5316\u3057\u305f\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08genetic risk score\uff1aGRS) <sup>\u203b4<\/sup>\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3044\u305a\u308c\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3082\u3001GRS\u69cb\u7bc9\u306e\u305f\u3081\u306b\u6570\u500b\u301c\u6570\u5341\u500b\u306eSNP\u3057\u304b\u7528\u3044\u3066\u304a\u3089\u305a\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u7cbe\u5ea6\u306b\u8ab2\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\u306f\u591a\u56e0\u5b50\u907a\u4f1d\u5f62\u8cea<sup>\u203b5<\/sup>\u3067\u3042\u308a\u3001\u591a\u6570\u306eSNP\u3068\u74b0\u5883\u8981\u56e0\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u95a2\u9023\u3059\u308b\u5c11\u6570\u306eSNP\u3092\u7528\u3044\u308b\u3060\u3051\u3067\u306f\u7cbe\u5ea6\u9ad8\u304f\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff082\uff09<strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h4>\n<p>\u305d\u3053\u3067\u6211\u3005\u306f\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u5b58\u5728\u3059\u308b\u7121\u6570\u306eSNP\u304c\u76f8\u52a0\u7684\u306b\u5f62\u8cea\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u3044\u3046\u4eee\u8aac\uff08polygenic model\uff09\u306b\u57fa\u3065\u304d\u3001\u6570\u5341\u4e07\u306eSNP\u306e\u5f71\u97ff\u3092\u70b9\u6570\u5316\u3057\u305f\u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08polygenic risk score\uff1aPRS) <sup>\u203b6<\/sup>\u3092\u3001\u80a5\u6e80\u3001\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\uff08\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3001\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff09\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u3068\u3044\u3063\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u5bfe\u3057\u3066\u305d\u308c\u305e\u308c\u69cb\u7bc9\u3057\u307e\u3057\u305f\uff08\u56f31\uff09\u3002PRS\u3092\u7528\u3044\u3066\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3088\u308a\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u5bfe\u3059\u308b\u5168\u8eab\u6301\u4e45\u529b\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u3088\u308a\u7cbe\u5ea6\u9ad8\u304f\u691c\u8a0e\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-77576\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/05\/tanisawa_1.png\" alt=\"\" width=\"673\" height=\"478\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/05\/tanisawa_1.png 673w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/05\/tanisawa_1-610x433.png 610w\" sizes=\"auto, (max-width: 673px) 100vw, 673px\" \/><\/p>\n<p>\u5177\u4f53\u7684\u306b\u306f\u3001\u65e9\u7a32\u7530\u5927\u5b66\u306e\u6821\u53cb\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5065\u5eb7\u3065\u304f\u308a\u7814\u7a76\u300c<a href=\"https:\/\/wasedas-health-study.jp\/survey\/\" target=\"_blank\" rel=\"noopener\">WASEDA\u2019S Health Study<\/a><sup>\u203b7<\/sup>\u300d\u306b\u53c2\u52a0\u3057\u305f40\uff5e87\u6b73\u306e\u7537\u59731296\u540d\u304b\u3089\u63a1\u53d6\u3057\u305fDNA\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u3066\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u5b58\u5728\u3059\u308b\u6570\u767e\u4e07\u500b\u306eSNP\u3092\u7db2\u7f85\u7684\u306b\u89e3\u6790\u3057\u3001\u305d\u306e\u3046\u3061\u306e\u7d0481\u4e07\u500b\u306eSNP\u3092\u7528\u3044\u3066\u3001\u5404\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50\u306ePRS\u3092\u500b\u4eba\u6bce\u306b\u8a08\u7b97\u3057\u307e\u3057\u305f\u3002\u5404SNP\u306e\u5f71\u97ff\u306e\u5927\u304d\u3055\uff08\u52b9\u679c\u91cf\uff09\u306f\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u305f\u3081\u3001\u904e\u53bb\u306b\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u30fb\u30b8\u30e3\u30d1\u30f3<sup>\u203b8<\/sup>\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u305f\u81e8\u5e8a\u691c\u67fb\u5024\u304a\u3088\u3073BMI\u306e\u5927\u898f\u6a21\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790<sup>\u203b9<\/sup>\u306e\u8981\u7d04\u7d71\u8a08\u91cf\u3092\u7528\u3044\u3066SNP\u306e\u91cd\u307f\u4ed8\u3051\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u5168\u8eab\u6301\u4e45\u529b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001\u81ea\u8ee2\u8eca\u30a8\u30eb\u30b4\u30e1\u30fc\u30bf\u30fc\u3092\u7528\u3044\u305f\u904b\u52d5\u8ca0\u8377\u8a66\u9a13\u3092\u884c\u3044\u6700\u9ad8\u9178\u7d20\u6442\u53d6\u91cf<sup>\u203b10<\/sup>\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002PRS\u306b\u3064\u3044\u3066\u306f\u5404PRS\u306e\u4e09\u5206\u4f4d\u3067\u4f4e\u30fb\u4e2d\u30fb\u9ad8PRS\u7fa4\u306e3\u7fa4\u306b\u3001\u5168\u8eab\u6301\u4e45\u529b\u306b\u3064\u3044\u3066\u306f\u6027\u30fb\u5e74\u9f62\u968e\u7d1a\u5225\u306e\u6700\u9ad8\u9178\u7d20\u6442\u53d6\u91cf\u306e\u4e09\u5206\u4f4d\u3067\u4f4e\u30fb\u4e2d\u30fb\u9ad8\u5168\u8eab\u6301\u4e45\u529b\u7fa4\u306e3\u7fa4\u306b\u5206\u985e\u3057\u3001\u5404\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u6e2c\u5b9a\u5024\u3084\u6709\u75c5\u7387\u3092\u7fa4\u9593\u3067\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u5404\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u5bfe\u3059\u308bPRS\u3068\u5168\u8eab\u6301\u4e45\u529b\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5206\u6790\u3057\u305f\u7d50\u679c\u3001\u8840\u6e05\u4e2d\u6027\u8102\u80aa\u6fc3\u5ea6\u306b\u5bfe\u3059\u308b\u4e2d\u6027\u8102\u80aa\u306ePRS\u3068\u5168\u8eab\u6301\u4e45\u529b\u306e\u6709\u610f\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u8a8d\u3081\u3089\u308c\u3001\u5168\u8eab\u6301\u4e45\u529b\u304c\u9ad8\u3044\u307b\u3069\u3001\u4e2d\u6027\u8102\u80aa\u306ePRS\u3068\u8840\u6e05\u4e2d\u6027\u8102\u80aa\u6fc3\u5ea6\u306e\u95a2\u9023\u304c\u5f31\u307e\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u56f32\u306b\u793a\u3057\u305f\u901a\u308a\u3001\u4f4e\u5168\u8eab\u6301\u4e45\u529b\u7fa4\u306b\u304a\u3044\u3066\u306f\u4f4ePRS\u7fa4\u3068\u9ad8PRS\u7fa4\u9593\u306e\u4e2d\u6027\u8102\u80aa\u6fc3\u5ea6\u5dee\u306f50.1 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-77575\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/05\/tanisawa_3.png\" alt=\"\" width=\"569\" height=\"363\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-77578\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/05\/tanisawa_4.png\" alt=\"\" width=\"495\" height=\"384\" \/><\/p>\n<h4>\uff083\uff09<strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/strong><\/h4>\n<p>\u9ad8\u3044\u5168\u8eab\u6301\u4e45\u529b\u3092\u6709\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3084\u80a5\u6e80\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u6291\u5236\u3055\u308c\u308b\u3068\u3044\u3046\u672c\u7814\u7a76\u306e\u77e5\u898b\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u304a\u3051\u308b\u5168\u8eab\u6301\u4e45\u529b\u306e\u91cd\u8981\u6027\u3092\u3055\u3089\u306b\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u307e\u305f\u3001\u672c\u7814\u7a76\u3067\u9ad8\u5168\u8eab\u6301\u4e45\u529b\u7fa4\u306b\u8a72\u5f53\u3057\u305f\u53c2\u52a0\u8005\u306e\u307b\u307c\u5168\u54e1\u304c\u3001\u300c\u5065\u5eb7\u3065\u304f\u308a\u306e\u305f\u3081\u306e\u8eab\u4f53\u6d3b\u52d5\u30fb\u904b\u52d5\u30ac\u30a4\u30c9 2023\u300d\u3067\u793a\u3055\u308c\u305f\u65e5\u672c\u4eba\u306e\u5168\u8eab\u6301\u4e45\u529b\uff08\u6700\u9ad8\u9178\u7d20\u6442\u53d6\u91cf\uff09\u306e\u63a8\u5b9a\u6a19\u6e96\u5024\u3092\u4e0a\u56de\u3063\u3066\u3044\u305f\u3053\u3068\u304b\u3089\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306e\u6291\u5236\u3068\u3044\u3046\u70b9\u306b\u304a\u3044\u3066\u3082\u3053\u306e\u63a8\u5b9a\u6a19\u6e96\u5024\u304c\u59a5\u5f53\u306a\u5024\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u9ad8\u3044\u5168\u8eab\u6301\u4e45\u529b\u3092\u6709\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3001\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3001\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u9ad8\u8840\u5727\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u6291\u5236\u3055\u308c\u308b\u3068\u3044\u3046\u8a3c\u62e0\u306f\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u5168\u8eab\u6301\u4e45\u529b\u306b\u3088\u308b\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u6291\u5236\u52b9\u679c\u306e\u9650\u754c\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u304a\u3044\u3066\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3057\u3001\u5168\u8eab\u6301\u4e45\u529b\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u904b\u52d5\u7fd2\u6163\u3092\u8eab\u306b\u3064\u3051\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u304c\u518d\u8a8d\u8b58\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>\uff084\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u672c\u7814\u7a76\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3068\u5168\u8eab\u6301\u4e45\u529b\u3092\u540c\u3058\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u6e2c\u5b9a\u3059\u308b\u6a2a\u65ad\u7814\u7a76<sup>\u203b11<\/sup>\u3067\u3042\u308b\u305f\u3081\u3001\u5168\u8eab\u6301\u4e45\u529b\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u9006\u306e\u56e0\u679c\u95a2\u4fc2\u304c\u7814\u7a76\u7d50\u679c\u306b\u53cd\u6620\u3055\u308c\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u4eca\u5f8c\u306f\u7814\u7a76\u5bfe\u8c61\u8005\u3092\u9577\u671f\u306b\u6e21\u3063\u3066\u8ffd\u8de1\u3059\u308b\u30b3\u30db\u30fc\u30c8\u7814\u7a76<sup>\u203b12<\/sup>\u3092\u884c\u3044\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u6642\u70b9\u3067\u9ad8\u3044\u5168\u8eab\u6301\u4e45\u529b\u3092\u6709\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5c06\u6765\u306e\u907a\u4f1d\u7684\u306a\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u6291\u5236\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u76f8\u4e92\u4f5c\u7528\u306e\u89e3\u6790\u3092\u884c\u3046\u305f\u3081\u306e\u30b5\u30f3\u30d7\u30eb\u6570\u304c\u5341\u5206\u3067\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u3044\u304f\u3064\u304b\u306e\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\uff08\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306a\u3069\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u691c\u51fa\u3067\u304d\u306a\u304b\u3063\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u4eca\u5f8c\u306f\u3055\u3089\u306b\u30b5\u30f3\u30d7\u30eb\u6570\u3092\u5897\u3084\u3057\u3066\u7814\u7a76\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4>\uff085\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/h4>\n<p>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\u3000\u8c37\u6fa4 \u85ab\u5e73 \u51c6\u6559\u6388\uff09<br \/>\n\u672c\u7814\u7a76\u306b\u3088\u308a\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u304a\u3051\u308b\u5168\u8eab\u6301\u4e45\u529b\u306e\u91cd\u8981\u6027\u304c\u3001\u300c\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306e\u6291\u5236\u300d\u306e\u89b3\u70b9\u304b\u3089\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u907a\u4f1d\u7684\u306b\u300c\u4e2d\u6027\u8102\u80aa\u304c\u4e0a\u304c\u308a\u3084\u3059\u3044\u4eba\u300d\u3084\u300c\u592a\u308a\u3084\u3059\u3044\u4eba\u300d\u306f\u78ba\u304b\u306b\u5b58\u5728\u3057\u307e\u3059\u304c\u3001\u300c\u907a\u4f1d\u5b50\u304c\u60aa\u3044\u304b\u3089\u30fb\u30fb\u30fb\u300d\u3068\u8ae6\u3081\u305a\u3001\u5168\u8eab\u6301\u4e45\u529b\u5411\u4e0a\u306b\u53d6\u308a\u7d44\u3093\u3067\u307b\u3057\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff086\uff09\u7528\u8a9e\u89e3\u8aac<\/h4>\n<p><strong>\u203b1 \u5168\u8eab\u6301\u4e45\u529b<br \/>\n<\/strong>\u4f53\u529b\u306e\u69cb\u6210\u8981\u7d20\u306e\u4e00\u3064\u3067\u3001\u9577\u6642\u9593\u4e00\u5b9a\u306e\u5f37\u5ea6\u306e\u904b\u52d5\u3092\u7d9a\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u80fd\u529b\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><strong>\u203b2 \u76f8\u4e92\u4f5c\u7528<br \/>\n<\/strong>2\u3064\u4ee5\u4e0a\u306e\u8981\u56e0\u304c\u4e92\u3044\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u5408\u3046\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u904b\u52d5\u306b\u3088\u308b\u8840\u5727\u4f4e\u4e0b\u52b9\u679c\u3092\u8abf\u3079\u3001\u305d\u306e\u52b9\u679c\u306e\u5927\u304d\u3055\u304c\u55ab\u7159\u8005\u3068\u975e\u55ab\u7159\u8005\u3067\u7570\u306a\u308b\u5834\u5408\u3001\u904b\u52d5\u3068\u55ab\u7159\u3068\u306e\u9593\u306b\u76f8\u4e92\u4f5c\u7528\u304c\u3042\u308b\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n<p><strong>\u203b3 \u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphism\uff1aSNP\uff09<br \/>\n<\/strong>\u30b2\u30ce\u30e0\u306eDNA\u5869\u57fa\u914d\u5217\u306e\u500b\u4eba\u5dee\uff08\u591a\u578b\uff09\u306e\u3046\u3061\u3001\u4e00\u3064\u306e\u5869\u57fa\u304c\u4ed6\u306e\u5869\u57fa\u306b\u7f6e\u304d\u63db\u308f\u308b\u30bf\u30a4\u30d7\u306e\u591a\u578b\u3092\u6307\u3057\u307e\u3059\u3002SNP\u306f\u7d041000\u5869\u57fa\u306b1\u5869\u57fa\u7a0b\u5ea6\u5b58\u5728\u3057\u3001\u3053\u306e\u308f\u305a\u304b0.1%\u306eDNA\u5869\u57fa\u914d\u5217\u306e\u9055\u3044\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u306a\u500b\u6027\u304c\u751f\u307f\u51fa\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><strong>\u203b4 \u907a\u4f1d\u7684\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08genetic risk score\uff1aGRS)<br \/>\n<\/strong>\u3042\u308b\u5f62\u8cea\u3068\u95a2\u9023\u3059\u308bSNP\u3092\u8907\u6570\u5206\u6790\u3057\u3001\u305d\u308c\u3089\u306e\u5f71\u97ff\u3092\u70b9\u6570\u5316\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002\u30b9\u30b3\u30a2\u306e\u69cb\u7bc9\u306b\u7528\u3044\u308bSNP\u3092\u500b\u4eba\u6bce\u306b\u5206\u6790\u3057\u3001\u305d\u308c\u305e\u308c\u306eSNP\u306b\u304a\u3051\u308b\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u306e\u4fdd\u6709\u6570\u3092\u5408\u8a08\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30b9\u30b3\u30a2\u3092\u8a08\u7b97\u3057\u307e\u3059\u3002\u5404SNP\u306e\u5f71\u97ff\u306e\u5927\u304d\u3055\uff08\u52b9\u679c\u91cf\uff09\u306f\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u305f\u3081\u3001\u5148\u884c\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305fSNP\u306e\u52b9\u679c\u91cf\uff08\u30aa\u30c3\u30ba\u6bd4\u3084\u56de\u5e30\u4fc2\u6570\u306a\u3069\uff09\u3092\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u4fdd\u6709\u6570\u306b\u4e57\u3058\u308b\u3053\u3068\u3067\u91cd\u307f\u4ed8\u3051\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u203b5 \u591a\u56e0\u5b50\u907a\u4f1d\u5f62\u8cea<br \/>\n<\/strong>\u591a\u6570\u306e\u907a\u4f1d\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u5f62\u8cea\uff08\u751f\u7269\u306e\u5f62\u3084\u6027\u8cea\u306a\u3069\u306e\u7279\u5fb4\uff09\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><strong>\u203b6 \u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08polygenic risk score\uff1aPRS)<br \/>\n<\/strong>\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u5b58\u5728\u3059\u308b\u7121\u6570\u306eSNP\u304c\u76f8\u52a0\u7684\u306b\u5f62\u8cea\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u3044\u3046\u4eee\u8aac\uff08polygenic model\uff09\u306b\u57fa\u3065\u304d\u3001\u6570\u767e\u304b\u3089\u6570\u5341\u4e07\u306eSNP\u306e\u5f71\u97ff\u3092\u70b9\u6570\u5316\u3057\u3001\u75be\u60a3\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002\u30b9\u30b3\u30a2\u306e\u57fa\u672c\u7684\u306a\u8a08\u7b97\u65b9\u6cd5\u306fGRS\u3068\u540c\u3058\u3067\u3059\u304c\u3001\u30d9\u30a4\u30ba\u7d71\u8a08\u306b\u57fa\u3065\u304f\u624b\u6cd5\u306a\u3069\u3001\u69d8\u3005\u306a\u30b9\u30b3\u30a2\u306e\u8a08\u7b97\u65b9\u6cd5\u304c\u63d0\u6848\u3055\u308c\u3066\u3044\u307e\u3059\u3002SNP\u306e\u91cd\u307f\u4ed8\u3051\u306f\u3001PRS\u3092\u69cb\u7bc9\u3059\u308b\u96c6\u56e3\u3068\u306f\u7570\u306a\u308b\u96c6\u56e3\u3067\u884c\u308f\u308c\u305f\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\u306e\u8981\u7d04\u7d71\u8a08\u91cf\uff08\u5404SNP\u306e\u52b9\u679c\u91cf\u3092\u542b\u3080\uff09\u3092\u7528\u3044\u3066\u884c\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u203b7 <a href=\"https:\/\/wasedas-health-study.jp\/survey\/\" target=\"_blank\" rel=\"noopener\">WASEDA\u2019S Health Study<\/a><br \/>\n<\/strong>\u65e9\u7a32\u7530\u5927\u5b66\u6821\u53cb\uff08\u5352\u696d\u751f\uff09\u306e\u5143\u6c17\u3067\u9577\u751f\u304d\u306e\u79d8\u8a23\u3092\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\uff08\u904b\u52d5\u3084\u98df\u4e8b\u3001\u30b9\u30c8\u30ec\u30b9\u7b49\uff09\u306e\u89b3\u70b9\u304b\u3089\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u4e3b\u306a\u76ee\u7684\u3068\u3057\u305f\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3059\u300220\u5e74\u9593\u3068\u3044\u3046\u9577\u671f\u306b\u308f\u305f\u308b\u8ffd\u8de1\u8abf\u67fb\u3092\u901a\u3058\u3066\u3001\u6821\u53cb\u306e\u307f\u306a\u3089\u305a\u3001\u65e5\u672c\u56fd\u6c11\u306e\u4eca\u5f8c\u306e\u75be\u75c5\u4e88\u9632\u3084\u5bdd\u305f\u304d\u308a\u4e88\u9632\u3001\u30b9\u30c8\u30ec\u30b9\u5bfe\u7b56\u306b\u5f79\u7acb\u3064\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u793e\u4f1a\u306b\u63d0\u4f9b\u3057\u3066\u3044\u304f\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u203b8 \u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u30fb\u30b8\u30e3\u30d1\u30f3<br \/>\n<\/strong>\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u304f\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u306b\u5411\u3051\u30012003\u5e74\u306b\u6771\u4eac\u5927\u5b66\u533b\u79d1\u5b66\u7814\u7a76\u6240\u306b\u8a2d\u7f6e\u3055\u308c\u305f\u65e5\u672c\u6700\u5927\u306e\u75be\u60a3\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3067\u3059\u3002\u73fe\u5728\u3001\u7d0427\u4e07\u4eba\u306eDNA\u8a66\u6599\u3068\u81e8\u5e8a\u60c5\u5831\u3001\u7d0420\u4e07\u4eba\u306e\u8840\u6e05\u8a66\u6599\u304c\u4fdd\u7ba1\u3055\u308c\u3066\u304a\u308a\u3001\u53b3\u6b63\u306a\u5be9\u67fb\u3092\u7d4c\u3066\u3001\u30b2\u30ce\u30e0\u533b\u7642\u306e\u5b9f\u73fe\u3084\u65b0\u305f\u6cbb\u7642\u65b9\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3059\u7814\u7a76\u8005\u306b\u63d0\u4f9b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\u306e\u8981\u7d04\u7d71\u8a08\u91cf\u306a\u3069\u3001\u4e00\u90e8\u306e\u30c7\u30fc\u30bf\u306f\u975e\u5236\u9650\u516c\u958b\u3055\u308c\u3066\u304a\u308a\u3001\u5be9\u67fb\u306a\u3057\u3067\u8ab0\u3067\u3082\u5229\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><strong>\u203b9\u00a0\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790<br \/>\n<\/strong>\u30d2\u30c8\u30b2\u30ce\u30e0\u5168\u4f53\u3092\u30ab\u30d0\u30fc\u3059\u308b\u6570\u5341\u4e07\u301c\u6570\u767e\u4e07\u306eSNP\u3068\u75be\u60a3\u30fb\u5f62\u8cea\u3068\u306e\u95a2\u9023\u3092\u7db2\u7f85\u7684\u306b\u691c\u8a0e\u3059\u308b\u907a\u4f1d\u7d71\u8a08\u89e3\u6790\u624b\u6cd5\u3067\u3059\u3002<\/p>\n<p><strong>\u203b10 \u6700\u9ad8\u9178\u7d20\u6442\u53d6\u91cf<br \/>\n<\/strong>\u6f38\u5897\u904b\u52d5\u8ca0\u8377\u8a66\u9a13\u306b\u3088\u308a\u5f97\u3089\u308c\u305f\u9178\u7d20\u6442\u53d6\u91cf\u306e\u6700\u9ad8\u5024\u306e\u3053\u3068\u3067\u3059\u3002\u4f53\u91cd1kg\u3042\u305f\u308a\u306e\u6700\u9ad8\u9178\u7d20\u6442\u53d6\u91cf\u306f\u5168\u8eab\u6301\u4e45\u529b\u306e\u6307\u6a19\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><strong>\u203b11\u3000\u6a2a\u65ad\u7814\u7a76<br \/>\n<\/strong>\u3042\u308b\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u5065\u5eb7\u72b6\u614b\u3084\u75be\u60a3\u306e\u6709\u7121\u3068\u305d\u306e\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u308b\u8981\u56e0\u3092\u540c\u6642\u306b\u6e2c\u5b9a\u3057\u3001\u305d\u308c\u3089\u306e\u95a2\u9023\u6027\u3092\u8abf\u3079\u308b\u7814\u7a76\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><strong>\u203b12\u3000\u30b3\u30db\u30fc\u30c8\u7814\u7a76<br \/>\n<\/strong>\u75be\u60a3\u306e\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u308b\u8981\u56e0\u3092\u6301\u3064\u96c6\u56e3\u3068\u6301\u305f\u306a\u3044\u96c6\u56e3\u3092\u4e00\u5b9a\u671f\u9593\u8ffd\u8de1\u3057\u3001\u75be\u60a3\u306e\u7f79\u60a3\u7387\u3084\u6b7b\u4ea1\u7387\u306a\u3069\u3092\u6bd4\u8f03\u3059\u308b\u7814\u7a76\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4><strong>\uff087\uff09\u8ad6\u6587\u60c5\u5831<\/strong><\/h4>\n<p>\u96d1\u8a8c\u540d\uff1aMedicine &amp; Science in Sports &amp; Exercise<br \/>\n\u8ad6\u6587\u540d\uff1aPolygenic risk score, cardiorespiratory fitness, and cardiometabolic risk factors: WASEDA\u2019S Health Study<br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001823_ja.html\" target=\"_blank\" rel=\"noopener\">\u8c37\u6fa4 \u85ab\u5e73<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\uff09<br \/>\n\u7530\u7aef \u5b8f\u6a39\uff08\u9806\u5929\u5802\u5927\u5b66\u30b9\u30dd\u30fc\u30c8\u30ed\u30b8\u30fc\u30bb\u30f3\u30bf\u30fc\u3001\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100003031_ja.html\" target=\"_blank\" rel=\"noopener\">\u4e2d\u6751 \u5ba3\u535a<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\uff09<br \/>\n\u5ddd\u4e0a \u8ad2\u5b50\uff08\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u660e\u6cbb\u5b89\u7530\u539a\u751f\u4e8b\u696d\u56e3\u4f53\u529b\u533b\u5b66\u7814\u7a76\u6240\u3001\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09<br \/>\n\u8584\u4e95 \u6f84\u8a89\u5b50\uff08\u4e0a\u667a\u5927\u5b66\u57fa\u76e4\u6559\u80b2\u30bb\u30f3\u30bf\u30fc\u3001\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09<br \/>\n\u4f0a\u85e4 \u667a\u5b50\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09<br \/>\n\u6cb3\u6751 \u62d3\u53f2\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000184_ja.html\" target=\"_blank\" rel=\"noopener\">\u9ce5\u5c45 \u4fca<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001046_ja.html\" target=\"_blank\" rel=\"noopener\">\u77f3\u4e95 \u9999\u7e54<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000190_ja.html\" target=\"_blank\" rel=\"noopener\">\u6751\u5ca1 \u529f<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u540d\u8a89\u6559\u6388\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000637_ja.html\" target=\"_blank\" rel=\"noopener\">\u9234\u6728 \u514b\u5f66<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000649_ja.html\" target=\"_blank\" rel=\"noopener\">\u5742\u672c \u9759\u7537<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u540d\u8a89\u6559\u6388\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100002704_ja.html\" target=\"_blank\" rel=\"noopener\">\u6a0b\u53e3 \u6e80<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u540d\u8a89\u6559\u6388\uff09<br \/>\n<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100000055_ja.html\" target=\"_blank\" rel=\"noopener\">\u5ca1 \u6d69\u4e00\u6717<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\uff09<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u73fe\u5730\u6642\u9593\uff09\uff1a2024\u5e745\u670820\u65e5<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u65e5\u672c\u6642\u9593\uff09\uff1a2024\u5e745\u670821\u65e5<br \/>\n\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\uff09<br \/>\n\u63b2\u8f09URL: <a href=\"https:\/\/journals.lww.com\/acsm-msse\/abstract\/9900\/polygenic_risk_score,_cardiorespiratory_fitness,.539.aspx\" target=\"_blank\" rel=\"noopener\">https:\/\/journals.lww.com\/acsm-msse\/abstract\/9900\/polygenic_risk_score,_cardiorespiratory_fitness,.539.aspx<\/a><br \/>\nDOI: <a href=\"https:\/\/doi.org\/10.1249\/MSS.0000000000003477\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1249\/MSS.0000000000003477<\/a><\/p>\n<h4>\uff088\uff09\u7814\u7a76\u52a9\u6210<\/h4>\n<p>\u7814\u7a76\u8cbb\u540d\uff1a\u79c1\u7acb\u5927\u5b66\u6226\u7565\u7684\u7814\u7a76\u57fa\u76e4\u5f62\u6210\u652f\u63f4\u4e8b\u696d<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u56fd\u6c11\u306e\u8eab\u4f53\u6d3b\u52d5\u4e0d\u8db3\u89e3\u6d88\u3092\u5177\u73fe\u5316\u3059\u308b\u305f\u3081\u306e\u5065\u5eb7\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u7814\u7a76\u306e\u57fa\u76e4\u5f62\u6210<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u5ca1 \u6d69\u4e00\u6717\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5168\u8eab\u6301\u4e45\u529b\u5411\u4e0a\u3078\u306e\u53d6\u308a\u7d44\u307f\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u52b9\u679c \u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8 \u80a5\u6e80\u3001\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\uff08\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3001\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3001\u4f4eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff09\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001\u6570\u5341\u4e07\u306e\u4e00\u5869 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":77595,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[67,145,60,178],"class_list":["post-77567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-sports","tag-pressrelease","tag-health","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/77567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=77567"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/77567\/revisions"}],"predecessor-version":[{"id":77596,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/77567\/revisions\/77596"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/77595"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=77567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=77567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=77567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}